Marcin J. Suskiewicz
@msuskiewicz.bsky.social
Structural biologist and biochemist. CNRS researcher at CBM Orléans @cbm-upr4301.bsky.social. Interested in protein modifications & interactions. Also husband, dad of 2, friend, ☧. Personal website: msuskiewicz.github.io
Pinned
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Reposted by Marcin J. Suskiewicz
1/ Check out our newest paper where we ask: How fast can we experimentally discover binders from scratch?
And we mean scratch: a blinded study.
TLDR: 26 days. And the binders work…and led to new cancer biology.
We’re coming for you AI….
chemrxiv.org/engage/chemr...
And we mean scratch: a blinded study.
TLDR: 26 days. And the binders work…and led to new cancer biology.
We’re coming for you AI….
chemrxiv.org/engage/chemr...
December 26, 2025 at 6:24 PM
1/ Check out our newest paper where we ask: How fast can we experimentally discover binders from scratch?
And we mean scratch: a blinded study.
TLDR: 26 days. And the binders work…and led to new cancer biology.
We’re coming for you AI….
chemrxiv.org/engage/chemr...
And we mean scratch: a blinded study.
TLDR: 26 days. And the binders work…and led to new cancer biology.
We’re coming for you AI….
chemrxiv.org/engage/chemr...
Reposted by Marcin J. Suskiewicz
For all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. www.biorxiv.org/content/10.6...
DUCs are C2 domain containing plant-specific deubiquitinases stabilizing endocytic cargo at the plasma membrane
Deubiquitinases (DUBs) remove ubiquitin modifications from proteins in a substrate- or linkage-selective manner and regulate numerous cell-biological processes, including endocytosis. By performing ho...
www.biorxiv.org
December 5, 2025 at 3:36 PM
For all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. www.biorxiv.org/content/10.6...
Structural Basis for Substrate Recruitment and Catalytic Ubiquitin Transfer by the E2/E3 Hybrid Enzyme UBE2O.
Structural Basis for Substrate Recruitment and Catalytic Ubiquitin Transfer by the E2/E3 Hybrid Enzyme UBE2O.
UBE2O is a promiscuous ubiquitin ligase involved in cellular quality control pathways. Along with BIRC6, UBE2O is one of only two E2 enzymes that can …
www.sciencedirect.com
December 21, 2025 at 11:35 AM
Structural Basis for Substrate Recruitment and Catalytic Ubiquitin Transfer by the E2/E3 Hybrid Enzyme UBE2O.
Reposted by Marcin J. Suskiewicz
very unusual - a tRNA regulated anion channel
December 18, 2025 at 5:26 PM
very unusual - a tRNA regulated anion channel
Reposted by Marcin J. Suskiewicz
Physicist Leo Szilard, in a short science fiction story from 1948, describing how to retard science by making the funding application longer and harder than the proposed research - now called the ‘Szilard point’
December 19, 2025 at 9:38 AM
Physicist Leo Szilard, in a short science fiction story from 1948, describing how to retard science by making the funding application longer and harder than the proposed research - now called the ‘Szilard point’
Reposted by Marcin J. Suskiewicz
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
The vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
www.biorxiv.org
December 16, 2025 at 6:35 AM
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
Reposted by Marcin J. Suskiewicz
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
October 18, 2025 at 6:59 PM
📢 New preprint:
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
Reposted by Marcin J. Suskiewicz
Reposted by Marcin J. Suskiewicz
New research group leader @matthiasmuhar.bsky.social joins @mpi-cbg.de! 🥳 With his group "Functional genomics of proteome remodeling,” Matthias wants to pursue high-throughput genetic studies to understand how protein turnover is regulated. Welcome, Matthias! www.mpi-cbg.de/news-outreac...
New research group leader for functional genomics
Molecular biologist Matthias Muhar becomes part of the MPI-CBG faculty
www.mpi-cbg.de
December 11, 2025 at 2:15 PM
New research group leader @matthiasmuhar.bsky.social joins @mpi-cbg.de! 🥳 With his group "Functional genomics of proteome remodeling,” Matthias wants to pursue high-throughput genetic studies to understand how protein turnover is regulated. Welcome, Matthias! www.mpi-cbg.de/news-outreac...
Reposted by Marcin J. Suskiewicz
Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...
rdcu.be
December 9, 2025 at 1:21 PM
Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
Reposted by Marcin J. Suskiewicz
We are in the era of Science Slop! (and it's exciting): open.substack.com/pub/superpos...
We are in the era of Science Slop
(and it's exciting)
open.substack.com
December 5, 2025 at 4:36 PM
We are in the era of Science Slop! (and it's exciting): open.substack.com/pub/superpos...
