Boris Sieber
@borissieber.bsky.social
Postdoc @SophieMartinLab.bsky.social studying #GPCR and #MAPK signalling in fission yeast. Alumnus of @mjafreeman.bsky.social and @jordanraff.bsky.social
Sms1 shares key features with very structurally different scaffolds - membrane recruitment, MAPK binding and negative feedback loop - demonstrating the 𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝗮𝗿𝘆 𝗰𝗼𝗻𝘃𝗲𝗿𝗴𝗲𝗻𝗰𝗲 of the MAPK scaffolds
September 25, 2025 at 4:32 PM
Sms1 shares key features with very structurally different scaffolds - membrane recruitment, MAPK binding and negative feedback loop - demonstrating the 𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝗮𝗿𝘆 𝗰𝗼𝗻𝘃𝗲𝗿𝗴𝗲𝗻𝗰𝗲 of the MAPK scaffolds
The MAPK phosphorylates Sms1 as a 𝗻𝗲𝗴𝗮𝘁𝗶𝘃𝗲 𝗳𝗲𝗲𝗱𝗯𝗮𝗰𝗸 𝗹𝗼𝗼𝗽, to prevent hyperactivation and untimely mating, including after cell-cell fusion:
September 25, 2025 at 4:31 PM
The MAPK phosphorylates Sms1 as a 𝗻𝗲𝗴𝗮𝘁𝗶𝘃𝗲 𝗳𝗲𝗲𝗱𝗯𝗮𝗰𝗸 𝗹𝗼𝗼𝗽, to prevent hyperactivation and untimely mating, including after cell-cell fusion:
This plasma membrane localisation relies on its non-canonical 𝗵𝗲𝗺𝗶-𝗮𝗿𝗿𝗲𝘀𝘁𝗶𝗻 𝗱𝗼𝗺𝗮𝗶𝗻, that directly binds phospholipids and the active Galpha protein
September 25, 2025 at 4:29 PM
This plasma membrane localisation relies on its non-canonical 𝗵𝗲𝗺𝗶-𝗮𝗿𝗿𝗲𝘀𝘁𝗶𝗻 𝗱𝗼𝗺𝗮𝗶𝗻, that directly binds phospholipids and the active Galpha protein
Sms1 localises to 𝗺𝗲𝗺𝗯𝗿𝗮𝗻𝗲-𝗮𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗲𝗱 𝗱𝘆𝗻𝗮𝗺𝗶𝗰 𝗽𝗮𝘁𝗰𝗵𝗲𝘀 that sample the potential mating partners
September 25, 2025 at 4:28 PM
Sms1 localises to 𝗺𝗲𝗺𝗯𝗿𝗮𝗻𝗲-𝗮𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗲𝗱 𝗱𝘆𝗻𝗮𝗺𝗶𝗰 𝗽𝗮𝘁𝗰𝗵𝗲𝘀 that sample the potential mating partners
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
September 25, 2025 at 4:27 PM
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Looking forward to giving my talk at #Yeast2025 on Sms1 as the MAPK scaffold of fission yeast mating, and how it's removed from the zygote to prevent untimely mating
July 22, 2025 at 12:38 PM
Looking forward to giving my talk at #Yeast2025 on Sms1 as the MAPK scaffold of fission yeast mating, and how it's removed from the zygote to prevent untimely mating