Jay Hinton
@jayhinton.bsky.social
Salmonella admirer & Prof of Microbiology - Working on Salmonella bloodstream infections (iNTS) in sub- Saharan Africa context. Functional genomics. T1D.
I took this photo in Dec 2024 - it explains my belief that sunsets are incredible at this time of year…
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
November 24, 2025 at 8:07 PM
I took this photo in Dec 2024 - it explains my belief that sunsets are incredible at this time of year…
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
The sunsets at this time of year are incredible.
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
November 23, 2025 at 4:22 PM
The sunsets at this time of year are incredible.
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
📈 Reported cases of non-typhoidal Salmonella in England rose by 17% — from 8,872 in 2023 to 10,388 in 2024.
Main culprits are S. Enteritidis (up 17%) and S. Typhimurium (up 15%), the most common reported serovars
www.gov.uk/government/p...
Main culprits are S. Enteritidis (up 17%) and S. Typhimurium (up 15%), the most common reported serovars
www.gov.uk/government/p...
October 7, 2025 at 5:27 AM
📈 Reported cases of non-typhoidal Salmonella in England rose by 17% — from 8,872 in 2023 to 10,388 in 2024.
Main culprits are S. Enteritidis (up 17%) and S. Typhimurium (up 15%), the most common reported serovars
www.gov.uk/government/p...
Main culprits are S. Enteritidis (up 17%) and S. Typhimurium (up 15%), the most common reported serovars
www.gov.uk/government/p...
January 23, 2025 at 10:56 PM
#sunset from Thurstaton beach, with timbers from a shipwreck in the foreground…
#wirral #merseyside #westkirby
#sky #photography #clouds #photooftheday #beach #picoftheday #photo #skyphotography
January 2, 2025 at 7:08 PM
#sunset from Thurstaton beach, with timbers from a shipwreck in the foreground…
#wirral #merseyside #westkirby
#sky #photography #clouds #photooftheday #beach #picoftheday #photo #skyphotography
Happy 2025❗️
#sunset from West Kirby, this time with a navigation marker as contrast…
#wirral #merseyside #westkirby
#sky #photography #clouds #photooftheday #beach #picoftheday #photo #skyphotography
#sunset from West Kirby, this time with a navigation marker as contrast…
#wirral #merseyside #westkirby
#sky #photography #clouds #photooftheday #beach #picoftheday #photo #skyphotography
January 1, 2025 at 1:18 PM
Happy 2025❗️
#sunset from West Kirby, this time with a navigation marker as contrast…
#wirral #merseyside #westkirby
#sky #photography #clouds #photooftheday #beach #picoftheday #photo #skyphotography
#sunset from West Kirby, this time with a navigation marker as contrast…
#wirral #merseyside #westkirby
#sky #photography #clouds #photooftheday #beach #picoftheday #photo #skyphotography
For New Year’s Eve, here’s last night’s #sunset from West Kirby.
I’m looking forward to all the 🌅 of 2025…
#wirral #merseyside #westkirby
I’m looking forward to all the 🌅 of 2025…
#wirral #merseyside #westkirby
December 31, 2024 at 11:21 PM
For New Year’s Eve, here’s last night’s #sunset from West Kirby.
I’m looking forward to all the 🌅 of 2025…
#wirral #merseyside #westkirby
I’m looking forward to all the 🌅 of 2025…
#wirral #merseyside #westkirby
Here is Christmas Day’s #sunset reflected in the West Kirby Marine Lake - looking towards North Wales…
#wirral #merseyside #westkirby #MirrorLake #NoFilters
#wirral #merseyside #westkirby #MirrorLake #NoFilters
December 31, 2024 at 9:42 AM
Here is Christmas Day’s #sunset reflected in the West Kirby Marine Lake - looking towards North Wales…
#wirral #merseyside #westkirby #MirrorLake #NoFilters
#wirral #merseyside #westkirby #MirrorLake #NoFilters
For the holiday period, I’ll post some sunset photos I’ve taken in West Kirby on the Wirral peninsula in the UK.
Here’s one from tonight ❗️
#wirral #merseyside #westkirby
Here’s one from tonight ❗️
#wirral #merseyside #westkirby
December 30, 2024 at 7:52 PM
For the holiday period, I’ll post some sunset photos I’ve taken in West Kirby on the Wirral peninsula in the UK.
Here’s one from tonight ❗️
#wirral #merseyside #westkirby
Here’s one from tonight ❗️
#wirral #merseyside #westkirby
November 30, 2024 at 11:29 AM
Incredible graphic - the myriad of ways that bacteria defend themselves against antibiotics.
14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell
www.sciencedirect.com/science/arti...
14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell
www.sciencedirect.com/science/arti...
November 13, 2024 at 12:46 PM
Incredible graphic - the myriad of ways that bacteria defend themselves against antibiotics.
14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell
www.sciencedirect.com/science/arti...
14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell
www.sciencedirect.com/science/arti...
12/ This couldn’t have been done without funding from @wellcometrust
Thanks to @BrianKCoombes & @DrRobKingsley for their comments which improved the paper...
