Daniela Barillà
@danielabarilla.bsky.social
Microbial geneticist interested in large and small DNA 🧬 rings in bacteria and archaea.
Living in Brontë country and based at the University of Old York.
https://barillalabyork.weebly.com/
Living in Brontë country and based at the University of Old York.
https://barillalabyork.weebly.com/
Pinned
And the story is published now!🍾
www.nature.com/articles/s41...
Open access link: rdcu.be/exnOc
Many years in the making, great collaboration with @archaellum.bsky.social & @tunglejic.bsky.social
Thanks @ukri.org BBSRC & @leverhulme.ac.uk for funding, reviewers & editor!! 🙏
#microsky #archaeasky
www.nature.com/articles/s41...
Open access link: rdcu.be/exnOc
Many years in the making, great collaboration with @archaellum.bsky.social & @tunglejic.bsky.social
Thanks @ukri.org BBSRC & @leverhulme.ac.uk for funding, reviewers & editor!! 🙏
#microsky #archaeasky
Reposted by Daniela Barillà
Finally, we’ve solved a long-standing mystery: what tintinnid shells are actually made of:
A new class of biomaterial formed by remarkable structural proteins unique to tintinnids.
A major milestone after 3 years of work! Read about it in our preprint: doi.org/10.64898/202...
#ProtistsOnSky
A new class of biomaterial formed by remarkable structural proteins unique to tintinnids.
A major milestone after 3 years of work! Read about it in our preprint: doi.org/10.64898/202...
#ProtistsOnSky
December 27, 2025 at 10:30 AM
Finally, we’ve solved a long-standing mystery: what tintinnid shells are actually made of:
A new class of biomaterial formed by remarkable structural proteins unique to tintinnids.
A major milestone after 3 years of work! Read about it in our preprint: doi.org/10.64898/202...
#ProtistsOnSky
A new class of biomaterial formed by remarkable structural proteins unique to tintinnids.
A major milestone after 3 years of work! Read about it in our preprint: doi.org/10.64898/202...
#ProtistsOnSky
Reposted by Daniela Barillà
Il centro esatto del Mediterraneo è collocato nella città di Reggio Calabria, Rhèghion (ΡΗΓΙΩΝ), toponimo originario di radice Italica pre-ellenica che significa "Città del Re", mantenuto anche come polis della Magna Grecia.
#Calabria #storia #beauty #ancient #History #city #Map
#Calabria #storia #beauty #ancient #History #city #Map
December 27, 2025 at 4:39 PM
Reposted by Daniela Barillà
Multiplex mapping of protein–protein interaction interfaces | PNAS https://www.pnas.org/doi/10.1073/pnas.2425774122
Multiplex mapping of protein–protein interaction interfaces | PNAS
We describe peptide mapping through Split Antibiotic Resistance Complementation (SpARC-map), a method to identify the probable interface between tw...
www.pnas.org
December 26, 2025 at 11:17 AM
Multiplex mapping of protein–protein interaction interfaces | PNAS https://www.pnas.org/doi/10.1073/pnas.2425774122
Reposted by Daniela Barillà
Borghi più belli d'#Italia, inseguiamo la bellezza della #Calabria, questa è Rocca Imperiale (CS)❤️ che dall'alto della sua rupe domina la pianura costiera e le vie verso la Puglia.
Cittadina fondata per volere dell'Imperatore Federico II nel 1238.
#arte #beauty #heritage #art
Cittadina fondata per volere dell'Imperatore Federico II nel 1238.
#arte #beauty #heritage #art
December 26, 2025 at 10:26 AM
Reposted by Daniela Barillà
Alone at Christmas? #joinin is always good.
December 23, 2025 at 2:46 PM
Alone at Christmas? #joinin is always good.
Reposted by Daniela Barillà
Astronomical #winter starts today. It's the shortest day of the year in terms of daylight with the sun starting to set later each day until Summer Solstice.
The mosaic depicts the dancing Genii (protective spirits) of the four seasons. The Genius of winter is wrapped in a heavy cloak.🧵1/2
#Solstice
The mosaic depicts the dancing Genii (protective spirits) of the four seasons. The Genius of winter is wrapped in a heavy cloak.🧵1/2
#Solstice
December 21, 2025 at 8:06 AM
Reposted by Daniela Barillà
I wanted to finish this before year's end & I did. 😁
I LOVED it.
Such a pleasure to read, information-rich, fascinating but accessible. 🎁🎅
Air-Borne by Carl Zimmer
www.scientificamerican.com/article/book...
@carlzimmer.com
Plant pathogens covered as well as human 💚
Even Norman Bourlag!
I LOVED it.
