Aura Carreira
@acarreiralab.bsky.social
Scientist interested in genome integrity maintenance mechanisms and cancer
Reposted by Aura Carreira
Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
A comprehensive genetic catalog of human double-strand break repair
The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...
www.science.org
October 4, 2025 at 7:27 AM
Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
Reposted by Aura Carreira
Less than two weeks left to apply!
Postdoc positions in my lab to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists & structural biologists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Postdoc positions in my lab to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists & structural biologists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Postdoctoral Fellow - Costa Lab
Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...
crick.wd3.myworkdayjobs.com
July 21, 2025 at 2:57 PM
Less than two weeks left to apply!
Postdoc positions in my lab to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists & structural biologists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Postdoc positions in my lab to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists & structural biologists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Reposted by Aura Carreira
We just published our work in #ScienceAdvances
"Parallel evolution of salinity tolerance in Arabidopsis thaliana accessions from Cape Verde Islands"
www.science.org/doi/10.1126/...
Short summary and credits follow:
"Parallel evolution of salinity tolerance in Arabidopsis thaliana accessions from Cape Verde Islands"
www.science.org/doi/10.1126/...
Short summary and credits follow:
July 12, 2025 at 2:40 PM
We just published our work in #ScienceAdvances
"Parallel evolution of salinity tolerance in Arabidopsis thaliana accessions from Cape Verde Islands"
www.science.org/doi/10.1126/...
Short summary and credits follow:
"Parallel evolution of salinity tolerance in Arabidopsis thaliana accessions from Cape Verde Islands"
www.science.org/doi/10.1126/...
Short summary and credits follow:
Reposted by Aura Carreira
Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...
June 19, 2025 at 8:37 AM
Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...
Reposted by Aura Carreira
Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...
Ku limits RNA-induced innate immunity to allow Alu-expansion in primates - Nature
Nature - Ku limits RNA-induced innate immunity to allow Alu-expansion in primates
www.nature.com
May 16, 2025 at 11:11 PM
Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...
Reposted by Aura Carreira
A must for all DNA repair aficionados!
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
April 9, 2025 at 8:05 AM
A must for all DNA repair aficionados!
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
Reposted by Aura Carreira
We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 7, 2025 at 1:01 PM
We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Aura Carreira
👍Yeah: Just out in @naturecancer.bsky.social from my lab @cniostopcancer.bsky.social
Here, a video highlighting mechanisms of immune suppression in melanoma (hope you like the hot-to-cold shift via DCs)
Implications for immune resistance in different tumor types below
www.nature.com/articles/s43...
Here, a video highlighting mechanisms of immune suppression in melanoma (hope you like the hot-to-cold shift via DCs)
Implications for immune resistance in different tumor types below
www.nature.com/articles/s43...
March 29, 2025 at 7:20 PM
👍Yeah: Just out in @naturecancer.bsky.social from my lab @cniostopcancer.bsky.social
Here, a video highlighting mechanisms of immune suppression in melanoma (hope you like the hot-to-cold shift via DCs)
Implications for immune resistance in different tumor types below
www.nature.com/articles/s43...
Here, a video highlighting mechanisms of immune suppression in melanoma (hope you like the hot-to-cold shift via DCs)
Implications for immune resistance in different tumor types below
www.nature.com/articles/s43...
Reposted by Aura Carreira
📢#BGFP25 GRANTS AVAILABLE & TALK DEADLINE EXTENDED!
💰We are excited to announce we have at least 10 reg support grants ready to award to those submitting abstracts!
🧑💼Our short talk submission deadline has been extended and will now close on 01 April.
Submit your abstract HERE: bit.ly/3AnsVZF
💰We are excited to announce we have at least 10 reg support grants ready to award to those submitting abstracts!
🧑💼Our short talk submission deadline has been extended and will now close on 01 April.
Submit your abstract HERE: bit.ly/3AnsVZF
March 25, 2025 at 9:33 AM
📢#BGFP25 GRANTS AVAILABLE & TALK DEADLINE EXTENDED!
💰We are excited to announce we have at least 10 reg support grants ready to award to those submitting abstracts!
🧑💼Our short talk submission deadline has been extended and will now close on 01 April.
