Lluis Morey
@lluismorey.bsky.social
In the Morey lab we study chromatin dynamics in stem cells and cancer.
Associate Professor at Sylvester Comprehensive Cancer Center and University of Miami.
Science + Music
moreylab.com
Associate Professor at Sylvester Comprehensive Cancer Center and University of Miami.
Science + Music
moreylab.com
Reposted by Lluis Morey
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 23, 2025 at 11:38 PM
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lluis Morey
Bernie Sanders' office has put out a report this morning on Trump's NIH cuts: "Trump officials effectively cut $2.7 billion in [NIH] funding in the first three months of 2025 – including a 31 percent cut to cancer research through March, compared to the same timeframe last year."
May 13, 2025 at 12:51 PM
Bernie Sanders' office has put out a report this morning on Trump's NIH cuts: "Trump officials effectively cut $2.7 billion in [NIH] funding in the first three months of 2025 – including a 31 percent cut to cancer research through March, compared to the same timeframe last year."
Reposted by Lluis Morey
Northwestern just announced that the university will meet the funding needs of any research that is being impacted by stop orders. LET'S GOOOOOOOOOOOOO! #edusky #academicsky
wgntv.com/evanston/nor...
wgntv.com/evanston/nor...
Northwestern University to self-fund research despite Trump administration freeze
While university officials said they’ve still not received official word of such action, they acknowledged receiving about 100 stop-work orders from the federal government on roughly 100 fede…
wgntv.com
April 19, 2025 at 11:17 AM
Northwestern just announced that the university will meet the funding needs of any research that is being impacted by stop orders. LET'S GOOOOOOOOOOOOO! #edusky #academicsky
wgntv.com/evanston/nor...
wgntv.com/evanston/nor...
Reposted by Lluis Morey
Seven New Cancer Grand Challenges Announced
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
March 5, 2025 at 3:16 PM
Seven New Cancer Grand Challenges Announced
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
Reposted by Lluis Morey
Thank you to all the people who helped with making this work possible, inc. MSKCC Center for Epigenetic Research PJ Hamatd & Richard Koche @lluismorey.bsky.social . You all put a piece in this puzzle.
Thank you to our editor &reviewers for being scientific allies,making our work better 🙏🏻
Thank you to our editor &reviewers for being scientific allies,making our work better 🙏🏻
February 21, 2025 at 5:31 PM
Thank you to all the people who helped with making this work possible, inc. MSKCC Center for Epigenetic Research PJ Hamatd & Richard Koche @lluismorey.bsky.social . You all put a piece in this puzzle.
Thank you to our editor &reviewers for being scientific allies,making our work better 🙏🏻
Thank you to our editor &reviewers for being scientific allies,making our work better 🙏🏻
Reposted by Lluis Morey
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization
event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene.
The use of a small-molecule c...
www.cell.com
February 21, 2025 at 5:31 PM
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
Reposted by Lluis Morey
@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...
February 16, 2025 at 11:25 PM
@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...
Reposted by Lluis Morey
New paper from our lab is out! We investigated the function of the NuRD subunit CHD3 in cranial neural crest specification. CHD3 variants are the cause of Snijder-Block-Campeau Syndrome, which manifests with craniofacial anomalies and intellectual disability 1/n
CHD3 regulates BMP signalling response during cranial neural crest cell specification https://www.biorxiv.org/content/10.1101/2025.02.14.638260v1
February 15, 2025 at 7:55 AM
New paper from our lab is out! We investigated the function of the NuRD subunit CHD3 in cranial neural crest specification. CHD3 variants are the cause of Snijder-Block-Campeau Syndrome, which manifests with craniofacial anomalies and intellectual disability 1/n
Reposted by Lluis Morey
Killing cancer research, Trump and Musk are killing cancer research
February 14, 2025 at 10:01 PM
Killing cancer research, Trump and Musk are killing cancer research
Reposted by Lluis Morey
Today, along with 2,000 other NIH employees, I had to clear out my office 😭
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
February 14, 2025 at 11:31 PM
Today, along with 2,000 other NIH employees, I had to clear out my office 😭
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
Reposted by Lluis Morey
Are you a postdoc or PhD student interested in Histone and DNA modifications? Join us for the GRS on Histone and DNA Modifications!
🗓 When: July 19-20, 2025
📍 Where: Lucca, Italy
A great opportunity to present your work, engage in discussions, and network with peers.
🔗 Register now!
Register here
🗓 When: July 19-20, 2025
📍 Where: Lucca, Italy
A great opportunity to present your work, engage in discussions, and network with peers.
🔗 Register now!
Register here
2025 Histone and DNA Modifications (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Histone and DNA Modifications (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
February 14, 2025 at 3:48 PM
Are you a postdoc or PhD student interested in Histone and DNA modifications? Join us for the GRS on Histone and DNA Modifications!
