Jay Hinton
@jayhinton.bsky.social
Salmonella admirer & Prof of Microbiology - Working on Salmonella bloodstream infections (iNTS) in sub- Saharan Africa context. Functional genomics. T1D.
Reposted by Jay Hinton
#NewResearch
Diverse genomes of lytic phages are found in bacterial assemblies, challenging assumptions about the nature of the lytic lifestyle.
#MicroSky 🦠
www.nature.com/articles/s41...
Diverse genomes of lytic phages are found in bacterial assemblies, challenging assumptions about the nature of the lytic lifestyle.
#MicroSky 🦠
www.nature.com/articles/s41...
Large-scale analysis of bacterial genomes reveals thousands of lytic phages - Nature Microbiology
Diverse genomes of lytic phages are found in bacterial assemblies, challenging assumptions about the nature of the lytic lifestyle.
www.nature.com
January 2, 2026 at 2:06 PM
#NewResearch
Diverse genomes of lytic phages are found in bacterial assemblies, challenging assumptions about the nature of the lytic lifestyle.
#MicroSky 🦠
www.nature.com/articles/s41...
Diverse genomes of lytic phages are found in bacterial assemblies, challenging assumptions about the nature of the lytic lifestyle.
#MicroSky 🦠
www.nature.com/articles/s41...
Reposted by Jay Hinton
#NewResearch
The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical phage lifestyles.
#MicroSky 🦠 @peterdoug.bsky.social @emggroupucph.bsky.social
www.nature.com/articles/s41...
The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical phage lifestyles.
#MicroSky 🦠 @peterdoug.bsky.social @emggroupucph.bsky.social
www.nature.com/articles/s41...
Persistent virulent phages exist across bacterial isolates - Nature Microbiology
The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical phage lifestyles.
www.nature.com
January 2, 2026 at 2:05 PM
#NewResearch
The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical phage lifestyles.
#MicroSky 🦠 @peterdoug.bsky.social @emggroupucph.bsky.social
www.nature.com/articles/s41...
The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical phage lifestyles.
#MicroSky 🦠 @peterdoug.bsky.social @emggroupucph.bsky.social
www.nature.com/articles/s41...
Reposted by Jay Hinton
Friday we lost a brilliant mind, colleague, and friend to her battle with pancreatic cancer. Those who knew her will remember Helene Andrews-Polymenis for her warmth, generosity and leadership. She will be missed by many. RIP
December 23, 2025 at 8:36 AM
Friday we lost a brilliant mind, colleague, and friend to her battle with pancreatic cancer. Those who knew her will remember Helene Andrews-Polymenis for her warmth, generosity and leadership. She will be missed by many. RIP
Reposted by Jay Hinton
Our recent paper in npj Antimicrobials and Resistance is a great example of scientific serendipity: after staring at thousands of bacterial growth curves over many studies, we started wondering whether the curve shapes themselves carry mechanistic information 1/9 🦠🧪
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Predicting drug inactivation by changes in bacterial growth dynamics - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Predicting drug inactivation by changes in bacterial growth dynamics
www.nature.com
December 22, 2025 at 3:25 PM
Our recent paper in npj Antimicrobials and Resistance is a great example of scientific serendipity: after staring at thousands of bacterial growth curves over many studies, we started wondering whether the curve shapes themselves carry mechanistic information 1/9 🦠🧪
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by Jay Hinton
#microsky #phagesky
The 3rd (? Lost track!) manuscript on a CRISPR/anti-CRISPR -based transposon tool to study gene essentiality in #phages
www.biorxiv.org/content/10.6...
The 3rd (? Lost track!) manuscript on a CRISPR/anti-CRISPR -based transposon tool to study gene essentiality in #phages
www.biorxiv.org/content/10.6...
High-throughput transposon mutagenesis defines the essential genome of diverse phages
Phages are important drivers of bacterial evolution with therapeutic potential as antimicrobials. However, gaps in our understanding of phages and our inability to rapidly engineer them with new genet...
www.biorxiv.org
December 21, 2025 at 5:01 AM
#microsky #phagesky
The 3rd (? Lost track!) manuscript on a CRISPR/anti-CRISPR -based transposon tool to study gene essentiality in #phages
www.biorxiv.org/content/10.6...
