Luijsterburglab
@luijsterburglab.bsky.social
The Luijsterburg lab at the LUMC in Leiden investigates DNA repair mechanisms during gene transcription | luijsterburglab.org
Registration is open!🧬
Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers.
📅 Deadline for early registration: Jan 10, 2026
🔗 dnarepairmeeting-egmond2026.com
Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers.
📅 Deadline for early registration: Jan 10, 2026
🔗 dnarepairmeeting-egmond2026.com
November 12, 2025 at 3:04 PM
Registration is open!🧬
Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers.
📅 Deadline for early registration: Jan 10, 2026
🔗 dnarepairmeeting-egmond2026.com
Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers.
📅 Deadline for early registration: Jan 10, 2026
🔗 dnarepairmeeting-egmond2026.com
New paper alert! 🚨
We report two Cypriot XP-A patients with a mild phenotype caused by the homozygous c.389G>A (p.R130K) variant.
👉 The variant affects splicing, leading to reduced XPA mRNA/protein but residual NER activity.
www.sciencedirect.com/science/arti...
We report two Cypriot XP-A patients with a mild phenotype caused by the homozygous c.389G>A (p.R130K) variant.
👉 The variant affects splicing, leading to reduced XPA mRNA/protein but residual NER activity.
www.sciencedirect.com/science/arti...
September 29, 2025 at 1:47 PM
New paper alert! 🚨
We report two Cypriot XP-A patients with a mild phenotype caused by the homozygous c.389G>A (p.R130K) variant.
👉 The variant affects splicing, leading to reduced XPA mRNA/protein but residual NER activity.
www.sciencedirect.com/science/arti...
We report two Cypriot XP-A patients with a mild phenotype caused by the homozygous c.389G>A (p.R130K) variant.
👉 The variant affects splicing, leading to reduced XPA mRNA/protein but residual NER activity.
www.sciencedirect.com/science/arti...
Reposted by Luijsterburglab
📢 ERCC1-hepatorenal syndrome is defined as a severe, multisystem DNA repair disorder associated with high morbidity and mortality, including an elevated cancer risk. 🧬 @luijsterburglab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines - European Journal of Human Genetics
European Journal of Human Genetics - A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines
www.nature.com
August 17, 2025 at 6:38 AM
📢 ERCC1-hepatorenal syndrome is defined as a severe, multisystem DNA repair disorder associated with high morbidity and mortality, including an elevated cancer risk. 🧬 @luijsterburglab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dive into the step-by-step choreography of transcription-coupled DNA repair.
In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research!
www.nature.com/articles/s41...
In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research!
www.nature.com/articles/s41...
The molecular basis of human transcription-coupled DNA repair - Nature Cell Biology
This Review discusses transcription-coupled DNA repair in response to the stalling of RNA polymerase II on different types of DNA lesions and highlights the molecular details for the different steps i...
www.nature.com
August 5, 2025 at 9:49 AM
Dive into the step-by-step choreography of transcription-coupled DNA repair.
In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research!
www.nature.com/articles/s41...
In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research!
www.nature.com/articles/s41...
Happy to share I have been promoted to Full Professor of Transcription and DNA Repair! Huge thanks to all current and former Luijsterburg Lab members. Your hard work, dedication, and inspiring spirit made this possible! 💥🧬🙏 www.luijsterburglab.org
August 1, 2025 at 7:14 AM
Happy to share I have been promoted to Full Professor of Transcription and DNA Repair! Huge thanks to all current and former Luijsterburg Lab members. Your hard work, dedication, and inspiring spirit made this possible! 💥🧬🙏 www.luijsterburglab.org
Are transcription-associated histone marks involved in restoring transcription after DNA damage in human cells?
Read the surprising outcome in our new preprint 👇
www.biorxiv.org/content/10.1...
Read the surprising outcome in our new preprint 👇
www.biorxiv.org/content/10.1...
July 24, 2025 at 6:08 PM
Are transcription-associated histone marks involved in restoring transcription after DNA damage in human cells?
Read the surprising outcome in our new preprint 👇
www.biorxiv.org/content/10.1...
Read the surprising outcome in our new preprint 👇
www.biorxiv.org/content/10.1...
