The Mark Foundation for Cancer Research
@themarkfdn.bsky.social
Partnering with scientists to accelerate transformation in cancer research.
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The Mark Foundation for Cancer Research | Our Impact
Learn how The Mark Foundation for Cancer Research is accelerating progress in the fight against cancer.
vimeo.com
Hello, Bluesky! Follow along for updates on our work and the researchers we support. New to The Mark Foundation? Check out this video to learn how we accelerate progress in the fight against cancer.
#CancerResearch #ResearchFunding
vimeo.com/1013135446
#CancerResearch #ResearchFunding
vimeo.com/1013135446
Reposted by The Mark Foundation for Cancer Research
What a wonderful few days we've had together in Bergamo at The Rise of Early-Onset Cancers 🎉
Thank you to everyone who attended, our co-organisers @themarkfdn.bsky.social and to the Scientific Programme Committee for all the dedication they put into the great science showcased in the conference!
Thank you to everyone who attended, our co-organisers @themarkfdn.bsky.social and to the Scientific Programme Committee for all the dedication they put into the great science showcased in the conference!
November 14, 2025 at 12:32 PM
What a wonderful few days we've had together in Bergamo at The Rise of Early-Onset Cancers 🎉
Thank you to everyone who attended, our co-organisers @themarkfdn.bsky.social and to the Scientific Programme Committee for all the dedication they put into the great science showcased in the conference!
Thank you to everyone who attended, our co-organisers @themarkfdn.bsky.social and to the Scientific Programme Committee for all the dedication they put into the great science showcased in the conference!
Reposted by The Mark Foundation for Cancer Research
Members of NexTGen (co-funded by @themarkfdn.bsky.social), Nikolaos Sgourakis & John Maris, contributed to a new Nature paper from David Baker’s lab showing AI-designed antibodies with atomic-level precision
A potential game-changer 👉
nature.com/articles/s41586-025-09721-5
A potential game-changer 👉
nature.com/articles/s41586-025-09721-5
Atomically accurate de novo design of antibodies with RFdiffusion - Nature
The combination of computational design, laboratory-based screening and biophysical validation enables the de novo generation of variable heavy-chain antibody fragments and antibodies that precis...
nature.com
November 11, 2025 at 12:39 PM
Members of NexTGen (co-funded by @themarkfdn.bsky.social), Nikolaos Sgourakis & John Maris, contributed to a new Nature paper from David Baker’s lab showing AI-designed antibodies with atomic-level precision
A potential game-changer 👉
nature.com/articles/s41586-025-09721-5
A potential game-changer 👉
nature.com/articles/s41586-025-09721-5
It's been a productive 3 days in Bergamo, Italy, at the @helloeacr.bsky.social - Mark Foundation Joint Conference: The Rise of Early-Onset Cancers! Participants have shared new insights into the rise in cancer among young patients & identified paths forward for prevention, detection, & treatment.
November 13, 2025 at 12:26 PM
It's been a productive 3 days in Bergamo, Italy, at the @helloeacr.bsky.social - Mark Foundation Joint Conference: The Rise of Early-Onset Cancers! Participants have shared new insights into the rise in cancer among young patients & identified paths forward for prevention, detection, & treatment.
Reposted by The Mark Foundation for Cancer Research
Prof. Sir Mike Stratton delivers his keynote lecture at the close of The Rise of Early-Onset Cancers in Bergamo.
We're very grateful for the partnership of @themarkfdn.bsky.social in this groundbreaking joint conference, which has explored a critical and underexplored frontier in cancer biology.
We're very grateful for the partnership of @themarkfdn.bsky.social in this groundbreaking joint conference, which has explored a critical and underexplored frontier in cancer biology.
November 13, 2025 at 10:41 AM
Prof. Sir Mike Stratton delivers his keynote lecture at the close of The Rise of Early-Onset Cancers in Bergamo.
We're very grateful for the partnership of @themarkfdn.bsky.social in this groundbreaking joint conference, which has explored a critical and underexplored frontier in cancer biology.
We're very grateful for the partnership of @themarkfdn.bsky.social in this groundbreaking joint conference, which has explored a critical and underexplored frontier in cancer biology.
Reposted by The Mark Foundation for Cancer Research
We're so grateful to our partners at the @themarkfdn.bsky.social for supporting the NexTGen team and helping to make their research possible.
Thank you to all our #CancerGrandChallenge partners who make progress possible 👏
Thank you to all our #CancerGrandChallenge partners who make progress possible 👏
Team NexTGen, featured in @washingtonpost.com discussing their CAR T-cell immunotherapy trial.
