EpiCypher
@epicypher.bsky.social
Leading developer of CUT&RUN and CUT&Tag chromatin mapping assays and other tools for chromatin research. Follow us for the latest news in epigenetics.
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EpiCypher
@epicypher.bsky.social
· Sep 5
Just announced: CUTANA™ Fiber-seq — a game-changing platform for multiomic profiling of chromatin accessibility, DNA methylation, protein footprints, and genetic variants in a single assay.
🔗 www.epicypher.com/resources/bl...
#Epigenetics #Fiberseq #Chromatin
🔗 www.epicypher.com/resources/bl...
#Epigenetics #Fiberseq #Chromatin
New co-authored study in Genes & Development 📄
Patriotis et al. show that the conserved EZH2 SANT1-binding domain regulates PRC2 activity & genome-wide H3K27 methylation.
https://doi.org/10.1101/gad.353070.125
Patriotis et al. show that the conserved EZH2 SANT1-binding domain regulates PRC2 activity & genome-wide H3K27 methylation.
https://doi.org/10.1101/gad.353070.125
February 17, 2026 at 8:45 PM
New co-authored study in Genes & Development 📄
Patriotis et al. show that the conserved EZH2 SANT1-binding domain regulates PRC2 activity & genome-wide H3K27 methylation.
https://doi.org/10.1101/gad.353070.125
Patriotis et al. show that the conserved EZH2 SANT1-binding domain regulates PRC2 activity & genome-wide H3K27 methylation.
https://doi.org/10.1101/gad.353070.125
How do you study chromatin, DNA methylation, and genetic variation on the same DNA molecule? 🧬 Emily Madden, PhD will walk through Fiber-seq, a long-read, single-molecule epigenomic approach enabling genome-wide discovery with locus-level context.
📅 Feb 18 | ⏰ 11:00–11:30 am
📅 Feb 18 | ⏰ 11:00–11:30 am
February 16, 2026 at 6:00 PM
How do you study chromatin, DNA methylation, and genetic variation on the same DNA molecule? 🧬 Emily Madden, PhD will walk through Fiber-seq, a long-read, single-molecule epigenomic approach enabling genome-wide discovery with locus-level context.
📅 Feb 18 | ⏰ 11:00–11:30 am
📅 Feb 18 | ⏰ 11:00–11:30 am
This Valentine’s Day, don’t go it alone. 💕
Fiber-seq custom services pair you with an EpiCypher expert for hands-on assay setup, best practices, and bioinformatics support—so you get high-quality data with confidence.
👉 https://www.epicypher.com/services/cutana-fiber-seq-assay-services/
Fiber-seq custom services pair you with an EpiCypher expert for hands-on assay setup, best practices, and bioinformatics support—so you get high-quality data with confidence.
👉 https://www.epicypher.com/services/cutana-fiber-seq-assay-services/
February 14, 2026 at 6:00 PM
This Valentine’s Day, don’t go it alone. 💕
Fiber-seq custom services pair you with an EpiCypher expert for hands-on assay setup, best practices, and bioinformatics support—so you get high-quality data with confidence.
👉 https://www.epicypher.com/services/cutana-fiber-seq-assay-services/
Fiber-seq custom services pair you with an EpiCypher expert for hands-on assay setup, best practices, and bioinformatics support—so you get high-quality data with confidence.
👉 https://www.epicypher.com/services/cutana-fiber-seq-assay-services/
We recently welcomed Dr. Steve Henikoff to EpiCypher for a seminar on “Epigenomic profiling for personalized medicine.”
From chromatin mapping advances to thoughtful team discussions, it was an energizing visit.
Always grateful to learn alongside leaders in #Epigenetics 🔬
From chromatin mapping advances to thoughtful team discussions, it was an energizing visit.
Always grateful to learn alongside leaders in #Epigenetics 🔬
February 13, 2026 at 6:02 PM
We recently welcomed Dr. Steve Henikoff to EpiCypher for a seminar on “Epigenomic profiling for personalized medicine.”
From chromatin mapping advances to thoughtful team discussions, it was an energizing visit.
Always grateful to learn alongside leaders in #Epigenetics 🔬
From chromatin mapping advances to thoughtful team discussions, it was an energizing visit.
Always grateful to learn alongside leaders in #Epigenetics 🔬
It’s International Day of Women and Girls in Science. 🔬
We’re celebrating the women whose research, mentorship, and leadership continue to move science forward and open doors for the next generation.
#WomenInScience
We’re celebrating the women whose research, mentorship, and leadership continue to move science forward and open doors for the next generation.
