Reposted by Alex Chesler
Have you seen the latest result from the Julius lab showing mitochondrial electron transport chains tuning as an intrinsic cellular strategy protecting nociceptors against excitotoxicity? Check out this #EditorsPick from @alexchesler.bsky.social now! bit.ly/46jodto #PRF
September 8, 2025 at 12:00 PM
Have you seen the latest result from the Julius lab showing mitochondrial electron transport chains tuning as an intrinsic cellular strategy protecting nociceptors against excitotoxicity? Check out this #EditorsPick from @alexchesler.bsky.social now! bit.ly/46jodto #PRF
Reposted by Alex Chesler
The latest papers published in pain research are now on PRF! Dr. Alex Chesler provides a curated list for Aug. 22-28, 2025 and a commentary on his pick for Paper of the Week! painresearchforum.org/paper @utdpaincenter.bsky.social @nyupainresearch.bsky.social @iasp.bsky.social @usasp.bsky.social
August 31, 2025 at 12:08 PM
The latest papers published in pain research are now on PRF! Dr. Alex Chesler provides a curated list for Aug. 22-28, 2025 and a commentary on his pick for Paper of the Week! painresearchforum.org/paper @utdpaincenter.bsky.social @nyupainresearch.bsky.social @iasp.bsky.social @usasp.bsky.social
Reposted by Alex Chesler
Some very nice 50 year old immunostaining that showed for the first time that Substance P was in sensory neurons and their central terminals. Only three pictures, published in Science! www.science.org/doi/abs/10.1...
June 6, 2025 at 12:40 AM
Some very nice 50 year old immunostaining that showed for the first time that Substance P was in sensory neurons and their central terminals. Only three pictures, published in Science! www.science.org/doi/abs/10.1...
Sort of last minute but my group is looking to recruit a a recent college grad as postbac to start this summer and work on PIEZO channels. Project involves cell based assays, patch clamp recording, and imaging.
Info on the NIH program can be found here: www.training.nih.gov/research-tra...
Info on the NIH program can be found here: www.training.nih.gov/research-tra...
www.training.nih.gov
June 4, 2025 at 4:28 PM
Sort of last minute but my group is looking to recruit a a recent college grad as postbac to start this summer and work on PIEZO channels. Project involves cell based assays, patch clamp recording, and imaging.
Info on the NIH program can be found here: www.training.nih.gov/research-tra...
Info on the NIH program can be found here: www.training.nih.gov/research-tra...
Reposted by Alex Chesler
Vote today for SfN leadership! Ellen Lumpkin and Irene Tracey both there! www.directvote.net/SfN/
DirectVote Election: Login
www.directvote.net
May 20, 2025 at 7:31 PM
Vote today for SfN leadership! Ellen Lumpkin and Irene Tracey both there! www.directvote.net/SfN/
Reposted by Alex Chesler
The last 2 weeks have been a blur, but sadly I'm no longer at the NIH. Working for #painresearch at the NIH was a great honor and the best job of my life. As part of this amazing team, I'm proud to have worked on the HEAL 2025 Annual Report - pls share! heal.nih.gov/about/nih-he...
The NIH HEAL Initiative 2025 Annual Report: Research in Action | NIH HEAL Initiative
heal.nih.gov
May 14, 2025 at 8:51 PM
The last 2 weeks have been a blur, but sadly I'm no longer at the NIH. Working for #painresearch at the NIH was a great honor and the best job of my life. As part of this amazing team, I'm proud to have worked on the HEAL 2025 Annual Report - pls share! heal.nih.gov/about/nih-he...
Reposted by Alex Chesler
Read this #PapersoftheWeek #EditorsPick from Ghitani et al. and @Nature.com demonstrating that nociceptor activity is both necessary and sufficient for inflammatory tactile allodynia bit.ly/4mcTuV4 #PRF
May 13, 2025 at 5:00 PM
Read this #PapersoftheWeek #EditorsPick from Ghitani et al. and @Nature.com demonstrating that nociceptor activity is both necessary and sufficient for inflammatory tactile allodynia bit.ly/4mcTuV4 #PRF
Reposted by Alex Chesler
The feeling of a hug comes from the pressure and vibration of millions of nerve endings.
Touch, Our Most Complex Sense, Is a Landscape of Cellular Sensors | Quanta Magazine
Every soft caress of wind, searing burn and seismic rumble is detected by our skin’s tangle of touch sensors. David Ginty has spent his career cataloging the neurons beneath everyday sensations.
www.quantamagazine.org
May 7, 2025 at 8:04 PM
The feeling of a hug comes from the pressure and vibration of millions of nerve endings.
Happy “May the 4th” or as I like to call it “Piezo Day”.
May 4, 2025 at 1:10 PM
Happy “May the 4th” or as I like to call it “Piezo Day”.
Reposted by Alex Chesler
Here’s just the most recent of the many NCCIH studies of #pain (from colleague @alexchesler.bsky.social published last week in Nature). Nearly 50% of NCCIH funding goes to studying pain, with a focus on nonpharmacological treatments and mechanisms. The proposed budget eliminates NCCIH.
co-author @dimacd.bsky.social pointed out that the link was truncated in my post. Hope this works: www.nature.com/articles/s41...
