Ardem Patapoutian
@ardemp.bskyverified.social
Scripps Research Professor. HHMI Investigator. Nobel Prize Physiology or Medicine 2021. Opinions are my own and do not reflect those of my employer.
Pinned
Hey folks! I got a tattoo of my beloved PIEZO ion channel on my arm! Now I can show how they activate (flatten) under pressure by flexing—Will add a bit of performance art to my science talks 🧪🧠.
Reposted by Ardem Patapoutian
New York Times obituary for my dad. www.nytimes.com/2026/01/02/n...
Dick Zimmer, N.J. Congressman Who Sponsored Megan’s Law, Dies at 81
www.nytimes.com
January 2, 2026 at 10:38 PM
New York Times obituary for my dad. www.nytimes.com/2026/01/02/n...
Reposted by Ardem Patapoutian
Joel Habener led research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro.
Joel Habener, Whose Research Helped Develop Weight-Loss Drugs, Dies at 88
Habener led research that discovered the GLP-1 hormone, a key ingredient in Ozempic and Mounjaro.
on.wsj.com
December 29, 2025 at 7:15 PM
Joel Habener led research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro.
I have to be honest. I never thought I would read a manuscript that discusses PIEZO2, the Big Bang, and wormholes in the same place. But here we are:
www.researchgate.net/profile/Bala...
www.researchgate.net/profile/Bala...
December 29, 2025 at 6:52 PM
I have to be honest. I never thought I would read a manuscript that discusses PIEZO2, the Big Bang, and wormholes in the same place. But here we are:
www.researchgate.net/profile/Bala...
www.researchgate.net/profile/Bala...
👀
December 28, 2025 at 8:20 PM
👀
Thank you for your years of service, Walter!
More news (not good) from NIH
The renewal request from National Institute of Neurological Diseases and Stroke Director Walter Koroshetz has been denied.
I guess the NIH_leadership™ needed another position to fill with their time-tested recruitment process.
The renewal request from National Institute of Neurological Diseases and Stroke Director Walter Koroshetz has been denied.
I guess the NIH_leadership™ needed another position to fill with their time-tested recruitment process.
December 27, 2025 at 6:45 PM
Thank you for your years of service, Walter!
Reposted by Ardem Patapoutian
A new @cp-cell.bsky.social study led by @ardemp.bskyverified.social and @rose-hill.bsky.social identifies a kidney mechanism that allows renin to adjust in real time, showing that PIEZO2 enables cells to sense physical forces and fine-tune renin release.
Study reveals a key hormonal circuit in the kidneys
ow.ly
December 23, 2025 at 10:19 PM
A new @cp-cell.bsky.social study led by @ardemp.bskyverified.social and @rose-hill.bsky.social identifies a kidney mechanism that allows renin to adjust in real time, showing that PIEZO2 enables cells to sense physical forces and fine-tune renin release.
Reposted by Ardem Patapoutian
📣 The Science Friday team has spoken: Here’s a roundup of our favorite stories of 2025, from death metal to duck stamps, and that time we put kids in touch with astronauts on the International Space Station: buff.ly/96pM7H1
December 21, 2025 at 9:54 PM
📣 The Science Friday team has spoken: Here’s a roundup of our favorite stories of 2025, from death metal to duck stamps, and that time we put kids in touch with astronauts on the International Space Station: buff.ly/96pM7H1
Reposted by Ardem Patapoutian
What does it take to achieve the highest level of human performance? Across athletics, science, chess, and music
@science.org
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
science.org
December 18, 2025 at 10:47 PM
What does it take to achieve the highest level of human performance? Across athletics, science, chess, and music
@science.org
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
Reposted by Ardem Patapoutian
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 12:46 AM
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
My friend @alexchesler.bsky.social has left the NIH to become VP of Pain Research at Vertex. I am glad to welcome him to San Diego. Exciting for him and for Vertex. But NIH loses one of its superstars. Can’t help but wonder whether this government’s anti-science policies made that decision easier.
Some news. Exciting new challenges and opportunities ahead.
December 17, 2025 at 4:20 AM
My friend @alexchesler.bsky.social has left the NIH to become VP of Pain Research at Vertex. I am glad to welcome him to San Diego. Exciting for him and for Vertex. But NIH loses one of its superstars. Can’t help but wonder whether this government’s anti-science policies made that decision easier.
Go @cdelawalla.bsky.social! Straightforward question that deserved a straightforward answer. Head of NIH does not want to come out and say that vaccines have saved millions of lives 🤯. This is embarrassing 🙈 and irresponsible. Jay: you know better! We expect more from you.
We gave Jay Bhattacharya an opportunity to clarify his vaccine stance: does he REALLY believe that the vaccine is worse than the disease? Instead, he launched into a defense of MAHA as the future of scientific inquiry, and never really gave us a straight answer...
@repauchincloss.bsky.social
@repauchincloss.bsky.social
December 16, 2025 at 4:55 PM
Go @cdelawalla.bsky.social! Straightforward question that deserved a straightforward answer. Head of NIH does not want to come out and say that vaccines have saved millions of lives 🤯. This is embarrassing 🙈 and irresponsible. Jay: you know better! We expect more from you.