Thank you to @themarkfdn.bsky.social for supporting global science - working together to tackle one of the toughest challenges in cancer.
👉 If you have access - www.washingtonpost.com/science/2025...
Thank you to @themarkfdn.bsky.social for supporting global science - working together to tackle one of the toughest challenges in cancer.
👉 If you have access - www.washingtonpost.com/science/2025...
November 4, 2025 at 9:32 AM
We're so grateful to our partners at the @themarkfdn.bsky.social for supporting the NexTGen team and helping to make their research possible.
Thank you to all our #CancerGrandChallenge partners who make progress possible 👏
Thank you to all our #CancerGrandChallenge partners who make progress possible 👏
The @theaacr.bsky.social–Mark Foundation Chemistry in Cancer Research Grants are now accepting Letters of Intent!
We’re seeking bold, innovative approaches in chemistry and chemical biology to tackle the biggest challenges in cancer.
Learn more and apply: www.aacr.org/grants/aacr-...
We’re seeking bold, innovative approaches in chemistry and chemical biology to tackle the biggest challenges in cancer.
Learn more and apply: www.aacr.org/grants/aacr-...
November 5, 2025 at 1:13 PM
The @theaacr.bsky.social–Mark Foundation Chemistry in Cancer Research Grants are now accepting Letters of Intent!
We’re seeking bold, innovative approaches in chemistry and chemical biology to tackle the biggest challenges in cancer.
Learn more and apply: www.aacr.org/grants/aacr-...
We’re seeking bold, innovative approaches in chemistry and chemical biology to tackle the biggest challenges in cancer.
Learn more and apply: www.aacr.org/grants/aacr-...
🎉Three members of The Mark Foundation’s community —
@charlesswanton.bsky.social, Michel Sadelin, and Victor Velculescu — were elected to @nam.edu yesterday!🎉
Learn more about their remarkable achievements:
themarkfoundation.org/blog/three-m...
@charlesswanton.bsky.social, Michel Sadelin, and Victor Velculescu — were elected to @nam.edu yesterday!🎉
Learn more about their remarkable achievements:
themarkfoundation.org/blog/three-m...
Three Mark Foundation Community Members Elected to the National Academy of Medicine | The Mark Foundation for Cancer Research
Yesterday, the National Academy of Medicine announced the election of 90 new regular members and 10 international members in recognition of their outstanding professional achievement and commitment to...
themarkfoundation.org
October 21, 2025 at 9:29 PM
🎉Three members of The Mark Foundation’s community —
@charlesswanton.bsky.social, Michel Sadelin, and Victor Velculescu — were elected to @nam.edu yesterday!🎉
Learn more about their remarkable achievements:
themarkfoundation.org/blog/three-m...
@charlesswanton.bsky.social, Michel Sadelin, and Victor Velculescu — were elected to @nam.edu yesterday!🎉
Learn more about their remarkable achievements:
themarkfoundation.org/blog/three-m...
New in @nature.com: ASPIRE awardee @loisher.bsky.social of @petermaccc.bsky.social shows that pregnancy & breastfeeding cause long-lasting immunological changes that significantly reduce breast cancer risk, especially for triple-negative breast cancer. themarkfoundation.org/blog/aspire-...
ASPIRE Awardee Reveals How Pregnancy and Breastfeeding Protect Against Breast Cancer | The Mark Foundation for Cancer Research
Since the 1980s, researchers have known that pregnancy and breastfeeding reduce women’s risk of later developing breast cancer — but the reason why has remained a mystery…
themarkfoundation.org
October 20, 2025 at 4:26 PM
New in @nature.com: ASPIRE awardee @loisher.bsky.social of @petermaccc.bsky.social shows that pregnancy & breastfeeding cause long-lasting immunological changes that significantly reduce breast cancer risk, especially for triple-negative breast cancer. themarkfoundation.org/blog/aspire-...
📢Calling all Mark Foundation grantees (past and current) & advisors! 📢
Check your inboxes - you should have received your invite to our 2026 Scientific Symposium. Haven't seen it? Send us a note at events@themarkfoundation.org.
Check your inboxes - you should have received your invite to our 2026 Scientific Symposium. Haven't seen it? Send us a note at events@themarkfoundation.org.
October 20, 2025 at 3:23 PM
📢Calling all Mark Foundation grantees (past and current) & advisors! 📢
Check your inboxes - you should have received your invite to our 2026 Scientific Symposium. Haven't seen it? Send us a note at events@themarkfoundation.org.
