Stirling Churchman
@stirlingchurchman.bsky.social
Genetics professor at Harvard Medical School. Interested in RNA life cycles and genome organization across the cell, from the nucleus to mitochondria.
Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)
HuD controls widespread RNA stability to drive neuronal activity-dependent responses
Neuronal activity shapes brain development and refines synaptic connectivity in part through dynamic changes in gene expression. While activity-regulated transcriptional programs have been extensively...
www.biorxiv.org
September 9, 2025 at 2:41 PM
Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)
Reposted by Stirling Churchman
First time posting here — and first-ever Single Molecule Conference 🧬
Held right at @embl.org Heidelberg, where I work!
4 days full of great science and great people. Fantastic meeting! 🔬
Curious to see where the single molecule field is going next! 👀
#EMBLSingleMolecule @events.embl.org
Held right at @embl.org Heidelberg, where I work!
4 days full of great science and great people. Fantastic meeting! 🔬
Curious to see where the single molecule field is going next! 👀
#EMBLSingleMolecule @events.embl.org
July 21, 2025 at 12:41 PM
First time posting here — and first-ever Single Molecule Conference 🧬
Held right at @embl.org Heidelberg, where I work!
4 days full of great science and great people. Fantastic meeting! 🔬
Curious to see where the single molecule field is going next! 👀
#EMBLSingleMolecule @events.embl.org
Held right at @embl.org Heidelberg, where I work!
4 days full of great science and great people. Fantastic meeting! 🔬
Curious to see where the single molecule field is going next! 👀
#EMBLSingleMolecule @events.embl.org
Reposted by Stirling Churchman
Honored to receive 1st Place Poster Award 🏆 at the EMBL meeting "Gene Regulation: One Molecule at a Time"!
Thank you to all who visited and engaged in exciting discussions.
Grateful to the organizers for an excellent event! #EMBLSingleMolecule
Thank you to all who visited and engaged in exciting discussions.
Grateful to the organizers for an excellent event! #EMBLSingleMolecule
July 18, 2025 at 1:56 PM
Honored to receive 1st Place Poster Award 🏆 at the EMBL meeting "Gene Regulation: One Molecule at a Time"!
Thank you to all who visited and engaged in exciting discussions.
Grateful to the organizers for an excellent event! #EMBLSingleMolecule
Thank you to all who visited and engaged in exciting discussions.
Grateful to the organizers for an excellent event! #EMBLSingleMolecule
Reposted by Stirling Churchman
#EMBLsinglemolecule was a blast! Happy to host the birth of single molecule genomics as a field and to think about the future with the microscopy crowd. Thanks to participants and organizers!
July 18, 2025 at 12:04 PM
#EMBLsinglemolecule was a blast! Happy to host the birth of single molecule genomics as a field and to think about the future with the microscopy crowd. Thanks to participants and organizers!
The molecular feedback mechanisms that maintain yeast mito-nuclear balance represent elegant solutions to a major vulnerability in eukaryotic cells. I was privileged to be involved in this fascinating study!
In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...
A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome b synthesis
Abstract. Mitochondrial gene expression needs to be balanced with cytosolic translation to produce oxidative phosphorylation complexes. In yeast, translati
academic.oup.com
July 18, 2025 at 9:03 AM
The molecular feedback mechanisms that maintain yeast mito-nuclear balance represent elegant solutions to a major vulnerability in eukaryotic cells. I was privileged to be involved in this fascinating study!
Reposted by Stirling Churchman
In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...
A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome b synthesis
Abstract. Mitochondrial gene expression needs to be balanced with cytosolic translation to produce oxidative phosphorylation complexes. In yeast, translati
academic.oup.com
July 18, 2025 at 7:35 AM
In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...