🗓 When: July 19-20, 2025
📍 Where: Lucca, Italy
A great opportunity to present your work, engage in discussions, and network with peers.
🔗 Register now!
Register here
🗓 When: July 19-20, 2025
📍 Where: Lucca, Italy
A great opportunity to present your work, engage in discussions, and network with peers.
🔗 Register now!
Register here
Reposted by Lluis Morey
You can read the letter for yourself 👉
January 28, 2025 at 6:17 PM
You can read the letter for yourself 👉
Reposted by Lluis Morey
Dear meeting organizers:
Picking the same senior PIs to keynote/give talks at meetings, who's talks I've seen a dozen times already, is not a great use of everyone's time. Nor does it highlight all of the rich talent in your field from more junior folks and peeps not at "elite" institutions.
Picking the same senior PIs to keynote/give talks at meetings, who's talks I've seen a dozen times already, is not a great use of everyone's time. Nor does it highlight all of the rich talent in your field from more junior folks and peeps not at "elite" institutions.
January 13, 2025 at 11:00 PM
Dear meeting organizers:
Picking the same senior PIs to keynote/give talks at meetings, who's talks I've seen a dozen times already, is not a great use of everyone's time. Nor does it highlight all of the rich talent in your field from more junior folks and peeps not at "elite" institutions.
Picking the same senior PIs to keynote/give talks at meetings, who's talks I've seen a dozen times already, is not a great use of everyone's time. Nor does it highlight all of the rich talent in your field from more junior folks and peeps not at "elite" institutions.
Very interesting paper by Philipp Voigt about nucleosomal asymmetry at bivalent domains. "Bivalency recruits H3K27me3 but not H3K4me3 readers, promoting a poised state" www.cell.com/molecular-ce...
Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains
Bivalent promoters are thought to poise developmental genes for expression. Bryan et al. show that asymmetric bivalent nucleosomes recruit repressive H3K27me3 but not activating H3K4me3 readers, thereby promoting poising. Bivalency further attracts specific factors, including the acetylase KAT6B, which is required for proper activation of bivalent genes during differentiation.
www.cell.com
December 29, 2024 at 3:58 AM
Very interesting paper by Philipp Voigt about nucleosomal asymmetry at bivalent domains. "Bivalency recruits H3K27me3 but not H3K4me3 readers, promoting a poised state" www.cell.com/molecular-ce...
Reposted by Lluis Morey
The world's richest man managed to take $190 million away from a *child cancer research center* with his posts yesterday. Funding now stripped in the new bill.
December 19, 2024 at 10:22 PM
The world's richest man managed to take $190 million away from a *child cancer research center* with his posts yesterday. Funding now stripped in the new bill.
Reposted by Lluis Morey
We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused:
sciencedirect.com/science/arti...
A big thank you to Tom Fillot for his efforts on this and to
@hansen_lab
@marcelonollmann
for their help as editors.
sciencedirect.com/science/arti...
A big thank you to Tom Fillot for his efforts on this and to
@hansen_lab
@marcelonollmann
for their help as editors.
December 20, 2024 at 3:46 PM
We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused:
sciencedirect.com/science/arti...
A big thank you to Tom Fillot for his efforts on this and to
@hansen_lab
@marcelonollmann
for their help as editors.
sciencedirect.com/science/arti...
A big thank you to Tom Fillot for his efforts on this and to
@hansen_lab
@marcelonollmann
for their help as editors.
Reposted by Lluis Morey
We have two fully funded #Postdoctoral
positions:
-One dark genome explorer to lead a curiosity-driven project on #lncRNA
in #cancer #therapyresistance
-One experienced researcher interested in working on #drugdevelopment in collaboration with industrial partners
The links to apply below:
positions:
-One dark genome explorer to lead a curiosity-driven project on #lncRNA
in #cancer #therapyresistance
-One experienced researcher interested in working on #drugdevelopment in collaboration with industrial partners
The links to apply below:
December 16, 2024 at 10:17 AM
We have two fully funded #Postdoctoral
positions:
-One dark genome explorer to lead a curiosity-driven project on #lncRNA
in #cancer #therapyresistance
-One experienced researcher interested in working on #drugdevelopment in collaboration with industrial partners
The links to apply below:
positions:
-One dark genome explorer to lead a curiosity-driven project on #lncRNA
in #cancer #therapyresistance
-One experienced researcher interested in working on #drugdevelopment in collaboration with industrial partners
The links to apply below:
Reposted by Lluis Morey
Has anyone had success modeling histone peptides (with PTMs) or nuclesomes (with histone tail PTMs) with chromatin reader proteins using Alphafold or Chai1? If so, any tips? Most iterations I try have the histone tail flopping off to the side #Chromatin #Alphafold #Epigenetics
December 12, 2024 at 6:30 PM
Has anyone had success modeling histone peptides (with PTMs) or nuclesomes (with histone tail PTMs) with chromatin reader proteins using Alphafold or Chai1? If so, any tips? Most iterations I try have the histone tail flopping off to the side #Chromatin #Alphafold #Epigenetics
Reposted by Lluis Morey
Despite the intense research, very few mutations are specific of metastatic cells. However, mew research @cellpress.bsky.social shows that most of us carry a variant in PCSK9 that promotes metastasis www.cell.com/cell/abstrac...