Submit your abstract HERE: bit.ly/3AnsVZF
💰We are excited to announce we have at least 10 reg support grants ready to award to those submitting abstracts!
🧑💼Our short talk submission deadline has been extended and will now close on 01 April.
Submit your abstract HERE: bit.ly/3AnsVZF
Reposted by Aura Carreira
📢The programme for #DDRCT25 is now available! Visit our website to explore the exciting sessions, speakers, and key topics we have in store.
➡️Check it out here: fusion-conferences.com/conference/177
➡️Check it out here: fusion-conferences.com/conference/177
March 25, 2025 at 8:38 AM
📢The programme for #DDRCT25 is now available! Visit our website to explore the exciting sessions, speakers, and key topics we have in store.
➡️Check it out here: fusion-conferences.com/conference/177
➡️Check it out here: fusion-conferences.com/conference/177
Reposted by Aura Carreira
Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...
March 25, 2025 at 4:00 PM
Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...
Reposted by Aura Carreira
Entrevista con nuestra investigadora Aura Carreira: “Buscamos formas de atacar el cáncer de mama hereditario resistente a la quimioterapia” www.20minutos.es/salud/actual... a través de @20m
Aura Carreira, investigadora: “Buscamos formas de atacar el cáncer de mama hereditario resistente a la quimioterapia”
El equipo de esta doctora trabaja en un complejo proyecto para volver ciertos tipos de cánceres resistentes más vulnerables a la radioterapia, permitiendo combatirlos con dosis más bajas y seguras.
www.20minutos.es
March 25, 2025 at 1:58 PM
Entrevista con nuestra investigadora Aura Carreira: “Buscamos formas de atacar el cáncer de mama hereditario resistente a la quimioterapia” www.20minutos.es/salud/actual... a través de @20m
Reposted by Aura Carreira
How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @karimmekhail.bsky.social, @chiololab.bsky.social, and @lablegube.bsky.social. @natrevmcb.bsky.social Link to article: rdcu.be/edViW
Nuclear and genome dynamics underlying DNA double-strand break repair
Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...
rdcu.be
March 18, 2025 at 4:32 PM
How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @karimmekhail.bsky.social, @chiololab.bsky.social, and @lablegube.bsky.social. @natrevmcb.bsky.social Link to article: rdcu.be/edViW
Reposted by Aura Carreira
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
March 17, 2025 at 9:58 PM
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
Reposted by Aura Carreira
Lu Gan (甘露) and collaborators use cryo-electron tomography to reveal the nanoscale architecture of human #chromatin in situ: G1 and metaphase chromatin is devoid of mega-complexes beyond dinucleosome regularities
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
March 17, 2025 at 7:06 PM
Lu Gan (甘露) and collaborators use cryo-electron tomography to reveal the nanoscale architecture of human #chromatin in situ: G1 and metaphase chromatin is devoid of mega-complexes beyond dinucleosome regularities
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Aura Carreira
#CIBseminars
Destroying the eukaryotic replisome
Karim Labib,
MRC Protein Phosphorylation and Ubiquitylation Unit, U. Dundee
📅March 13
🕙12pm
The seminar will take place at @cib-csic.bsky.social and streamed online ➡️https://m.mtrbio.com/etxkvhixds
Destroying the eukaryotic replisome
Karim Labib,
MRC Protein Phosphorylation and Ubiquitylation Unit, U. Dundee
📅March 13
🕙12pm
The seminar will take place at @cib-csic.bsky.social and streamed online ➡️https://m.mtrbio.com/etxkvhixds
March 6, 2025 at 9:01 AM
#CIBseminars
Destroying the eukaryotic replisome
Karim Labib,
MRC Protein Phosphorylation and Ubiquitylation Unit, U. Dundee
📅March 13
🕙12pm
The seminar will take place at @cib-csic.bsky.social and streamed online ➡️https://m.mtrbio.com/etxkvhixds
Destroying the eukaryotic replisome
Karim Labib,
MRC Protein Phosphorylation and Ubiquitylation Unit, U. Dundee
📅March 13
🕙12pm
The seminar will take place at @cib-csic.bsky.social and streamed online ➡️https://m.mtrbio.com/etxkvhixds
Reposted by Aura Carreira
Last day to apply for a postdoctoral position at the Vall d'Hebron Institute of Oncology (VHIO) @vhio.bsky.social. Visit or web and contact us for your next training position in cancer research! malumbreslab.org vhiovidaprogramme.eu
March 13, 2025 at 7:54 AM
Last day to apply for a postdoctoral position at the Vall d'Hebron Institute of Oncology (VHIO) @vhio.bsky.social. Visit or web and contact us for your next training position in cancer research! malumbreslab.org vhiovidaprogramme.eu
Reposted by Aura Carreira
For all of you who cannot access pubmed, here is a good alternative:
europepmc.org
europepmc.org
Europe PMCHome - Europe PMC
Europe PMC is an archive of life sciences journal literature.
