Agnel Sfeir
@agnelsfeir.bsky.social
Scientist. https://www.sfeirlab.com/
Prof. at MSKCC and co-founder of Repare Therapeutics. 🇱🇧+🇺🇸 in NYC
Prof. at MSKCC and co-founder of Repare Therapeutics. 🇱🇧+🇺🇸 in NYC
Reposted by Agnel Sfeir
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted by Agnel Sfeir
Meet #MSKPostdoc Megan E. Kelley (@meganekelley.bsky.social) in the @agnelsfeir.bsky.social Lab, where she studies error-prone DNA 🧬 damage repair in the context of cancer and drug resistance.
👏 Congrats to Megan on receiving both the NCI F32 and MSK Society Scholar awards!
#NPAW2025
👏 Congrats to Megan on receiving both the NCI F32 and MSK Society Scholar awards!
#NPAW2025
September 26, 2025 at 3:28 PM
Meet #MSKPostdoc Megan E. Kelley (@meganekelley.bsky.social) in the @agnelsfeir.bsky.social Lab, where she studies error-prone DNA 🧬 damage repair in the context of cancer and drug resistance.
👏 Congrats to Megan on receiving both the NCI F32 and MSK Society Scholar awards!
#NPAW2025
👏 Congrats to Megan on receiving both the NCI F32 and MSK Society Scholar awards!
#NPAW2025
Congrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social
Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience
Developmental biologist Maria Jasin wins the 2025 Pearl Meister Greengard Prize - News
Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Awarded annually by ...
www.rockefeller.edu
September 17, 2025 at 2:29 PM
Congrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social
Reposted by Agnel Sfeir
🎉 Congratulations to our 10 MSK Postdoc Slam finalists! 👏 You were all fantastic and it was truly inspiring to learn about the incredible and diverse work happening at @mskcancercenter.bsky.social. Our #MSKPostdocs gave the judges a real challenge… choosing winners was no easy task! 🤗 #NPAW2025
September 15, 2025 at 9:51 PM
🎉 Congratulations to our 10 MSK Postdoc Slam finalists! 👏 You were all fantastic and it was truly inspiring to learn about the incredible and diverse work happening at @mskcancercenter.bsky.social. Our #MSKPostdocs gave the judges a real challenge… choosing winners was no easy task! 🤗 #NPAW2025
Reposted by Agnel Sfeir
While our judges deliberate the top 3 winners of MSK Postdoc Slam, let’s celebrate our #NPAW2025 📸 contest champs! 🎉
🥇 @meganekelley.bsky.social – @agnelsfeir.bsky.social lab
🥈 Zhendong Cao – @sawyerslabmskcc.bsky.social
🥉 Manendra Lankadasari – Jones lab
Congrats to our amazing #MSKPostdocs! 👏📷
🥇 @meganekelley.bsky.social – @agnelsfeir.bsky.social lab
🥈 Zhendong Cao – @sawyerslabmskcc.bsky.social
🥉 Manendra Lankadasari – Jones lab
Congrats to our amazing #MSKPostdocs! 👏📷
September 15, 2025 at 8:44 PM
While our judges deliberate the top 3 winners of MSK Postdoc Slam, let’s celebrate our #NPAW2025 📸 contest champs! 🎉
🥇 @meganekelley.bsky.social – @agnelsfeir.bsky.social lab
🥈 Zhendong Cao – @sawyerslabmskcc.bsky.social
🥉 Manendra Lankadasari – Jones lab
Congrats to our amazing #MSKPostdocs! 👏📷
🥇 @meganekelley.bsky.social – @agnelsfeir.bsky.social lab
🥈 Zhendong Cao – @sawyerslabmskcc.bsky.social
🥉 Manendra Lankadasari – Jones lab
Congrats to our amazing #MSKPostdocs! 👏📷
Reposted by Agnel Sfeir
It’s SHOW TIME! 🎤 Kicking off the MSK Postdoc Slam is @meganekelley.bsky.social from the @agnelsfeir.bsky.social lab, diving into how error-prone DNA repair fuels drug resistance in cancer 🧬💊
September 15, 2025 at 8:09 PM
It’s SHOW TIME! 🎤 Kicking off the MSK Postdoc Slam is @meganekelley.bsky.social from the @agnelsfeir.bsky.social lab, diving into how error-prone DNA repair fuels drug resistance in cancer 🧬💊
Reposted by Agnel Sfeir
Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose & treat cancer.
