altmeyerlab
@altmeyerlab.bsky.social
Genome integrity maintenance during cell cycle progression: This is what we care about, this is what we study. #GenomeStability #ReplicationStress #DNADamage #UZH #Science #AcademicSky
https://www.altmeyerlab.org/
https://www.altmeyerlab.org/
Pinned
altmeyerlab
@altmeyerlab.bsky.social
· May 21
Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...
Reposted by altmeyerlab
Excited to share our new Nature study! 🧬
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
January 15, 2026 at 7:45 AM
Excited to share our new Nature study! 🧬
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
Reposted by altmeyerlab
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 12:46 AM
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Reposted by altmeyerlab
📢 Telomere community: Registration and abstract submission are now open for the EMBO Workshop “Telomere function and maintenance in health and disease”, May 25–30, 2026, in Lazise, Italy 🇮🇹. Looking forward to an exciting meeting! Please re-post. meetings.embo.org/event/26-tel...
Telomere function and maintenance in health and disease
Telomeres are specialized structures that protect the ends of linear chromosomes in eukaryotes. Research in this area has revealed that telomere maintenance is critical for stem cell function and nor…
meetings.embo.org
December 15, 2025 at 5:57 PM
📢 Telomere community: Registration and abstract submission are now open for the EMBO Workshop “Telomere function and maintenance in health and disease”, May 25–30, 2026, in Lazise, Italy 🇮🇹. Looking forward to an exciting meeting! Please re-post. meetings.embo.org/event/26-tel...
Reposted by altmeyerlab
🚨 Exciting news! Our latest study is out in Nature Communications!
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription - Nature Communications
Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another...
www.nature.com
December 10, 2025 at 12:11 PM
🚨 Exciting news! Our latest study is out in Nature Communications!
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
Reposted by altmeyerlab
We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!
Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668
The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a Tenure Track Professors...
www.nature.com
December 9, 2025 at 6:11 PM
We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!
Reposted by altmeyerlab
‼️ Excited to share our new paper out now in @science.org ‼️
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
November 7, 2025 at 10:15 AM
‼️ Excited to share our new paper out now in @science.org ‼️
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
A comprehensive genetic catalog of human double-strand break repair | Science www.science.org/doi/10.1126/...
A comprehensive genetic catalog of human double-strand break repair
The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...
www.science.org
October 2, 2025 at 6:47 PM
A comprehensive genetic catalog of human double-strand break repair | Science www.science.org/doi/10.1126/...
Reposted by altmeyerlab
The world has lost its most powerful advocate for nature and hope. Yet many remain who will continue her legacy and I know she will continue to inspire generations more.
October 1, 2025 at 6:01 PM
The world has lost its most powerful advocate for nature and hope. Yet many remain who will continue her legacy and I know she will continue to inspire generations more.
Reposted by altmeyerlab
Come and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.
Professors x 10, Faculty of Medicine & Dentistry | Veredus
QUEEN MARY UNIVERSITY OF LONDON Professors x 10, Faculty of Medicine and Dentistry London Competitive Remuneration Package Queen Mary University of London seeks up to 10 world-leading translational re...
www.veredus.co.uk
October 1, 2025 at 7:34 AM
Come and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.
Reposted by altmeyerlab
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
September 18, 2025 at 4:09 PM
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
Reposted by altmeyerlab
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
September 11, 2025 at 1:07 PM
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
Reposted by altmeyerlab
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
www.nature.com
September 3, 2025 at 3:59 PM
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
Reposted by altmeyerlab
📢Deadline extended!
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
September 2, 2025 at 2:38 PM
📢Deadline extended!
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4
Reposted by altmeyerlab
@efapostolou29.bsky.social @thecesarelab.bsky.social we're looking forward to your presentations at this fantastic meeting!
September 2, 2025 at 2:39 PM
@efapostolou29.bsky.social @thecesarelab.bsky.social we're looking forward to your presentations at this fantastic meeting!
Reposted by altmeyerlab
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
August 28, 2025 at 6:34 AM
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
Reposted by altmeyerlab
Deadline approaching for #SGO25
🗓 31 Oct – 03 Nov 2025
📍Riviera Maya, Mexico
Poster & Reg deadline: 01 Sept 2025
Details & Reg: bit.ly/45Mmhtv
$250 registration grants available! Email amy@fusion-conferences.com with your name, position & current research topic.
🗓 31 Oct – 03 Nov 2025
📍Riviera Maya, Mexico
Poster & Reg deadline: 01 Sept 2025
Details & Reg: bit.ly/45Mmhtv
$250 registration grants available! Email amy@fusion-conferences.com with your name, position & current research topic.