The 3rd (? Lost track!) manuscript on a CRISPR/anti-CRISPR -based transposon tool to study gene essentiality in #phages
www.biorxiv.org/content/10.6...
Reposted by Jay Hinton
The final form of my 2nd postdoc paper with the Bassler Lab! Turns out our favorite quorum-sensing phage isn’t a one-off, but rather a member of a globally dispersed family of phages that sense a universal autoinducer.
#phagesky #microsky
journals.asm.org/doi/10.1128/...
#phagesky #microsky
journals.asm.org/doi/10.1128/...
A family of linear plasmid phages that detect a quorum-sensing autoinducer exists in multiple bacterial species | mBio
The discovery of quorum-sensing responsive linear plasmid phages has transformed understanding
of phage-bacterial interactions by demonstrating inter-domain chemical communication.
To date, however, e...
journals.asm.org
December 21, 2025 at 4:19 PM
The final form of my 2nd postdoc paper with the Bassler Lab! Turns out our favorite quorum-sensing phage isn’t a one-off, but rather a member of a globally dispersed family of phages that sense a universal autoinducer.
#phagesky #microsky
journals.asm.org/doi/10.1128/...
#phagesky #microsky
journals.asm.org/doi/10.1128/...
Reposted by Jay Hinton
Thank you Shaopu_Wang and colleagues for highlighting our latest work in a nice N&V
www.cell.com/cell-metabol...
www.cell.com/cell/abstrac...
www.cell.com/cell-metabol...
www.cell.com/cell/abstrac...
Embracing the unknown: Proteomic insights into the human microbiome
Protein-level investigations into the human microbiome provide insights into active
microbial functions. Recently, Valdés-Mas et al. introduced a metagenome-informed
metaproteomics approach to functio...
www.cell.com
April 7, 2025 at 4:45 PM
Thank you Shaopu_Wang and colleagues for highlighting our latest work in a nice N&V
www.cell.com/cell-metabol...
www.cell.com/cell/abstrac...
www.cell.com/cell-metabol...
www.cell.com/cell/abstrac...
Reposted by Jay Hinton
#MachineLearning methods are used to predict #AntimicrobialResistance #AMR from genomic data. @lbarquist.bsky.social &co show that sampling biases driven by population structure severely undermine the accuracy of AMR prediction models even with large datasets @plosbiology.org 🧪 plos.io/4iZ0zXQ
December 17, 2025 at 5:35 PM
#MachineLearning methods are used to predict #AntimicrobialResistance #AMR from genomic data. @lbarquist.bsky.social &co show that sampling biases driven by population structure severely undermine the accuracy of AMR prediction models even with large datasets @plosbiology.org 🧪 plos.io/4iZ0zXQ
Reposted by Jay Hinton
🔔New Preprint🔔
Just posted on Access Microbiology (first time using this platform, seems great!) our work on looking for antimicrobial proteins in snake venom. This is work from the first bit of funding I received and the project (1/3)
www.microbiologyresearch.org/content/jour...
#MicroSky
Just posted on Access Microbiology (first time using this platform, seems great!) our work on looking for antimicrobial proteins in snake venom. This is work from the first bit of funding I received and the project (1/3)
www.microbiologyresearch.org/content/jour...
#MicroSky
An iterative fractionation approach to identify antimicrobial proteins in snake venom
Antimicrobial resistance (AMR) increasingly poses a significant global health challenge. New antimicrobials are desperately needed, driving the need to explore novel sources of natural products. Snake...
www.microbiologyresearch.org
December 10, 2025 at 3:19 PM
🔔New Preprint🔔
Just posted on Access Microbiology (first time using this platform, seems great!) our work on looking for antimicrobial proteins in snake venom. This is work from the first bit of funding I received and the project (1/3)
www.microbiologyresearch.org/content/jour...
#MicroSky
Just posted on Access Microbiology (first time using this platform, seems great!) our work on looking for antimicrobial proteins in snake venom. This is work from the first bit of funding I received and the project (1/3)
www.microbiologyresearch.org/content/jour...
#MicroSky
Reposted by Jay Hinton
New paper from the lab!
Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides.
A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides.
A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
December 9, 2025 at 10:33 AM
New paper from the lab!
Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides.
A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides.
