Yad Ghavi-Helm
@yghavi.bsky.social
Researcher @CNRS, PI @igflyon.bsky.social, Scientific coordinator #spatialOMICs facility @Spatial_Cell_ID facility @ENSdeLyon #enhancer #transcription #development #3Dgenome #Drosophila
Pinned
Yad Ghavi-Helm
@yghavi.bsky.social
· Oct 16
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Congratulations to Dr @baalberti.bsky.social !! 🎉
And many thanks to his jury members @randersson.bsky.social @arnausebe.bsky.social @olivier-gandrillon.mastodon.social.ap.brid.gy Marie Sémon Anouck Necsulea and co-supervizor @paulvilloutreix.bsky.social
And many thanks to his jury members @randersson.bsky.social @arnausebe.bsky.social @olivier-gandrillon.mastodon.social.ap.brid.gy Marie Sémon Anouck Necsulea and co-supervizor @paulvilloutreix.bsky.social
November 10, 2025 at 9:37 AM
Congratulations to Dr @baalberti.bsky.social !! 🎉
And many thanks to his jury members @randersson.bsky.social @arnausebe.bsky.social @olivier-gandrillon.mastodon.social.ap.brid.gy Marie Sémon Anouck Necsulea and co-supervizor @paulvilloutreix.bsky.social
And many thanks to his jury members @randersson.bsky.social @arnausebe.bsky.social @olivier-gandrillon.mastodon.social.ap.brid.gy Marie Sémon Anouck Necsulea and co-supervizor @paulvilloutreix.bsky.social
Reposted by Yad Ghavi-Helm
This is so cool! It’s also nice to see how careful genetic dissection of loci is still at the forefront of discovery!
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 18, 2025 at 8:00 AM
This is so cool! It’s also nice to see how careful genetic dissection of loci is still at the forefront of discovery!
Reposted by Yad Ghavi-Helm
a really cool work! everyone check it out! congratulations 🎉👏🏽
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 1:55 PM
a really cool work! everyone check it out! congratulations 🎉👏🏽
Reposted by Yad Ghavi-Helm
super cool to see this out! looking forward to now read the details! Congratulations, Yad and @mmasoura.bsky.social
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 6:31 PM
super cool to see this out! looking forward to now read the details! Congratulations, Yad and @mmasoura.bsky.social
A must read! Check out @blanka-majchrzycka.bsky.social and @danielibrahim.bsky.social 's latest work
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 6:39 PM
A must read! Check out @blanka-majchrzycka.bsky.social and @danielibrahim.bsky.social 's latest work
Reposted by Yad Ghavi-Helm
Check out our new story on how broad enhancer inputs are restricted into tissue-specific gene expression 🧬
Hint: Promoter-proximal regions are the key!
Hint: Promoter-proximal regions are the key!
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 4:53 PM
Check out our new story on how broad enhancer inputs are restricted into tissue-specific gene expression 🧬
Hint: Promoter-proximal regions are the key!
Hint: Promoter-proximal regions are the key!
Reposted by Yad Ghavi-Helm
you must check out @yghavi.bsky.social and @mmasoura.bsky.social's story, who found a similar mechanism in Drosophila. it's so cool if two works align!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 3:06 PM
you must check out @yghavi.bsky.social and @mmasoura.bsky.social's story, who found a similar mechanism in Drosophila. it's so cool if two works align!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 12:34 PM
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
In the starting blocks for #EDRC2025!
Come see our work at posters 100 and 155 and during the Gene expression in the 3D nuclear space workshop!
Come see our work at posters 100 and 155 and during the Gene expression in the 3D nuclear space workshop!
September 25, 2025 at 8:02 AM
In the starting blocks for #EDRC2025!
Come see our work at posters 100 and 155 and during the Gene expression in the 3D nuclear space workshop!
Come see our work at posters 100 and 155 and during the Gene expression in the 3D nuclear space workshop!
