Manuel Mendoza
@longchrom.bsky.social
Nuclear pore complexes and RNA export, Chromosomes and cytokinesis @igbmc.bsky.social Strasbourg. Who took the Bomp from the Bompalompalomp? Who took the Ram from the Ramalamading-dong? 🇻🇪 🇪🇸 🇫🇷
Pinned
Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
Our story on Srs2/PARI family DNA helicases linking chromatin bridges to the Aurora-B dependent NoCut checkpoint is now out in its peer-reviewed version. Thanks to @reviewcommons.org and @jcb.org for a smooth review process! Original preprint thread here: bsky.app/profile/long...
What a wonderful surprise this morning to see our work highlighted. Thanks @juanmartin-serrano.bsky.social and @jcb.org !
Spotlight: @juanmartin-serrano.bsky.social highlights work from Dam, Moreno, Brownlow, @longchrom.bsky.social et al. (rupress.org/jcb/article/...), which reveals how Srs2/PARI act as a missegregated chromatin sensor for NoCut, delaying cytokinetic abscission. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
November 13, 2025 at 11:32 AM
What a wonderful surprise this morning to see our work highlighted. Thanks @juanmartin-serrano.bsky.social and @jcb.org !
Reposted by Manuel Mendoza
Spotlight: @juanmartin-serrano.bsky.social highlights work from Dam, Moreno, Brownlow, @longchrom.bsky.social et al. (rupress.org/jcb/article/...), which reveals how Srs2/PARI act as a missegregated chromatin sensor for NoCut, delaying cytokinetic abscission. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
November 12, 2025 at 5:01 PM
Spotlight: @juanmartin-serrano.bsky.social highlights work from Dam, Moreno, Brownlow, @longchrom.bsky.social et al. (rupress.org/jcb/article/...), which reveals how Srs2/PARI act as a missegregated chromatin sensor for NoCut, delaying cytokinetic abscission. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
Reposted by Manuel Mendoza
it was a pleasure to write this spotlight article. Many questions remain about sensing of missegregated DNA by NoCut, but the @longchrom.bsky.social lab makes exciting progress. They put the helicases Srs2/PARI in the picture, suggesting new mechanisms for genome protection.
Spotlight: @juanmartin-serrano.bsky.social highlights work from Dam, Moreno, Brownlow, @longchrom.bsky.social et al. (rupress.org/jcb/article/...), which reveals how Srs2/PARI act as a missegregated chromatin sensor for NoCut, delaying cytokinetic abscission. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
November 13, 2025 at 6:15 AM
it was a pleasure to write this spotlight article. Many questions remain about sensing of missegregated DNA by NoCut, but the @longchrom.bsky.social lab makes exciting progress. They put the helicases Srs2/PARI in the picture, suggesting new mechanisms for genome protection.
Reposted by Manuel Mendoza
Interesting paper, although if I'm going to be nit-picky--SF3B1 does not have catalytic activity (it is a RNA binding protein/protein scaffold). In addition, potential non-splicing roles for SF3B1 have been found elsewhere, e.g.,in histone pre-mRNA maturation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
RNA splicing is required for timely completion of abscission and is modulated by the abscission checkpoint
The abscission checkpoint pauses the progression of cytokinetic abscission at the intercellular bridge when various checkpoint-sustaining errors are sensed. A unique cytoplasmic organelle, the absciss...
www.biorxiv.org
November 11, 2025 at 6:44 PM
Interesting paper, although if I'm going to be nit-picky--SF3B1 does not have catalytic activity (it is a RNA binding protein/protein scaffold). In addition, potential non-splicing roles for SF3B1 have been found elsewhere, e.g.,in histone pre-mRNA maturation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Manuel Mendoza
lol she got his ass and he knows it
November 9, 2025 at 3:36 PM
lol she got his ass and he knows it
Reposted by Manuel Mendoza
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 8, 2025 at 1:39 PM
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Reposted by Manuel Mendoza
just in time for the opening of the @hohmannulrich.bsky.social group at @imbmainz.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 7, 2025 at 6:03 PM
just in time for the opening of the @hohmannulrich.bsky.social group at @imbmainz.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
Reposted by Manuel Mendoza
Homeostasis! Membranes! Evolution! Yay
Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes https://www.biorxiv.org/content/10.1101/2025.11.06.686945v1
November 7, 2025 at 11:29 PM
Homeostasis! Membranes! Evolution! Yay
Reposted by Manuel Mendoza
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
November 8, 2025 at 6:02 AM
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
Reposted by Manuel Mendoza
Good argument here for not reducing childcare ratios.
economist.com/finance-and-...
economist.com/finance-and-...
Universal child care can hurt children
Its growing popularity in America is a concern
economist.com
November 8, 2025 at 7:48 AM
Good argument here for not reducing childcare ratios.
economist.com/finance-and-...
economist.com/finance-and-...
Reposted by Manuel Mendoza
Roles of Srs2/PARI-family DNA helicases in NoCut checkpoint signaling and abscission regulation. New study from Monica Dam, David F. Moreno, Nicola Brownlow, Manuel Mendoza (@longchrom.bsky.social) and colleagues @igbmc.bsky.social: rupress.org/jcb/article/...
#Genetics #CellDivision #Cytokinesis
#Genetics #CellDivision #Cytokinesis
November 7, 2025 at 2:45 PM
Roles of Srs2/PARI-family DNA helicases in NoCut checkpoint signaling and abscission regulation. New study from Monica Dam, David F. Moreno, Nicola Brownlow, Manuel Mendoza (@longchrom.bsky.social) and colleagues @igbmc.bsky.social: rupress.org/jcb/article/...
