Jess Kelley
@jesskelley.bsky.social
Postdoc with Dominika Gruszka at the University of Oxford. Previously DPhil student in the Klose lab. Interested in the molecular mechanisms of chromatin-based processes. She/her
Reposted by Jess Kelley
Come to hear Alan's great new story on SET1/MLL proteins and transcription next Wednesday. @fnucleosome.bsky.social
🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026!
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
January 21, 2026 at 7:53 PM
Come to hear Alan's great new story on SET1/MLL proteins and transcription next Wednesday. @fnucleosome.bsky.social
Reposted by Jess Kelley
Unbelievably, #DuvetKnowItsChristmas generates such good will on social media that over the years we've raised somewhere approaching a quarter of a million quid for homeless charities. If you can spare a bob or two, sling some to Centrepoint, and here's the link: www.gofundme.com/f/duvet-know...
Donate to Duvet Know It's Christmas, 2025, organized by Rhodri Marsden
Unbelievably, it's the 15th year of this thing.
What is it?
Improbably, the nig… Rhodri Marsden needs your support for Duvet Know It's Christmas, 2025
www.gofundme.com
December 24, 2025 at 7:35 PM
Unbelievably, #DuvetKnowItsChristmas generates such good will on social media that over the years we've raised somewhere approaching a quarter of a million quid for homeless charities. If you can spare a bob or two, sling some to Centrepoint, and here's the link: www.gofundme.com/f/duvet-know...
This year I'm hosting Christmas in my 1-bed flat. My brother has inherited last year's airbed setup and I've upgraded to an actual bed!
Just a (freezing) 10-minute cycle down the road to my friend's house to get to it...
I get to hang out with Imogen though so I'm still happy
#DuvetKnowItsChristmas
Just a (freezing) 10-minute cycle down the road to my friend's house to get to it...
I get to hang out with Imogen though so I'm still happy
#DuvetKnowItsChristmas
December 24, 2025 at 11:34 PM
This year I'm hosting Christmas in my 1-bed flat. My brother has inherited last year's airbed setup and I've upgraded to an actual bed!
Just a (freezing) 10-minute cycle down the road to my friend's house to get to it...
I get to hang out with Imogen though so I'm still happy
#DuvetKnowItsChristmas
Just a (freezing) 10-minute cycle down the road to my friend's house to get to it...
I get to hang out with Imogen though so I'm still happy
#DuvetKnowItsChristmas
Reposted by Jess Kelley
Excited to share our new preprint from the Klose lab, where we investigate how SET1/MLL complexes shape H3K4me3 and regulate transcription in mouse ES cells. www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
www.biorxiv.org
December 11, 2025 at 4:07 PM
Excited to share our new preprint from the Klose lab, where we investigate how SET1/MLL complexes shape H3K4me3 and regulate transcription in mouse ES cells. www.biorxiv.org/content/10.6...
Reposted by Jess Kelley
Very proud to have our latest work now online in
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
Heterochromatin boundaries maintain centromere position, size and number - Nature Structural & Molecular Biology
Carty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining functional centromeres.
www.nature.com
November 27, 2025 at 9:58 PM
Very proud to have our latest work now online in
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
Reposted by Jess Kelley
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 20/31
Prompt RIVALS
Pdb: 8V27 & 8G6S
Two rival histone modifications on a nucleosome. Ubiquitination of H2BK120 activates genes while H2AK119 represses them.
Next: BLAST
Suggestions?
Day 20/31
Prompt RIVALS
Pdb: 8V27 & 8G6S
Two rival histone modifications on a nucleosome. Ubiquitination of H2BK120 activates genes while H2AK119 represses them.
Next: BLAST
Suggestions?
November 2, 2025 at 3:11 AM
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 20/31
Prompt RIVALS
Pdb: 8V27 & 8G6S
Two rival histone modifications on a nucleosome. Ubiquitination of H2BK120 activates genes while H2AK119 represses them.
Next: BLAST
Suggestions?
Day 20/31
Prompt RIVALS
Pdb: 8V27 & 8G6S
Two rival histone modifications on a nucleosome. Ubiquitination of H2BK120 activates genes while H2AK119 represses them.
Next: BLAST
Suggestions?
Reposted by Jess Kelley
Time to talk about one of my favourite Oxford buildings, 26-27-28 Cornmarket!!
