Neel Shah
@nshahlab.bsky.social
Assistant Professor at Columbia Chemistry. PI of a chemical biology lab full of awesome people. Internal conflicts: Chemist or biologist? Kinase or phosphatase?
Lab website: https://shahlab.wixsite.com/home
ORCiD: 0000-0002-1186-0626
Lab website: https://shahlab.wixsite.com/home
ORCiD: 0000-0002-1186-0626
Reposted by Neel Shah
Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants https://www.biorxiv.org/content/10.1101/2025.11.04.686643v1
November 6, 2025 at 6:48 PM
Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants https://www.biorxiv.org/content/10.1101/2025.11.04.686643v1
Congrats, Jeanine! @amacherlab.bsky.social
Congratulations to Dr. Jeanine Amacher at Western Washington University for being named a 2025 Henry Dreyfus Teacher-Scholar! #DreyfusAwards
November 6, 2025 at 5:08 PM
Congrats, Jeanine! @amacherlab.bsky.social
Reposted by Neel Shah
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
www.nature.com
October 30, 2025 at 10:27 AM
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Congrats, Eunhee and the whole team. This is really cool!
Excited to share our new publication in Nature Communications! 🧬
We explored how evolution shaped the structure–function relationship of the insulin receptor (IR) family using a simplified model — the fruit fly. 🪰
rdcu.be/eM7zG
We explored how evolution shaped the structure–function relationship of the insulin receptor (IR) family using a simplified model — the fruit fly. 🪰
rdcu.be/eM7zG
October 30, 2025 at 1:00 AM
Congrats, Eunhee and the whole team. This is really cool!
Reposted by Neel Shah
New work from the lab of Dr. Wan-Lin Lo at @utah.edu demonstrates that age-dependent Zap70 expression regulates negative selection and thymic #Treg cell development.
Study🗒️: https://go.nature.com/4o9oqWn
Episode 🔊: https://bit.ly/3LlRCeo
Study🗒️: https://go.nature.com/4o9oqWn
Episode 🔊: https://bit.ly/3LlRCeo
October 24, 2025 at 4:52 PM
New work from the lab of Dr. Wan-Lin Lo at @utah.edu demonstrates that age-dependent Zap70 expression regulates negative selection and thymic #Treg cell development.
Study🗒️: https://go.nature.com/4o9oqWn
Episode 🔊: https://bit.ly/3LlRCeo
Study🗒️: https://go.nature.com/4o9oqWn
Episode 🔊: https://bit.ly/3LlRCeo
Reposted by Neel Shah
Please share🔉 We’re #hiring #AI #Engineers
@columbiaseas.bsky.social @cancerdynamics.bsky.social
🚀Join us to build foundation models that learn & reason about cancer systems, integrating #LLMs #causalAI and multi-modal #genomics. Shape the next-generation of cancer therapies! tinyurl.com/5n7wp8ck
@columbiaseas.bsky.social @cancerdynamics.bsky.social
🚀Join us to build foundation models that learn & reason about cancer systems, integrating #LLMs #causalAI and multi-modal #genomics. Shape the next-generation of cancer therapies! tinyurl.com/5n7wp8ck
October 24, 2025 at 2:37 PM
Please share🔉 We’re #hiring #AI #Engineers
@columbiaseas.bsky.social @cancerdynamics.bsky.social
🚀Join us to build foundation models that learn & reason about cancer systems, integrating #LLMs #causalAI and multi-modal #genomics. Shape the next-generation of cancer therapies! tinyurl.com/5n7wp8ck
@columbiaseas.bsky.social @cancerdynamics.bsky.social
🚀Join us to build foundation models that learn & reason about cancer systems, integrating #LLMs #causalAI and multi-modal #genomics. Shape the next-generation of cancer therapies! tinyurl.com/5n7wp8ck
Reposted by Neel Shah
Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...
pubs.acs.org
October 21, 2025 at 3:55 PM
Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
Reposted by Neel Shah
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
October 20, 2025 at 11:26 AM
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
Reposted by Neel Shah
Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️
A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria
A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria
Endogenous structure of antimalarial target PfATP4 reveals an apicomplexan-specific P-type ATPase modulator
Nature Communications - Here, the authors present the 3.7 Å cryoEM structure of native sodium efflux pump PfATP4 from Plasmodium falciparum, revealing a bound protein that they term...
rdcu.be
October 20, 2025 at 12:55 PM
Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️
A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria
A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria
Happy to share that our paper with Harmen Bussemaker’s group entitled “Accurate affinity models for SH2 domains from peptide binding assays and free-energy regression” is out in its final form at Protein Science!
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
October 16, 2025 at 12:40 AM
Happy to share that our paper with Harmen Bussemaker’s group entitled “Accurate affinity models for SH2 domains from peptide binding assays and free-energy regression” is out in its final form at Protein Science!
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Neel Shah
Skeetorial on our BRAF preprint!
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer
The RAF/MEK/ERK signaling cascade regulates cell proliferation and differentiation and is frequently dysregulated in cancer. Approximately 90% of RAF-mutant cancers harbour mutations in B-type of Rapi...
tinyurl.com
October 14, 2025 at 8:17 AM
Skeetorial on our BRAF preprint!