#Genetics #CellDivision #Cytokinesis
#Genetics #CellDivision #Cytokinesis
Reposted by Manuel Mendoza
The reaction to this is fascinating. It's like a microcosm of all discussions around AI: lots of enthusiasm, lots of loathing (much of it reflexive), and some wise 'let's maybe try it and see' responses.
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 7, 2025 at 1:43 PM
The reaction to this is fascinating. It's like a microcosm of all discussions around AI: lots of enthusiasm, lots of loathing (much of it reflexive), and some wise 'let's maybe try it and see' responses.
Reposted by Manuel Mendoza
Just read this great quote from one of my scientific heroes: Franklin Harold: ‘The way of science is for the best of our achievements to endure in substance but lose their individuality, like raindrops falling into a pond.’
November 7, 2025 at 10:38 AM
Just read this great quote from one of my scientific heroes: Franklin Harold: ‘The way of science is for the best of our achievements to endure in substance but lose their individuality, like raindrops falling into a pond.’
Reposted by Manuel Mendoza
Research briefings in @nature.com about our latest story on large genomic variations and trait diversity!
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Yeast genomes show how large genomic variations affect trait diversity
Structural variants have a disproportionately large effect on traits such as growth and gene expression.
www.nature.com
November 3, 2025 at 10:46 AM
Research briefings in @nature.com about our latest story on large genomic variations and trait diversity!
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Our story on Srs2/PARI family DNA helicases linking chromatin bridges to the Aurora-B dependent NoCut checkpoint is now out in its peer-reviewed version. Thanks to @reviewcommons.org and @jcb.org for a smooth review process! Original preprint thread here: bsky.app/profile/long...
Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
November 1, 2025 at 8:06 AM
Our story on Srs2/PARI family DNA helicases linking chromatin bridges to the Aurora-B dependent NoCut checkpoint is now out in its peer-reviewed version. Thanks to @reviewcommons.org and @jcb.org for a smooth review process! Original preprint thread here: bsky.app/profile/long...
Reposted by Manuel Mendoza
New in @jcb.org: Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
October 31, 2025 at 4:01 PM
New in @jcb.org: Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
Reposted by Manuel Mendoza
Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
October 31, 2025 at 4:02 PM
Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
Reposted by Manuel Mendoza
Reposted by Manuel Mendoza
C.S. Lewis responding to a letter from an American schoolgirl asking him for some writing advice.
(Worth reading? ✅️)
(Worth reading? ✅️)
October 24, 2025 at 8:19 PM
C.S. Lewis responding to a letter from an American schoolgirl asking him for some writing advice.
(Worth reading? ✅️)
(Worth reading? ✅️)
Reposted by Manuel Mendoza
we are witnessing a genuine decline in the taste of american elites
October 24, 2025 at 10:27 PM
we are witnessing a genuine decline in the taste of american elites
Reposted by Manuel Mendoza
What is the Times doing calling this extrajudicial murder spree “cartel strikes”? On what evidence do they ape the killers’ propaganda?
www.nytimes.com/2025/10/23/u...
www.nytimes.com/2025/10/23/u...
Trump Says He Will Not Seek Authorization for Cartel Strikes
www.nytimes.com
October 24, 2025 at 4:07 AM
What is the Times doing calling this extrajudicial murder spree “cartel strikes”? On what evidence do they ape the killers’ propaganda?
www.nytimes.com/2025/10/23/u...
www.nytimes.com/2025/10/23/u...
Reposted by Manuel Mendoza
I would like the leadership to address this someday. It would be nice 🧪
Success rates for Europe’s leading research grants are declining as a surge in applications far outweighs the funds available
go.nature.com/479Sni6
go.nature.com/479Sni6
Is academic research becoming too competitive? Nature examines the data
Applications for European research grants increased in 2025. Scientists say they’re feeling the competition.
go.nature.com
October 20, 2025 at 4:56 AM
I would like the leadership to address this someday. It would be nice 🧪
Reposted by Manuel Mendoza
A three-year PhD position is available within the team, starting no later than October 2026, to decipher the molecular signatures of chromosomal instability in response to replication stress and how nuclear architecture shapes these signatures in yeast. Please RT.
fr.scribd.com/document/934...
fr.scribd.com/document/934...
Offer PhD Position Team Lambert | PDF | Genetics | Life Sciences
3-year PhD offer in biology to mechanisms of complex rearrangements of the genome.
fr.scribd.com
October 19, 2025 at 7:32 PM
A three-year PhD position is available within the team, starting no later than October 2026, to decipher the molecular signatures of chromosomal instability in response to replication stress and how nuclear architecture shapes these signatures in yeast. Please RT.
fr.scribd.com/document/934...
fr.scribd.com/document/934...
Reposted by Manuel Mendoza
I think people adjacent to science (but who now find themselves deciding the fate of US science somehow) undervalue humility, valuing braggadocios hubris instead.
Yes it’s true that some scientific discoveries are complete paradigm changers, and we celebrate these. 1/
Yes it’s true that some scientific discoveries are complete paradigm changers, and we celebrate these. 1/
October 16, 2025 at 4:11 PM
I think people adjacent to science (but who now find themselves deciding the fate of US science somehow) undervalue humility, valuing braggadocios hubris instead.
Yes it’s true that some scientific discoveries are complete paradigm changers, and we celebrate these. 1/
Yes it’s true that some scientific discoveries are complete paradigm changers, and we celebrate these. 1/
Reposted by Manuel Mendoza
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)