Björn Schumacher
@bjornschumacher.bsky.social
I'm a scientist 👨⚕️, author 📕and chair for genome stability in aging and disease at the University of Cologne. https://igsad.de
Pinned
Targeting DNA damage in ageing: towards supercharging DNA repair - Nature Reviews Drug Discovery
DNA damage to the somatic genome has been identified as a major cause of ageing. This Perspective provides an overview of current understanding of the role of genome instability in the ageing process and assesses therapeutic strategies targeting the cellular response to DNA damage to delay ageing and prevent associated diseases.
www.nature.com
Now out in print: Targeting DNA damage in ageing: towards supercharging DNA repair. New perspectives how we could tackle cancer and aging at their mechanistic root cause: I
www.nature.com/articles/s41...
www.nature.com/articles/s41...
It's a great pleasure to introduce the RACE ERA Chair Initiative for Establishing a Research and Innovation Program of Excellence on Ageing and Longevity at the University of Crete with @garinis.bsky.social
October 30, 2025 at 8:52 PM
It's a great pleasure to introduce the RACE ERA Chair Initiative for Establishing a Research and Innovation Program of Excellence on Ageing and Longevity at the University of Crete with @garinis.bsky.social
🧬🧬🧬Targeting Genome Stability to Mitigate Human Aging and Disease - read now our comprehensive review article written with Debbie Toiber how we can target the most fundamental mechanisms of aging and cancer. @annualreviews.bsky.social 🔗 go.shr.lc/3JohYMp
a computer generated image of a dna molecule with a dark background
ALT: a computer generated image of a dna molecule with a dark background
media.tenor.com
October 24, 2025 at 3:18 PM
🧬🧬🧬Targeting Genome Stability to Mitigate Human Aging and Disease - read now our comprehensive review article written with Debbie Toiber how we can target the most fundamental mechanisms of aging and cancer. @annualreviews.bsky.social 🔗 go.shr.lc/3JohYMp
Reposted by Björn Schumacher
🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉
🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
onlinelibrary.wiley.com
October 20, 2025 at 8:28 AM
🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉
Reposted by Björn Schumacher
📢 Check out this new paper by our #CRC1678 members @bjornschumacher.bsky.social, @meyerdh.bsky.social and Walter Sandt: Age Deceleration and Reversal Gene Patterns in Dauer Diapause! Nature shows us how aging can slow—and even reverse—at the whole-organism level.
🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
onlinelibrary.wiley.com
October 20, 2025 at 1:33 PM
📢 Check out this new paper by our #CRC1678 members @bjornschumacher.bsky.social, @meyerdh.bsky.social and Walter Sandt: Age Deceleration and Reversal Gene Patterns in Dauer Diapause! Nature shows us how aging can slow—and even reverse—at the whole-organism level.
🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
onlinelibrary.wiley.com
October 17, 2025 at 2:06 PM
🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Björn Schumacher
Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny.
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!
August 12, 2025 at 2:35 PM
Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny.
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!
What Jane Goodall Taught Us About Living a Long Life
The scientist, who died at 91 on Wednesday, was a model for healthy aging.
www.nytimes.com/2025/10/02/w...
The scientist, who died at 91 on Wednesday, was a model for healthy aging.
www.nytimes.com/2025/10/02/w...
What Jane Goodall Taught Us About Living a Long Life
www.nytimes.com
October 4, 2025 at 7:18 AM
What Jane Goodall Taught Us About Living a Long Life
The scientist, who died at 91 on Wednesday, was a model for healthy aging.
www.nytimes.com/2025/10/02/w...
The scientist, who died at 91 on Wednesday, was a model for healthy aging.
www.nytimes.com/2025/10/02/w...
