Karim-Jean Armache
@kjarmache.bsky.social
GirlDad, Husband, Scientist
Very cool story! Congrats Lluis and team
Very excited to share our new Molecular Cell paper on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders
Borges, González-Blanco, Arigela, et al. report new missense mutations in the PRC1
genes RNF2 and RING1 in individuals with neurodevelopmental disorders. Functional
dissection of a deleterious variant...
www.cell.com
February 7, 2026 at 12:39 PM
Very cool story! Congrats Lluis and team
MECHANISMS, EPIGENETICS, CHROMATIN and DISEASE!
Amazing speakers, fun organizers (@ckadoch.bsky.social and I) and excellent venue!
Just ~1 month until our Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease! Join us!
www.keystonesymposia.org/conferences/...
Amazing speakers, fun organizers (@ckadoch.bsky.social and I) and excellent venue!
Just ~1 month until our Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease! Join us!
www.keystonesymposia.org/conferences/...
January 30, 2026 at 7:23 PM
MECHANISMS, EPIGENETICS, CHROMATIN and DISEASE!
Amazing speakers, fun organizers (@ckadoch.bsky.social and I) and excellent venue!
Just ~1 month until our Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease! Join us!
www.keystonesymposia.org/conferences/...
Amazing speakers, fun organizers (@ckadoch.bsky.social and I) and excellent venue!
Just ~1 month until our Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease! Join us!
www.keystonesymposia.org/conferences/...
Congrats JP, Mike and Jess and colleagues on the paper. Very interesting work.
A wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch.
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org
January 16, 2026 at 3:35 PM
Congrats JP, Mike and Jess and colleagues on the paper. Very interesting work.
Reposted by Karim-Jean Armache
Last chance to save $250! Register by Jan. 6 (11:59 pm MST) for the Keystone Symposium Epigenetics & Gene Regulation in Health and Disease. Hear from organizers @kjarmache.bsky.social & @ckadoch.bsky.social 🎥 youtu.be/sLfyuQuH8F0
🔗 hubs.la/Q03ZfFF80
#KSEpigenetics26 #Epigenetics #GeneRegulation
🔗 hubs.la/Q03ZfFF80
#KSEpigenetics26 #Epigenetics #GeneRegulation
KSQA: Dr Karim-Jean Armache / Dr. Cigall Kadoch (Epigenetics and Gene Regulation)
YouTube video by KeystoneSymposia
youtu.be
January 3, 2026 at 6:49 PM
Last chance to save $250! Register by Jan. 6 (11:59 pm MST) for the Keystone Symposium Epigenetics & Gene Regulation in Health and Disease. Hear from organizers @kjarmache.bsky.social & @ckadoch.bsky.social 🎥 youtu.be/sLfyuQuH8F0
🔗 hubs.la/Q03ZfFF80
#KSEpigenetics26 #Epigenetics #GeneRegulation
🔗 hubs.la/Q03ZfFF80
#KSEpigenetics26 #Epigenetics #GeneRegulation
Reposted by Karim-Jean Armache
⏰ Deadline Nov 4 (11:59pm MDT)! Submit your short talk abstract or scholarship app for Epigenetics & Gene Regulation in Health & Disease (Feb 15–18, 2026, Santa Fe). Join @kjarmache.bsky.social & @ckadoch.bsky.social ! 🎥 youtu.be/sLfyuQuH8F0
keysym.us/KSEpigenetic... #KSEpigenetics26
keysym.us/KSEpigenetic... #KSEpigenetics26
KSQA: Dr Karim-Jean Armache / Dr. Cigall Kadoch (Epigenetics and Gene Regulation)
YouTube video by KeystoneSymposia
youtu.be
November 3, 2025 at 6:54 PM
⏰ Deadline Nov 4 (11:59pm MDT)! Submit your short talk abstract or scholarship app for Epigenetics & Gene Regulation in Health & Disease (Feb 15–18, 2026, Santa Fe). Join @kjarmache.bsky.social & @ckadoch.bsky.social ! 🎥 youtu.be/sLfyuQuH8F0
keysym.us/KSEpigenetic... #KSEpigenetics26
keysym.us/KSEpigenetic... #KSEpigenetics26
@ckadoch.bsky.social and I are excited to welcome you to Geneva for the 2026 Keystone Symposium on Epigenetics and Gene Regulation in Health and Disease — short talk and poster slots are still open. Don’t miss the deadlines.