Reposted by Stirling Churchman
🗨️💡Great conversations during well-attended lunch time panel discussions at #EMBLSingleMolecule
Panel 1️⃣: Single molecule genomics data analysis
Chair: @stirlingchurchman.bsky.social
Panel 2️⃣: Single molecule microscopy data analysis
Chairs: @laghalab.bsky.social, Dan Larson
@arnaudkr.bsky.social
Panel 1️⃣: Single molecule genomics data analysis
Chair: @stirlingchurchman.bsky.social
Panel 2️⃣: Single molecule microscopy data analysis
Chairs: @laghalab.bsky.social, Dan Larson
@arnaudkr.bsky.social
July 17, 2025 at 2:07 PM
🗨️💡Great conversations during well-attended lunch time panel discussions at #EMBLSingleMolecule
Panel 1️⃣: Single molecule genomics data analysis
Chair: @stirlingchurchman.bsky.social
Panel 2️⃣: Single molecule microscopy data analysis
Chairs: @laghalab.bsky.social, Dan Larson
@arnaudkr.bsky.social
Panel 1️⃣: Single molecule genomics data analysis
Chair: @stirlingchurchman.bsky.social
Panel 2️⃣: Single molecule microscopy data analysis
Chairs: @laghalab.bsky.social, Dan Larson
@arnaudkr.bsky.social
Reposted by Stirling Churchman
Absolutely thrilled of hosting the #EMBLSingleMolecule community together @embl.org for the first time under one roof! Exciting data and prospects!
💬❓ We like a good Q&A session – a lot of great questions following every talk at 'Genre regulation: one molecule at a time'! Keep asking yours, both in the auditorium and online 🙌🏼 #EMBLSingleMolecule
@arnaudkr.bsky.social @embl.org
@arnaudkr.bsky.social @embl.org
July 17, 2025 at 7:31 AM
Absolutely thrilled of hosting the #EMBLSingleMolecule community together @embl.org for the first time under one roof! Exciting data and prospects!
Reposted by Stirling Churchman
🍪 Taking a breather at 'Gene regulation: one molecule at a time' — where the science is complex, but the coffee is simple (and much needed!).
From single-molecule insights to lively hallway conversations, it's clear: breakthroughs happen both in the lab and over lattes. ☕🧬
#EMBLSingleMolecule
From single-molecule insights to lively hallway conversations, it's clear: breakthroughs happen both in the lab and over lattes. ☕🧬
#EMBLSingleMolecule
July 15, 2025 at 3:05 PM
🍪 Taking a breather at 'Gene regulation: one molecule at a time' — where the science is complex, but the coffee is simple (and much needed!).
From single-molecule insights to lively hallway conversations, it's clear: breakthroughs happen both in the lab and over lattes. ☕🧬
#EMBLSingleMolecule
From single-molecule insights to lively hallway conversations, it's clear: breakthroughs happen both in the lab and over lattes. ☕🧬
#EMBLSingleMolecule
Reposted by Stirling Churchman
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
July 17, 2025 at 1:25 AM
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Stirling Churchman
Welcome to the inaugural edition of 'Gene regulation: one molecule at a time' 🤩🧬 #EMBLSingleMolecule
Most of the participants are already on site – now time for some science!
Our Scientific Organisers:
🔹 @stirlingchurchman.bsky.social
🔹@arnaudkr.bsky.social
🔹 @laghalab.bsky.social
🔹 Daniel Larson
Most of the participants are already on site – now time for some science!
Our Scientific Organisers:
🔹 @stirlingchurchman.bsky.social
🔹@arnaudkr.bsky.social
🔹 @laghalab.bsky.social
🔹 Daniel Larson
July 15, 2025 at 1:51 PM
Welcome to the inaugural edition of 'Gene regulation: one molecule at a time' 🤩🧬 #EMBLSingleMolecule
Most of the participants are already on site – now time for some science!
Our Scientific Organisers:
🔹 @stirlingchurchman.bsky.social
🔹@arnaudkr.bsky.social
🔹 @laghalab.bsky.social
🔹 Daniel Larson
Most of the participants are already on site – now time for some science!
Our Scientific Organisers:
🔹 @stirlingchurchman.bsky.social
🔹@arnaudkr.bsky.social
🔹 @laghalab.bsky.social
🔹 Daniel Larson
Reposted by Stirling Churchman
🧬 🧪The world’s on 🔥 BUT in the interest of sharing small wins, I am helping build something cool at EpiCypher that I'm proud of:
Fiber-seq is an LRS assay that maps chromatin accessibility, DNAme, and DNA sequence on single molecules.
If your jam is functional genomics/epigenetics, check this out.
Fiber-seq is an LRS assay that maps chromatin accessibility, DNAme, and DNA sequence on single molecules.