#WomenInScience
February 11, 2026 at 6:01 PM
It’s International Day of Women and Girls in Science. 🔬
We’re celebrating the women whose research, mentorship, and leadership continue to move science forward and open doors for the next generation.
#WomenInScience
We’re celebrating the women whose research, mentorship, and leadership continue to move science forward and open doors for the next generation.
#WomenInScience
New paper out in ACS Central Science from EpiCypher + the Kelleher lab: “Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nuc-MS” (Lee et al., 2026). Love seeing intact nucleosomes used to capture multivalent reader behavior, plus the role of dNucs™ and Captify™🧬
February 10, 2026 at 6:01 PM
New paper out in ACS Central Science from EpiCypher + the Kelleher lab: “Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nuc-MS” (Lee et al., 2026). Love seeing intact nucleosomes used to capture multivalent reader behavior, plus the role of dNucs™ and Captify™🧬
Using EpiCypher reagents for DIY CUT&RUN or CUT&Tag? 🧪
Our updated DIY protocols are live with clearer handling guidance, optimized bead ratios, and the CUTANA™ Wash Buffer Enhancer Set to help reduce variability, especially for nuclei inputs. Take a look and tell us how it works in your lab.
Our updated DIY protocols are live with clearer handling guidance, optimized bead ratios, and the CUTANA™ Wash Buffer Enhancer Set to help reduce variability, especially for nuclei inputs. Take a look and tell us how it works in your lab.
February 9, 2026 at 4:01 PM
Using EpiCypher reagents for DIY CUT&RUN or CUT&Tag? 🧪
Our updated DIY protocols are live with clearer handling guidance, optimized bead ratios, and the CUTANA™ Wash Buffer Enhancer Set to help reduce variability, especially for nuclei inputs. Take a look and tell us how it works in your lab.
Our updated DIY protocols are live with clearer handling guidance, optimized bead ratios, and the CUTANA™ Wash Buffer Enhancer Set to help reduce variability, especially for nuclei inputs. Take a look and tell us how it works in your lab.
Recently, our CSO Michael-Christopher Keogh, PhD shared a talk at New England Biolabs on multi-omic views of chromatin function.
Thanks to NEB for hosting and for the ongoing scientific collaboration. 🧬🔬
#Epigenetics #Chromatin
Thanks to NEB for hosting and for the ongoing scientific collaboration. 🧬🔬
#Epigenetics #Chromatin
February 6, 2026 at 6:02 PM
Recently, our CSO Michael-Christopher Keogh, PhD shared a talk at New England Biolabs on multi-omic views of chromatin function.
Thanks to NEB for hosting and for the ongoing scientific collaboration. 🧬🔬
#Epigenetics #Chromatin
Thanks to NEB for hosting and for the ongoing scientific collaboration. 🧬🔬
#Epigenetics #Chromatin
Reposted by EpiCypher
We've got two exciting chromatin talks coming up on Wednesday next week:
@epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social!
register and join us: us06web.zoom.us/webinar/regi...
@epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social!
register and join us: us06web.zoom.us/webinar/regi...
February 6, 2026 at 2:58 PM
We've got two exciting chromatin talks coming up on Wednesday next week:
@epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social!
register and join us: us06web.zoom.us/webinar/regi...
@epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social!
register and join us: us06web.zoom.us/webinar/regi...
On #WorldCancerDay, we reflect on the impact of cancer and the progress we’re making together.
EpiCypher is proud to support labs decoding chromatin dynamics in cancer—because understanding epigenetics changes the game. 🧬 Let’s keep pushing forward.
EpiCypher is proud to support labs decoding chromatin dynamics in cancer—because understanding epigenetics changes the game. 🧬 Let’s keep pushing forward.
February 4, 2026 at 3:25 PM
On #WorldCancerDay, we reflect on the impact of cancer and the progress we’re making together.
EpiCypher is proud to support labs decoding chromatin dynamics in cancer—because understanding epigenetics changes the game. 🧬 Let’s keep pushing forward.
EpiCypher is proud to support labs decoding chromatin dynamics in cancer—because understanding epigenetics changes the game. 🧬 Let’s keep pushing forward.
Punxsutawney Phil says winter’s sticking around ❄
But so are we—in the lab, at the bench, decoding chromatin one nucleosome at a time. What’s your go-to winter epigenetics workflow? #Epigenetics
But so are we—in the lab, at the bench, decoding chromatin one nucleosome at a time. What’s your go-to winter epigenetics workflow? #Epigenetics
February 2, 2026 at 3:01 PM
Punxsutawney Phil says winter’s sticking around ❄
But so are we—in the lab, at the bench, decoding chromatin one nucleosome at a time. What’s your go-to winter epigenetics workflow? #Epigenetics
But so are we—in the lab, at the bench, decoding chromatin one nucleosome at a time. What’s your go-to winter epigenetics workflow? #Epigenetics
Attention: Researchers in genomics, epigenetics, and single-cell biology! Watch our on-demand webinar to explore how Paired-Damage-seq integrates DNA damage mapping with transcriptomics to reveal cell-type-specific genome instability.