Merci au @cnrsbiologie.bsky.social de mettre en avant notre travail! @baalberti.bsky.social @paulvilloutreix.bsky.social
@igflyon.bsky.social @ensdelyon.bsky.social
@igflyon.bsky.social @ensdelyon.bsky.social
Un embryon virtuel pour cartographier l’activité des régions régulatrices du génome
🤝 @yghavi.bsky.social @cnrs-rhoneauvergne.bsky.social
👉 Lire l'article dans @narjournal.bsky.social buff.ly/e41cZQD
🤝 @yghavi.bsky.social @cnrs-rhoneauvergne.bsky.social
👉 Lire l'article dans @narjournal.bsky.social buff.ly/e41cZQD
Un embryon virtuel pour cartographier l’activité des régions régulatrices du génome
Dans un article publié dans Nucleic Acids Research, des scientifiques décrivent spatial-scERA, une méthode combinant biologie moléculaire, séquençage
buff.ly
July 28, 2025 at 2:25 PM
Merci au @cnrsbiologie.bsky.social de mettre en avant notre travail! @baalberti.bsky.social @paulvilloutreix.bsky.social
@igflyon.bsky.social @ensdelyon.bsky.social
@igflyon.bsky.social @ensdelyon.bsky.social
📢 We are recruiting!
Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies.
Please share and RT 🙏
Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies.
Please share and RT 🙏
July 23, 2025 at 2:37 PM
📢 We are recruiting!
Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies.
Please share and RT 🙏
Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies.
Please share and RT 🙏
Reposted by Yad Ghavi-Helm
🚨 Our paper is out! 🚨
Check how spatial-scERA can predict enhancer activity in a virtual Drosophila embryo.
Very proud of this first step in the research world published in @narjournal.bsky.social
Thanks to @yghavi.bsky.social, @paulvilloutreix.bsky.social and all the scientists who made it real!
Check how spatial-scERA can predict enhancer activity in a virtual Drosophila embryo.
Very proud of this first step in the research world published in @narjournal.bsky.social
Thanks to @yghavi.bsky.social, @paulvilloutreix.bsky.social and all the scientists who made it real!
Now available in its final form @narjournal.bsky.social !
doi.org/10.1093/nar/...
Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.
doi.org/10.1093/nar/...
Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.
July 23, 2025 at 8:03 AM
🚨 Our paper is out! 🚨
Check how spatial-scERA can predict enhancer activity in a virtual Drosophila embryo.
Very proud of this first step in the research world published in @narjournal.bsky.social
Thanks to @yghavi.bsky.social, @paulvilloutreix.bsky.social and all the scientists who made it real!
Check how spatial-scERA can predict enhancer activity in a virtual Drosophila embryo.
Very proud of this first step in the research world published in @narjournal.bsky.social
Thanks to @yghavi.bsky.social, @paulvilloutreix.bsky.social and all the scientists who made it real!
Now available in its final form @narjournal.bsky.social !
doi.org/10.1093/nar/...
Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.
doi.org/10.1093/nar/...
Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.
July 23, 2025 at 7:44 AM
Now available in its final form @narjournal.bsky.social !
doi.org/10.1093/nar/...
Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.
doi.org/10.1093/nar/...
Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.
Reposted by Yad Ghavi-Helm
300 000 signatures dont plus de 200000 en moins de 48h !
L’objectif des 500 000 signatures est possible d’ici dimanche soir, afin d’obtenir un vrai débat à l’Assemblée nationale sur la loi Duplomb.
L’objectif des 500 000 signatures est possible d’ici dimanche soir, afin d’obtenir un vrai débat à l’Assemblée nationale sur la loi Duplomb.
July 19, 2025 at 6:18 AM
300 000 signatures dont plus de 200000 en moins de 48h !
L’objectif des 500 000 signatures est possible d’ici dimanche soir, afin d’obtenir un vrai débat à l’Assemblée nationale sur la loi Duplomb.
L’objectif des 500 000 signatures est possible d’ici dimanche soir, afin d’obtenir un vrai débat à l’Assemblée nationale sur la loi Duplomb.
Honored and extremely grateful to see our project in collaboration with @hilaryashe.bsky.social and @hilsawh.bsky.social awarded an #HFSPReseachGrant @hfspo.bsky.social
Stay tuned for exciting job offers!
Stay tuned for exciting job offers!
🥳Congratulations to the 104 pioneering scientists from 30 nations awarded 2025 #HFSPResearchGrants! 🎉Your frontier research is shaping the future of #LifeSciences! 🌍🔬🧪
🏆 Meet the awardees & their projects: www.hfsp.org/bookletRG202...