Video: youtu.be/sLfyuQuH8F0
Video: youtu.be/sLfyuQuH8F0
KSQA: Dr Karim-Jean Armache / Dr. Cigall Kadoch (Epigenetics and Gene Regulation)
YouTube video by KeystoneSymposia
youtu.be
November 3, 2025 at 2:43 PM
@ckadoch.bsky.social and I are excited to welcome you to Geneva for the 2026 Keystone Symposium on Epigenetics and Gene Regulation in Health and Disease — short talk and poster slots are still open. Don’t miss the deadlines.
Video: youtu.be/sLfyuQuH8F0
Video: youtu.be/sLfyuQuH8F0
Reposted by Karim-Jean Armache
Come join us in Geneva for everything epigenetics and gene regulation. It will be a great meeting! Please repost!
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
www.keystonesymposia.org
October 17, 2025 at 2:36 PM
Come join us in Geneva for everything epigenetics and gene regulation. It will be a great meeting! Please repost!
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Honored to be named the Laura and Isaac Perlmutter Endowed Chair in Biochemistry at NYU Grossman School of Medicine. Grateful to my mentors, lab members, and the NYU community—and most of all, to my amazing family for their constant support!
October 17, 2025 at 4:03 PM
Honored to be named the Laura and Isaac Perlmutter Endowed Chair in Biochemistry at NYU Grossman School of Medicine. Grateful to my mentors, lab members, and the NYU community—and most of all, to my amazing family for their constant support!
Reposted by Karim-Jean Armache
This will be *the* place to be to hear about hot-off-the-press new findings from academic and industry leaders, bridging basic chromatin and gene regulatory mechanisms with new precision medicine approaches! Don’t miss it!! @kjarmache.bsky.social and I are looking forward to welcoming you!
Join us in Geneva (March, 2026) for the Keystone Symposium Epigenetics & Gene Regulation in Health and Disease, co-organized with @ckadoch.bsky.social — linking epigenetic mechanisms with therapeutic innovation. Apply for a short talk!
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
keysym.us
October 14, 2025 at 4:15 PM
This will be *the* place to be to hear about hot-off-the-press new findings from academic and industry leaders, bridging basic chromatin and gene regulatory mechanisms with new precision medicine approaches! Don’t miss it!! @kjarmache.bsky.social and I are looking forward to welcoming you!
Join us in Geneva (March, 2026) for the Keystone Symposium Epigenetics & Gene Regulation in Health and Disease, co-organized with @ckadoch.bsky.social — linking epigenetic mechanisms with therapeutic innovation. Apply for a short talk!
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
keysym.us
October 10, 2025 at 2:49 PM
Join us in Geneva (March, 2026) for the Keystone Symposium Epigenetics & Gene Regulation in Health and Disease, co-organized with @ckadoch.bsky.social — linking epigenetic mechanisms with therapeutic innovation. Apply for a short talk!
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
#KSEpigenetics26 #epigenetics #chromatin #KeystoneSymposia
Reposted by Karim-Jean Armache
Our Department is recruiting as well. As a public institution we can’t afford professional quality videos so this post will have to suffice😱.
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:32 PM
Our Department is recruiting as well. As a public institution we can’t afford professional quality videos so this post will have to suffice😱.
Reposted by Karim-Jean Armache
The Emerging Leader Award program “lets people follow where the science goes,” says 2019 winner Andrew Lane. That flexibility has allowed him to bring discoveries from bench to bedside with impressive speed. Learn more in our 2024 Annual Report: 2024.themarkfoundation.org/an-emerging-...
October 9, 2025 at 2:32 PM
The Emerging Leader Award program “lets people follow where the science goes,” says 2019 winner Andrew Lane. That flexibility has allowed him to bring discoveries from bench to bedside with impressive speed. Learn more in our 2024 Annual Report: 2024.themarkfoundation.org/an-emerging-...
Reposted by Karim-Jean Armache
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
keysym.us
September 16, 2025 at 4:01 PM
On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...