Now out in print: Targeting DNA damage in ageing: towards supercharging DNA repair. New perspectives how we could tackle cancer and aging at their mechanistic root cause: I
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeting DNA damage in ageing: towards supercharging DNA repair - Nature Reviews Drug Discovery
DNA damage to the somatic genome has been identified as a major cause of ageing. This Perspective provides an overview of current understanding of the role of genome instability in the ageing process and assesses therapeutic strategies targeting the cellular response to DNA damage to delay ageing and prevent associated diseases.
www.nature.com
September 30, 2025 at 3:24 PM
Now out in print: Targeting DNA damage in ageing: towards supercharging DNA repair. New perspectives how we could tackle cancer and aging at their mechanistic root cause: I
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Amazing retreat of the @dfg.de Research Unit FOR5504 on the Physiological Causes and Consequences of Genome Instability and the Institute for Genome Stability in Aging and Disease with keynotes by @apoetsch.bsky.social and @garinis.bsky.social
September 30, 2025 at 11:03 AM
Amazing retreat of the @dfg.de Research Unit FOR5504 on the Physiological Causes and Consequences of Genome Instability and the Institute for Genome Stability in Aging and Disease with keynotes by @apoetsch.bsky.social and @garinis.bsky.social
It was great fun speaking with Debbie Toiber and @barakrotblat.bsky.social on my path to science and why studying aging is so important to me. open.spotify.com/episode/2brg...
September 30, 2025 at 5:33 AM
It was great fun speaking with Debbie Toiber and @barakrotblat.bsky.social on my path to science and why studying aging is so important to me. open.spotify.com/episode/2brg...
Reposted by Björn Schumacher
This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!
🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 22, 2025 at 11:22 AM
This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!
Reposted by Björn Schumacher
Aging by the clock and yet without a program [perspective by David Meyer, Alexei Maklakov & Björn Schumacher] www.nature.com/articles/s43...
September 19, 2025 at 10:45 AM
Aging by the clock and yet without a program [perspective by David Meyer, Alexei Maklakov & Björn Schumacher] www.nature.com/articles/s43...
🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 20, 2025 at 4:31 AM
🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Björn Schumacher
👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳
🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 18, 2025 at 12:22 PM
👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳
Reposted by Björn Schumacher
🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 18, 2025 at 9:08 AM
🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social
Registration open now! Join us for the most exciting Gordon Research Conferences on Systems Aging in 2026. Super exciting program with outstanding speakers from across the entire field. Ample opportunity to discuss your science with leaders in the Systems Aging Feld. www.grc.org/systems-agin...
2026 Systems Aging Conference GRC
The 2026 Gordon Research Conference on Systems Aging will be held in Newry, Maine. Apply today to reserve your spot.
www.grc.org
August 14, 2025 at 2:30 PM
Registration open now! Join us for the most exciting Gordon Research Conferences on Systems Aging in 2026. Super exciting program with outstanding speakers from across the entire field. Ample opportunity to discuss your science with leaders in the Systems Aging Feld. www.grc.org/systems-agin...
🔥🔥🔥 Read now our latest article: The Somatic Impact on Inheritance and the Germline Control of the Soma | Annual Reviews - www.annualreviews.org/content/jour...
The Somatic Impact on Inheritance and the Germline Control of the Soma | Annual Reviews
The faithful transmission of genomic DNA over succeeding generations is an essential prerequisite for species maintenance. The germplasm theory by August Weismann has been foundational for the current...
www.annualreviews.org
July 18, 2025 at 10:54 AM
🔥🔥🔥 Read now our latest article: The Somatic Impact on Inheritance and the Germline Control of the Soma | Annual Reviews - www.annualreviews.org/content/jour...
Reposted by Björn Schumacher
mtor and DNA damage in kidney health 👇
🔥🔥🔥Check out our latest paper on the kidney, wonderful collaboration with Fabian Braun & Christine Kurschat @cecad.bsky.social. Read now: JCI Insight - Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage insight.jci.org/articles/vie...
June 24, 2025 at 3:58 PM
mtor and DNA damage in kidney health 👇
🔥🔥🔥Check out our latest paper on the kidney, wonderful collaboration with Fabian Braun & Christine Kurschat @cecad.bsky.social. Read now: JCI Insight - Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage insight.jci.org/articles/vie...
June 24, 2025 at 2:09 PM
🔥🔥🔥Check out our latest paper on the kidney, wonderful collaboration with Fabian Braun & Christine Kurschat @cecad.bsky.social. Read now: JCI Insight - Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage insight.jci.org/articles/vie...
Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...
June 19, 2025 at 8:37 AM
Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...