Check your inboxes - you should have received your invite to our 2026 Scientific Symposium. Haven't seen it? Send us a note at events@themarkfoundation.org.
Huge congratulations to @rosslevinemd.bsky.social, who has been named @mskcancercenter.bsky.social's new Chief Scientific Officer! We’re deeply grateful to have his expertise on our Board of Directors and as Chair of our Scientific Advisory Committee.
www.mskcc.org/news-release...
www.mskcc.org/news-release...
October 16, 2025 at 8:26 PM
Huge congratulations to @rosslevinemd.bsky.social, who has been named @mskcancercenter.bsky.social's new Chief Scientific Officer! We’re deeply grateful to have his expertise on our Board of Directors and as Chair of our Scientific Advisory Committee.
www.mskcc.org/news-release...
www.mskcc.org/news-release...
Why does immunotherapy rarely lead to a complete cure?|
In @cellpress.bsky.social, ASPIRE awardee Charles Swanton tracks the lineages of tumor subclones & suggests that subclonal evolution allows some cells to evade immune attack. #CancerResearch #Immunology
www.cell.com/cancer-cell/...
In @cellpress.bsky.social, ASPIRE awardee Charles Swanton tracks the lineages of tumor subclones & suggests that subclonal evolution allows some cells to evade immune attack. #CancerResearch #Immunology
www.cell.com/cancer-cell/...
Subclonal immune evasion in non-small cell lung cancer
Dijkstra et al. investigate whether individual cancer subclones differ in their immune
evasion capacity. They establish organoids representing distinct subclones from multi-region
lung cancer biopsies...
www.cell.com
October 15, 2025 at 2:10 PM
Why does immunotherapy rarely lead to a complete cure?|
In @cellpress.bsky.social, ASPIRE awardee Charles Swanton tracks the lineages of tumor subclones & suggests that subclonal evolution allows some cells to evade immune attack. #CancerResearch #Immunology
www.cell.com/cancer-cell/...
In @cellpress.bsky.social, ASPIRE awardee Charles Swanton tracks the lineages of tumor subclones & suggests that subclonal evolution allows some cells to evade immune attack. #CancerResearch #Immunology
www.cell.com/cancer-cell/...
Reposted by The Mark Foundation for Cancer Research
This collaborative project would not have be possible w/o JP and our wonderful colleagues (many not on social), and support from @damonrunyon.org and @themarkfdn.bsky.social!
October 10, 2025 at 4:13 PM
This collaborative project would not have be possible w/o JP and our wonderful colleagues (many not on social), and support from @damonrunyon.org and @themarkfdn.bsky.social!
The Emerging Leader Award program “lets people follow where the science goes,” says 2019 winner Andrew Lane. That flexibility has allowed him to bring discoveries from bench to bedside with impressive speed. Learn more in our 2024 Annual Report: 2024.themarkfoundation.org/an-emerging-...
October 9, 2025 at 2:32 PM
The Emerging Leader Award program “lets people follow where the science goes,” says 2019 winner Andrew Lane. That flexibility has allowed him to bring discoveries from bench to bedside with impressive speed. Learn more in our 2024 Annual Report: 2024.themarkfoundation.org/an-emerging-...
A dual breakthrough in #CancerResearch: ASPIRE awardees Bennie Lemmens & Jira Bartek of @ki.se & @scilifelab.se developed tech to visualize DNA replication in stunning detail AND uncovered a key protein that acts as an “on-switch” for the replication process.
themarkfoundation.org/blog/aspire-...
themarkfoundation.org/blog/aspire-...
ASPIRE Awardees Uncover DNA Replication Dynamics with Unprecedented Precision | The Mark Foundation for Cancer Research
DNA replication is a critical biological process that cells use to copy their genome – but when it goes wrong, those failures can have dire consequences. Missteps in the replication process are key…
themarkfoundation.org
October 8, 2025 at 7:33 PM
A dual breakthrough in #CancerResearch: ASPIRE awardees Bennie Lemmens & Jira Bartek of @ki.se & @scilifelab.se developed tech to visualize DNA replication in stunning detail AND uncovered a key protein that acts as an “on-switch” for the replication process.
themarkfoundation.org/blog/aspire-...
themarkfoundation.org/blog/aspire-...
