Alessandro Costa
@costalaboratory.bsky.social
Principal Group Leader at the Francis Crick Institute. DNA replication, cryo-EM and molecular mechanism.
Pinned
8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷
Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️
Organised by @lapassmore.bsky.social, Dana Branzei, me.
Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️
Organised by @lapassmore.bsky.social, Dana Branzei, me.
plus ...
Ana Casañal
Claudio Ciferri
Hitoshi Kurumizaka
Meindert Lamers
David Rueda
Yuanling Zhai
Xiaodong Zhang
🧬🔬✨❄️ 🧫⚗️🧑🔬🏖️
Ana Casañal
Claudio Ciferri
Hitoshi Kurumizaka
Meindert Lamers
David Rueda
Yuanling Zhai
Xiaodong Zhang
🧬🔬✨❄️ 🧫⚗️🧑🔬🏖️
January 9, 2026 at 10:21 AM
plus ...
Ana Casañal
Claudio Ciferri
Hitoshi Kurumizaka
Meindert Lamers
David Rueda
Yuanling Zhai
Xiaodong Zhang
🧬🔬✨❄️ 🧫⚗️🧑🔬🏖️
Ana Casañal
Claudio Ciferri
Hitoshi Kurumizaka
Meindert Lamers
David Rueda
Yuanling Zhai
Xiaodong Zhang
🧬🔬✨❄️ 🧫⚗️🧑🔬🏖️
🌞✈️🇬🇷🏝️ 🧬 Machines on Genes 2026 🧬 🌞✈️🇬🇷🏝️
What an amazing list of speakers 🤩
@nynkedekkerlab.bsky.social
@dodonova-sveta.bsky.social
@yuanhejhu.bsky.social
@uwmadisonrna.bsky.social
@kowaeva.bsky.social
@fmattiroli.bsky.social
@aliciakmichael.bsky.social
@lisaracki.bsky.social
@yeeles-lab.bsky.social
What an amazing list of speakers 🤩
@nynkedekkerlab.bsky.social
@dodonova-sveta.bsky.social
@yuanhejhu.bsky.social
@uwmadisonrna.bsky.social
@kowaeva.bsky.social
@fmattiroli.bsky.social
@aliciakmichael.bsky.social
@lisaracki.bsky.social
@yeeles-lab.bsky.social
January 9, 2026 at 10:21 AM
🌞✈️🇬🇷🏝️ 🧬 Machines on Genes 2026 🧬 🌞✈️🇬🇷🏝️
What an amazing list of speakers 🤩
@nynkedekkerlab.bsky.social
@dodonova-sveta.bsky.social
@yuanhejhu.bsky.social
@uwmadisonrna.bsky.social
@kowaeva.bsky.social
@fmattiroli.bsky.social
@aliciakmichael.bsky.social
@lisaracki.bsky.social
@yeeles-lab.bsky.social
What an amazing list of speakers 🤩
@nynkedekkerlab.bsky.social
@dodonova-sveta.bsky.social
@yuanhejhu.bsky.social
@uwmadisonrna.bsky.social
@kowaeva.bsky.social
@fmattiroli.bsky.social
@aliciakmichael.bsky.social
@lisaracki.bsky.social
@yeeles-lab.bsky.social
🔔 Register now and send an abstract!
Lots of opportunities to talk!
👉 www.eventsforce.net/biochemsoc/f...
Lots of opportunities to talk!
👉 www.eventsforce.net/biochemsoc/f...
www.eventsforce.net
January 9, 2026 at 10:19 AM
🔔 Register now and send an abstract!
Lots of opportunities to talk!
👉 www.eventsforce.net/biochemsoc/f...
Lots of opportunities to talk!
👉 www.eventsforce.net/biochemsoc/f...
8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷
Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️
Organised by @lapassmore.bsky.social, Dana Branzei, me.
Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️
Organised by @lapassmore.bsky.social, Dana Branzei, me.
January 9, 2026 at 10:14 AM
8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷
Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️
Organised by @lapassmore.bsky.social, Dana Branzei, me.
Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️
Organised by @lapassmore.bsky.social, Dana Branzei, me.
Reposted by Alessandro Costa
Reposted by Alessandro Costa
Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
www.eventsforce.net
January 5, 2026 at 4:52 PM
Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
Less than two weeks left to apply!
Postdoc positions in my lab to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists & structural biologists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Postdoc positions in my lab to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists & structural biologists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Postdoctoral Fellow - Costa Lab
Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...
crick.wd3.myworkdayjobs.com
July 21, 2025 at 2:57 PM
Less than two weeks left to apply!
Postdoc positions in my lab to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists & structural biologists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Postdoc positions in my lab to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists & structural biologists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
June 20, 2025 at 9:38 AM
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
How does ATP hydrolysis by MCM enable replicative helicase loading onto DNA?
Find the answer in our latest article
rdcu.be/d6D8D
Congratulations to Agata Butryn who led the entire project, with contributions from Julia Greiwe at the start. 🎉❄️🔬🧬
Find the answer in our latest article
rdcu.be/d6D8D
Congratulations to Agata Butryn who led the entire project, with contributions from Julia Greiwe at the start. 🎉❄️🔬🧬
Unidirectional MCM translocation away from ORC drives origin licensing
Nature Communications - When the MCM motor of the replicative helicase becomes loaded onto chromatin, origin DNA is licensed for replication. Here, the authors show why the ATPase function of MCM...
rdcu.be
January 20, 2025 at 9:24 AM
How does ATP hydrolysis by MCM enable replicative helicase loading onto DNA?
Find the answer in our latest article
rdcu.be/d6D8D
Congratulations to Agata Butryn who led the entire project, with contributions from Julia Greiwe at the start. 🎉❄️🔬🧬
Find the answer in our latest article
rdcu.be/d6D8D
Congratulations to Agata Butryn who led the entire project, with contributions from Julia Greiwe at the start. 🎉❄️🔬🧬
definitely, let's meet up. I will be doing my first cryoFIB experiment but will make time for a chat! It must be 7 years since I last saw you!
December 14, 2024 at 12:41 PM
definitely, let's meet up. I will be doing my first cryoFIB experiment but will make time for a chat! It must be 7 years since I last saw you!
Thank you, Dan!
December 14, 2024 at 10:00 AM
Thank you, Dan!
Amazing work, Jon.
December 12, 2024 at 9:49 PM
Amazing work, Jon.
Great to see this, Lucas. Congratulations!
December 12, 2024 at 9:48 PM
Great to see this, Lucas. Congratulations!
Thank you, Alexey!
December 12, 2024 at 12:13 AM
Thank you, Alexey!
Could I afford you? is the appropriate question! ;-) BTW, it is only thanks to the work that you and your lab mates did over the years that I could receive this grant!
December 11, 2024 at 11:48 PM
Could I afford you? is the appropriate question! ;-) BTW, it is only thanks to the work that you and your lab mates did over the years that I could receive this grant!
Thank you, Rob!
December 11, 2024 at 2:23 PM
Thank you, Rob!
December 11, 2024 at 1:53 PM
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
December 11, 2024 at 1:53 PM
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Well done, Gideon! Very well deserved.
December 6, 2024 at 9:07 AM
Well done, Gideon! Very well deserved.
Great work, Alex and colleagues!
December 5, 2024 at 7:39 PM
Great work, Alex and colleagues!
Drew, breathtaking!
December 4, 2024 at 12:05 PM
Drew, breathtaking!
Thank you, Andrew!
November 28, 2024 at 9:23 AM
Thank you, Andrew!
Happy to be of help, Anna! 😀
November 28, 2024 at 9:21 AM
Happy to be of help, Anna! 😀
Thanks Tim! Lucky to work with a great group of people!
November 28, 2024 at 9:20 AM
Thanks Tim! Lucky to work with a great group of people!
Thank you, Francesca!
November 28, 2024 at 9:19 AM
Thank you, Francesca!