Very proud of this international collaborative team effort published in EJHG defining ERCC1-hepatorenal syndrome as a severe multisystem DNA repair disorder with high mortality and pediatric liver cancer risk. Thanks to all families and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines - European Journal of Human Genetics
European Journal of Human Genetics - A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines
www.nature.com
July 19, 2025 at 5:58 PM
Very proud of this international collaborative team effort published in EJHG defining ERCC1-hepatorenal syndrome as a severe multisystem DNA repair disorder with high mortality and pediatric liver cancer risk. Thanks to all families and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Luijsterburglab
📢 Only 2 more days left until the early bird registration deadline! Secure your spot and join us at the 8th EU-US Conference on Endogenous DNA Damage and Repair!
May 23, 2025 at 12:03 PM
📢 Only 2 more days left until the early bird registration deadline! Secure your spot and join us at the 8th EU-US Conference on Endogenous DNA Damage and Repair!
A must for all DNA repair aficionados!
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
April 9, 2025 at 8:05 AM
A must for all DNA repair aficionados!
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
It was wonderful to have our lab symposium yesterday, filled with great science, new ideas, good company, and delicious food. What a pleasure it is to work with such a fantastic group of people!
February 18, 2025 at 11:22 AM
It was wonderful to have our lab symposium yesterday, filled with great science, new ideas, good company, and delicious food. What a pleasure it is to work with such a fantastic group of people!
Our letter-to-the-editor providing evidence that ARK2N is not a core factor in transcription-coupled DNA repair is now online in PNAS | www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 24, 2025 at 7:43 PM
Our letter-to-the-editor providing evidence that ARK2N is not a core factor in transcription-coupled DNA repair is now online in PNAS | www.pnas.org/doi/10.1073/...
Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24!
You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond
Registration will open by June 2025/
You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond
Registration will open by June 2025/
December 23, 2024 at 12:46 PM
Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24!
You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond
Registration will open by June 2025/
You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond
Registration will open by June 2025/
Lovely Christmas party with the @luijsterburglab.bsky.social ! Looking forward to great science with this amazing group in 2025.
December 14, 2024 at 1:10 AM
Lovely Christmas party with the @luijsterburglab.bsky.social ! Looking forward to great science with this amazing group in 2025.
Reposted by Luijsterburglab
Our review on the recently discovered transcription-coupled DPC repair pathway is out in Trends in Cell Biology. Yet another wonderful collaboration with @cjcarnie.bsky.social and Steve Jackson.
Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns.
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Transcription-coupled repair of DNA–protein crosslinks
DNA–protein crosslinks (DPCs) are highly toxic DNA lesions that are relevant to multiple
human diseases. They are caused by various endogenous and environmental agents, and
from the actions of enzymes...
www.cell.com
December 2, 2024 at 7:51 AM
Our review on the recently discovered transcription-coupled DPC repair pathway is out in Trends in Cell Biology. Yet another wonderful collaboration with @cjcarnie.bsky.social and Steve Jackson.
It's a wrap! The 12th 3R+3C meeting in Fukuoka was amazing. Looking forward to the next edition!
November 22, 2024 at 1:01 PM
It's a wrap! The 12th 3R+3C meeting in Fukuoka was amazing. Looking forward to the next edition!
Leaving Kyoto for the 3R+3C meeting in Fukuoka! Looking forward to great science, catching up with old friends, and making new ones.
November 18, 2024 at 2:40 AM
Leaving Kyoto for the 3R+3C meeting in Fukuoka! Looking forward to great science, catching up with old friends, and making new ones.
Reposted by Luijsterburglab
Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg
November 10, 2024 at 9:43 PM
Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg
En route to the 3R&3C meeting in Fukuoka, but first some time for sightseeing in Kyoto!
November 16, 2024 at 3:12 PM
En route to the 3R&3C meeting in Fukuoka, but first some time for sightseeing in Kyoto!
Happy to share our new paper with Goran Kokic and the Svejstrup lab in Cell!
We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.
Great teamwork by Diana, Marta and Paula!
www.cell.com/cell/fulltex...
We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.
Great teamwork by Diana, Marta and Paula!
www.cell.com/cell/fulltex...
November 16, 2024 at 2:06 PM
Happy to share our new paper with Goran Kokic and the Svejstrup lab in Cell!
We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.
Great teamwork by Diana, Marta and Paula!
www.cell.com/cell/fulltex...
We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.
Great teamwork by Diana, Marta and Paula!
www.cell.com/cell/fulltex...