😬😳😱😥
Anyone else find it alarming that the FDA Commissioner is sharing deranged conspiracy theories about HIV coming from a lab and Lyme disease being a bioweapon made by Nazi war criminals in a USDA lab during the Cold War? Just me?
rasmussenretorts.substack.com/p/commission...
rasmussenretorts.substack.com/p/commission...
December 14, 2025 at 10:46 PM
😬😳😱😥
I added my name to this and so should all of you who are US citizens: Standupforscience.net/impeach-rfkjr
December 12, 2025 at 2:10 PM
I added my name to this and so should all of you who are US citizens: Standupforscience.net/impeach-rfkjr
gift article: www.nytimes.com/2025/12/10/s...
A Scientific Pipeline to the Nobel Prize Fueled by Immigrants
www.nytimes.com
December 11, 2025 at 11:27 AM
gift article: www.nytimes.com/2025/12/10/s...
It was awesome to attend the @nobelprize.org ceremony as an alumnus. Wonderful to experience the celebration of the arts and sciences with @nancyhong.bsky.social. It feels especially important now when these fields are under attack.
December 11, 2025 at 6:01 AM
It was awesome to attend the @nobelprize.org ceremony as an alumnus. Wonderful to experience the celebration of the arts and sciences with @nancyhong.bsky.social. It feels especially important now when these fields are under attack.
Live from @nobelprize.org ceremonies. At the podium with some laureate alumni.
December 10, 2025 at 2:32 PM
Live from @nobelprize.org ceremonies. At the podium with some laureate alumni.
The @nobelprize.org concert is one of the highlights of Nobel week! Powerful and dramatic performances in the presence of the King & the Queen. We got to meet the 2025 Physiology or Medicine Laureates: Shimon Sakaguchi, Mary Brunkow, and Fred Ramsdell (not pictured).
December 8, 2025 at 9:44 PM
The @nobelprize.org concert is one of the highlights of Nobel week! Powerful and dramatic performances in the presence of the King & the Queen. We got to meet the 2025 Physiology or Medicine Laureates: Shimon Sakaguchi, Mary Brunkow, and Fred Ramsdell (not pictured).
One of my Oxford visit highlights? I got to see these priceless slides that Ruffini sent to Sherrington of various sensory end organs. And yes, Ruffini had to excise these receptors from his own skin 😳🔬🧠
December 8, 2025 at 9:21 AM
One of my Oxford visit highlights? I got to see these priceless slides that Ruffini sent to Sherrington of various sensory end organs. And yes, Ruffini had to excise these receptors from his own skin 😳🔬🧠
At the Nobel Prize Museum you can find the phone Thomas Perlmann uses to call medicine laureates, including the call I assume that reached my 94 year old dad when I had do not disturb on. You can see the confidentiality steps taken by literature committee members. Even find PIEZO paraphernalia.
December 7, 2025 at 6:10 PM
At the Nobel Prize Museum you can find the phone Thomas Perlmann uses to call medicine laureates, including the call I assume that reached my 94 year old dad when I had do not disturb on. You can see the confidentiality steps taken by literature committee members. Even find PIEZO paraphernalia.
Mary Brunkow was generous in thanking her mentors during her The Nobel Prize lecture! Always good to look back and remember those who have made an impact in your career. She is among a long line of pre-med students who worked in a lab and fell in love with research and changed plans!
December 7, 2025 at 5:35 PM
Mary Brunkow was generous in thanking her mentors during her The Nobel Prize lecture! Always good to look back and remember those who have made an impact in your career. She is among a long line of pre-med students who worked in a lab and fell in love with research and changed plans!
Fred Ramsdell showed a photo of himself standing by a trailer labeled “Nobel Museum” and joked, “this is as close as I will get to a Nobel Prize.” Turns out he was wrong, and he is a recipient this year. He even thanked the mouse for the research. Love it!
December 7, 2025 at 5:29 PM
Fred Ramsdell showed a photo of himself standing by a trailer labeled “Nobel Museum” and joked, “this is as close as I will get to a Nobel Prize.” Turns out he was wrong, and he is a recipient this year. He even thanked the mouse for the research. Love it!
The Nobel Prize Physiology lecture about to start!
www.nobelprize.org
www.nobelprize.org
December 7, 2025 at 12:44 PM
The Nobel Prize Physiology lecture about to start!
www.nobelprize.org
www.nobelprize.org
Sophisticated Stockholm!
December 7, 2025 at 11:30 AM
Sophisticated Stockholm!
Have we lost some of the academic magic in the US? A true privilege to give the Sherrington Prize Lecture at Oxford. A wonderful audience, a fantastic dinner at Merton College, and even the Merton Choir. Special for me since Sherrington coined proprioception and interoception.
December 4, 2025 at 11:48 PM
Have we lost some of the academic magic in the US? A true privilege to give the Sherrington Prize Lecture at Oxford. A wonderful audience, a fantastic dinner at Merton College, and even the Merton Choir. Special for me since Sherrington coined proprioception and interoception.
Reposted by Ardem Patapoutian
Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘 www.sciencedirect.com:5037/science/arti...
www.sciencedirect.com
December 4, 2025 at 4:42 PM
Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘 www.sciencedirect.com:5037/science/arti...