If your jam is functional genomics/epigenetics, check this out.
🚀 We’re launching Fiber-seq, a multiomic approach that combines chromatin accessibility, CpG methylation, and DNA sequence in one long-read sequencing assay.
We’re inviting a limited group of early users to try Fiber-seq at no cost.
Interested? Learn more 👉 explore.epicypher.com/fiber-seq-su...
We’re inviting a limited group of early users to try Fiber-seq at no cost.
Interested? Learn more 👉 explore.epicypher.com/fiber-seq-su...
June 18, 2025 at 8:45 PM
🧬 🧪The world’s on 🔥 BUT in the interest of sharing small wins, I am helping build something cool at EpiCypher that I'm proud of:
Fiber-seq is an LRS assay that maps chromatin accessibility, DNAme, and DNA sequence on single molecules.
If your jam is functional genomics/epigenetics, check this out.
Fiber-seq is an LRS assay that maps chromatin accessibility, DNAme, and DNA sequence on single molecules.
If your jam is functional genomics/epigenetics, check this out.
Reposted by Stirling Churchman
Mitochondrial RNAs can be found in mitochondrial RNA granules (MRGs) where they are processed. However, here the authors show that during transcription arrest, mt-mRNAs form granules distinct from MRGs.
@stirlingchurchman.bsky.social
www.life-science-alliance.org/content/8/9/...
@stirlingchurchman.bsky.social
www.life-science-alliance.org/content/8/9/...
June 17, 2025 at 2:29 PM
Mitochondrial RNAs can be found in mitochondrial RNA granules (MRGs) where they are processed. However, here the authors show that during transcription arrest, mt-mRNAs form granules distinct from MRGs.
@stirlingchurchman.bsky.social
www.life-science-alliance.org/content/8/9/...
@stirlingchurchman.bsky.social
www.life-science-alliance.org/content/8/9/...
Reposted by Stirling Churchman
Want to write to your community about the importance of science funding?
Join me on zoom this Friday at 12pm ET / 9am PT to learn to write an op-ed as part of the #McClintockLetters initiative!
Sign up to write a letter and register for the workshop here:
blogs.cornell.edu/asap/events-...
Join me on zoom this Friday at 12pm ET / 9am PT to learn to write an op-ed as part of the #McClintockLetters initiative!
Sign up to write a letter and register for the workshop here:
blogs.cornell.edu/asap/events-...
June 3, 2025 at 2:37 PM
Want to write to your community about the importance of science funding?
Join me on zoom this Friday at 12pm ET / 9am PT to learn to write an op-ed as part of the #McClintockLetters initiative!
Sign up to write a letter and register for the workshop here:
blogs.cornell.edu/asap/events-...
Join me on zoom this Friday at 12pm ET / 9am PT to learn to write an op-ed as part of the #McClintockLetters initiative!
Sign up to write a letter and register for the workshop here:
blogs.cornell.edu/asap/events-...
Reposted by Stirling Churchman
Make America Love Harvard Again
May 30, 2025 at 9:36 PM
Make America Love Harvard Again
Reposted by Stirling Churchman
I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too
May 24, 2025 at 5:47 PM
I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too
Reposted by Stirling Churchman
REMINDER.....REMINDER......REMINDER
3 DAYS LEFT TO COMMENT ON SCHEDULE F
1/n
3 DAYS LEFT TO COMMENT ON SCHEDULE F
1/n
gumball and anais from the amazing world of gumball are sitting at a table
ALT: gumball and anais from the amazing world of gumball are sitting at a table
media.tenor.com
May 20, 2025 at 8:33 PM
REMINDER.....REMINDER......REMINDER
3 DAYS LEFT TO COMMENT ON SCHEDULE F
1/n
3 DAYS LEFT TO COMMENT ON SCHEDULE F
1/n
Reposted by Stirling Churchman
Our papers, device designs, and protocols are used by biotech companies every day. Basic science is not a luxury - federal funding drives the very earliest R&D that powers biotech and trains the next generation of scientists (3/3). #WithoutNSF
May 5, 2025 at 1:55 PM
Our papers, device designs, and protocols are used by biotech companies every day. Basic science is not a luxury - federal funding drives the very earliest R&D that powers biotech and trains the next generation of scientists (3/3). #WithoutNSF
Reposted by Stirling Churchman
In 100 days in office, US President Donald Trump has destabilized eight decades of government support for science.
