Arnaud Krebs
@arnaudkr.bsky.social
Epigenetics that matters! Very cool work on hard to hard-to-access cell types . Finally some solid epigenetics examples that should be used in textbooks! Congrats to Mathieu and team @embl.org Rome!
This went under the radar but answers a fundamental question in Epigenetics...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers
The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...
www.biorxiv.org
January 7, 2026 at 3:53 PM
Epigenetics that matters! Very cool work on hard to hard-to-access cell types . Finally some solid epigenetics examples that should be used in textbooks! Congrats to Mathieu and team @embl.org Rome!
This is nuts. Dead ringers fused. Cronenberg would have loved that.
A fascinating case report.
The DNA of a female murder victim was genotyped and it turns out that she has been a chimera: a mixture of 46XX/46XY cell lines.
The analysis (STR-based) found:
1. The maternal chromosome was identical between the two cell lines.
www.fsigenetics.com/article/S187...
1/6
The DNA of a female murder victim was genotyped and it turns out that she has been a chimera: a mixture of 46XX/46XY cell lines.
The analysis (STR-based) found:
1. The maternal chromosome was identical between the two cell lines.
www.fsigenetics.com/article/S187...
1/6
Forensic analysis of a parthenogenetic 46, XX/46, XY congenital chimera: A case report
In forensic identification, chimerism is an extremely rare phenomenon in which DNA
samples can easily be misidentified as mixtures from two individuals. If only a single
cell population from the chime...
www.fsigenetics.com
January 7, 2026 at 8:27 AM
This is nuts. Dead ringers fused. Cronenberg would have loved that.
Reposted by Arnaud Krebs
Join @stirlingchurchman.bsky.social,
@moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
@moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
December 29, 2025 at 9:01 AM
Join @stirlingchurchman.bsky.social,
@moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
@moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
Reposted by Arnaud Krebs
Still time to apply until January, 19th!
We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!
Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668
The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a Tenure Track Professors...
www.nature.com
January 3, 2026 at 8:15 PM
Still time to apply until January, 19th!
The best chromatin kickstart pack you will find this year - please consider it if you want to get in the field or consolidate your skills. Hands on training and top notch speakers!
👉 Chromatin Summer School 2026 – Apply Now!
Join us in Munich 17–29 August 2026 for an immersive program on chromatin biology:
🔬 Expert lectures
🧪 Hands-on training
🤝 Global networking
Open to 14 PhD students worldwide (sponsorship available)
👉 Apply here: bit.ly/4oGDR8f
#ChromatinBiology
Join us in Munich 17–29 August 2026 for an immersive program on chromatin biology:
🔬 Expert lectures
🧪 Hands-on training
🤝 Global networking
Open to 14 PhD students worldwide (sponsorship available)
👉 Apply here: bit.ly/4oGDR8f
#ChromatinBiology
Summary - Summer School on Chromatin Biology: A Hands-On Expedition
bit.ly
December 15, 2025 at 7:41 AM
The best chromatin kickstart pack you will find this year - please consider it if you want to get in the field or consolidate your skills. Hands on training and top notch speakers!
Reposted by Arnaud Krebs
After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out!
In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.
www.biorxiv.org/content/10.1...
In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.
www.biorxiv.org/content/10.1...
Programmatic design and editing of cis-regulatory elements
The development of modern genome editing and DNA synthesis has enabled researchers to edit DNA sequences with high precision but has left unsolved the problem of designing these edits. We introduce Le...
www.biorxiv.org
December 10, 2025 at 3:18 PM
After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out!
In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.
www.biorxiv.org/content/10.1...
In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.
www.biorxiv.org/content/10.1...
Reposted by Arnaud Krebs
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
www.biorxiv.org
December 11, 2025 at 6:09 AM
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Arnaud Krebs
Are you ready for the 17th edition of 'Transcription and chromatin'? Our conference remains a must-attend event for anyone engaged in the forefront of transcription research and we hope you can join us! 🧬
25 – 28 August 2026
Submit your abstract by 25 May: s.embl.org/trm26-01-bl
#EMBLTranscript
25 – 28 August 2026
Submit your abstract by 25 May: s.embl.org/trm26-01-bl
#EMBLTranscript
December 10, 2025 at 8:59 AM
Are you ready for the 17th edition of 'Transcription and chromatin'? Our conference remains a must-attend event for anyone engaged in the forefront of transcription research and we hope you can join us! 🧬
25 – 28 August 2026
Submit your abstract by 25 May: s.embl.org/trm26-01-bl
#EMBLTranscript
25 – 28 August 2026
Submit your abstract by 25 May: s.embl.org/trm26-01-bl
#EMBLTranscript
Reposted by Arnaud Krebs
👉 Chromatin Summer School 2026 – Apply Now!
