Mike Cohen
@michaelnadbio.bsky.social
Chemical biologist passionate about post-translational modifications (PTMs) and a keen interest in drug development. Professor at OHSU leading a team dedicated to unraveling the mysteries of PARPs and ADP-ribosylation.
Agreed! This review thoughtfully and comprehensively dives into the world of HPF1. The questions at the end are on point!
Beautiful review from J. Rudolph on Histone PARylation factor 1: a review of its role in the DNA damage response url: academic.oup.com/nar/article/...
Histone PARylation factor 1: a review of its role in the DNA damage response
Abstract. Although poly-(ADP ribose) polymerase 1 (PARP1) and PARylation of histones have been known for over 50 years and have been successfully targeted
academic.oup.com
November 11, 2025 at 4:21 PM
Agreed! This review thoughtfully and comprehensively dives into the world of HPF1. The questions at the end are on point!
Reposted by Mike Cohen
Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
October 30, 2025 at 3:33 PM
Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Mike Cohen
My quote of the day
A Video Quote
Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble.
(From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)
A Video Quote
Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble.
(From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)
July 17, 2025 at 10:44 AM
My quote of the day
A Video Quote
Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble.
(From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)
A Video Quote
Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble.
(From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)
Reposted by Mike Cohen
'Particularly at risk is the category of basic research — the blue-sky variety meant to push back the frontiers of human knowledge and sow practical spinoffs and breakthroughs in such everyday fields as health care and artificial intelligence.'
www.nytimes.com/2025/07/10/s...
www.nytimes.com/2025/07/10/s...
Trump Seeks to Cut Basic Scientific Research by Roughly One-Third, Report Shows
www.nytimes.com
July 13, 2025 at 8:05 AM
'Particularly at risk is the category of basic research — the blue-sky variety meant to push back the frontiers of human knowledge and sow practical spinoffs and breakthroughs in such everyday fields as health care and artificial intelligence.'
www.nytimes.com/2025/07/10/s...
www.nytimes.com/2025/07/10/s...
Reposted by Mike Cohen
A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
www.nature.com
July 10, 2025 at 6:11 AM
A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Reposted by Mike Cohen
An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
www.nature.com
July 10, 2025 at 10:44 AM
An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story
Cool new paper from Matic lab showing that MARUbylation occurs on serines in response to DNA damage.
Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
July 9, 2025 at 4:15 PM
Cool new paper from Matic lab showing that MARUbylation occurs on serines in response to DNA damage.
Check out this story about my OHSU colleague’s work describing a previously unknown critical neurological function for dystroglycan with important implication for neuromuscular disease.
July 7, 2025 at 6:46 PM
Check out this story about my OHSU colleague’s work describing a previously unknown critical neurological function for dystroglycan with important implication for neuromuscular disease.
Check out this great review on the fascinating field of renal interoception by our newest faculty member, @rose-hill.bsky.social!
Our review on kidney sensory innervation is out! It was such an honor to write about all the amazing work from my colleagues in this growing field of renal interoception. Yay kidneys! www.sciencedirect.com/science/arti...
July 3, 2025 at 3:48 AM
Check out this great review on the fascinating field of renal interoception by our newest faculty member, @rose-hill.bsky.social!
💯 👇!
Despite ~20 years in/around #chembio research, I went to my first Bioorganic GRC this week. This community is amazing and so supportive. I feel energized (and tired, lol) and find myself rooting for the next generation of chemical biologists. Sooooo much awesome science - We can’t/won’t be stopped!
June 22, 2025 at 6:01 PM
💯 👇!
Reposted by Mike Cohen
Today they have crossed a deep red line.
We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.
We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.
June 12, 2025 at 8:05 PM
Today they have crossed a deep red line.
We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.
We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.
Excellent paper by first author @andriigorelik.bsky.social and @ahellab.bsky.social team that uncovers new insights into PARP7-AHR biology in PARP7i-sensitive cancer cells.
Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity | PNAS
PARP7 is an enzyme that uses donor substrate NAD+ to attach a single ADP-ribose moiety
onto proteins related to immunity, transcription, and cell g...
www.pnas.org
June 12, 2025 at 7:08 PM
Excellent paper by first author @andriigorelik.bsky.social and @ahellab.bsky.social team that uncovers new insights into PARP7-AHR biology in PARP7i-sensitive cancer cells.
Reposted by Mike Cohen
Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸
June 9, 2025 at 3:33 PM
Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸
@doc-jlmeier.bsky.social got my swag, and now I’m ready for some good science and basketball at the #2025BioorganicGRC. It’s been too long!
June 8, 2025 at 4:08 PM
@doc-jlmeier.bsky.social got my swag, and now I’m ready for some good science and basketball at the #2025BioorganicGRC. It’s been too long!
Reposted by Mike Cohen
Lots of exciting work to do at this interface between #ubiquitin and #ADP-ribosylation! In the coming months, @michaelnadbio.bsky.social and I hope to be recruiting new team members to explore this space. Here is a thread of other exciting opportunities to check out!
Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation
Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...
www.biorxiv.org
June 8, 2025 at 12:21 AM
Lots of exciting work to do at this interface between #ubiquitin and #ADP-ribosylation! In the coming months, @michaelnadbio.bsky.social and I hope to be recruiting new team members to explore this space. Here is a thread of other exciting opportunities to check out!
Cool new manuscript by @tafesselab.bsky.social and colleagues revealing a fascinating connection between SARS-CoV-2 infection and host lipid metabolism. Perhaps this opens up new therapeutic opportunities? Congrats!
Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection
The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...
www.biorxiv.org
June 4, 2025 at 11:26 PM
Cool new manuscript by @tafesselab.bsky.social and colleagues revealing a fascinating connection between SARS-CoV-2 infection and host lipid metabolism. Perhaps this opens up new therapeutic opportunities? Congrats!
Reposted by Mike Cohen
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
'
my.corehr.com
May 24, 2025 at 5:29 AM
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
Awesome review by Braden Lobingier and colleagues on ways to study compartmentalized GPCR signaling.
A new Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of signaling protein networks and mechanistic screening
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chemical biology approaches to resolve the subcellular GPCR signaling landscape - Nature Chemical Biology
This Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of sign...
www.nature.com
June 3, 2025 at 10:35 PM
Awesome review by Braden Lobingier and colleagues on ways to study compartmentalized GPCR signaling.
Reposted by Mike Cohen
Tagging a few bioorganic aficionados @laurakiessling.bsky.social @carolynbertozzi.bskyverified.social @krishnanyamuna.bsky.social @chembiobryan.bsky.social @chembiohub.bsky.social @pottslab.bsky.social @dannomura.bsky.social @danharki.bsky.social @craigmcrews.bsky.social @ritastrack.bsky.social
June 3, 2025 at 12:45 PM
Reposted by Mike Cohen
I have had the privilege to train many chinese students over many years. They enriched our lives and did great science. Many are still here and contribute to the US scientific enterprise. The push to revoke student visas is cruel and unnecessary. We must push back.
www.npr.org/2025/05/28/g...
www.npr.org/2025/05/28/g...
Rubio says U.S. will 'aggressively' revoke visas for many Chinese students
The announcement to revoke visas is the most drastic move yet to curtail the numbers of international students studying in the U.S.
www.npr.org
May 29, 2025 at 12:49 PM
I have had the privilege to train many chinese students over many years. They enriched our lives and did great science. Many are still here and contribute to the US scientific enterprise. The push to revoke student visas is cruel and unnecessary. We must push back.
www.npr.org/2025/05/28/g...
www.npr.org/2025/05/28/g...
Reposted by Mike Cohen
Crystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4 - Journal of Biological Chemistry www.jbc.org/article/S002...
Crystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4
PARP4 is an ADP-ribosyltransferase typically associated with the cytoplasmic vault
organelle. PARP4 has a distinct domain composition relative to other PARP enzymes;
however, the N-terminal region of ...
www.jbc.org
May 27, 2025 at 4:42 PM
Crystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4 - Journal of Biological Chemistry www.jbc.org/article/S002...
Reposted by Mike Cohen
📣New from Palafox et al!
📄Prioritizing disease-associated missense variants with chemoproteomic-detected amino acids
📄Prioritizing disease-associated missense variants with chemoproteomic-detected amino acids
Prioritizing disease-associated missense variants with chemoproteomic-detected amino acids
Mass spectrometry-based chemoproteomics can provide a high-throughput assessment of
the likely functionality of specific sites on proteins. Here, we show that chemoproteomic
measures of protein-based ...
www.cell.com
May 23, 2025 at 2:32 PM
📣New from Palafox et al!
📄Prioritizing disease-associated missense variants with chemoproteomic-detected amino acids
📄Prioritizing disease-associated missense variants with chemoproteomic-detected amino acids
Reposted by Mike Cohen
Fucking hell
Rep. Jim McGovern pleads for NIH funding in budget bill after daughter dies of cancer: "This is personal"
Weeks after his daughter died of a rare cancer, Rep. Jim McGovern pushed for the restoration of NIH grants in President Trump's budget bill.
www.cbsnews.com
May 22, 2025 at 6:18 PM
Fucking hell
Another awesome collaboration with @jnpruneda.bsky.social and team providing deeper insight into the writers of MARUbylation. Check out thread 👇!
Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation
Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...
www.biorxiv.org
May 17, 2025 at 4:29 PM
Another awesome collaboration with @jnpruneda.bsky.social and team providing deeper insight into the writers of MARUbylation. Check out thread 👇!
Reposted by Mike Cohen
Online now - the Spotlight "Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells" from @kfeijszaja.bsky.social and colleagues.
#ADPribosylation #ubiquitination #MARUbylation #crosstalk
authors.elsevier.com/sd/article/S...
#ADPribosylation #ubiquitination #MARUbylation #crosstalk
authors.elsevier.com/sd/article/S...
April 25, 2025 at 3:41 PM
Online now - the Spotlight "Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells" from @kfeijszaja.bsky.social and colleagues.
#ADPribosylation #ubiquitination #MARUbylation #crosstalk
authors.elsevier.com/sd/article/S...
#ADPribosylation #ubiquitination #MARUbylation #crosstalk
authors.elsevier.com/sd/article/S...