& help from @MlwTrust @EarlhamInst
@LivUni_IVES @LivUni @livuninews
Thanks to @BrianKCoombes & @DrRobKingsley for their comments which improved the paper...
& help from @MlwTrust @EarlhamInst
@LivUni_IVES @LivUni @livuninews
December 31, 2024 at 11:16 AM
12/ This couldn’t have been done without funding from @wellcometrust
Thanks to @BrianKCoombes & @DrRobKingsley for their comments which improved the paper...
& help from @MlwTrust @EarlhamInst
@LivUni_IVES @LivUni @livuninews
Thanks to @BrianKCoombes & @DrRobKingsley for their comments which improved the paper...
& help from @MlwTrust @EarlhamInst
@LivUni_IVES @LivUni @livuninews
11/ This was an important collaboration between @MelitaGordon5, @nfeasey1, @RHeyderman @flashton2003 & scientists at @MlwTrust
Invaluable contributions by @APredeus & @knalsal + members of HintonLab including @KroegerLab @zxj931_zhu @1caiseypulford @NWenner @yan_salsa @implosian
Invaluable contributions by @APredeus & @knalsal + members of HintonLab including @KroegerLab @zxj931_zhu @1caiseypulford @NWenner @yan_salsa @implosian
December 31, 2024 at 11:10 AM
11/ This was an important collaboration between @MelitaGordon5, @nfeasey1, @RHeyderman @flashton2003 & scientists at @MlwTrust
Invaluable contributions by @APredeus & @knalsal + members of HintonLab including @KroegerLab @zxj931_zhu @1caiseypulford @NWenner @yan_salsa @implosian
Invaluable contributions by @APredeus & @knalsal + members of HintonLab including @KroegerLab @zxj931_zhu @1caiseypulford @NWenner @yan_salsa @implosian
8/ A series of pairwise fitness experiments by @zxj931_zhu showed the L2.2 strain to have a significant competitive advantage over L2.0 strain during mixed growth in minimal media
Has the increased fitness of L2.2 contributed to the replacement of ST313 L2.0 in Malawi ❓
Has the increased fitness of L2.2 contributed to the replacement of ST313 L2.0 in Malawi ❓
December 31, 2024 at 10:54 AM
8/ A series of pairwise fitness experiments by @zxj931_zhu showed the L2.2 strain to have a significant competitive advantage over L2.0 strain during mixed growth in minimal media
Has the increased fitness of L2.2 contributed to the replacement of ST313 L2.0 in Malawi ❓
Has the increased fitness of L2.2 contributed to the replacement of ST313 L2.0 in Malawi ❓
7/ Transcripts can be viewed in genomic context & directly compared with Typhimurium strains D23580 & 4/74 here: ...
December 31, 2024 at 10:43 AM
7/ Transcripts can be viewed in genomic context & directly compared with Typhimurium strains D23580 & 4/74 here: ...
6/ RNA-seq revealed transcriptional profile of L2.2 in multiple in vitro growth conditions & within murine macrophages
We announce SalComD37712, where all gene expression data can be interrogated: 👇...
We announce SalComD37712, where all gene expression data can be interrogated: 👇...
December 31, 2024 at 10:32 AM
6/ RNA-seq revealed transcriptional profile of L2.2 in multiple in vitro growth conditions & within murine macrophages
We announce SalComD37712, where all gene expression data can be interrogated: 👇...
We announce SalComD37712, where all gene expression data can be interrogated: 👇...
5/ In terms of accessory genome, L2.2 and L2.0 share the same prophages, including BTP1 & BTP5
L2.2 lacks the pBT1 & pBT2 plasmids
L2.2 lacks the pBT1 & pBT2 plasmids
December 31, 2024 at 10:27 AM
5/ In terms of accessory genome, L2.2 and L2.0 share the same prophages, including BTP1 & BTP5
L2.2 lacks the pBT1 & pBT2 plasmids
L2.2 lacks the pBT1 & pBT2 plasmids
4/ Genomic comparison of L2.2 strain D37712 with L2.0 strain D23580 identified 26 chromosomal SNP differences
The sseI gene is absent: L2.2 does not encode the SPI2-translocated SseI effector protein
Important pseudogenes include spvD, ratB, bcsG & lpxO. macB gene is functional
The sseI gene is absent: L2.2 does not encode the SPI2-translocated SseI effector protein
Important pseudogenes include spvD, ratB, bcsG & lpxO. macB gene is functional
December 31, 2024 at 10:22 AM
4/ Genomic comparison of L2.2 strain D37712 with L2.0 strain D23580 identified 26 chromosomal SNP differences
The sseI gene is absent: L2.2 does not encode the SPI2-translocated SseI effector protein
Important pseudogenes include spvD, ratB, bcsG & lpxO. macB gene is functional
The sseI gene is absent: L2.2 does not encode the SPI2-translocated SseI effector protein
Important pseudogenes include spvD, ratB, bcsG & lpxO. macB gene is functional
3/ Building on seminal papers from @DrRobKingsley @sandravanpuy and @1caiseypulford
Our study shows that ST313 lineage 2 has continued to evolve since 2008
New analysis of data from 10,000 Salmonella Genomes project #10KGSP, which was led by @BlancaPerSep & @neilhall_uk
Our study shows that ST313 lineage 2 has continued to evolve since 2008
New analysis of data from 10,000 Salmonella Genomes project #10KGSP, which was led by @BlancaPerSep & @neilhall_uk
December 31, 2024 at 10:16 AM
3/ Building on seminal papers from @DrRobKingsley @sandravanpuy and @1caiseypulford
Our study shows that ST313 lineage 2 has continued to evolve since 2008
New analysis of data from 10,000 Salmonella Genomes project #10KGSP, which was led by @BlancaPerSep & @neilhall_uk
Our study shows that ST313 lineage 2 has continued to evolve since 2008
New analysis of data from 10,000 Salmonella Genomes project #10KGSP, which was led by @BlancaPerSep & @neilhall_uk
2/ Salmonella Typhimurium ST313 lineage L2.2 first emerged in 2006, followed by L2.3 in 2008.