Reposted by The Mark Foundation for Cancer Research
The Mark Foundation for Cancer Research is making a huge impact - in the US and globally 🙌
Very grateful for their support 🙏 - for an #ASPIRE award that funded our microbiome research, and for two #Momentum Fellows in our lab @lbejarano.bsky.social & @ale-matera.bsky.social
@themarkfdn.bsky.social
Very grateful for their support 🙏 - for an #ASPIRE award that funded our microbiome research, and for two #Momentum Fellows in our lab @lbejarano.bsky.social & @ale-matera.bsky.social
@themarkfdn.bsky.social
$34.5 million in awarded grants. 7 new interventional trials. 212 peer-reviewed publications. Read our newly released 2024 Annual Report to catch up on our grantees’ achievements and discover how we’re accelerating progress in the fight against cancer.
2024.themarkfoundation.org
2024.themarkfoundation.org
October 7, 2025 at 8:43 PM
The Mark Foundation for Cancer Research is making a huge impact - in the US and globally 🙌
Very grateful for their support 🙏 - for an #ASPIRE award that funded our microbiome research, and for two #Momentum Fellows in our lab @lbejarano.bsky.social & @ale-matera.bsky.social
@themarkfdn.bsky.social
Very grateful for their support 🙏 - for an #ASPIRE award that funded our microbiome research, and for two #Momentum Fellows in our lab @lbejarano.bsky.social & @ale-matera.bsky.social
@themarkfdn.bsky.social
$34.5 million in awarded grants. 7 new interventional trials. 212 peer-reviewed publications. Read our newly released 2024 Annual Report to catch up on our grantees’ achievements and discover how we’re accelerating progress in the fight against cancer.
2024.themarkfoundation.org
2024.themarkfoundation.org
October 7, 2025 at 7:52 PM
$34.5 million in awarded grants. 7 new interventional trials. 212 peer-reviewed publications. Read our newly released 2024 Annual Report to catch up on our grantees’ achievements and discover how we’re accelerating progress in the fight against cancer.
2024.themarkfoundation.org
2024.themarkfoundation.org
New in @nature.com: past ASPIRE Awardee Trudy Oliver identifies the likely origin of some SCLC tumors. This breakthrough discovery for an aggressive, hard-to-treat disease could enable therapies that target lineage plasticity—a major challenge in cancer.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer - Nature
Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.
www.nature.com
October 5, 2025 at 3:38 PM
New in @nature.com: past ASPIRE Awardee Trudy Oliver identifies the likely origin of some SCLC tumors. This breakthrough discovery for an aggressive, hard-to-treat disease could enable therapies that target lineage plasticity—a major challenge in cancer.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
📣Introducing the Samuel Waxman Institute for Aging & Cancer! 📣
As today's NYTimes DealBook reports, the Samuel Waxman Cancer Research Foundation is joining us to launch a world-first institute focused on how the biology of aging drives cancer risk at all life stages.
www.nytimes.com/2025/09/09/b...
As today's NYTimes DealBook reports, the Samuel Waxman Cancer Research Foundation is joining us to launch a world-first institute focused on how the biology of aging drives cancer risk at all life stages.
www.nytimes.com/2025/09/09/b...
September 9, 2025 at 7:02 PM
📣Introducing the Samuel Waxman Institute for Aging & Cancer! 📣
As today's NYTimes DealBook reports, the Samuel Waxman Cancer Research Foundation is joining us to launch a world-first institute focused on how the biology of aging drives cancer risk at all life stages.
www.nytimes.com/2025/09/09/b...
As today's NYTimes DealBook reports, the Samuel Waxman Cancer Research Foundation is joining us to launch a world-first institute focused on how the biology of aging drives cancer risk at all life stages.
www.nytimes.com/2025/09/09/b...
Sometimes, research is personal. In @cp-neuron.bsky.social, Endeavor awardee Tobias Janowitz shares how his late mother’s experience with cancer-associated cachexia, a debilitating wasting syndrome, continues to shape his perspective and research.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Of hope from fading will: Interoceptive signaling and the behavioral biology of cachexia
This NeuroView explores how systemic cancer signals induce behavioral changes via
brain-body communication pathways, framing cachexia as an adaptive yet unsustainable
interoceptive response. Recognizi...
