Manuel Mendoza
@longchrom.bsky.social
Nuclear pore complexes and RNA export, Chromosomes and cytokinesis @igbmc.bsky.social Strasbourg. Who took the Bomp from the Bompalompalomp? Who took the Ram from the Ramalamading-dong? 🇻🇪 🇪🇸 🇫🇷
That's a brilliant story, reminds me of this
October 9, 2025 at 1:37 PM
That's a brilliant story, reminds me of this
Some studies suggest that the Earth is flat, but many experts are skeptical
September 22, 2025 at 12:26 PM
Some studies suggest that the Earth is flat, but many experts are skeptical
War is Peace. Freedom is Slavery. Ignorance is Strength.
June 24, 2025 at 5:39 AM
War is Peace. Freedom is Slavery. Ignorance is Strength.
david lynch once said “get me six singing black dancers, an Eurasian with a monkey on her shoulder, nastassja kinski, a lumberjack, and a beautiful one-legged girl” and someone actually delivered.
at least once in a lifetime may we all have LYNCH SUMMONING POWER
at least once in a lifetime may we all have LYNCH SUMMONING POWER
![From “Room to Dream” by David Lynch and Kristine McKenna, on the making of INLAND EMPIRE: "Part of my job was to make sure David could smoke at any location where we were shooting," said Alter.
"I had to find some unusual things, too, of course. One day he said, 'Jer-emy, get a piece of paper and a pen and write this down. I need six black dancers, including one that can sing, a blond Eurasian with a monkey on her shoulder, a lumberjack sawing wood, Nastassja Kinski, a tattooed person, [meditation instructor] Penny Bell, Dominic who's an ex-French Foreign Legionnaire, Laura Harring in her Mulholland Drive outfit, and a beautiful one-legged girl." Alter got it all.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5l5fzdwkjspjupsovzlldsvm/bafkreihgb2v4vyink6abuacpzz5f525h2mkb2jjy27xhvkwkyq75ircr6u@jpeg)
June 7, 2025 at 8:47 AM
david lynch once said “get me six singing black dancers, an Eurasian with a monkey on her shoulder, nastassja kinski, a lumberjack, and a beautiful one-legged girl” and someone actually delivered.
at least once in a lifetime may we all have LYNCH SUMMONING POWER
at least once in a lifetime may we all have LYNCH SUMMONING POWER
Almost 17 years after opening our yeast cell division lab, our first transcription paper in mouse embryonic stem cells! www.science.org/doi/10.1126/...
March 19, 2025 at 6:59 PM
Almost 17 years after opening our yeast cell division lab, our first transcription paper in mouse embryonic stem cells! www.science.org/doi/10.1126/...
We're hiring! The Development & Stem Cells department at @igbmc.bsky.social, Strasbourg 🇫🇷 is recruiting a group leader working in cell & developmental biology. Our Integrated Structural Biology department also has an open call. More details below! + contact me for informal enquiries #sciencejobs
February 28, 2025 at 9:01 AM
We're hiring! The Development & Stem Cells department at @igbmc.bsky.social, Strasbourg 🇫🇷 is recruiting a group leader working in cell & developmental biology. Our Integrated Structural Biology department also has an open call. More details below! + contact me for informal enquiries #sciencejobs
For slow people like me who don’t know the meaning of 14 in this context; now you know 😳
February 16, 2025 at 5:05 PM
For slow people like me who don’t know the meaning of 14 in this context; now you know 😳
I wonder if ChatGPT will give this same answer one year from now
February 1, 2025 at 9:51 AM
I wonder if ChatGPT will give this same answer one year from now
What a time to be alive
January 26, 2025 at 11:18 AM
What a time to be alive
David Lynch knew exactly what is so wonderful about doing scientific research.
January 19, 2025 at 12:00 PM
David Lynch knew exactly what is so wonderful about doing scientific research.
Christmas lunch with my wonderful lab. I wish I could say the hats were photoshopped in!
December 13, 2024 at 6:20 PM
Christmas lunch with my wonderful lab. I wish I could say the hats were photoshopped in!
7/ We found that power law scaling persists into mitosis, though the scaling exponent decreases. This reflects a shift in chromatin behavior during mitotic compaction, likely linked to phase separation dynamics, that explains how the memory from interphase compaction is carried over to mitosis.
December 9, 2024 at 3:44 PM
7/ We found that power law scaling persists into mitosis, though the scaling exponent decreases. This reflects a shift in chromatin behavior during mitotic compaction, likely linked to phase separation dynamics, that explains how the memory from interphase compaction is carried over to mitosis.
6/ To extend this finding to mitosis, we developed a novel method to quantify chromatin volume using fluorescence intensity distributions, bypassing limitations of traditional segmentation. This allowed us to track compaction dynamics live.
