Scripps Research
@scripps.edu
Scripps Research is one of the world's largest, private, non-profit biomedical research organizations. We are Science Changing Life.
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Scripps Research
@scripps.edu
· Jun 17
A major concern this flu season is reassortment, when seasonal flu and bird flu infect the same host and swap genetic material, potentially creating a new, more dangerous strain. With H5N1 in cows and human cases emerging, our virology labs are closely tracking its evolution. More: ow.ly/thLP50WafhH
Celebrating another year of discoveries and the people behind them. Happy holidays from Scripps Research! 🎄🎉
December 25, 2025 at 4:09 PM
Celebrating another year of discoveries and the people behind them. Happy holidays from Scripps Research! 🎄🎉
A new @cp-cell.bsky.social study led by @ardemp.bskyverified.social and @rose-hill.bsky.social identifies a kidney mechanism that allows renin to adjust in real time, showing that PIEZO2 enables cells to sense physical forces and fine-tune renin release.
Study reveals a key hormonal circuit in the kidneys
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December 23, 2025 at 10:19 PM
A new @cp-cell.bsky.social study led by @ardemp.bskyverified.social and @rose-hill.bsky.social identifies a kidney mechanism that allows renin to adjust in real time, showing that PIEZO2 enables cells to sense physical forces and fine-tune renin release.
Electrically charged condensates are shown to induce localized changes in cell membrane voltage upon contact, according to a new Scripps Research study, revealing a previously unknown form of electrical transmission in cells with implications for bioelectric regulation.
A jolt to the system: Scripps Research biophysicists uncover new electrical transmission in cells
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December 19, 2025 at 11:07 PM
Electrically charged condensates are shown to induce localized changes in cell membrane voltage upon contact, according to a new Scripps Research study, revealing a previously unknown form of electrical transmission in cells with implications for bioelectric regulation.
A structure-guided nanoparticle designed by Professor Jiang Zhu published in @natcomms.nature.com stabilizes Ebola and Marburg surface proteins in their pre-fusion shape—prompting a strong antibody response in preclinical models and laying the foundation for a universal filovirus vaccine.
Nanoparticle vaccine strategy could protect against Ebola and other deadly filoviruses
www.scripps.edu
December 18, 2025 at 11:21 PM
A structure-guided nanoparticle designed by Professor Jiang Zhu published in @natcomms.nature.com stabilizes Ebola and Marburg surface proteins in their pre-fusion shape—prompting a strong antibody response in preclinical models and laying the foundation for a universal filovirus vaccine.
Congrats to Yuzhong Liu, PhD, who is named as a #PhF26 awardee of the @phrmafoundation.bsky.social Faculty Starter Grant in Drug Discovery, supporting her work in synthetic chemistry & biology to advance glycoside-based molecules for vaccine development. ow.ly/v5OP50XL48w
Scripps Research assistant professor Yuzhong Liu receives PhRMA Foundation Faculty Starter Grant in Drug Discovery - Scripps Research Magazine
Yuzhong Liu, an assistant professor at Scripps Research, has been awarded the 2026 PhRMA Foundation Faculty Starter Grant in Drug Discovery to support her work in synthetic chemistry and synthetic bio...
ow.ly
December 18, 2025 at 6:08 PM
Congrats to Yuzhong Liu, PhD, who is named as a #PhF26 awardee of the @phrmafoundation.bsky.social Faculty Starter Grant in Drug Discovery, supporting her work in synthetic chemistry & biology to advance glycoside-based molecules for vaccine development. ow.ly/v5OP50XL48w
Reposted by Scripps Research
Excited to share research co-led by Gabby & Adam in @jem.org! Grateful to the NIH & @scripps.edu for support.
LeBlanc, Sobel, Constantinides et al. @scripps.edu show that antibiotic treatment in early life can deplete riboflavin-synthesizing commensals & impair #MAIT cell development, rendering adult animals more susceptible to bacterial #pneumonia. rupress.org/jem/article/...
#Microbiome
#Microbiome
December 16, 2025 at 9:52 PM
Excited to share research co-led by Gabby & Adam in @jem.org! Grateful to the NIH & @scripps.edu for support.
Research from Assoc. Prof. @mikerobe.bsky.social's lab identifies a probiotic-based solution to antibiotic-linked MAIT cell depletion. In preclinical models, pairing necessary antibiotics with a riboflavin-producing gut bacterium restored MAIT cell development during a key early-life window.