www.cell.com
September 5, 2025 at 1:33 PM
Sometimes, research is personal. In @cp-neuron.bsky.social, Endeavor awardee Tobias Janowitz shares how his late mother’s experience with cancer-associated cachexia, a debilitating wasting syndrome, continues to shape his perspective and research.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
⏳Reminder: Letters of Intent for our next round of Endeavor Award funding are due next Wednesday, September 3! #ResearchFunding
themarkfoundation.org/endeavor/
themarkfoundation.org/endeavor/
Endeavor | The Mark Foundation for Cancer Research
themarkfoundation.org
August 26, 2025 at 2:15 PM
⏳Reminder: Letters of Intent for our next round of Endeavor Award funding are due next Wednesday, September 3! #ResearchFunding
themarkfoundation.org/endeavor/
themarkfoundation.org/endeavor/
🎉Mark Foundation portfolio company Interius BioTherapeutics
has been acquired by Kite Pharma!🎉 The move advances a game-changing in vivo CAR T-cell platform that originated with Saar Gill’s Emerging Leader Award project.
themarkfoundation.org/2025/08/kite...
has been acquired by Kite Pharma!🎉 The move advances a game-changing in vivo CAR T-cell platform that originated with Saar Gill’s Emerging Leader Award project.
themarkfoundation.org/2025/08/kite...
August 22, 2025 at 1:57 PM
🎉Mark Foundation portfolio company Interius BioTherapeutics
has been acquired by Kite Pharma!🎉 The move advances a game-changing in vivo CAR T-cell platform that originated with Saar Gill’s Emerging Leader Award project.
themarkfoundation.org/2025/08/kite...
has been acquired by Kite Pharma!🎉 The move advances a game-changing in vivo CAR T-cell platform that originated with Saar Gill’s Emerging Leader Award project.
themarkfoundation.org/2025/08/kite...
Yesterday we wrapped up a 2-day scientific review meeting for the Mark Foundation Center for Advanced Genomics and Imaging at @jhu.edu. The Center’s brilliant scientists are driving breakthroughs in genomics, imaging & data science that will make immunotherapy effective for more patients.
August 15, 2025 at 2:46 PM
Yesterday we wrapped up a 2-day scientific review meeting for the Mark Foundation Center for Advanced Genomics and Imaging at @jhu.edu. The Center’s brilliant scientists are driving breakthroughs in genomics, imaging & data science that will make immunotherapy effective for more patients.
Reposted by The Mark Foundation for Cancer Research
Submissions are open for the EACR - @themarkfdn.bsky.social Postdoctoral Fellowships until 20 August!
This funding is awarded for a period of three years to support excellent postdoctoral researchers in laboratories throughout Europe 🌍
Learn more: eacr.org/eacr-fellows...
This funding is awarded for a period of three years to support excellent postdoctoral researchers in laboratories throughout Europe 🌍
Learn more: eacr.org/eacr-fellows...
August 6, 2025 at 8:02 AM
Submissions are open for the EACR - @themarkfdn.bsky.social Postdoctoral Fellowships until 20 August!
This funding is awarded for a period of three years to support excellent postdoctoral researchers in laboratories throughout Europe 🌍
Learn more: eacr.org/eacr-fellows...
This funding is awarded for a period of three years to support excellent postdoctoral researchers in laboratories throughout Europe 🌍
Learn more: eacr.org/eacr-fellows...
Cancer-related cachexia is responsible for ~1/3 of cancer deaths, yet its causes & treatments have proven elusive—until now. In @cellpress.bsky.social, Endeavor Award team leader Ayelet Erez identifies a cause for the syndrome—and a path forward for patients. www.cell.com/cell/abstrac...
Vagal blockade of the brain-liver axis deters cancer-associated cachexia
Vagal dysfunction mediates the impact of tumor on liver metabolism, leading to cachexia.
Blocking the right cervical vagus nerve with various invasive or non-invasive approaches
alleviates cachexia, d...
www.cell.com
August 11, 2025 at 8:50 PM
Cancer-related cachexia is responsible for ~1/3 of cancer deaths, yet its causes & treatments have proven elusive—until now. In @cellpress.bsky.social, Endeavor Award team leader Ayelet Erez identifies a cause for the syndrome—and a path forward for patients. www.cell.com/cell/abstrac...
Do the types of dietary fats that patients consume impact cancer progression? In a new @nature.com paper, Emerging Leader Award winner @lydialynch.bsky.social shows that diets high in some types of fats suppress anti-tumor responses in patients with obesity.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
www.nature.com
August 6, 2025 at 1:42 PM
Do the types of dietary fats that patients consume impact cancer progression? In a new @nature.com paper, Emerging Leader Award winner @lydialynch.bsky.social shows that diets high in some types of fats suppress anti-tumor responses in patients with obesity.
www.nature.com/articles/s42...
www.nature.com/articles/s42...