A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
Reposted by Jay Hinton
Very interesting new protective response in live (!) neutrophils against bacterial infection:
Thrilled to share that neutrophils produce extra long fibrillar components named proteoglycofili or PGF. PGF are released by living neutrophils and do not contain DNA. They might look like NETs but are not NETs…
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Proteoglycofili are glycosaminoglycan-containing fibrillar components released by neutrophils to neutralize bacteria
Alternative to the formation of NETs, André et al. describe here that viable neutrophils
may release a fibrillar component named proteoglycofili or PGF upon stimulation. PGF
formation is associated wi...
www.cell.com
November 27, 2025 at 10:03 PM
Very interesting new protective response in live (!) neutrophils against bacterial infection:
Reposted by Jay Hinton
#ConsensusStatement
A new Consensus Statement presents the standards for technical reporting in environmental and host-associated microbiome studies (STREAMS) guidelines.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
A new Consensus Statement presents the standards for technical reporting in environmental and host-associated microbiome studies (STREAMS) guidelines.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
STREAMS guidelines: standards for technical reporting in environmental and host-associated microbiome studies - Nature Microbiology
This Consensus Statement presents the standards for technical reporting in environmental and host-associated microbiome studies (STREAMS) guidelines.
www.nature.com
December 3, 2025 at 5:09 PM
#ConsensusStatement
A new Consensus Statement presents the standards for technical reporting in environmental and host-associated microbiome studies (STREAMS) guidelines.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
A new Consensus Statement presents the standards for technical reporting in environmental and host-associated microbiome studies (STREAMS) guidelines.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Reposted by Jay Hinton
#microsky #phagesky #phge defence
Preprint from the @soreklab.bsky.social reporting a plethora of novel TIR-based immune signalling systems
www.biorxiv.org/content/10.6...
Preprint from the @soreklab.bsky.social reporting a plethora of novel TIR-based immune signalling systems
www.biorxiv.org/content/10.6...
Systematic discovery of TIR-based immune signaling systems in bacteria
Toll/interleukin-1 receptor (TIR) domains are important for immune signaling across humans, plants and bacteria. These domains were recently found to produce immune signaling molecules in plant immuni...
www.biorxiv.org
December 4, 2025 at 6:31 AM
#microsky #phagesky #phge defence
Preprint from the @soreklab.bsky.social reporting a plethora of novel TIR-based immune signalling systems
www.biorxiv.org/content/10.6...
Preprint from the @soreklab.bsky.social reporting a plethora of novel TIR-based immune signalling systems
www.biorxiv.org/content/10.6...
Congratulations to Dr Annis Newman ‼️
It was a pleasure to read Dr Newman’s PhD thesis - and then to spend this morning’s Viva discussing the elegant science she did in @drprernavohra.bsky.social’s group at @edinburgh-uni.bsky.social
It was a pleasure to read Dr Newman’s PhD thesis - and then to spend this morning’s Viva discussing the elegant science she did in @drprernavohra.bsky.social’s group at @edinburgh-uni.bsky.social
December 1, 2025 at 11:38 PM
Congratulations to Dr Annis Newman ‼️
It was a pleasure to read Dr Newman’s PhD thesis - and then to spend this morning’s Viva discussing the elegant science she did in @drprernavohra.bsky.social’s group at @edinburgh-uni.bsky.social
It was a pleasure to read Dr Newman’s PhD thesis - and then to spend this morning’s Viva discussing the elegant science she did in @drprernavohra.bsky.social’s group at @edinburgh-uni.bsky.social
Reposted by Jay Hinton
If you’re interested in solving bacterial mysteries, this PhD project is for you!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh on FindAPhD.com
PhD Project - Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
November 2, 2025 at 6:07 PM
If you’re interested in solving bacterial mysteries, this PhD project is for you!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Jay Hinton
Had such a great time with @jayhinton.bsky.social strolling around Liverpool, discussing science &life, visiting Hinton Lab & other microbiology labs at Liverpool
November 29, 2025 at 9:25 AM
Had such a great time with @jayhinton.bsky.social strolling around Liverpool, discussing science &life, visiting Hinton Lab & other microbiology labs at Liverpool
Reposted by Jay Hinton
Impact of Small RNA Sponges on Regulatory RNA Networks in Bacteria
#microsky
www.annualreviews.org/content/jour...
#microsky
www.annualreviews.org/content/jour...