Watch now 👉 https://ow.ly/kAUg50Y4Seu
Watch now 👉 https://ow.ly/kAUg50Y4Seu
January 29, 2026 at 9:00 PM
Attention: Researchers in genomics, epigenetics, and single-cell biology! Watch our on-demand webinar to explore how Paired-Damage-seq integrates DNA damage mapping with transcriptomics to reveal cell-type-specific genome instability.
Watch now 👉 https://ow.ly/kAUg50Y4Seu
Watch now 👉 https://ow.ly/kAUg50Y4Seu
Last Chance To Register!
Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies.
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies.
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
January 28, 2026 at 3:00 PM
Last Chance To Register!
Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies.
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies.
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
See EpiCypher at the Festival of Genomics & Biodata (London), Jan 28 - 29, 2026. Poster: “Fiber-seq connects genetic variation to epigenomic function on single DNA molecules”. Not attending?
Download the poster: https://explore.epicypher.com/posters/LRS-emily/FOG2026 #Epigenomics #Genomics
Download the poster: https://explore.epicypher.com/posters/LRS-emily/FOG2026 #Epigenomics #Genomics
January 27, 2026 at 2:00 PM
See EpiCypher at the Festival of Genomics & Biodata (London), Jan 28 - 29, 2026. Poster: “Fiber-seq connects genetic variation to epigenomic function on single DNA molecules”. Not attending?
Download the poster: https://explore.epicypher.com/posters/LRS-emily/FOG2026 #Epigenomics #Genomics
Download the poster: https://explore.epicypher.com/posters/LRS-emily/FOG2026 #Epigenomics #Genomics
EpiCypher’s at #KeystoneSymposia this week!
🧬 Poster #2001: Fiber-seq connects genetic variation to epigenomic function on single DNA molecules
📍 Jan 28, 7:30 PM ET | Cary, NC
Missed it in person? Download the full poster:
https://explore.epicypher.com/posters/Keystone-Jan2026/fiber-seq
🧬 Poster #2001: Fiber-seq connects genetic variation to epigenomic function on single DNA molecules
📍 Jan 28, 7:30 PM ET | Cary, NC
Missed it in person? Download the full poster:
https://explore.epicypher.com/posters/Keystone-Jan2026/fiber-seq
January 26, 2026 at 6:00 PM
EpiCypher’s at #KeystoneSymposia this week!
🧬 Poster #2001: Fiber-seq connects genetic variation to epigenomic function on single DNA molecules
📍 Jan 28, 7:30 PM ET | Cary, NC
Missed it in person? Download the full poster:
https://explore.epicypher.com/posters/Keystone-Jan2026/fiber-seq
🧬 Poster #2001: Fiber-seq connects genetic variation to epigenomic function on single DNA molecules
📍 Jan 28, 7:30 PM ET | Cary, NC
Missed it in person? Download the full poster:
https://explore.epicypher.com/posters/Keystone-Jan2026/fiber-seq
Reposted by EpiCypher
🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026!
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
January 21, 2026 at 10:48 AM
🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026!
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
How can you profile chromatin accessibility, DNA methylation, and protein footprints in a single assay?
🔗 Read more: https://www.epicypher.com/resources/blog/fiber-seq-101/
#Epigenomics #Chromatin #ATACseq #Multiomics #Fiberseq #EpiCypher
🔗 Read more: https://www.epicypher.com/resources/blog/fiber-seq-101/
#Epigenomics #Chromatin #ATACseq #Multiomics #Fiberseq #EpiCypher
Fiber-seq 101: A Multiomic Assay That Goes Beyond ATAC-seq - EpiCypher
Fiber-seq is a powerful new long-read sequencing assay to simultaneously study genetic and epigenetic features. Read more!
www.epicypher.com
January 22, 2026 at 3:00 PM
How can you profile chromatin accessibility, DNA methylation, and protein footprints in a single assay?
🔗 Read more: https://www.epicypher.com/resources/blog/fiber-seq-101/
#Epigenomics #Chromatin #ATACseq #Multiomics #Fiberseq #EpiCypher
🔗 Read more: https://www.epicypher.com/resources/blog/fiber-seq-101/
#Epigenomics #Chromatin #ATACseq #Multiomics #Fiberseq #EpiCypher
Running into issues with CUT&RUN, CUT&Tag, or Fiber-seq? 🧬 You’re not alone. Our Tech Support Center has in-depth guides, from antibody selection to CUTANA™ Cloud analysis.