Join us in Munich 17–29 August 2026 for an immersive program on chromatin biology:
🔬 Expert lectures
🧪 Hands-on training
🤝 Global networking
Open to 14 PhD students worldwide (sponsorship available)
👉 Apply here: bit.ly/4oGDR8f
#ChromatinBiology
Join us in Munich 17–29 August 2026 for an immersive program on chromatin biology:
🔬 Expert lectures
🧪 Hands-on training
🤝 Global networking
Open to 14 PhD students worldwide (sponsorship available)
👉 Apply here: bit.ly/4oGDR8f
#ChromatinBiology
Summary - Summer School on Chromatin Biology: A Hands-On Expedition
bit.ly
December 10, 2025 at 9:30 AM
👉 Chromatin Summer School 2026 – Apply Now!
Join us in Munich 17–29 August 2026 for an immersive program on chromatin biology:
🔬 Expert lectures
🧪 Hands-on training
🤝 Global networking
Open to 14 PhD students worldwide (sponsorship available)
👉 Apply here: bit.ly/4oGDR8f
#ChromatinBiology
Join us in Munich 17–29 August 2026 for an immersive program on chromatin biology:
🔬 Expert lectures
🧪 Hands-on training
🤝 Global networking
Open to 14 PhD students worldwide (sponsorship available)
👉 Apply here: bit.ly/4oGDR8f
#ChromatinBiology
Reposted by Arnaud Krebs
Its out!!!
A little reading before the Christmas break by the one and only @nucleosomepolice.bsky.social in @annualreviews.bsky.social
The expanding Histone universe: Histone-Based DNA organization in noneukaryotic organisms
www.annualreviews.org/content/jour...
The expanding Histone universe: Histone-Based DNA organization in noneukaryotic organisms
www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms
Histones are small basic proteins that form the proteinaceous core of the nucleosome, the repeating building block of chromatin in all eukaryotes. Long thought to be exclusive to eukaryotes, histones ...
www.annualreviews.org
December 9, 2025 at 1:47 PM
Its out!!!
Reposted by Arnaud Krebs
Please RT 📧
Registration open for ➡️"Summer School on Chromatin Biology" Our 2 weeks hands on expedition 🧪👩💻August 2026. 3. edition. Learn CUT@Tag, CUT@Run, ChIPseq, ATACseq AND to analyse your own data at @helmholtzmunich.bsky.social Daily letures by experts in the field !
▶️ shorturl.at/jrA8i
Registration open for ➡️"Summer School on Chromatin Biology" Our 2 weeks hands on expedition 🧪👩💻August 2026. 3. edition. Learn CUT@Tag, CUT@Run, ChIPseq, ATACseq AND to analyse your own data at @helmholtzmunich.bsky.social Daily letures by experts in the field !
▶️ shorturl.at/jrA8i
December 9, 2025 at 11:59 AM
Please RT 📧
Registration open for ➡️"Summer School on Chromatin Biology" Our 2 weeks hands on expedition 🧪👩💻August 2026. 3. edition. Learn CUT@Tag, CUT@Run, ChIPseq, ATACseq AND to analyse your own data at @helmholtzmunich.bsky.social Daily letures by experts in the field !
▶️ shorturl.at/jrA8i
Registration open for ➡️"Summer School on Chromatin Biology" Our 2 weeks hands on expedition 🧪👩💻August 2026. 3. edition. Learn CUT@Tag, CUT@Run, ChIPseq, ATACseq AND to analyse your own data at @helmholtzmunich.bsky.social Daily letures by experts in the field !
▶️ shorturl.at/jrA8i
Reposted by Arnaud Krebs
It's always exciting when the latest edition of JASPAR comes out. Great leadership by @amathelier.bsky.social and pleased to welcome @anshulkundaje.bsky.social to the journey. #Jaspar2026
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
December 3, 2025 at 4:52 AM
It's always exciting when the latest edition of JASPAR comes out. Great leadership by @amathelier.bsky.social and pleased to welcome @anshulkundaje.bsky.social to the journey. #Jaspar2026
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Reposted by Arnaud Krebs
We are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below:
(TLDR; low-affinity motifs matter as pioneers!)
(TLDR; low-affinity motifs matter as pioneers!)
Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs
Low-affinity transcription factor (TF) motifs are an important element of the cis-regulatory code, yet they are notoriously difficult to map and mechanistically incompletely understood, limiting our a...
www.biorxiv.org
November 19, 2025 at 8:57 PM
We are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below:
(TLDR; low-affinity motifs matter as pioneers!)