Impact of Small RNA Sponges on Regulatory RNA Networks in Bacteria
Decades of research into the noncoding transcriptome have unveiled a complex, multilayered web of molecular interactions that govern gene expression, protein synthesis, and cellular function, challeng...
www.annualreviews.org
November 29, 2025 at 4:12 AM
Impact of Small RNA Sponges on Regulatory RNA Networks in Bacteria
#microsky
www.annualreviews.org/content/jour...
#microsky
www.annualreviews.org/content/jour...
Reposted by Jay Hinton
It’s not only medications—environmental chemicals can also inadvertently harm our gut microbes. Excited to have contributed a bit to this important study!
Our paper mapping the effects of hundreds of pesticides and industrial chemicals on gut bacteria is out in @natmicrobiol.nature.com today!
Turns out many such chemicals, although labelled as 'fungicides' or similar, can inadvertently inhibit friendly gut bacteria.
www.nature.com/articles/s41...
Turns out many such chemicals, although labelled as 'fungicides' or similar, can inadvertently inhibit friendly gut bacteria.
www.nature.com/articles/s41...
November 26, 2025 at 1:02 PM
It’s not only medications—environmental chemicals can also inadvertently harm our gut microbes. Excited to have contributed a bit to this important study!
Reposted by Jay Hinton
#microsky #phagesky #phage
Anyone who’s tried deleting prophages in the lab by HR knows the difficulties of the task. Here we have an example of how HR-mediated natural transformation might hit the same hurdle in a more native context.
academic.oup.com/mbe/article/...
Anyone who’s tried deleting prophages in the lab by HR knows the difficulties of the task. Here we have an example of how HR-mediated natural transformation might hit the same hurdle in a more native context.
academic.oup.com/mbe/article/...
Chromosomal Curing Drives an Arms Race Between Bacterial Transformation and Prophage
Abstract. Transformation occurs when bacteria import exogenous DNA via the competence machinery and integrate it into their genome through homologous recom
academic.oup.com
November 23, 2025 at 4:39 PM
#microsky #phagesky #phage
Anyone who’s tried deleting prophages in the lab by HR knows the difficulties of the task. Here we have an example of how HR-mediated natural transformation might hit the same hurdle in a more native context.
academic.oup.com/mbe/article/...
Anyone who’s tried deleting prophages in the lab by HR knows the difficulties of the task. Here we have an example of how HR-mediated natural transformation might hit the same hurdle in a more native context.
academic.oup.com/mbe/article/...
I took this photo in Dec 2024 - it explains my belief that sunsets are incredible at this time of year…
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
November 24, 2025 at 8:07 PM
I took this photo in Dec 2024 - it explains my belief that sunsets are incredible at this time of year…
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Reposted by Jay Hinton
if you are interested in a PhD in tuberculosis drug discovery, check out our opportunities 🧪🦠 #Tuberculosis lstm.ac/PhD
PhD opportunities
lstm.ac
November 24, 2025 at 3:18 PM
if you are interested in a PhD in tuberculosis drug discovery, check out our opportunities 🧪🦠 #Tuberculosis lstm.ac/PhD
The sunsets at this time of year are incredible.
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
November 23, 2025 at 4:22 PM
The sunsets at this time of year are incredible.
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Reposted by Jay Hinton
🚀New preprint from our lab!
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
November 20, 2025 at 6:52 PM
🚀New preprint from our lab!
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
Reposted by Jay Hinton
🧫🦠🌍🧬
Alexander Harms group just made TnSeq possible for phages, enabling the possibility to infer functions over different hosts and conditions.
This will revolutionise our toolbox to understand not only phage physiology, but also ecological plasticity!
Congrats @aharms485.bsky.social!
Alexander Harms group just made TnSeq possible for phages, enabling the possibility to infer functions over different hosts and conditions.
This will revolutionise our toolbox to understand not only phage physiology, but also ecological plasticity!
Congrats @aharms485.bsky.social!
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
November 20, 2025 at 11:20 PM
🧫🦠🌍🧬
Alexander Harms group just made TnSeq possible for phages, enabling the possibility to infer functions over different hosts and conditions.
This will revolutionise our toolbox to understand not only phage physiology, but also ecological plasticity!
Congrats @aharms485.bsky.social!
Alexander Harms group just made TnSeq possible for phages, enabling the possibility to infer functions over different hosts and conditions.
This will revolutionise our toolbox to understand not only phage physiology, but also ecological plasticity!
Congrats @aharms485.bsky.social!