Study reveals high stakes of early immune development—and a potential probiotic fix
www.scripps.edu
December 17, 2025 at 6:19 PM
Research from Assoc. Prof. @mikerobe.bsky.social's lab identifies a probiotic-based solution to antibiotic-linked MAIT cell depletion. In preclinical models, pairing necessary antibiotics with a riboflavin-producing gut bacterium restored MAIT cell development during a key early-life window.
Reposted by Scripps Research
LeBlanc, Sobel, Constantinides et al. @scripps.edu show that antibiotic treatment in early life can deplete riboflavin-synthesizing commensals & impair #MAIT cell development, rendering adult animals more susceptible to bacterial #pneumonia. rupress.org/jem/article/...
#Microbiome
#Microbiome
December 16, 2025 at 5:30 PM
LeBlanc, Sobel, Constantinides et al. @scripps.edu show that antibiotic treatment in early life can deplete riboflavin-synthesizing commensals & impair #MAIT cell development, rendering adult animals more susceptible to bacterial #pneumonia. rupress.org/jem/article/...
#Microbiome
#Microbiome
Scripps Research professor Stuart Lipton has been inducted as a 2025 #NAIFellow into the National Academy of Inventors
for pioneering work on the molecular drivers of brain disorders and for helping bring FDA-approved therapies for Alzheimer’s and Parkinson’s disease to patients.
for pioneering work on the molecular drivers of brain disorders and for helping bring FDA-approved therapies for Alzheimer’s and Parkinson’s disease to patients.
Stuart Lipton elected to the National Academy of Inventors - Scripps Research Magazine
Stuart Lipton, the Step Family Foundation Endowed Chair, professor in the Department of Molecular and Cellular Biology, and co-founding director of the Neurodegeneration New Medicines Center at Scripp...
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December 15, 2025 at 7:18 PM
Scripps Research professor Stuart Lipton has been inducted as a 2025 #NAIFellow into the National Academy of Inventors
for pioneering work on the molecular drivers of brain disorders and for helping bring FDA-approved therapies for Alzheimer’s and Parkinson’s disease to patients.
for pioneering work on the molecular drivers of brain disorders and for helping bring FDA-approved therapies for Alzheimer’s and Parkinson’s disease to patients.
The Yu lab reports a one-step method to stereoselectively attach fluorine to drug-like molecules using low-cost fluoride. The approach uses fluorine-18 for PET imaging to track bioactive compounds and accelerate drug discovery. More: ow.ly/kttg50XHyPg
December 12, 2025 at 6:58 PM
The Yu lab reports a one-step method to stereoselectively attach fluorine to drug-like molecules using low-cost fluoride. The approach uses fluorine-18 for PET imaging to track bioactive compounds and accelerate drug discovery. More: ow.ly/kttg50XHyPg
Scripps Research prides itself on offering all students a tuition-free graduate education, and philanthropy-funded endowed fellowships give graduate students the freedom to pursue higher-impact science whose questions could transform science and medicine.
Supporting the next generation of scientists - Scripps Research Magazine
Tomorrow’s innovators need advocates today How can we better protect newborns from respiratory viruses? To answer this question, Nancy Cheong, a recipient of The Schimmel Family Endowed Fellowship Fun...
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December 9, 2025 at 11:02 PM
Scripps Research prides itself on offering all students a tuition-free graduate education, and philanthropy-funded endowed fellowships give graduate students the freedom to pursue higher-impact science whose questions could transform science and medicine.