By 2018, L2.2 & L2.3 lineages were more frequently observed than L2.0 in Blantyre
@microLifeJrnl @MelitaGordon5...
By 2018, L2.2 & L2.3 lineages were more frequently observed than L2.0 in Blantyre
@microLifeJrnl @MelitaGordon5...
December 31, 2024 at 10:05 AM
2/ Salmonella Typhimurium ST313 lineage L2.2 first emerged in 2006, followed by L2.3 in 2008.
By 2018, L2.2 & L2.3 lineages were more frequently observed than L2.0 in Blantyre
@microLifeJrnl @MelitaGordon5...
By 2018, L2.2 & L2.3 lineages were more frequently observed than L2.0 in Blantyre
@microLifeJrnl @MelitaGordon5...
1/ Excited to announce our latest contribution to understanding genomic epidemiology of Salmonella Typhimurium ST313 #iNTS
Analysis of genomes of Salmonella bloodstream isolates from Blantyre, Malawi 1996-2018 identified two new ST313 sub-lineages: L2.2 & L2.3
@microLifeJrnl
Analysis of genomes of Salmonella bloodstream isolates from Blantyre, Malawi 1996-2018 identified two new ST313 sub-lineages: L2.2 & L2.3
@microLifeJrnl
December 31, 2024 at 9:59 AM
1/ Excited to announce our latest contribution to understanding genomic epidemiology of Salmonella Typhimurium ST313 #iNTS
Analysis of genomes of Salmonella bloodstream isolates from Blantyre, Malawi 1996-2018 identified two new ST313 sub-lineages: L2.2 & L2.3
@microLifeJrnl
Analysis of genomes of Salmonella bloodstream isolates from Blantyre, Malawi 1996-2018 identified two new ST313 sub-lineages: L2.2 & L2.3
@microLifeJrnl
The HintonLab SalCom transcriptomic databases are back on online TODAY❗️#Salmonella
SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack
SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack
February 24, 2024 at 10:38 PM
The HintonLab SalCom transcriptomic databases are back on online TODAY❗️#Salmonella
SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack
SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack
I’m liking this shiny app that gives you a word cloud based on your Google Scholar profile:
shiny.rcg.sfu.ca/u/rdmorin/sc...
#rstats #genomics #bioinformatics #Salmonella
shiny.rcg.sfu.ca/u/rdmorin/sc...
#rstats #genomics #bioinformatics #Salmonella
February 6, 2024 at 12:30 PM
I’m liking this shiny app that gives you a word cloud based on your Google Scholar profile:
shiny.rcg.sfu.ca/u/rdmorin/sc...
#rstats #genomics #bioinformatics #Salmonella
shiny.rcg.sfu.ca/u/rdmorin/sc...
#rstats #genomics #bioinformatics #Salmonella
This shiny app that gives you a word cloud based on your Google Scholar profile is pretty slick... https://shiny.rcg.sfu.ca/u/rdmorin/scholar_googler3/ #rstats #genomics #bioinformatics #Salmonella
December 31, 2024 at 9:59 AM
This shiny app that gives you a word cloud based on your Google Scholar profile is pretty slick... https://shiny.rcg.sfu.ca/u/rdmorin/scholar_googler3/ #rstats #genomics #bioinformatics #Salmonella
Benchmarking of computational predictions of antimicrobial resistance phenotypes
- from genomes of a variety of bacterial species
https://www.biorxiv.org/content/10.1101/2024.01.31.578169v1
- from genomes of a variety of bacterial species
https://www.biorxiv.org/content/10.1101/2024.01.31.578169v1
December 31, 2024 at 9:59 AM
Benchmarking of computational predictions of antimicrobial resistance phenotypes
- from genomes of a variety of bacterial species
https://www.biorxiv.org/content/10.1101/2024.01.31.578169v1
- from genomes of a variety of bacterial species
https://www.biorxiv.org/content/10.1101/2024.01.31.578169v1