#ScienceDiplomacy #HFSP #FrontierScience #sts
🏆 Meet the awardees & their projects: www.hfsp.org/bookletRG202...
#ScienceDiplomacy #HFSP #FrontierScience #sts
April 2, 2025 at 5:10 PM
Honored and extremely grateful to see our project in collaboration with @hilaryashe.bsky.social and @hilsawh.bsky.social awarded an #HFSPReseachGrant @hfspo.bsky.social
Stay tuned for exciting job offers!
Stay tuned for exciting job offers!
Thanks @evodevogenomeub.bsky.social @criscanestro.bsky.social for having us and showing us all the secrets of beautiful Oikopleura!! 😍
January 23, 2025 at 9:16 AM
Thanks @evodevogenomeub.bsky.social @criscanestro.bsky.social for having us and showing us all the secrets of beautiful Oikopleura!! 😍
Lovely day at @biom-banyuls.bsky.social
So much exciting science on cool marine species!
So much exciting science on cool marine species!
January 21, 2025 at 8:26 PM
Lovely day at @biom-banyuls.bsky.social
So much exciting science on cool marine species!
So much exciting science on cool marine species!
Reposted by Yad Ghavi-Helm
Poster #5 is a collaboration with @yghavi.bsky.social led by Baptiste Alberti where we propose a method for reconstructing of the spatial single-cell enhancer activity in a multicellular organism
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Spatial reconstruction of single-cell enhancer activity in a multicellular organism
Enhancers play an essential role in developmental processes by orchestrating the spatial and temporal regulation of gene expression. However, mapping the location of these regulatory elements in the g...
www.biorxiv.org
December 12, 2024 at 3:36 PM
Poster #5 is a collaboration with @yghavi.bsky.social led by Baptiste Alberti where we propose a method for reconstructing of the spatial single-cell enhancer activity in a multicellular organism
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
On my way to Heidelberg @EMBL #EMBLOmics to present our work. Looking forward!!!
🚨Preprint alert!
tinyurl.com/2zkmynsd
Did you ever dream of reconstruction #spatial single-cell #enhancer activity in a multicellular organism using massively parallel enhancer-reporter assays?
Then Spatial-scERA is the method for you!
#spatialOMICs
tinyurl.com/2zkmynsd
Did you ever dream of reconstruction #spatial single-cell #enhancer activity in a multicellular organism using massively parallel enhancer-reporter assays?
Then Spatial-scERA is the method for you!
#spatialOMICs
Spatial reconstruction of single-cell enhancer activity in a multicellular organism
Enhancers play an essential role in developmental processes by orchestrating the spatial and temporal regulation of gene expression. However, mapping the location of these regulatory elements in the g...
tinyurl.com
November 18, 2024 at 11:06 AM
On my way to Heidelberg @EMBL #EMBLOmics to present our work. Looking forward!!!
🚨Preprint alert!
tinyurl.com/2zkmynsd
Did you ever dream of reconstruction #spatial single-cell #enhancer activity in a multicellular organism using massively parallel enhancer-reporter assays?
Then Spatial-scERA is the method for you!
#spatialOMICs
tinyurl.com/2zkmynsd
Did you ever dream of reconstruction #spatial single-cell #enhancer activity in a multicellular organism using massively parallel enhancer-reporter assays?
Then Spatial-scERA is the method for you!
#spatialOMICs
Spatial reconstruction of single-cell enhancer activity in a multicellular organism
Enhancers play an essential role in developmental processes by orchestrating the spatial and temporal regulation of gene expression. However, mapping the location of these regulatory elements in the g...
tinyurl.com
November 18, 2024 at 11:05 AM
🚨Preprint alert!
tinyurl.com/2zkmynsd
Did you ever dream of reconstruction #spatial single-cell #enhancer activity in a multicellular organism using massively parallel enhancer-reporter assays?
Then Spatial-scERA is the method for you!
#spatialOMICs
tinyurl.com/2zkmynsd
Did you ever dream of reconstruction #spatial single-cell #enhancer activity in a multicellular organism using massively parallel enhancer-reporter assays?
Then Spatial-scERA is the method for you!
#spatialOMICs