Jean-Paul Armache
@valendraica.bsky.social
Assistant Professor at Penn State University.
Looking at cool tiny complex things through electromagnetic lens.
Today, chromatin remodeling. Tomorrow? Who knows.
Opinions my own
Looking at cool tiny complex things through electromagnetic lens.
Today, chromatin remodeling. Tomorrow? Who knows.
Opinions my own
Pinned
A competitive regulatory mechanism of the Chd1 remodeler is integral to distorting nucleosomal DNA - Nature Structural & Molecular Biology
Nodelman, Folkwein et al. define a regulatory region in Chd1 containing adjacent inhibitor and activator elements that compete for binding to the remodeler ATPase. The competition between these elemen...
www.nature.com
New collaborative paper between JPArmache and Bowman (@bowmanlab-jhu.bsky.social) labs show how the yeast CHD1 chromatin remodeler depends on activator elements to distort nucleosomal DNA. This explains how the NegC inhibitor blocks activity. www.nature.com/articles/s41...
Reposted by Jean-Paul Armache
Honored to be named the Laura and Isaac Perlmutter Endowed Chair in Biochemistry at NYU Grossman School of Medicine. Grateful to my mentors, lab members, and the NYU community—and most of all, to my amazing family for their constant support!
October 17, 2025 at 4:03 PM
Honored to be named the Laura and Isaac Perlmutter Endowed Chair in Biochemistry at NYU Grossman School of Medicine. Grateful to my mentors, lab members, and the NYU community—and most of all, to my amazing family for their constant support!
New collaborative paper between JPArmache and Bowman (@bowmanlab-jhu.bsky.social) labs show how the yeast CHD1 chromatin remodeler depends on activator elements to distort nucleosomal DNA. This explains how the NegC inhibitor blocks activity. www.nature.com/articles/s41...
A competitive regulatory mechanism of the Chd1 remodeler is integral to distorting nucleosomal DNA - Nature Structural & Molecular Biology
Nodelman, Folkwein et al. define a regulatory region in Chd1 containing adjacent inhibitor and activator elements that compete for binding to the remodeler ATPase. The competition between these elemen...
www.nature.com
May 30, 2025 at 2:35 PM
New collaborative paper between JPArmache and Bowman (@bowmanlab-jhu.bsky.social) labs show how the yeast CHD1 chromatin remodeler depends on activator elements to distort nucleosomal DNA. This explains how the NegC inhibitor blocks activity. www.nature.com/articles/s41...
We did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...
February 5, 2025 at 1:02 AM
We did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...
Reposted by Jean-Paul Armache
Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ
Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1
Nature - Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their...
rdcu.be
November 13, 2024 at 6:23 PM
Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