Explore the help hub 👉 support.epicypher.com
#Epigenetics #ChromatinMapping
Explore the help hub 👉 support.epicypher.com
#Epigenetics #ChromatinMapping
January 21, 2026 at 8:00 PM
Running into issues with CUT&RUN, CUT&Tag, or Fiber-seq? 🧬 You’re not alone. Our Tech Support Center has in-depth guides, from antibody selection to CUTANA™ Cloud analysis.
Explore the help hub 👉 support.epicypher.com
#Epigenetics #ChromatinMapping
Explore the help hub 👉 support.epicypher.com
#Epigenetics #ChromatinMapping
Genomics & single-cell researchers—expand your toolkit. 👨🔬Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies.
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
January 20, 2026 at 2:01 PM
Genomics & single-cell researchers—expand your toolkit. 👨🔬Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies.
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
CUTANA™ Cloud — the easiest way to analyze CUT&RUN and CUT&Tag data.
No coding needed. Upload, analyze, and discover with just a few clicks.
☁️ www.epicypher.com/CUTANA-Cloud
No coding needed. Upload, analyze, and discover with just a few clicks.
☁️ www.epicypher.com/CUTANA-Cloud
January 16, 2026 at 3:00 PM
CUTANA™ Cloud — the easiest way to analyze CUT&RUN and CUT&Tag data.
No coding needed. Upload, analyze, and discover with just a few clicks.
☁️ www.epicypher.com/CUTANA-Cloud
No coding needed. Upload, analyze, and discover with just a few clicks.
☁️ www.epicypher.com/CUTANA-Cloud
Reposted by EpiCypher
A wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch.
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org
January 16, 2026 at 2:15 PM
A wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch.
doi.org/10.64898/202...
doi.org/10.64898/202...
Congrats to the 2025 PacBio Epigenetics SMRT Grant awardees! 🧬🎊 Excited to see their work with Fiber-seq in epigenomics. 🔬🧪 Learn more here: https://www.pacb.com/blog/2025-epigenetics-smrt-grant-awardees/
January 15, 2026 at 9:00 PM
Congrats to the 2025 PacBio Epigenetics SMRT Grant awardees! 🧬🎊 Excited to see their work with Fiber-seq in epigenomics. 🔬🧪 Learn more here: https://www.pacb.com/blog/2025-epigenetics-smrt-grant-awardees/
PAG 33 wrap-up ✅ Thanks to everyone who kept booth 329 busy and shared great questions about Fiber-seq and beyond. Also, shoutout to everyone who stopped by Keith and Hannah’s posters. What was your favorite session or takeaway from PAG this year? 🧬🔬
#PAG2026 #Epigenomics
#PAG2026 #Epigenomics
January 14, 2026 at 4:01 PM
PAG 33 wrap-up ✅ Thanks to everyone who kept booth 329 busy and shared great questions about Fiber-seq and beyond. Also, shoutout to everyone who stopped by Keith and Hannah’s posters. What was your favorite session or takeaway from PAG this year? 🧬🔬
#PAG2026 #Epigenomics
#PAG2026 #Epigenomics
Genomics & single-cell researchers—expand your toolkit. 👨🔬Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies.
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
January 13, 2026 at 7:00 PM
Genomics & single-cell researchers—expand your toolkit. 👨🔬Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies.
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
Register Here: 👉 https://app.livestorm.co/epicypher/single-cell-dna-damage-analysis-reveals-selective-genome-vulnerability
Great poster session at #PAG33. We were proud to have two EpiCypher presenters on the floor. Thanks to everyone who stopped by!
Download the posters here:
• Keith: https://explore.epicypher.com/posters/LRS-keith/pag2025
• Hannah: https://explore.epicypher.com/posters/DNAme/pag2025
Download the posters here:
• Keith: https://explore.epicypher.com/posters/LRS-keith/pag2025
• Hannah: https://explore.epicypher.com/posters/DNAme/pag2025
January 13, 2026 at 3:01 PM
Great poster session at #PAG33. We were proud to have two EpiCypher presenters on the floor. Thanks to everyone who stopped by!
Download the posters here:
• Keith: https://explore.epicypher.com/posters/LRS-keith/pag2025
• Hannah: https://explore.epicypher.com/posters/DNAme/pag2025
Download the posters here:
• Keith: https://explore.epicypher.com/posters/LRS-keith/pag2025
• Hannah: https://explore.epicypher.com/posters/DNAme/pag2025