August 27, 2025 at 11:43 AM
Deadline approaching for #SGO25
🗓 31 Oct – 03 Nov 2025
📍Riviera Maya, Mexico
Poster & Reg deadline: 01 Sept 2025
Details & Reg: bit.ly/45Mmhtv
$250 registration grants available! Email amy@fusion-conferences.com with your name, position & current research topic.
🗓 31 Oct – 03 Nov 2025
📍Riviera Maya, Mexico
Poster & Reg deadline: 01 Sept 2025
Details & Reg: bit.ly/45Mmhtv
$250 registration grants available! Email amy@fusion-conferences.com with your name, position & current research topic.
Reposted by altmeyerlab
Advertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences:
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515
Department of Biochemistry, School of Medicine—Basic Sciences
www.nature.com
August 14, 2025 at 4:57 PM
Advertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences:
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Reposted by altmeyerlab
Another exciting research article from a member of the #RepliFate network!
The Altmeyer lab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis.
Check out their findings here: doi.org/10.1016/j.ce...
The Altmeyer lab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis.
Check out their findings here: doi.org/10.1016/j.ce...
August 11, 2025 at 9:26 AM
Another exciting research article from a member of the #RepliFate network!
The Altmeyer lab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis.
Check out their findings here: doi.org/10.1016/j.ce...
The Altmeyer lab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis.
Check out their findings here: doi.org/10.1016/j.ce...
New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @cp-cellreports.bsky.social. Congratulations to first author Antonio Galarreta and to all co-authors. www.cell.com/cell-reports.... #Microscopy #RNAiScreen #Condensates
July 31, 2025 at 2:09 PM
New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @cp-cellreports.bsky.social. Congratulations to first author Antonio Galarreta and to all co-authors. www.cell.com/cell-reports.... #Microscopy #RNAiScreen #Condensates
Reposted by altmeyerlab
Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications
A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...
www.nature.com
July 21, 2025 at 10:53 AM
Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
Reposted by altmeyerlab
📣 We are recruiting new group leaders in Innovative Biology!
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
May 28, 2025 at 12:12 PM
📣 We are recruiting new group leaders in Innovative Biology!
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
Reposted by altmeyerlab
New @nature.com
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
May 21, 2025 at 5:17 PM
New @nature.com
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
Reposted by altmeyerlab
🔬Under the microscope: DNA damage tracked through cell generations🔬
It was a pleasure to write this #NewsAndViews with our PhD student Emma Reilly, online today @nature.com
rdcu.be/em0qi
@cruk-ci.bsky.social @spjacksongroup.bsky.social @yalepathology.bsky.social @yalecancer.bsky.social
It was a pleasure to write this #NewsAndViews with our PhD student Emma Reilly, online today @nature.com
rdcu.be/em0qi
@cruk-ci.bsky.social @spjacksongroup.bsky.social @yalepathology.bsky.social @yalecancer.bsky.social
Under the microscope: DNA damage tracked through cell generations | Nature
An ingenious technique reveals how stressed cells divide to produce progeny that have different traits — a phenomenon that can initiate cancer. An ingenious technique reveals how stressed cells divide to produce progeny that have different traits — a phenomenon that can initiate cancer.
rdcu.be
May 21, 2025 at 3:56 PM
🔬Under the microscope: DNA damage tracked through cell generations🔬
It was a pleasure to write this #NewsAndViews with our PhD student Emma Reilly, online today @nature.com
rdcu.be/em0qi
@cruk-ci.bsky.social @spjacksongroup.bsky.social @yalepathology.bsky.social @yalecancer.bsky.social
It was a pleasure to write this #NewsAndViews with our PhD student Emma Reilly, online today @nature.com
rdcu.be/em0qi
@cruk-ci.bsky.social @spjacksongroup.bsky.social @yalepathology.bsky.social @yalecancer.bsky.social
Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...
May 21, 2025 at 3:57 PM
Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...
Looking very much forward to the 2nd edition of the Fusion Conference on Spatial Genome Organisation #SGO25 @fusionconf.bsky.social @karimmekhail.bsky.social @chiololab.bsky.social. Early bird registration closes soon: June 2nd, 2025. Slots available for selected talks from abstracts: bit.ly/4492G6i
2nd Spatial Genome Organisation Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
www.fusion-conferences.com
May 15, 2025 at 12:25 PM
Looking very much forward to the 2nd edition of the Fusion Conference on Spatial Genome Organisation #SGO25 @fusionconf.bsky.social @karimmekhail.bsky.social @chiololab.bsky.social. Early bird registration closes soon: June 2nd, 2025. Slots available for selected talks from abstracts: bit.ly/4492G6i