Reposted by Marcin J. Suskiewicz
OpenAI leadership are promoting a paper in Physics Letters B where GPT-5 proposed the main idea — possibly the first peer-reviewed paper where an LLM generated the core contribution. One small problem: GPT-5's idea tests the wrong thing. My technical comment: scirate.com/arxiv/2512.0... 1/
![As part of a broader effort to demonstrate AI’s po-
tential in scientific research [1], OpenAI executives have
pointed to a recently published paper by Hsu [2] as evi-
dence that AI can contribute original ideas to physics [3,
4]. Hsu credits GPT-5 with proposing the core idea of the
paper de novo, possibly the first published physics article
where the main idea came from an LLM, and discusses
the methodology in a companion piece [5]. We examine
whether GPT-5’s criterion is correct.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:uknpj5mh4cfutreceecdbv7x/bafkreia3jerjfcqdui45n4upaqci5u5r6st7o7pqmdzahhjtidtostpooq@jpeg)
December 9, 2025 at 5:17 PM
OpenAI leadership are promoting a paper in Physics Letters B where GPT-5 proposed the main idea — possibly the first peer-reviewed paper where an LLM generated the core contribution. One small problem: GPT-5's idea tests the wrong thing. My technical comment: scirate.com/arxiv/2512.0... 1/
Reposted by Marcin J. Suskiewicz
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
December 9, 2025 at 3:14 PM
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
Reposted by Marcin J. Suskiewicz
Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
December 9, 2025 at 10:13 PM
Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
Reposted by Marcin J. Suskiewicz
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 7:52 AM
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
Reposted by Marcin J. Suskiewicz
Congratulations to @fraenzehana.bsky.social and all the other authors on this work! Franze is currently on the job market, and she would love to help build a structural proteomics facility 🤗
New paper alert! Researchers at the Proteomics Tech Hub at the Vienna BioCenter have developed a new cross-linking mass spectrometry workflow that allows scientists to more easily detect and study protein interactions that were previously undetectable. More: https://imba.science/47QaCJA
December 9, 2025 at 5:43 AM
Congratulations to @fraenzehana.bsky.social and all the other authors on this work! Franze is currently on the job market, and she would love to help build a structural proteomics facility 🤗
Reposted by Marcin J. Suskiewicz
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Multiscale structure of chromatin condensates explains phase separation and material properties
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...
www.science.org
December 5, 2025 at 5:24 AM
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Reposted by Marcin J. Suskiewicz
Arrows are tricky. For us, as the designer of the visual, it will be super clear what it means. But for someone looking at our visual for the first time, it can be highly ambiguous. Depending on the reader, the same arrow can mean sequence, zoom, range, label, movement,...
1/2
1/2
December 4, 2025 at 8:17 AM
Arrows are tricky. For us, as the designer of the visual, it will be super clear what it means. But for someone looking at our visual for the first time, it can be highly ambiguous. Depending on the reader, the same arrow can mean sequence, zoom, range, label, movement,...
1/2
1/2
Reposted by Marcin J. Suskiewicz
We’ve made some new tools to manipulate N-recognins. Check them out in our preprint.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 29, 2025 at 3:24 AM
We’ve made some new tools to manipulate N-recognins. Check them out in our preprint.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Marcin J. Suskiewicz
Happy to share that my PhD project is finally published!🪱✨
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis - Nature Ecology & Evolution
In Caenorhabditis tropicalis, three toxin–antidote elements arose via gene duplication from the essential tRNA-synthetase subunit FARS-3. The ancestral antidote probably acquired affinity for FARS-3, ...
www.nature.com
November 24, 2025 at 9:10 PM
Happy to share that my PhD project is finally published!🪱✨
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Very interesting studies on the transcription factor SALL4, including the demonstration of the essential role of its multimerisation (tetramerisation).
1/8🧵 Excited to share two studies in which I was involved within the Bird Lab📄📄 We have explored how the transcription factor SALL4 assembles and shapes chromatin in embryonic stem cells.
@kashyapchhatbar.bsky.social @saragiuliani.bsky.social @drphcb-uoe.bsky.social @edinburghbiology.bsky.social
@kashyapchhatbar.bsky.social @saragiuliani.bsky.social @drphcb-uoe.bsky.social @edinburghbiology.bsky.social
December 1, 2025 at 7:58 PM
Very interesting studies on the transcription factor SALL4, including the demonstration of the essential role of its multimerisation (tetramerisation).
Reposted by Marcin J. Suskiewicz
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
November 30, 2025 at 2:36 PM
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
Reposted by Marcin J. Suskiewicz
Structural insights into autophosphorylation-mediated heat shock response by the protein-arginine kinase McsAB https://www.biorxiv.org/content/10.1101/2025.11.26.690658v1
November 27, 2025 at 2:46 AM
Structural insights into autophosphorylation-mediated heat shock response by the protein-arginine kinase McsAB https://www.biorxiv.org/content/10.1101/2025.11.26.690658v1
Lucija, the first PhD student with whom I had an honour to work, will defend on 15th December!
And on December 15 @ 2 PM we will follow Lucija Mance
November 30, 2025 at 8:47 AM
Lucija, the first PhD student with whom I had an honour to work, will defend on 15th December!
How I imagine it must be like to work in a small university town
November 30, 2025 at 8:46 AM