Such a pleasure to read, information-rich, fascinating but accessible. 🎁🎅
Air-Borne by Carl Zimmer
www.scientificamerican.com/article/book...
@carlzimmer.com
Plant pathogens covered as well as human 💚
Even Norman Bourlag!
December 20, 2025 at 1:46 PM
I wanted to finish this before year's end & I did. 😁
I LOVED it.
Such a pleasure to read, information-rich, fascinating but accessible. 🎁🎅
Air-Borne by Carl Zimmer
www.scientificamerican.com/article/book...
@carlzimmer.com
Plant pathogens covered as well as human 💚
Even Norman Bourlag!
I LOVED it.
Such a pleasure to read, information-rich, fascinating but accessible. 🎁🎅
Air-Borne by Carl Zimmer
www.scientificamerican.com/article/book...
@carlzimmer.com
Plant pathogens covered as well as human 💚
Even Norman Bourlag!
Reposted by Daniela Barillà
Reposted by Daniela Barillà
"..based on a common wavefront design that can be adapted to support a variety of dynamic programming algorithms: local, global, and semi-global alignment of genomic and protein sequences with a variety of commonly used scoring schemes" from
@martinsteinegger.bsky.social andco
@martinsteinegger.bsky.social andco
Accelign: a GPU-based Library for Accelerating Pairwise Sequence Alignment https://www.biorxiv.org/content/10.64898/2025.12.17.694868v1
December 20, 2025 at 11:05 AM
"..based on a common wavefront design that can be adapted to support a variety of dynamic programming algorithms: local, global, and semi-global alignment of genomic and protein sequences with a variety of commonly used scoring schemes" from
@martinsteinegger.bsky.social andco
@martinsteinegger.bsky.social andco
Reposted by Daniela Barillà
The discovery of organisms that have been alive for many thousands of years requires a revolution in how we understand life. An Essay by @karenlloyd.bsky.social
The discovery of aeonophiles expands our definition of life | Aeon Essays
The discovery of organisms that have been alive for many thousands of years requires a revolution in how we understand life
aeon.co
December 18, 2025 at 11:05 PM
The discovery of organisms that have been alive for many thousands of years requires a revolution in how we understand life. An Essay by @karenlloyd.bsky.social
Reposted by Daniela Barillà
December 19, 2025 at 10:31 AM
Reposted by Daniela Barillà
Thrilled to share that my first-author paper is now published in Nature Communications! 🎉 Huge thanks to my PI, Dr. Drew Bridges (@bridgesbio.bsky.social), my collaborators, and all the incredible lab members for their support throughout this project
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A small periplasmic protein governs broad physiological adaptations in Vibrio cholerae via regulation of the DbfRS two-component system - Nature Communications
A two-component system, DbfRS, regulates biofilm formation in Vibrio cholerae. Here, Nguyen et al. identify a small periplasmic protein that controls the activity of the system’s receptor, and show th...
www.nature.com
December 19, 2025 at 4:34 PM
Thrilled to share that my first-author paper is now published in Nature Communications! 🎉 Huge thanks to my PI, Dr. Drew Bridges (@bridgesbio.bsky.social), my collaborators, and all the incredible lab members for their support throughout this project
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Daniela Barillà
Excellent news for the end of the year!
Our project on past and present bacteria with @jmuurine.bsky.social and great collaborators got funded.
We will be looking for a postdoc for 2026-27 with expertise in bacterial genomics and/or molecular dating methods.
If interested, DM me.
Please share.
Our project on past and present bacteria with @jmuurine.bsky.social and great collaborators got funded.
We will be looking for a postdoc for 2026-27 with expertise in bacterial genomics and/or molecular dating methods.
If interested, DM me.
Please share.
December 19, 2025 at 6:29 PM
Excellent news for the end of the year!
Our project on past and present bacteria with @jmuurine.bsky.social and great collaborators got funded.
We will be looking for a postdoc for 2026-27 with expertise in bacterial genomics and/or molecular dating methods.
If interested, DM me.
Please share.
Our project on past and present bacteria with @jmuurine.bsky.social and great collaborators got funded.
We will be looking for a postdoc for 2026-27 with expertise in bacterial genomics and/or molecular dating methods.
If interested, DM me.
Please share.
Reposted by Daniela Barillà
What is better than one? Two connected papers!
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
December 19, 2025 at 2:06 PM
What is better than one? Two connected papers!
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
Reposted by Daniela Barillà
Now part of the University of York campus, Heslington Hall is a Grade II listed manor house dating from 1565–8, It was largely rebuilt between 1852-4. It was constructed for Sir Thomas Eynns, the Secretary and Keeper of the Seal to the Council of the North; and his wife Elizabeth.