Popularly known as The Old Pret
Popularly known as The Old Pret
September 22, 2025 at 4:10 PM
Time to talk about one of my favourite Oxford buildings, 26-27-28 Cornmarket!!
Popularly known as The Old Pret
Popularly known as The Old Pret
If you're looking for Oxford local news that actually reports local news, the Oxford Clarion is worth a follow and subscribe!
Oxfordshire’s weekly news update with all the stories we’ve broken this week:
✅ 10,000-home new town in North Oxfordshire
✅ Why Oxford–Milton Keynes trains haven’t started
✅ The new café run by monks
❌ Cotswold celebrities and Emma Watson
Read it online or by email: oxfordclarion.uk/clarion-week...
✅ 10,000-home new town in North Oxfordshire
✅ Why Oxford–Milton Keynes trains haven’t started
✅ The new café run by monks
❌ Cotswold celebrities and Emma Watson
Read it online or by email: oxfordclarion.uk/clarion-week...
Clarion Weekly, 5 September 2025
Kids are back at school, traffic is back… and the news never went away. We bring you a smorgasbord of exclusives, events and some dodgy monastic puns. Trigger warning: there is a picture of a spider i...
oxfordclarion.uk
September 5, 2025 at 11:11 AM
If you're looking for Oxford local news that actually reports local news, the Oxford Clarion is worth a follow and subscribe!
Reposted by Jess Kelley
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!
June 13, 2025 at 4:30 AM
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!
Reposted by Jess Kelley
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
April 6, 2025 at 9:45 AM
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
Reposted by Jess Kelley
Reposted by Jess Kelley
Research @oxfordbiochemistry.bsky.social @ox.ac.uk supported by the Wellcome Trust (UK) and NIH (USA) reveals essential new player in the process of deciding whether genes should be made or not. Great work @jesskelley.bsky.social
@robklose.bsky.social @edimitrova.bsky.social 👏 bit.ly/202502-klose
@robklose.bsky.social @edimitrova.bsky.social 👏 bit.ly/202502-klose
Unlocking the Pause: A new player in gene transcription
A new work from the Klose lab published in the journal Molecular Cell
bit.ly
February 10, 2025 at 1:50 PM
Research @oxfordbiochemistry.bsky.social @ox.ac.uk supported by the Wellcome Trust (UK) and NIH (USA) reveals essential new player in the process of deciding whether genes should be made or not. Great work @jesskelley.bsky.social
@robklose.bsky.social @edimitrova.bsky.social 👏 bit.ly/202502-klose
@robklose.bsky.social @edimitrova.bsky.social 👏 bit.ly/202502-klose
Reposted by Jess Kelley
@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...
February 5, 2025 at 5:33 PM
@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...
Reposted by Jess Kelley
I love scientists
Delightful and insightful paper on phase behavior in pasta sauce. Includes an optimized recipe for cacio e pepe which helps avoid the dreaded clumpy "Mozzarella phase".
Can't wait for a follow-up on lasagna manifolds.
arxiv.org/abs/2501.00536
Can't wait for a follow-up on lasagna manifolds.
arxiv.org/abs/2501.00536
Phase behavior of Cacio and Pepe sauce
"Pasta alla Cacio e pepe" is a traditional Italian dish made with pasta, pecorino cheese, and pepper. Despite its simple ingredient list, achieving the perfect texture and creaminess of the sauce can ...
arxiv.org
January 25, 2025 at 1:05 AM
I love scientists
Reposted by Jess Kelley
Do you know a UK-based wheelchair user who works in a lab and would be willing to user-test our prototype of what is believed to be the first-ever lab coat adapted for wheelchair users?
Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT
More info: www.ucl.ac.uk/ucl-east/new...
Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT
More info: www.ucl.ac.uk/ucl-east/new...
January 7, 2025 at 2:52 PM
Do you know a UK-based wheelchair user who works in a lab and would be willing to user-test our prototype of what is believed to be the first-ever lab coat adapted for wheelchair users?
Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT
More info: www.ucl.ac.uk/ucl-east/new...
Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT
More info: www.ucl.ac.uk/ucl-east/new...
Reposted by Jess Kelley
So I'll be back around then. We'll be trying to raise a bit of money for Centrepoint, bearing in mind that there are a bunch of people who have nowhere to go this evening. gofund.me/637d21d0 ENDS FOR NOW 🎄🛏️
Donate to Duvet Know It's Christmas, 2024, organized by Rhodri Marsden
Unbelievably, it's the 14th year of this thing.
