Petr Cejka
@cejkalab.bsky.social
Research group leader. Interested in DNA repair.
Reposted by Petr Cejka
Dear Colleagues,
Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊
We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.
👉 rdcu.be/e1bBt
Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊
We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.
👉 rdcu.be/e1bBt
PAF15–PCNA exhaustion governs the strand-specific control of DNA replication
Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.
rdcu.be
January 29, 2026 at 6:30 PM
Dear Colleagues,
Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊
We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.
👉 rdcu.be/e1bBt
Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊
We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.
👉 rdcu.be/e1bBt
Middle of January in central Switzerland, but very little snow. More for hiking than skiing…
January 18, 2026 at 2:54 PM
Middle of January in central Switzerland, but very little snow. More for hiking than skiing…
Reposted by Petr Cejka
New paper in collaboration with @unterholznerlab.bsky.social @cejkalab.bsky.social IFI16 protects stalled replication forks.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
IFI16 senses and protects stalled replication forks
Replication stress is a key driver of DNA damage and genome instability. Here, we report that replication stress induces an inflammatory response in t…
www.sciencedirect.com
January 8, 2026 at 4:07 PM
New paper in collaboration with @unterholznerlab.bsky.social @cejkalab.bsky.social IFI16 protects stalled replication forks.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Petr Cejka
We've got a new paper out! In collaboration with @stapleslab.bsky.social @cejkalab.bsky.social @lucyhjackson-j.bsky.social, we show that IFI16 binds to stalled replication forks, protects nascent DNA and mediates an inflammatory response to replication stress.
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
January 8, 2026 at 5:55 PM
We've got a new paper out! In collaboration with @stapleslab.bsky.social @cejkalab.bsky.social @lucyhjackson-j.bsky.social, we show that IFI16 binds to stalled replication forks, protects nascent DNA and mediates an inflammatory response to replication stress.
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...
Reposted by Petr Cejka
🚨 Exciting news! Our latest study is out in Nature Communications!
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription - Nature Communications
Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another...
www.nature.com
December 10, 2025 at 12:11 PM
🚨 Exciting news! Our latest study is out in Nature Communications!
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
Reposted by Petr Cejka
What does phosphorylation do to RPA?
This has been a long-standing question in the field of genome integrity.
In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer.
Thanks to funding from NIGMS to our groups.
This has been a long-standing question in the field of genome integrity.
In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer.
Thanks to funding from NIGMS to our groups.
December 10, 2025 at 3:49 PM
What does phosphorylation do to RPA?
This has been a long-standing question in the field of genome integrity.
In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer.
Thanks to funding from NIGMS to our groups.
This has been a long-standing question in the field of genome integrity.
In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer.
Thanks to funding from NIGMS to our groups.
Late fall impressions from Lugano lake.
November 29, 2025 at 4:54 PM
Late fall impressions from Lugano lake.
Reposted by Petr Cejka
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
ANTONY LAB SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE
Edwin Antony Lab Website
www.antonylab.org
November 18, 2025 at 7:05 PM
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
November magic in Graubünden
November 8, 2025 at 6:48 PM
November magic in Graubünden
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 30, 2025 at 8:41 PM
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 27, 2025 at 1:12 PM
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lake Como with plenty of fall sunshine today
October 26, 2025 at 5:29 PM
Lake Como with plenty of fall sunshine today
Golden October in its glory. Mountains in Ticino today.
October 18, 2025 at 4:55 PM
Golden October in its glory. Mountains in Ticino today.
Trip to Greina plateau, northern Ticino
September 20, 2025 at 3:00 PM
Trip to Greina plateau, northern Ticino
Last hike in August with first snow
August 31, 2025 at 1:20 PM
Last hike in August with first snow
Reposted by Petr Cejka
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
August 28, 2025 at 6:34 AM
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
Hiking in Switzerland today, Val Poschiavo
May 31, 2025 at 6:11 PM
Hiking in Switzerland today, Val Poschiavo
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
May 5, 2025 at 7:22 AM
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
Reposted by Petr Cejka
🧬 New research discovers sequential phosphorylation of MRE11 by ATM and ATR prevents extensive DNA degradation at stalled replication forks
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
ATM priming and end resection–coupled phosphorylation of MRE11 is important for fork protection and replication restart | PNAS
The MRE11/RAD50/NBS1 (MRN) complex plays multiple roles in the maintenance of genome
stability. MRN is associated with replication forks to preserv...
www.pnas.org
April 29, 2025 at 4:12 AM
🧬 New research discovers sequential phosphorylation of MRE11 by ATM and ATR prevents extensive DNA degradation at stalled replication forks
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Nice weekend everyone from sunny Bellinzona
April 11, 2025 at 3:00 PM
Nice weekend everyone from sunny Bellinzona
Great news, thank you
The SNSF welcomes #Switzerland’s retroactive association to #HorizonEurope from 1 Jan 2025, enabling researchers to join nearly all calls following the Federal Council’s approval of the EU Programmes Agreement.
Find out more here ➡️
Find out more here ➡️
April 10, 2025 at 9:47 AM
Great news, thank you
Reposted by Petr Cejka
New preprint from the lab, revealing new roles for IFI16 during replication stress. Great collab with @unterholznerlab.bsky.social and @cejkalab.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
IFI16 senses and protects stalled replication forks
Replication stress is a key driver of DNA damage and genome instability. Replication stress-induced fork remodelling generates a new DNA end that is vulnerable to the action of nucleases, and which is...
www.biorxiv.org
April 9, 2025 at 4:08 PM
New preprint from the lab, revealing new roles for IFI16 during replication stress. Great collab with @unterholznerlab.bsky.social and @cejkalab.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Spring is here. Valleys and lakesides are green, and snow is melting fast in the mountains.
April 5, 2025 at 8:05 PM
Spring is here. Valleys and lakesides are green, and snow is melting fast in the mountains.
Reposted by Petr Cejka
ICYMI - New #Review on #DNARepair
In this Review, Raphael Ceccaldi and @cejkalab.bsky.social discuss the mechanisms and regulation of DNA-end resection, which is crucial for the repair of DNA double-strand breaks by most repair pathways.
🔗 go.nature.com/4iSKphQ
In this Review, Raphael Ceccaldi and @cejkalab.bsky.social discuss the mechanisms and regulation of DNA-end resection, which is crucial for the repair of DNA double-strand breaks by most repair pathways.
🔗 go.nature.com/4iSKphQ
Mechanisms and regulation of DNA end resection in the maintenance of genome stability - Nature Reviews Molecular Cell Biology
DNA end resection is crucial for most DNA double-strand break repair pathways. This Review discusses the molecular mechanisms of end resection and its regulation, focusing on the roles of post-transla...
go.nature.com
April 4, 2025 at 5:46 AM
ICYMI - New #Review on #DNARepair
In this Review, Raphael Ceccaldi and @cejkalab.bsky.social discuss the mechanisms and regulation of DNA-end resection, which is crucial for the repair of DNA double-strand breaks by most repair pathways.
🔗 go.nature.com/4iSKphQ
In this Review, Raphael Ceccaldi and @cejkalab.bsky.social discuss the mechanisms and regulation of DNA-end resection, which is crucial for the repair of DNA double-strand breaks by most repair pathways.
🔗 go.nature.com/4iSKphQ