Paradigmenwechsel in der Medizin, um gesunde Lebenszeit verlängern www.nd-aktuell.de/artikel/1191...
Gesunde Lebenszeit verlängern
Viele Menschen wissen durchaus, was ein gesunder Lebensstil wäre. Umsetzbar sind diese Ansprüche trotzdem nicht für jeden. Ein Paradigmenwechsel in der Medizin könnte helfen.
www.nd-aktuell.de
June 17, 2025 at 2:57 PM
Paradigmenwechsel in der Medizin, um gesunde Lebenszeit verlängern www.nd-aktuell.de/artikel/1191...
Gesundes Altern ermöglichen: Leopoldina-Diskussionspapier empfiehlt Umdenken in Forschung und Medizin nachrichten.idw-online.de/pressrelease...
Gesundes Altern ermöglichen: Leopoldina-Diskussionspapier empfiehlt Umdenken in Forschung und Medizin
nachrichten.idw-online.de
June 17, 2025 at 9:10 AM
Gesundes Altern ermöglichen: Leopoldina-Diskussionspapier empfiehlt Umdenken in Forschung und Medizin nachrichten.idw-online.de/pressrelease...
Enabling healthy ageing: @leopoldina.org discussion paper recommends shift in focus in research and medicine. We are proposing a Health-Extending Medicine in an Aging Society and define Prospects for Medical Research and Practice
www.leopoldina.org/en/press-1/p...
www.leopoldina.org/en/press-1/p...
June 17, 2025 at 8:49 AM
Enabling healthy ageing: @leopoldina.org discussion paper recommends shift in focus in research and medicine. We are proposing a Health-Extending Medicine in an Aging Society and define Prospects for Medical Research and Practice
www.leopoldina.org/en/press-1/p...
www.leopoldina.org/en/press-1/p...
Gesundes Altern ermöglichen: Leopoldina-Diskussionspapier empfiehlt Umdenken in Forschung und Medizin. Hier sind die Ergebnisse unserer Diskussionen bei der @leopoldina.org für eine neue Medizin in einer alternden Gesellschaft. Lebenslange Gesundheit und Prävention ist erreichbar.
Umdenken in #Alternsmedizin: Ein heute erschienenes Leopoldina-Diskussionspapier empfiehlt in Forschung u. klinischer Praxis den Prozess des Alterns in den Fokus zu nehmen. Statt altersbedingte Krankheiten zu behandeln, sollten bereits deren Risiken gesenkt werden. www.leopoldina.org/presse-1/nac...
June 17, 2025 at 8:35 AM
Gesundes Altern ermöglichen: Leopoldina-Diskussionspapier empfiehlt Umdenken in Forschung und Medizin. Hier sind die Ergebnisse unserer Diskussionen bei der @leopoldina.org für eine neue Medizin in einer alternden Gesellschaft. Lebenslange Gesundheit und Prävention ist erreichbar.
Reposted by Björn Schumacher
Targeting DNA damage in ageing: towards supercharging DNA repair www.nature.com/articles/s41...
rdcu.be/eqQ7R
This new Perspective discusses approaches to pharmacologically mitigate the adverse effects of DNA damage to prevent mutation-driven cancers and mitigate age-related degenerative diseases
rdcu.be/eqQ7R
This new Perspective discusses approaches to pharmacologically mitigate the adverse effects of DNA damage to prevent mutation-driven cancers and mitigate age-related degenerative diseases
Targeting DNA damage in ageing: towards supercharging DNA repair - Nature Reviews Drug Discovery
DNA damage to the somatic genome has been identified as a major cause of ageing. This Perspective provides an overview of current understanding of the role of genome instability in the ageing process ...
www.nature.com
June 13, 2025 at 3:52 PM
Targeting DNA damage in ageing: towards supercharging DNA repair www.nature.com/articles/s41...
rdcu.be/eqQ7R
This new Perspective discusses approaches to pharmacologically mitigate the adverse effects of DNA damage to prevent mutation-driven cancers and mitigate age-related degenerative diseases
rdcu.be/eqQ7R
This new Perspective discusses approaches to pharmacologically mitigate the adverse effects of DNA damage to prevent mutation-driven cancers and mitigate age-related degenerative diseases