This has included terminating more than 1,000 grants in areas such as climate change, cancer, and HIV prevention.
Will US science survive Trump 2.0?
www.nature.com/articles/d41...
This has included terminating more than 1,000 grants in areas such as climate change, cancer, and HIV prevention.
Will US science survive Trump 2.0?
www.nature.com/articles/d41...
April 29, 2025 at 11:42 AM
In 100 days in office, US President Donald Trump has destabilized eight decades of government support for science.
This has included terminating more than 1,000 grants in areas such as climate change, cancer, and HIV prevention.
Will US science survive Trump 2.0?
www.nature.com/articles/d41...
This has included terminating more than 1,000 grants in areas such as climate change, cancer, and HIV prevention.
Will US science survive Trump 2.0?
www.nature.com/articles/d41...
Reposted by Stirling Churchman
📅 Genomic Technologies Open Science Day - June 9
FREE event featuring expert developers and users!
Register: www.jax.org/scienceday25/
Happening in person at @washu.bsky.social and online in partnership with NHGRI and @jacksonlab.bsky.social
🧪🧬🖥️👩🔬 #STS
Learn more at genometdcc.org#outreachevents
FREE event featuring expert developers and users!
Register: www.jax.org/scienceday25/
Happening in person at @washu.bsky.social and online in partnership with NHGRI and @jacksonlab.bsky.social
🧪🧬🖥️👩🔬 #STS
Learn more at genometdcc.org#outreachevents
April 23, 2025 at 3:29 PM
📅 Genomic Technologies Open Science Day - June 9
FREE event featuring expert developers and users!
Register: www.jax.org/scienceday25/
Happening in person at @washu.bsky.social and online in partnership with NHGRI and @jacksonlab.bsky.social
🧪🧬🖥️👩🔬 #STS
Learn more at genometdcc.org#outreachevents
FREE event featuring expert developers and users!
Register: www.jax.org/scienceday25/
Happening in person at @washu.bsky.social and online in partnership with NHGRI and @jacksonlab.bsky.social
🧪🧬🖥️👩🔬 #STS
Learn more at genometdcc.org#outreachevents
Reposted by Stirling Churchman
Don’t forget to register for this special conference. If you like gene regulation from single molecule approaches, please join us #EMBLSingleMolecule. Imaging and Omics and a bit of theory for lots of fun!
📢 Have you registered for 'Gene regulation: one molecule at a time' yet?
Submit your abstract by 8 April!
👉🏼 s.embl.org/grg25-01-bl
#EMBLSingleMolecule will bring together single molecule genomics and imaging to study mechanisms across the central dogma at molecular resolution 🧬🔍
Submit your abstract by 8 April!
👉🏼 s.embl.org/grg25-01-bl
#EMBLSingleMolecule will bring together single molecule genomics and imaging to study mechanisms across the central dogma at molecular resolution 🧬🔍
March 16, 2025 at 10:59 AM
Don’t forget to register for this special conference. If you like gene regulation from single molecule approaches, please join us #EMBLSingleMolecule. Imaging and Omics and a bit of theory for lots of fun!
Reposted by Stirling Churchman
This is a pitch-perfect version of the argument we all need to be making. Thank you so much, Stirling and Jack.
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Opinion | Science Suffers With Trump’s Funding Freeze
America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.
www.wsj.com
April 22, 2025 at 12:08 AM
This is a pitch-perfect version of the argument we all need to be making. Thank you so much, Stirling and Jack.
Reposted by Stirling Churchman
Reposted by Stirling Churchman
This is a much more important letter in WSJ than their recent Op-Ed from Hillsdale College. This is very important about what public funding of science means
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Opinion | Science Suffers With Trump’s Funding Freeze
America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.
www.wsj.com
April 21, 2025 at 6:35 PM
This is a much more important letter in WSJ than their recent Op-Ed from Hillsdale College. This is very important about what public funding of science means
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Opinion | Science Suffers With Trump’s Funding Freeze
America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.
www.wsj.com
April 21, 2025 at 6:21 PM
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...