bit.ly/3WUiuo1
bit.ly/3WUiuo1
Gerstner Sloan Kettering Graduate School of Biomedical Sciences
The Gerstner Sloan Kettering Graduate School of Biomedical Sciences offers the next generation of basic scientists a program to study the biological sciences through the lens of cancer
bit.ly
September 11, 2025 at 5:06 PM
Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose & treat cancer.
bit.ly/3WUiuo1
bit.ly/3WUiuo1
Reposted by Agnel Sfeir
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
September 4, 2025 at 4:32 PM
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Reposted by Agnel Sfeir
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Postdoctoral Research Associate in the Blackford Group
A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th
candidate.hr-manager.net
May 29, 2025 at 11:26 AM
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Congrats!! Not a bad way to start your own lab 😜
Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)
May 12, 2025 at 6:37 PM
Congrats!! Not a bad way to start your own lab 😜
Reposted by Agnel Sfeir
Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)
May 12, 2025 at 5:49 PM
Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)
Reposted by Agnel Sfeir
Here is the link to the Last Week Tonight with John Oliver about RFK, Jr, public health, and HHS (including NIH)
www.youtube.com/watch?v=8H34...
www.youtube.com/watch?v=8H34...
RFK Jr. & HHS: Last Week Tonight with John Oliver (HBO)
YouTube video by LastWeekTonight
www.youtube.com
April 28, 2025 at 12:44 PM
Here is the link to the Last Week Tonight with John Oliver about RFK, Jr, public health, and HHS (including NIH)
www.youtube.com/watch?v=8H34...
www.youtube.com/watch?v=8H34...
Reposted by Agnel Sfeir
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Opinion | Science Suffers With Trump’s Funding Freeze
America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.
www.wsj.com
April 21, 2025 at 6:21 PM
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Reposted by Agnel Sfeir
Take a look at the harvard web site...We have our break-throughs and next generation drugs on full display! Come take a look at the new wonders of medicine! So proud to be a part of it!!! Harvard.edu
Harvard University
Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.
Harvard.edu
April 16, 2025 at 1:24 AM
Take a look at the harvard web site...We have our break-throughs and next generation drugs on full display! Come take a look at the new wonders of medicine! So proud to be a part of it!!! Harvard.edu
Reposted by Agnel Sfeir
🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
April 12, 2025 at 1:42 PM
🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Reposted by Agnel Sfeir
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
www.cnn.com
April 9, 2025 at 11:30 AM
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Reposted by Agnel Sfeir
📢#BGFP25 GRANTS AVAILABLE & TALK DEADLINE EXTENDED!
💰We are excited to announce we have at least 10 reg support grants ready to award to those submitting abstracts!
🧑💼Our short talk submission deadline has been extended and will now close on 01 April.
Submit your abstract HERE: bit.ly/3AnsVZF
💰We are excited to announce we have at least 10 reg support grants ready to award to those submitting abstracts!
🧑💼Our short talk submission deadline has been extended and will now close on 01 April.
Submit your abstract HERE: bit.ly/3AnsVZF
March 25, 2025 at 9:33 AM
📢#BGFP25 GRANTS AVAILABLE & TALK DEADLINE EXTENDED!
💰We are excited to announce we have at least 10 reg support grants ready to award to those submitting abstracts!
🧑💼Our short talk submission deadline has been extended and will now close on 01 April.
Submit your abstract HERE: bit.ly/3AnsVZF
💰We are excited to announce we have at least 10 reg support grants ready to award to those submitting abstracts!
🧑💼Our short talk submission deadline has been extended and will now close on 01 April.
Submit your abstract HERE: bit.ly/3AnsVZF
Reposted by Agnel Sfeir
Harvey Society lecture tonight features Eric Olson. Come listen to an absolute giant in muscle biology! Bonus roast/ appreciation by me and Mary Baylies!
harveysociety.org/lectures/abs...
harveysociety.org/lectures/abs...
