Further thoughts about AI brought together for me by the AI Science Summit organized by the European Commission and the Danish Presidency of the Council of the EU 2025 - in lovely Copenhagen - this ti...

Accurate structure prediction of biomolecular complexes is crucial for understanding biological processes and enabling drug discovery. While AlphaF...

Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts between individual motifs within cis-regulatory elements and reveal a unified model of biophysically mediated enhan...

Fluorescence microscopy has become an indispensable tool to investigate the dynamics of macromolecules directly in living cells on length scales ranging from the nanoscale via super-resolution microscopy (SRM) to the macroscale by light sheet technology. Advances in these microscopy techniques and the desire to perform experiments with high spatial and temporal resolution in living cells increase the requirements imposed on the fluorophores used. Tailor-made synthetic small-molecule fluorophores in combination with innovative labeling strategies help to overcome these challenges and continue to push the boundaries in live-cell microscopy. This Review discusses important advances in improving the performance of synthetic fluorophores for live-cell applications and how synergistic effects can be produced by using clever labeling strategies. We detail how synthetic fluorophores advance different microscopy modalities including live-cell SRM and showcase how they can be implemented into bi

Recently I started a Twitter thread highlighting a couple of seminal discoveries in molecular biology going back in the 40’s 50’s #classicpaper. I received many positive feedback and the thread was…

Liu et al. show that poly-ubiquitylation increases the internalization efficiency of transmembrane proteins by clathrin-coated vesicles. Highly ubiquitylated proteins outcompete non-ubiquitylated ones for vesicle incorporation, revealing a competitive sorting mechanism that may help cells selectively remove damaged surface receptors.

Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...

L’atrophie multisystématisée (MSA) est une maladie neurodégénérative rare et incurable marquée par la présence d’inclusions intracellulaires faites de f

SUMOylation – a protein post-translational modification (PTM) related to ubiquitylation – involves the reversible covalent attachment of the small ubiquitin-like modifier (SUMO) to proteins. During th...