Mike Cohen
@michaelnadbio.bsky.social
700 followers
240 following
94 posts
Chemical biologist passionate about post-translational modifications (PTMs) and a keen interest in drug development. Professor at OHSU leading a team dedicated to unraveling the mysteries of PARPs and ADP-ribosylation.
Posts
Media
Videos
Starter Packs
Beautiful review from J. Rudolph on Histone PARylation factor 1: a review of its role in the DNA damage response url: academic.oup.com/nar/article/...
Histone PARylation factor 1: a review of its role in the DNA damage response
Abstract. Although poly-(ADP ribose) polymerase 1 (PARP1) and PARylation of histones have been known for over 50 years and have been successfully targeted
academic.oup.com
Reposted by Mike Cohen
Reposted by Mike Cohen
Reposted by Mike Cohen
Reposted by Mike Cohen
ahellab.bsky.social
@ahellab.bsky.social
· Jul 10
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
www.nature.com
Reposted by Mike Cohen
Andrii Gorelik
@andriigorelik.bsky.social
· Jul 10
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
www.nature.com
Mike Cohen
@michaelnadbio.bsky.social
· Jul 10
Mike Cohen
@michaelnadbio.bsky.social
· Jul 9
Mike Cohen
@michaelnadbio.bsky.social
· Jul 9
Mike Cohen
@michaelnadbio.bsky.social
· Jul 9
Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
Mike Cohen
@michaelnadbio.bsky.social
· Jul 3
Our review on kidney sensory innervation is out! It was such an honor to write about all the amazing work from my colleagues in this growing field of renal interoception. Yay kidneys! www.sciencedirect.com/science/arti...
Mike Cohen
@michaelnadbio.bsky.social
· Jun 25
Mike Cohen
@michaelnadbio.bsky.social
· Jun 22
Despite ~20 years in/around #chembio research, I went to my first Bioorganic GRC this week. This community is amazing and so supportive. I feel energized (and tired, lol) and find myself rooting for the next generation of chemical biologists. Sooooo much awesome science - We can’t/won’t be stopped!
Mike Cohen
@michaelnadbio.bsky.social
· Jun 20
Reposted by Mike Cohen
Mike Cohen
@michaelnadbio.bsky.social
· Jun 12
Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity | PNAS
PARP7 is an enzyme that uses donor substrate NAD+ to attach a single ADP-ribose moiety
onto proteins related to immunity, transcription, and cell g...
www.pnas.org
Reposted by Mike Cohen
Mike Cohen
@michaelnadbio.bsky.social
· Jun 8
Reposted by Mike Cohen
Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation
Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...
www.biorxiv.org
Mike Cohen
@michaelnadbio.bsky.social
· Jun 8
Mike Cohen
@michaelnadbio.bsky.social
· Jun 4
Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection
The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...
www.biorxiv.org
Reposted by Mike Cohen
Mike Cohen
@michaelnadbio.bsky.social
· Jun 3
A new Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of signaling protein networks and mechanistic screening
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chemical biology approaches to resolve the subcellular GPCR signaling landscape - Nature Chemical Biology
This Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of sign...
www.nature.com