December 9, 2024 at 3:41 PM
6/ To extend this finding to mitosis, we developed a novel method to quantify chromatin volume using fluorescence intensity distributions, bypassing limitations of traditional segmentation. This allowed us to track compaction dynamics live.
5/ This scaling reflects molecular regulation rather than mere physical packing—when we blocked histone deacetylase activity, the precise relationship broke down.
December 9, 2024 at 3:37 PM
5/ This scaling reflects molecular regulation rather than mere physical packing—when we blocked histone deacetylase activity, the precise relationship broke down.
4/ To address this, we used super-resolution STORM microscopy to generate detailed spatial maps of DNA organisation in interphase nuclei. Using 3D super-resolution STORM imaging, we found that nanoscale chromatin density follows a power law relationship with nuclear volume.
December 9, 2024 at 3:34 PM
4/ To address this, we used super-resolution STORM microscopy to generate detailed spatial maps of DNA organisation in interphase nuclei. Using 3D super-resolution STORM imaging, we found that nanoscale chromatin density follows a power law relationship with nuclear volume.
2/ As cells divide during development, their size evolves while DNA content remains constant. For instance, Drosophila large neural stem cells (neuroblasts) generate smaller ganglion mother cells (GMCs). How does chromosome compaction adjust to these size changes?
December 9, 2024 at 3:27 PM
2/ As cells divide during development, their size evolves while DNA content remains constant. For instance, Drosophila large neural stem cells (neuroblasts) generate smaller ganglion mother cells (GMCs). How does chromosome compaction adjust to these size changes?
Christmas time is here, happiness and cheer
November 28, 2024 at 6:32 PM
Christmas time is here, happiness and cheer
Afraid I'm the first to point out in this platform that the article is not about open access but about excessive use of jargon in scientific papers. It is funny though :)
November 19, 2024 at 8:24 AM
Afraid I'm the first to point out in this platform that the article is not about open access but about excessive use of jargon in scientific papers. It is funny though :)
November: last month without Mariah Carey
November 16, 2024 at 3:30 PM
November: last month without Mariah Carey
This project was started almost a decade ago in my old lab in CRG Barcelona (!) by the great Nicola Brownlow, and developed over the next years in IGBMC Strasbourg by Monica Dam: she grinds it til she owns it. Thanks to all involved - and to you for reading and for feedback! / END
November 14, 2024 at 9:25 AM
This project was started almost a decade ago in my old lab in CRG Barcelona (!) by the great Nicola Brownlow, and developed over the next years in IGBMC Strasbourg by Monica Dam: she grinds it til she owns it. Thanks to all involved - and to you for reading and for feedback! / END
6/ These findings highlight an ancient, conserved strategy across species to delay abscission in response to DNA bridges. We propose Srs2/PARI work as part of the NoCut / abscission checkpoint - as for the molecular mechanism: we have only concepts of a plan :(
November 14, 2024 at 9:10 AM
6/ These findings highlight an ancient, conserved strategy across species to delay abscission in response to DNA bridges. We propose Srs2/PARI work as part of the NoCut / abscission checkpoint - as for the molecular mechanism: we have only concepts of a plan :(
4/ HeLa cells have a similar mechanism: the PARI protein delays key events during cytokinesis when DNA bridges are present. This includes slowing down the disassembly of actin patches and midbody severing, which are required for abscission. Oh, and we have gorgeous CLEM too!
November 14, 2024 at 8:57 AM
4/ HeLa cells have a similar mechanism: the PARI protein delays key events during cytokinesis when DNA bridges are present. This includes slowing down the disassembly of actin patches and midbody severing, which are required for abscission. Oh, and we have gorgeous CLEM too!
3/ In budding yeast cells, Srs2 is crucial for delaying abscission when chromatin bridges appear. This pause prevents the cell from damaging the DNA bridge. Not all bridges are equal though - check the preprint for a comparison of replication stress vs dicentric bridges.
November 14, 2024 at 8:51 AM
3/ In budding yeast cells, Srs2 is crucial for delaying abscission when chromatin bridges appear. This pause prevents the cell from damaging the DNA bridge. Not all bridges are equal though - check the preprint for a comparison of replication stress vs dicentric bridges.
1/ When cells divide, it's critical they split their DNA perfectly into each new cell. But sometimes, DNA gets "stuck" in the middle, forming what's called a "chromatin bridge." If not managed, these bridges can lead to mistakes that cause genetic instability—a major factor in diseases like cancer.
November 14, 2024 at 8:40 AM
1/ When cells divide, it's critical they split their DNA perfectly into each new cell. But sometimes, DNA gets "stuck" in the middle, forming what's called a "chromatin bridge." If not managed, these bridges can lead to mistakes that cause genetic instability—a major factor in diseases like cancer.