December 14, 2024 at 5:38 AM
Despite the intense research, very few mutations are specific of metastatic cells. However, mew research @cellpress.bsky.social shows that most of us carry a variant in PCSK9 that promotes metastasis www.cell.com/cell/abstrac...
Reposted by Lluis Morey
I'm quite concerned that AI will now summarise a paper or make a podcast out of it so students don't have to actually read it.
That means no looking at the data, no evaluating what was really done and how, no deciding what was really proven.
That's the opposite of what research is about.
That means no looking at the data, no evaluating what was really done and how, no deciding what was really proven.
That's the opposite of what research is about.
1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field
December 14, 2024 at 8:02 AM
I'm quite concerned that AI will now summarise a paper or make a podcast out of it so students don't have to actually read it.
That means no looking at the data, no evaluating what was really done and how, no deciding what was really proven.
That's the opposite of what research is about.
That means no looking at the data, no evaluating what was really done and how, no deciding what was really proven.
That's the opposite of what research is about.
Hello to my small Bsky community. We have postdoc positions open to study epigenetic mechanisms contributing to resistance to chemo+immuno in TNBC, and projects related to epigenetic determinants of neurodevelopmental disorders. Feel free to reach out to me here/via email. Please like and repost!
December 11, 2024 at 6:57 PM
Hello to my small Bsky community. We have postdoc positions open to study epigenetic mechanisms contributing to resistance to chemo+immuno in TNBC, and projects related to epigenetic determinants of neurodevelopmental disorders. Feel free to reach out to me here/via email. Please like and repost!
Reposted by Lluis Morey
I am recruiting a postdoc with experience in Protein Biochemistry, Structural Biology & Chromatin Biology. If you are passionate about the complex world of chromatin modifications, please contact me for more details 🙏.
Location: SAiGENCI, Adelaide, Australia
🦘🍷🏄🏖️🇦🇺
Location: SAiGENCI, Adelaide, Australia
🦘🍷🏄🏖️🇦🇺
December 10, 2024 at 5:12 AM
I am recruiting a postdoc with experience in Protein Biochemistry, Structural Biology & Chromatin Biology. If you are passionate about the complex world of chromatin modifications, please contact me for more details 🙏.
Location: SAiGENCI, Adelaide, Australia
🦘🍷🏄🏖️🇦🇺
Location: SAiGENCI, Adelaide, Australia
🦘🍷🏄🏖️🇦🇺
Reposted by Lluis Morey
Read the Letter From Nobel Laureates Urging That Mr. Kennedy Not be Confirmed www.nytimes.com/interactive/...
Read the Letter From Nobel Laureates Urging That Mr. Kennedy Not be Confirmed
More than 75 laureates have written an open letter describing Mr. Kennedy’s selection for H.H.S. secretary as detrimental to public health.
www.nytimes.com
December 9, 2024 at 10:43 PM
Read the Letter From Nobel Laureates Urging That Mr. Kennedy Not be Confirmed www.nytimes.com/interactive/...
@robklose.bsky.social is on a roll! Another beautiful and insightful paper from Klose's lab. This time about the role of PNUTS in transcription pause release.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
The PNUTS phosphatase complex controls transcription pause release
Kelley et al. discover that the PNUTS phosphatase complex plays an essential role
in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves
this through its TND, which recog...
www.cell.com
November 26, 2024 at 4:53 PM
@robklose.bsky.social is on a roll! Another beautiful and insightful paper from Klose's lab. This time about the role of PNUTS in transcription pause release.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Very interesting paper from @mitchguttman.bsky.social previously in @biorxivpreprint.bsky.social out in Nature Genetics. "ChIP-DIP generates context-specific protein localization maps at consortium scale"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature Genetics
ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...
www.nature.com
November 25, 2024 at 4:59 PM
Very interesting paper from @mitchguttman.bsky.social previously in @biorxivpreprint.bsky.social out in Nature Genetics. "ChIP-DIP generates context-specific protein localization maps at consortium scale"
www.nature.com/articles/s41...
www.nature.com/articles/s41...