Reposted by Karim-Jean Armache
2nd Meeting on Epigenetics & Epigenomics - 24th - 26th September, Brussels 🇧🇪
Speakers Line-up looks fantastic including @adelmanlab.bsky.social @kjarmache.bsky.social @mariekeoudelaar.bsky.social @tinekelenstra.bsky.social @lucianodicroce.bsky.social
www.xcellsconferences.com/epigenetics2...
Speakers Line-up looks fantastic including @adelmanlab.bsky.social @kjarmache.bsky.social @mariekeoudelaar.bsky.social @tinekelenstra.bsky.social @lucianodicroce.bsky.social
www.xcellsconferences.com/epigenetics2...
Epigenetics 2025 | Xcells Conferences
www.xcellsconferences.com
June 10, 2025 at 10:48 AM
2nd Meeting on Epigenetics & Epigenomics - 24th - 26th September, Brussels 🇧🇪
Speakers Line-up looks fantastic including @adelmanlab.bsky.social @kjarmache.bsky.social @mariekeoudelaar.bsky.social @tinekelenstra.bsky.social @lucianodicroce.bsky.social
www.xcellsconferences.com/epigenetics2...
Speakers Line-up looks fantastic including @adelmanlab.bsky.social @kjarmache.bsky.social @mariekeoudelaar.bsky.social @tinekelenstra.bsky.social @lucianodicroce.bsky.social
www.xcellsconferences.com/epigenetics2...
Reposted by Karim-Jean Armache
As the incoming Chair of Biochemistry and Biophysics at Weill Cornell Medicine, I am looking for a Director of Research. Exciting opportunity for a PhD scientist to shape the future of this new Department! Apply here: jobs.weill.cornell.edu/NY/job/New-Y...
Director of Research, Biochemistry & Biophysics
Director of Research, Biochemistry & Biophysics
jobs.weill.cornell.edu
May 13, 2025 at 5:01 PM
As the incoming Chair of Biochemistry and Biophysics at Weill Cornell Medicine, I am looking for a Director of Research. Exciting opportunity for a PhD scientist to shape the future of this new Department! Apply here: jobs.weill.cornell.edu/NY/job/New-Y...
Reposted by Karim-Jean Armache
Excited for this summer’s NYC Chromatin Club!
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
May 5, 2025 at 3:01 AM
Excited for this summer’s NYC Chromatin Club!
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Great work! Congrats Anja and colleagues!
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability
Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.
tinyurl.com
February 21, 2025 at 12:55 PM
Great work! Congrats Anja and colleagues!
Structural biology of native transcription complexes! Congrats JP and team!
We did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...
February 5, 2025 at 2:25 AM
Structural biology of native transcription complexes! Congrats JP and team!
Congratulations to all authors on this very interesting work! Regarding EZH1, it aligns well with what our group and Danny Reinberg's group have proposed based on structural and functional data.
Please see 🧵by @evhealy.bsky.social about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇
🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇
January 15, 2025 at 4:00 PM
Congratulations to all authors on this very interesting work! Regarding EZH1, it aligns well with what our group and Danny Reinberg's group have proposed based on structural and functional data.
Congrats Ale, Zawar and colleagues! This is great work.
Excited to share the (hard) work of @zawarshah.bsky.social in its final form: www.nature.com/articles/s41...
A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work
A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work
Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters - Nature Communications
The snRNA Activating Protein Complex (SNAPc) mediates snRNA transcription by RNA Pol II and III. Here, the authors have used cryo-EM to resolve the structure of the SNAPc-bound RNA Pol III pre-initiat...
www.nature.com
January 3, 2025 at 12:58 PM
Congrats Ale, Zawar and colleagues! This is great work.
Congrats Hiten et al!
Check out our work that aims to decipher Cryptococcus neoformans on an global scale. 4300 knockout strains, 142 genetic screens, 6 in depth follow up stories (too many to summarize here, but rach is cool!). AlphaFold, AP-MS, microscopy, secretomics, mice, machine learning and more.
Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology https://www.biorxiv.org/content/10.1101/2024.10.22.619677v1
December 8, 2024 at 3:07 PM
Congrats Hiten et al!
Reposted by Karim-Jean Armache
Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ
Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1
Nature - Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their...
rdcu.be
November 13, 2024 at 6:23 PM
Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ
Well done! Congrats Rob and colleagues.
Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
November 27, 2024 at 8:31 PM
Well done! Congrats Rob and colleagues.
So much fun!
November 16, 2024 at 11:22 PM
So much fun!