europepmc.org
March 2, 2025 at 9:56 AM
For all of you who cannot access pubmed, here is a good alternative:
europepmc.org
europepmc.org
Reposted by Aura Carreira
Reposted by Aura Carreira
Happy to share our new collaboration paper in Cell Reports. We show that translation synthesis in cancer cells occurs predominantly behind the replication fork, to fill ssDNA gaps, rather than to restart stalled replication forks “on the fly”. www.sciencedirect.com/science/arti...
Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPol
The bypass of DNA lesions by translesion synthesis (TLS) polymerases is a critical step for DNA damage tolerance, allowing the completion of DNA synth…
www.sciencedirect.com
February 27, 2025 at 4:04 PM
Happy to share our new collaboration paper in Cell Reports. We show that translation synthesis in cancer cells occurs predominantly behind the replication fork, to fill ssDNA gaps, rather than to restart stalled replication forks “on the fly”. www.sciencedirect.com/science/arti...
Reposted by Aura Carreira
It is absolutely heartbreaking to see international postdoc fellows (some of them who just came into the country) breaking down in tears as their dreams have been shattered. These folks are having their contracts abruptly terminated. Many of them have kids in schools.
February 27, 2025 at 7:29 PM
It is absolutely heartbreaking to see international postdoc fellows (some of them who just came into the country) breaking down in tears as their dreams have been shattered. These folks are having their contracts abruptly terminated. Many of them have kids in schools.
Reposted by Aura Carreira
SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
DNA replication and genome maintenance: from basic biology to disease
www.embl.org
February 26, 2025 at 3:22 PM
SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Reposted by Aura Carreira
Happy that I got to handle and help publish this cool new work for @embojournal.org
And after many years of PARPi/(poly-ADP)ribose craze, exciting to see mono-ADP-ribosylation starting to reveal its secrets in so many ways now!
And after many years of PARPi/(poly-ADP)ribose craze, exciting to see mono-ADP-ribosylation starting to reveal its secrets in so many ways now!
I'm super excited to share our study in collaboration with @jnpruneda.bsky.social, published today in @embojournal.org! We show that PARPs are modified with a non-canonical ester-linked mono-ADP-ribosylated ubiquitin species for the first time in cells: www.embopress.org/doi/full/10....
Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal
imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and
ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification
has remained ...
www.embopress.org
February 26, 2025 at 4:49 PM
Happy that I got to handle and help publish this cool new work for @embojournal.org
And after many years of PARPi/(poly-ADP)ribose craze, exciting to see mono-ADP-ribosylation starting to reveal its secrets in so many ways now!
And after many years of PARPi/(poly-ADP)ribose craze, exciting to see mono-ADP-ribosylation starting to reveal its secrets in so many ways now!
Reposted by Aura Carreira
🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro - Nature
A biochemical system recapitulates the hallmarks of meiotic double-strand break formation, with mouse SPO11 catalysing break formation in the absence of any partners and remaining covalently atta...
www.nature.com
February 19, 2025 at 4:52 PM
🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Looking forward to my visit to Cabimer in Seville tomorrow to talk about our work on BRCA2, genome instability and cancer done at @cbm-csic-uam.bsky.social
February 20, 2025 at 12:46 PM
Looking forward to my visit to Cabimer in Seville tomorrow to talk about our work on BRCA2, genome instability and cancer done at @cbm-csic-uam.bsky.social