An enzyme-enabled route to synthesize saxitoxin—a nerve-blocking molecule—led by the Baran lab with Merck and the Roberto lab, bypasses marine sources and expands access to saxitoxin analogs for pain-therapy research, as shown in @nature.com. More at: ow.ly/b0Lq50XFXBs
An easier approach to recreate the powerful nerve-blocking molecule found in shellfish
ow.ly
December 9, 2025 at 5:46 PM
An enzyme-enabled route to synthesize saxitoxin—a nerve-blocking molecule—led by the Baran lab with Merck and the Roberto lab, bypasses marine sources and expands access to saxitoxin analogs for pain-therapy research, as shown in @nature.com. More at: ow.ly/b0Lq50XFXBs
Congrats to Scripps Research President & CEO Peter Schultz and EVP @erictopol.bsky.social for being named to the 2025 #SD500 list by the San Diego Business Journal, recognizing their leadership in advancing biomedical research, innovation and San Diego’s life sciences sector. More: ow.ly/iUqN50XFXsh
December 8, 2025 at 11:29 PM
Congrats to Scripps Research President & CEO Peter Schultz and EVP @erictopol.bsky.social for being named to the 2025 #SD500 list by the San Diego Business Journal, recognizing their leadership in advancing biomedical research, innovation and San Diego’s life sciences sector. More: ow.ly/iUqN50XFXsh
A @cp-cellreports.bsky.social study from @scripps.edu finds that SETX-deficient tumors can survive DNA breaks by activating a backup repair pathway called break-induced replication (BIR). Blocking key BIR factors prevents these cells from repairing DNA, revealing a synthetic-lethal vulnerability.
Scientists find cancer weak spot in backup DNA repair system
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December 5, 2025 at 11:18 PM
A @cp-cellreports.bsky.social study from @scripps.edu finds that SETX-deficient tumors can survive DNA breaks by activating a backup repair pathway called break-induced replication (BIR). Blocking key BIR factors prevents these cells from repairing DNA, revealing a synthetic-lethal vulnerability.
“It really gave me a lot of peace of mind that I could just focus on science without having to worry about where my next paycheck was coming from,” says Jose Colom-Lapetina, reflecting on how philanthropy shaped his experience at
the Skaggs Graduate School. More: ow.ly/IqUK50Xyp1Y
the Skaggs Graduate School. More: ow.ly/IqUK50Xyp1Y
December 3, 2025 at 6:10 PM
“It really gave me a lot of peace of mind that I could just focus on science without having to worry about where my next paycheck was coming from,” says Jose Colom-Lapetina, reflecting on how philanthropy shaped his experience at
the Skaggs Graduate School. More: ow.ly/IqUK50Xyp1Y
the Skaggs Graduate School. More: ow.ly/IqUK50Xyp1Y
From the genetic code underlying diseases to the chemical data driving drug discovery, scientists generate massive datasets. How do we organize this information to accelerate discovery?
Scripps Research bioinformatician Andrew Su is tackling that question.
Scripps Research bioinformatician Andrew Su is tackling that question.
Community Corner: - Scripps Research Magazine
From the genetic code that underpins diseases to the chemical data driving drug discovery, scientists produce a tremendous number of large datasets, How do we best organize all this data so that we ca...
ow.ly
December 1, 2025 at 9:05 PM
From the genetic code underlying diseases to the chemical data driving drug discovery, scientists generate massive datasets. How do we organize this information to accelerate discovery?
Scripps Research bioinformatician Andrew Su is tackling that question.
Scripps Research bioinformatician Andrew Su is tackling that question.
#ICYMI: @erictopol.bsky.social, Scripps Research EVP and founder of the Scripps Research Translational Institute, was listed among @usnews.com’s 2025 “Best Leaders”, recognized for his significant impact in business, education, health care and public service.
Eric Topol among U.S. News & World Report’s Best Leaders of 2025 - Scripps Research Magazine
The U.S. News & World Report has recognized Eric Topol among 25 individuals in the country who are making a significant impact in business, education, public health and public service. In addition to ...
magazine.scripps.edu
December 1, 2025 at 6:40 PM
#ICYMI: @erictopol.bsky.social, Scripps Research EVP and founder of the Scripps Research Translational Institute, was listed among @usnews.com’s 2025 “Best Leaders”, recognized for his significant impact in business, education, health care and public service.
In a @nytimes.com feature on interoception, the body’s sixth internal sense, Scripps Research Nobel laureate @ardemp.bskyverified.social describes his lab’s work on Piezo proteins and a collaborative effort to build an atlas revealing how these internal signals shape emotions, decisions and health.
Mapping the Sense of What’s Going On Inside
www.nytimes.com
November 25, 2025 at 10:15 PM
In a @nytimes.com feature on interoception, the body’s sixth internal sense, Scripps Research Nobel laureate @ardemp.bskyverified.social describes his lab’s work on Piezo proteins and a collaborative effort to build an atlas revealing how these internal signals shape emotions, decisions and health.
A single gift from Ellen Browning Scripps helped launch Scripps Research. Since then, 18 FDA-approved drugs have originated within our labs, improving the lives of people around the world.
