GL Moldovan Laboratory
@moldovanlab.bsky.social
Genome stability, DNA repair, replication stress, functional genomics, basic cancer biology
Thrilled to announce that Alexandra Nusawardhana, graduate student in the lab, was awarded an F31 National Research Service Award fellowship by the NCI to investigate the role of EXO1 in genomic stability. Congratulations Lexi!
September 8, 2025 at 6:15 PM
Thrilled to announce that Alexandra Nusawardhana, graduate student in the lab, was awarded an F31 National Research Service Award fellowship by the NCI to investigate the role of EXO1 in genomic stability. Congratulations Lexi!
So happy and proud to hood Drs. Lindsey Pale, Jude Khatib and Josh Straka at the 2025 Penn State College of Medicine Commencement ceremony. Congratulations and all the best in your careers!
May 11, 2025 at 1:12 AM
So happy and proud to hood Drs. Lindsey Pale, Jude Khatib and Josh Straka at the 2025 Penn State College of Medicine Commencement ceremony. Congratulations and all the best in your careers!
Happy to share our new collaboration paper in Cell Reports. We show that translation synthesis in cancer cells occurs predominantly behind the replication fork, to fill ssDNA gaps, rather than to restart stalled replication forks “on the fly”. www.sciencedirect.com/science/arti...
Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPol
The bypass of DNA lesions by translesion synthesis (TLS) polymerases is a critical step for DNA damage tolerance, allowing the completion of DNA synth…
www.sciencedirect.com
February 27, 2025 at 4:04 PM
Happy to share our new collaboration paper in Cell Reports. We show that translation synthesis in cancer cells occurs predominantly behind the replication fork, to fill ssDNA gaps, rather than to restart stalled replication forks “on the fly”. www.sciencedirect.com/science/arti...
Our year in pictures. Happy holidays everyone!
December 23, 2024 at 8:20 PM
Our year in pictures. Happy holidays everyone!
Congratulations Dr. Straka! Josh successfully defended his PhD thesis today. Wishing him all the best in his future career!
December 21, 2024 at 12:28 AM
Congratulations Dr. Straka! Josh successfully defended his PhD thesis today. Wishing him all the best in his future career!
Today we said goodbye to Jude and Josh, two outstanding graduate students who joined us in the middle of the pandemic and are now moving on to bigger and better things. Congratulations on your degrees and all the best in the future!
December 19, 2024 at 8:30 PM
Today we said goodbye to Jude and Josh, two outstanding graduate students who joined us in the middle of the pandemic and are now moving on to bigger and better things. Congratulations on your degrees and all the best in the future!
2) The histone chaperone CAF1 promotes PRIMPOL recruitment to restart stalled forks through ssDNA gap formation. doi.org/10.1093/nar/...
CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
Abstract. Suppression of single-stranded DNA (ssDNA) gap accumulation at replication forks has emerged as a potential determinant of chemosensitivity in ho
doi.org
December 18, 2024 at 3:45 PM
2) The histone chaperone CAF1 promotes PRIMPOL recruitment to restart stalled forks through ssDNA gap formation. doi.org/10.1093/nar/...
Sharing our two recent papers on PRIMPOL in ssDNA gap metabolism published in NAR: 1) HELQ and RAD52 regulate ssDNA gap repair doi.org/10.1093/nar/...
CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single-stranded DNA gaps
Abstract. Treatment with genotoxic agents, such as platinum compounds, is still the mainstay therapeutical approach for the majority of cancers. Our unders
doi.org
December 18, 2024 at 3:44 PM
Sharing our two recent papers on PRIMPOL in ssDNA gap metabolism published in NAR: 1) HELQ and RAD52 regulate ssDNA gap repair doi.org/10.1093/nar/...
Our lab is now on Bluesky! To start off on a happy note, we are happy to share that two senior grad students in the lab, Ana and Lexi, received Alumni Society Awards today!
December 17, 2024 at 7:44 PM
Our lab is now on Bluesky! To start off on a happy note, we are happy to share that two senior grad students in the lab, Ana and Lexi, received Alumni Society Awards today!