March 20, 2025 at 7:57 PM
Harvey Society lecture tonight features Eric Olson. Come listen to an absolute giant in muscle biology! Bonus roast/ appreciation by me and Mary Baylies!
harveysociety.org/lectures/abs...
harveysociety.org/lectures/abs...
Reposted by Agnel Sfeir
Scientists have just cured pancreatic cancer in some patients with personalized mRNA vaccines. Pancreatic cancer. And this Trump administration wants to throw it all away.
They’re throwing away a cure for cancer.
They’re throwing away a cure for cancer.
Exclusive: NIH officials have advised scientists to remove reference to mRNA vaccines from their grant applications, in expectation the Trump administration intends to abandon most research in the field.
By @arthurallen202.bsky.social
kffhealthnews.org/news/article...
By @arthurallen202.bsky.social
kffhealthnews.org/news/article...
Scientists Say NIH Officials Told Them To Scrub mRNA References on Grants - KFF Health News
Two senior scientists say National Institutes of Health officials advised them to remove references to mRNA vaccines in grant applications, and they fear the Trump administration will abandon a promis...
kffhealthnews.org
March 17, 2025 at 1:16 AM
Scientists have just cured pancreatic cancer in some patients with personalized mRNA vaccines. Pancreatic cancer. And this Trump administration wants to throw it all away.
They’re throwing away a cure for cancer.
They’re throwing away a cure for cancer.
Reposted by Agnel Sfeir
A new collection of papers on #mitochondrialdiseases is ready: biomed.news/bims-mitdis/...
Congratulations to all authors!
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Highlight: Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Congratulations to all authors!
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Highlight: Engineering mtDNA deletions by reconstituting end joining in human mitochondria
March 16, 2025 at 10:04 AM
A new collection of papers on #mitochondrialdiseases is ready: biomed.news/bims-mitdis/...
Congratulations to all authors!
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Highlight: Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Congratulations to all authors!
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Highlight: Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Reposted by Agnel Sfeir
Congrats Agnel! As a side note, also an example of how studying diverse systems of DNA repair yields unexpected benefits across domains of life, in this case the NHEJ system of mycobacteria, the first prokaryotic NHEJ system to be characterized: www.nature.com/articles/nsm...
March 14, 2025 at 1:05 PM
Congrats Agnel! As a side note, also an example of how studying diverse systems of DNA repair yields unexpected benefits across domains of life, in this case the NHEJ system of mycobacteria, the first prokaryotic NHEJ system to be characterized: www.nature.com/articles/nsm...
Reposted by Agnel Sfeir
This publication is deeply meaningful to us, as Ignas tragically passed away last year from a sudden and aggressive cancer. Proud that his incredible scientific legacy lives on through this work. We will never forget him, and it has only strengthened our dedication to the work we do at MSKCC.
March 13, 2025 at 3:36 PM
This publication is deeply meaningful to us, as Ignas tragically passed away last year from a sudden and aggressive cancer. Proud that his incredible scientific legacy lives on through this work. We will never forget him, and it has only strengthened our dedication to the work we do at MSKCC.
No matter what Rocket Man says, the NIH offers a strong return on investment www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 13, 2025 at 12:58 AM
No matter what Rocket Man says, the NIH offers a strong return on investment www.forbes.com/sites/michae...
Reposted by Agnel Sfeir
Postdoc Night Science NYC! Next session is Friday 4-6pm at MSK, to learn and practice the creative scientific process! The topic this time is the import/export of ideas. Yael David join us too! @davidlabmsk.bsky.social
Limited spots: docs.google.com/forms/d/12bB... @kelseymonson.bsky.social
Limited spots: docs.google.com/forms/d/12bB... @kelseymonson.bsky.social
March 10, 2025 at 2:04 PM
Postdoc Night Science NYC! Next session is Friday 4-6pm at MSK, to learn and practice the creative scientific process! The topic this time is the import/export of ideas. Yael David join us too! @davidlabmsk.bsky.social
Limited spots: docs.google.com/forms/d/12bB... @kelseymonson.bsky.social
Limited spots: docs.google.com/forms/d/12bB... @kelseymonson.bsky.social
Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...
Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled precise base substitutions and the efficient elimination of…
www.sciencedirect.com
March 10, 2025 at 6:38 PM
Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...