A distributed coding logic for thermosensation and inflammatory pain - Nature
Functional imaging and multiplexed in situ hybridization were combined to investigate how trigeminal neurons encode heat and mechanical stimuli, revealing distinct cellular mechanisms for continuing p...
www.nature.com
May 3, 2025 at 11:33 AM
Here’s just the most recent of the many NCCIH studies of #pain (from colleague @alexchesler.bsky.social published last week in Nature). Nearly 50% of NCCIH funding goes to studying pain, with a focus on nonpharmacological treatments and mechanisms. The proposed budget eliminates NCCIH.
Reposted by Alex Chesler
I am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply! www.training.nih.gov/jobs/pdf-mb-...
www.training.nih.gov
April 29, 2025 at 2:59 PM
I am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply! www.training.nih.gov/jobs/pdf-mb-...
Four old men from NYC. Reunited to see a punk band that I last saw live at CBGBs in high school. Friends for four decades.
April 26, 2025 at 6:37 PM
Four old men from NYC. Reunited to see a punk band that I last saw live at CBGBs in high school. Friends for four decades.
Reposted by Alex Chesler
Nice article in NY Times today about AgRP neurons, GLP1s, and hunger. By Gina Kolata. www.nytimes.com/2025/04/26/h...
What Nearly Brainless Rodents Know About Weight Loss and Hunger
www.nytimes.com
April 26, 2025 at 3:21 PM
Nice article in NY Times today about AgRP neurons, GLP1s, and hunger. By Gina Kolata. www.nytimes.com/2025/04/26/h...
An example of what we in the NIH Intramural program can accomplish. Excited to share our latest paper in close collaboration with Nick Ryba's group. We examined how inflammation transforms representation in somatosensory neurons to cause pain. Lots of surprises here: www.nature.com/articles/s41...
www.nature.com
April 23, 2025 at 5:31 PM
An example of what we in the NIH Intramural program can accomplish. Excited to share our latest paper in close collaboration with Nick Ryba's group. We examined how inflammation transforms representation in somatosensory neurons to cause pain. Lots of surprises here: www.nature.com/articles/s41...
Huge congratulations to the always amazing, truly brilliant @clairelepichon.bsky.social who just received TENURE from our NIH intramural program.
April 21, 2025 at 9:21 PM
Huge congratulations to the always amazing, truly brilliant @clairelepichon.bsky.social who just received TENURE from our NIH intramural program.
Reposted by Alex Chesler
Reposted by Alex Chesler
Turns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel.
buff.ly/ypISrtx
buff.ly/ypISrtx
April 19, 2025 at 3:21 AM
Turns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel.
buff.ly/ypISrtx
buff.ly/ypISrtx
F.D.A. Approves Drug to Treat Pain Without Opioid Effects
www.nytimes.com
January 31, 2025 at 12:12 AM
Finished my holiday project. Gutted a $150 Gaggia Classic I found on Craigslist and turned it into a Gaggiuino (gaggiuino.github.io#/). Stop by my office for coffee sometime.
January 7, 2025 at 8:35 PM
Finished my holiday project. Gutted a $150 Gaggia Classic I found on Craigslist and turned it into a Gaggiuino (gaggiuino.github.io#/). Stop by my office for coffee sometime.
Great start to 2025
January 1, 2025 at 4:34 PM
Great start to 2025
Absolute Bagels mysteriously closes??? A staple of my graduate student life at Columbia. Although I live over 200 miles away, I need answers.
www.nytimes.com/2024/12/12/n...
www.nytimes.com/2024/12/12/n...
A Bagel Shop Closes, and the Upper West Side Is Absolutely Losing It
The neighborhood reaction to the sudden, mysterious closure of a Manhattan bagel shop was intense: “No no no no no no no no no no no!!”
www.nytimes.com
December 13, 2024 at 12:40 PM
Absolute Bagels mysteriously closes??? A staple of my graduate student life at Columbia. Although I live over 200 miles away, I need answers.
www.nytimes.com/2024/12/12/n...
www.nytimes.com/2024/12/12/n...
NIH’s own @mikekrashes.bsky.social telling it like it is.
Everyone is talking about #Ozempic #Wegovy which are agonists of the GLP-1 receptor. For more about this receptor and its physiological role, see the quickguide by Michael Krashes in our latest issue
www.cell.com/current-biol...
www.cell.com/current-biol...
Glucagon-like peptide-1 receptor
Michael Krashes discusses glucagon-like peptide-1 receptors, their physiological role
in glucose metabolism and the mode of action of their agonists that are used to treat
obesity and were later shown...
www.cell.com
December 4, 2024 at 2:04 AM
NIH’s own @mikekrashes.bsky.social telling it like it is.
There goes the neighborhood @mikekrashes.bsky.social is here.
November 23, 2024 at 12:59 AM
There goes the neighborhood @mikekrashes.bsky.social is here.
Kate Zernike and Nancy Hopkins taking questions from the crowd at NIH.
November 20, 2024 at 5:44 PM
Kate Zernike and Nancy Hopkins taking questions from the crowd at NIH.