What is it?
Improbably, the nig… Rhodri Marsden needs your support for Duvet Know It's Christmas, 2024
gofund.me
December 24, 2024 at 9:14 AM
So I'll be back around then. We'll be trying to raise a bit of money for Centrepoint, bearing in mind that there are a bunch of people who have nowhere to go this evening. gofund.me/637d21d0 ENDS FOR NOW 🎄🛏️
I finally get to join an honoured festive tradition in #DuvetKnowItsChristmas
Parents are stopping over in my 1-bed flat before we go join the family gathering in the morning. They get my bed, I get the airbed on my own living room floor.
Also featuring camping chair to supplement my 2-seat sofa
Parents are stopping over in my 1-bed flat before we go join the family gathering in the morning. They get my bed, I get the airbed on my own living room floor.
Also featuring camping chair to supplement my 2-seat sofa
December 24, 2024 at 11:06 PM
I finally get to join an honoured festive tradition in #DuvetKnowItsChristmas
Parents are stopping over in my 1-bed flat before we go join the family gathering in the morning. They get my bed, I get the airbed on my own living room floor.
Also featuring camping chair to supplement my 2-seat sofa
Parents are stopping over in my 1-bed flat before we go join the family gathering in the morning. They get my bed, I get the airbed on my own living room floor.
Also featuring camping chair to supplement my 2-seat sofa
Reposted by Jess Kelley
Googling Stuff: Then v Now.
December 11, 2024 at 5:15 PM
Googling Stuff: Then v Now.
Reposted by Jess Kelley
We have had multiple discussions about why people have not previously observed the very dramatic reduction in transcription upon PNUTS depletion. So I looked at our own TT-seq data and analysed it without including the spike-in. The numbers speak for themselves! Spike-in calibration is important!
December 12, 2024 at 10:50 AM
We have had multiple discussions about why people have not previously observed the very dramatic reduction in transcription upon PNUTS depletion. So I looked at our own TT-seq data and analysed it without including the spike-in. The numbers speak for themselves! Spike-in calibration is important!
Reposted by Jess Kelley
Join Oxford Biological Physics! #KavliOxford is inviting applications for Fellows to establish independent research groups in this dynamic, interdisciplinary field. Apply now: kavli.web.ox.ac.uk/article/2025...
2025 Application Round for Fellows in Oxford Biological Physics
kavli.web.ox.ac.uk
December 5, 2024 at 10:53 AM
Join Oxford Biological Physics! #KavliOxford is inviting applications for Fellows to establish independent research groups in this dynamic, interdisciplinary field. Apply now: kavli.web.ox.ac.uk/article/2025...
Reposted by Jess Kelley
Turns out that, for me, news sites are a great way to become usefully informed about what's happening in the world, and Twitter is a great way to get uselessly stressed about it.
November 29, 2024 at 11:17 AM
Turns out that, for me, news sites are a great way to become usefully informed about what's happening in the world, and Twitter is a great way to get uselessly stressed about it.
Nice thread collating all these exciting new reviews! My 'to read' list has definitely just got even longer...
As you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...
Controlling Transcription Elongation and Termination: More Than a Means to An End
www.sciencedirect.com
November 27, 2024 at 8:56 PM
Nice thread collating all these exciting new reviews! My 'to read' list has definitely just got even longer...
Reposted by Jess Kelley
On the reading list
A special JMB issue on Transcription elongation and termination with really great reviews including @triggerloop.bsky.social @voslab.org @lucas.farnunglab.com
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Controlling Transcription Elongation and Termination: More Than a Means to An End
www.sciencedirect.com
November 27, 2024 at 9:54 AM
On the reading list
Reposted by Jess Kelley
This paper is genuinely amazing! Not only is the science very cool, it is also a masterclass in scientific writing, as are most @robklose.bsky.social lab papers!
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
The PNUTS phosphatase complex controls transcription pause release
Kelley et al. discover that the PNUTS phosphatase complex plays an essential role
in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves
this through its TND, which recog...
www.cell.com
November 27, 2024 at 9:25 AM
This paper is genuinely amazing! Not only is the science very cool, it is also a masterclass in scientific writing, as are most @robklose.bsky.social lab papers!