This #GivingTuesday, you can also be a part of that legacy. Visit scripps.edu/givingtuesday.
This #GivingTuesday, you can also be a part of that legacy. Visit scripps.edu/givingtuesday.
November 25, 2025 at 8:03 PM
A single gift from Ellen Browning Scripps helped launch Scripps Research. Since then, 18 FDA-approved drugs have originated within our labs, improving the lives of people around the world.
This #GivingTuesday, you can also be a part of that legacy. Visit scripps.edu/givingtuesday.
This #GivingTuesday, you can also be a part of that legacy. Visit scripps.edu/givingtuesday.
Reposted by Scripps Research
After immigrating to the U.S. from Lebanon, neuroscientist @ardemp.bskyverified.social found belonging in science—and did Nobel-winning work on the sense of touch: buff.ly/boCE6ZY
November 24, 2025 at 1:07 PM
After immigrating to the U.S. from Lebanon, neuroscientist @ardemp.bskyverified.social found belonging in science—and did Nobel-winning work on the sense of touch: buff.ly/boCE6ZY
Reposted by Scripps Research
Great story by @carlzimmer.com in @nytimes.com that nicely conveys the excitement for the emerging field of interoception. @dulaclab.bsky.social and others are featured, including my tattoo 😳!
Gift article link: www.nytimes.com/2025/11/25/s...
Gift article link: www.nytimes.com/2025/11/25/s...
November 25, 2025 at 1:42 PM
Great story by @carlzimmer.com in @nytimes.com that nicely conveys the excitement for the emerging field of interoception. @dulaclab.bsky.social and others are featured, including my tattoo 😳!
Gift article link: www.nytimes.com/2025/11/25/s...
Gift article link: www.nytimes.com/2025/11/25/s...
Reposted by Scripps Research
I have a story today about interoception--a kind of sixth sense that delivers information from within our bodies to our brains. nyti.ms/4rfTDtn
nyti.ms
November 25, 2025 at 12:49 PM
I have a story today about interoception--a kind of sixth sense that delivers information from within our bodies to our brains. nyti.ms/4rfTDtn
In his Front Row lecture, Benjamin Cravatt presented activity-based proteomics, an approach that tracks how small molecules interact with proteins in their natural environment. His lab is using it to uncover drug candidates for targets long considered “undruggable.” More: ow.ly/Osb550XvaTG
November 24, 2025 at 5:39 PM
In his Front Row lecture, Benjamin Cravatt presented activity-based proteomics, an approach that tracks how small molecules interact with proteins in their natural environment. His lab is using it to uncover drug candidates for targets long considered “undruggable.” More: ow.ly/Osb550XvaTG
San Diego families connected with Scripps Researchers at the Fleet Science Center for our second annual Discovery Day! 🧪🥼
More than 60 grad students and postdocs led hands-on demos in chemistry, neuroscience, cancer research, vaccines, and more.
More than 60 grad students and postdocs led hands-on demos in chemistry, neuroscience, cancer research, vaccines, and more.
Scripps Research Discovery Day | Fleet Science Center
YouTube video by Scripps Research
youtu.be
November 21, 2025 at 10:14 PM
San Diego families connected with Scripps Researchers at the Fleet Science Center for our second annual Discovery Day! 🧪🥼
More than 60 grad students and postdocs led hands-on demos in chemistry, neuroscience, cancer research, vaccines, and more.
More than 60 grad students and postdocs led hands-on demos in chemistry, neuroscience, cancer research, vaccines, and more.
Founder and director of the Scripps Research Translational Institute, @erictopol.bsky.social, and Julia Moore Vogel, co–principal investigator of the Long COVID Treatment Trial, were featured in @wired.com, sharing insights on a nationwide study testing GLP-1s for long COVID.
Weight-Loss Drug Zepbound Is Being Tested as a Treatment for Long Covid
GLP-1s are being studied for a wide range of conditions. Now, scientists will test whether their anti-inflammatory properties can help alleviate symptoms of long Covid.
ow.ly
November 21, 2025 at 9:32 PM
Founder and director of the Scripps Research Translational Institute, @erictopol.bsky.social, and Julia Moore Vogel, co–principal investigator of the Long COVID Treatment Trial, were featured in @wired.com, sharing insights on a nationwide study testing GLP-1s for long COVID.