December 19, 2025 at 7:27 AM
Now part of the University of York campus, Heslington Hall is a Grade II listed manor house dating from 1565–8, It was largely rebuilt between 1852-4. It was constructed for Sir Thomas Eynns, the Secretary and Keeper of the Seal to the Council of the North; and his wife Elizabeth.
Reposted by Daniela Barillà
Good morning from York and its majestic sky!
December 17, 2025 at 8:12 AM
Good morning from York and its majestic sky!
Reposted by Daniela Barillà
Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
December 13, 2025 at 7:00 AM
Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
Reposted by Daniela Barillà
Happy to share that our work on HLp, a bacterial histone from Leptospira perolatii, is now published in Nature Communications 🎉
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
December 13, 2025 at 8:09 AM
Happy to share that our work on HLp, a bacterial histone from Leptospira perolatii, is now published in Nature Communications 🎉
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.
www.nature.com/articles/s41...
Reposted by Daniela Barillà
We've come full circle! I began my postdoctoral career by identifying the peptidyl deformylase gene. Today, we show that half of bacterial species harbor multiple PDF genes (up to 7, for always a single Met-tRNA transformylase), and while the role of these PDFs ... academic.oup.com/mbe/article/...
Unraveling the Prevalence and Multifaceted Roles of Accessory Peptide Deformylases in Bacterial Adaptation and Resistance
Abstract. Peptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despit
academic.oup.com
December 12, 2025 at 8:57 AM
We've come full circle! I began my postdoctoral career by identifying the peptidyl deformylase gene. Today, we show that half of bacterial species harbor multiple PDF genes (up to 7, for always a single Met-tRNA transformylase), and while the role of these PDFs ... academic.oup.com/mbe/article/...
Reposted by Daniela Barillà
My first feature for @sciencenews.bsky.social:
The saga of the Asgard archaea: single-celled organisms found living in the seabed, which could explain the origin of all animals and plants.
https://www.sciencenews.org/article/cells-origin-of-life-asgard-archaea
The saga of the Asgard archaea: single-celled organisms found living in the seabed, which could explain the origin of all animals and plants.
https://www.sciencenews.org/article/cells-origin-of-life-asgard-archaea
December 12, 2025 at 6:11 PM
My first feature for @sciencenews.bsky.social:
The saga of the Asgard archaea: single-celled organisms found living in the seabed, which could explain the origin of all animals and plants.
https://www.sciencenews.org/article/cells-origin-of-life-asgard-archaea
The saga of the Asgard archaea: single-celled organisms found living in the seabed, which could explain the origin of all animals and plants.
https://www.sciencenews.org/article/cells-origin-of-life-asgard-archaea
Reposted by Daniela Barillà
Leaders at @ukri.org should be seriously looking at the lottery first idea. 68% lower economic costs, increase in diversity of award holders and well received.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lottery before peer review is associated with increased female representation and reduced estimated economic cost in a German funding line - Nature Communications
The authors show evidence from a German funding line that a lottery-first approach followed by peer review is accompanied by increased female representation both at the submission stage and among fund...
www.nature.com
December 11, 2025 at 4:01 PM
Leaders at @ukri.org should be seriously looking at the lottery first idea. 68% lower economic costs, increase in diversity of award holders and well received.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Daniela Barillà
Delighted to share our new preprint: www.biorxiv.org/content/10.6...
We address a longstanding question about the role of the topoisomerase reverse gyrase in hyperthermophiles. Great collaboration with Baranello and @tobiaswarnecke.bsky.social groups. #Archaeasky #Microsky
We address a longstanding question about the role of the topoisomerase reverse gyrase in hyperthermophiles. Great collaboration with Baranello and @tobiaswarnecke.bsky.social groups. #Archaeasky #Microsky
Localised activity of reverse gyrase at gene regulatory elements
DNA topoisomerases are essential enzymes found in all cells, where they regulate DNA supercoiling. Reverse gyrase (RG) is a unique type of topoisomerase that introduces positive supercoils into DNA an...
www.biorxiv.org
December 11, 2025 at 1:15 PM
Delighted to share our new preprint: www.biorxiv.org/content/10.6...
We address a longstanding question about the role of the topoisomerase reverse gyrase in hyperthermophiles. Great collaboration with Baranello and @tobiaswarnecke.bsky.social groups. #Archaeasky #Microsky
We address a longstanding question about the role of the topoisomerase reverse gyrase in hyperthermophiles. Great collaboration with Baranello and @tobiaswarnecke.bsky.social groups. #Archaeasky #Microsky
Reposted by Daniela Barillà
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems https://www.biorxiv.org/content/10.64898/2025.12.10.693275v1
December 11, 2025 at 5:16 AM
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems https://www.biorxiv.org/content/10.64898/2025.12.10.693275v1