Chris Estell
@thequietscientist.bsky.social
Shy-guy-chris is interested in all sciency stuff, especially RNA biology and transcription. Currently working for Westicles at the University of Exeter.
Love me a supplementary mass spec excel spreadsheet! Had a look at the ARS2 IP-MS, su(s) is one of the top hits!! More evidence L searles was right and su(s) is the fly orthologue of ZC3H4
Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis
Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis
Lee, Biasini et al. define the composition and functions of the Integrator, NEXT, and nuclear exosome complexes in the Drosophila female germline. The study combines proteomics and multiple RNA sequencing-based approaches to catalog the molecular roles of these complexes in maintaining nuclear RNA homeostasis during fly germ cell development.
dlvr.it
October 30, 2025 at 2:00 PM
Love me a supplementary mass spec excel spreadsheet! Had a look at the ARS2 IP-MS, su(s) is one of the top hits!! More evidence L searles was right and su(s) is the fly orthologue of ZC3H4
Ding ding! New Restrictor paper out showing that ZC3H4 affects transcription universally at a checkpoint downstream and distinct to Integrator!
Sequential verification of transcription by Integrator and Restrictor: Molecular Cell www.cell.com/molecular-ce...
Sequential verification of transcription by Integrator and Restrictor: Molecular Cell www.cell.com/molecular-ce...
Sequential verification of transcription by Integrator and Restrictor
Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways
for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal
pause site, whereas Restricto...
www.cell.com
October 17, 2025 at 2:49 PM
Ding ding! New Restrictor paper out showing that ZC3H4 affects transcription universally at a checkpoint downstream and distinct to Integrator!
Sequential verification of transcription by Integrator and Restrictor: Molecular Cell www.cell.com/molecular-ce...
Sequential verification of transcription by Integrator and Restrictor: Molecular Cell www.cell.com/molecular-ce...
Well this is shit :(
shocking to read over and over the stories of close colleagues who can't run their lab anymore. I know Karen well and it's heartbreaking. Also #PIinthelab! www.washingtonpost.com/education/20...
Harvard’s research is shrinking amid the Trump administration’s freeze
Even if grants at Harvard are suddenly restored, there is deep-rooted uncertainty about the damage already done and the future of basic science research in the U.S.
www.washingtonpost.com
August 29, 2025 at 11:13 AM
Well this is shit :(
Reposted by Chris Estell
The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
PhD position in Gene Regulation
Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!
www.uu.nl
August 15, 2025 at 10:22 AM
The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
New paper on the consequences of ZC3H4 loss, looking at Transcription-replication clashes
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
ZC3H4 safeguards genome integrity by preventing transcription-replication conflicts at noncoding RNA loci
A protein that suppresses noncoding RNA emerges as a guardian of genome stability.
www.science.org
June 19, 2025 at 1:00 PM
New paper on the consequences of ZC3H4 loss, looking at Transcription-replication clashes
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Chris Estell
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
The PNUTS phosphatase complex controls transcription pause release
Kelley et al. discover that the PNUTS phosphatase complex plays an essential role
in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves
this through its TND, which recog...
www.cell.com
November 26, 2024 at 4:18 PM
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
Great summary by @triggerloop.bsky.social for JMBs special on transcription!
As you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...
Controlling Transcription Elongation and Termination: More Than a Means to An End
www.sciencedirect.com
November 28, 2024 at 4:34 PM
Great summary by @triggerloop.bsky.social for JMBs special on transcription!