(TLDR; low-affinity motifs matter as pioneers!)
Reposted by Arnaud Krebs
Reposted by Arnaud Krebs
The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris).
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
Epigenetics - 21st Course on Epigenetics 2026: Towards a quantitative understanding of nuclear dynamics during development and diseases | Institut Curie Advanced Training
The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involvin...
minilien.curie.fr
November 12, 2025 at 10:58 AM
The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris).
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
And the science is amazing! Apply!
We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...
November 20, 2025 at 12:52 PM
And the science is amazing! Apply!
Reposted by Arnaud Krebs
This Thursday, we’re pleased to welcome Philipp Korber.
Prof Korber leads a research group on “Nucleosome Positioning & Remodeling in Yeasts” at the @bmc-lmu.bsky.social in Munich. His work has identified ATP-dependent chromatin remodelers as major determinants of nucleosome positioning.
Join us!
Prof Korber leads a research group on “Nucleosome Positioning & Remodeling in Yeasts” at the @bmc-lmu.bsky.social in Munich. His work has identified ATP-dependent chromatin remodelers as major determinants of nucleosome positioning.
Join us!
November 18, 2025 at 11:12 AM
This Thursday, we’re pleased to welcome Philipp Korber.
Prof Korber leads a research group on “Nucleosome Positioning & Remodeling in Yeasts” at the @bmc-lmu.bsky.social in Munich. His work has identified ATP-dependent chromatin remodelers as major determinants of nucleosome positioning.
Join us!
Prof Korber leads a research group on “Nucleosome Positioning & Remodeling in Yeasts” at the @bmc-lmu.bsky.social in Munich. His work has identified ATP-dependent chromatin remodelers as major determinants of nucleosome positioning.
Join us!
Reposted by Arnaud Krebs
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Arnaud Krebs
Vous êtes étudiant(e) en informatique, ingénierie ou mathématiques dans une université ou une grande école ? La biologie et le fonctionnement du vivant vous intéressent ? Envie d'élargir vos horizons ?
Ce stage pourrait vous convenir.
www.ebi.ac.uk/about/jobs/i...
Ce stage pourrait vous convenir.
www.ebi.ac.uk/about/jobs/i...
EMBL-EBI / Embassy of France in London Internships
In collaboration with the Embassy of France in London, we are offering a number of paid internships to computer-science, statistics and bioinformatics students.
www.ebi.ac.uk
October 23, 2025 at 7:33 AM
Vous êtes étudiant(e) en informatique, ingénierie ou mathématiques dans une université ou une grande école ? La biologie et le fonctionnement du vivant vous intéressent ? Envie d'élargir vos horizons ?
Ce stage pourrait vous convenir.
www.ebi.ac.uk/about/jobs/i...
Ce stage pourrait vous convenir.
www.ebi.ac.uk/about/jobs/i...
Reposted by Arnaud Krebs
Ding ding! New Restrictor paper out showing that ZC3H4 affects transcription universally at a checkpoint downstream and distinct to Integrator!
Sequential verification of transcription by Integrator and Restrictor: Molecular Cell www.cell.com/molecular-ce...
Sequential verification of transcription by Integrator and Restrictor: Molecular Cell www.cell.com/molecular-ce...
Sequential verification of transcription by Integrator and Restrictor
Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways
for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal
pause site, whereas Restricto...
www.cell.com
October 17, 2025 at 2:49 PM
Ding ding! New Restrictor paper out showing that ZC3H4 affects transcription universally at a checkpoint downstream and distinct to Integrator!
Sequential verification of transcription by Integrator and Restrictor: Molecular Cell www.cell.com/molecular-ce...
Sequential verification of transcription by Integrator and Restrictor: Molecular Cell www.cell.com/molecular-ce...
Reposted by Arnaud Krebs
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 12:34 PM
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Reposted by Arnaud Krebs
Out now! 🎉 Check the thread & preprint to see why we think E–P specificity is real in mammals — and, well, a few other interesting things popped up too 👀
Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬
Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 17, 2025 at 5:50 AM
Out now! 🎉 Check the thread & preprint to see why we think E–P specificity is real in mammals — and, well, a few other interesting things popped up too 👀
Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬
Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬
A genetic engineering tour de force by @blanka-majchrzycka.bsky.social. Systematic dissection of promoter function in relevant genomic context! Spoiler, promoter matters! Happy we could help on this!
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 4:05 PM
A genetic engineering tour de force by @blanka-majchrzycka.bsky.social. Systematic dissection of promoter function in relevant genomic context! Spoiler, promoter matters! Happy we could help on this!
Reposted by Arnaud Krebs
October 12, 2025 at 9:25 AM
Reposted by Arnaud Krebs
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...