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
Reposted by Neel Shah
Our work on developing a fluorescent probe to measure granzyme B activity in anti-tumor immunity is finally out! pubs.acs.org/doi/10.1021/...
Granzyme B-Targeting Quenched Activity-Based Probes for Assessing Tumor Response to Immunotherapy
Molecular imaging of immune activation holds tremendous potential for the development of novel immunotherapies. In particular, chemical probes capable of detecting immune responses before changes in t...
pubs.acs.org
October 8, 2025 at 11:44 PM
Our work on developing a fluorescent probe to measure granzyme B activity in anti-tumor immunity is finally out! pubs.acs.org/doi/10.1021/...
Reposted by Neel Shah
Come be my colleague! Tufts Chemistry is hiring a tenure-track Assistant Professor working on materials with energy applications. We have a fantastic, supportive environment for you to start your research career. Send questions to me or @chemysl.bsky.social
apply.interfolio.com/175284
apply.interfolio.com/175284
October 6, 2025 at 12:02 PM
Come be my colleague! Tufts Chemistry is hiring a tenure-track Assistant Professor working on materials with energy applications. We have a fantastic, supportive environment for you to start your research career. Send questions to me or @chemysl.bsky.social
apply.interfolio.com/175284
apply.interfolio.com/175284
Reposted by Neel Shah
New Blog Post:
Scholarly Communication Is a Research Problem. This Means You.
pracheeac.substack.com/p/scholarly-...
Scholarly Communication Is a Research Problem. This Means You.
pracheeac.substack.com/p/scholarly-...
Scholarly Communication Is a Research Problem. This Means You.
Scholarly Communication Is a Research Problem.
pracheeac.substack.com
October 4, 2025 at 4:11 PM
New Blog Post:
Scholarly Communication Is a Research Problem. This Means You.
pracheeac.substack.com/p/scholarly-...
Scholarly Communication Is a Research Problem. This Means You.
pracheeac.substack.com/p/scholarly-...
Reposted by Neel Shah
Excited to share our latest work in expanding AI-based protein design into targeting PTMs! I’m particularly excited in this work as there is so much we don’t know about PTMs despite their central role in signaling and hopefully we can start to decode their rules and functions.
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
September 30, 2025 at 11:42 PM
Excited to share our latest work in expanding AI-based protein design into targeting PTMs! I’m particularly excited in this work as there is so much we don’t know about PTMs despite their central role in signaling and hopefully we can start to decode their rules and functions.
Reposted by Neel Shah
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
September 30, 2025 at 9:55 PM
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
Reposted by Neel Shah
We’re hiring!📣
Exciting opportunity at the Irving Institute for Cancer Dynamics and School of Engineering and Applied Science at Columbia: Associate Research Scientist. Lead pooled CRISPR + Perturb-seq screens to close AI-identified knowledge gaps. Apply apply.interfolio.com/172825
Exciting opportunity at the Irving Institute for Cancer Dynamics and School of Engineering and Applied Science at Columbia: Associate Research Scientist. Lead pooled CRISPR + Perturb-seq screens to close AI-identified knowledge gaps. Apply apply.interfolio.com/172825
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 29, 2025 at 10:32 PM
We’re hiring!📣
Exciting opportunity at the Irving Institute for Cancer Dynamics and School of Engineering and Applied Science at Columbia: Associate Research Scientist. Lead pooled CRISPR + Perturb-seq screens to close AI-identified knowledge gaps. Apply apply.interfolio.com/172825
Exciting opportunity at the Irving Institute for Cancer Dynamics and School of Engineering and Applied Science at Columbia: Associate Research Scientist. Lead pooled CRISPR + Perturb-seq screens to close AI-identified knowledge gaps. Apply apply.interfolio.com/172825
Reposted by Neel Shah
First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1
September 28, 2025 at 10:33 AM
First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)
Reposted by Neel Shah
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…
www.sciencedirect.com
September 24, 2025 at 3:30 PM
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Neel Shah
Thank you @pennmedicine.bsky.social for highlighting my journey and this recognition.I'm honored to received the 2026 @asbmb.bsky.social Ruth Kirschstein Award for Maximizing Access in Science. — rooted in a vision to remove barriers and ensure everyone has the opportunity to contribute to science.
September 24, 2025 at 1:10 AM
Thank you @pennmedicine.bsky.social for highlighting my journey and this recognition.I'm honored to received the 2026 @asbmb.bsky.social Ruth Kirschstein Award for Maximizing Access in Science. — rooted in a vision to remove barriers and ensure everyone has the opportunity to contribute to science.
Reposted by Neel Shah
affinity, specificity, and selectivity as well as how targeting loops can allosterically alter protein activity.
We are looking to hire a postdoc to support this work, particularly allosteric mechanisms of molecular glue formation. If you are interested, check out our ad: lnkd.in/g-kyiTST (1/2)
We are looking to hire a postdoc to support this work, particularly allosteric mechanisms of molecular glue formation. If you are interested, check out our ad: lnkd.in/g-kyiTST (1/2)
University of Notre Dame hiring Postdoctoral Researcher in Notre Dame, IN | LinkedIn
Posted 1:31:15 AM. The STAR2 Lab (Selective Targeting Approaches for RNA and RNA-binding proteins) at the University…See this and similar jobs on LinkedIn.
lnkd.in
September 10, 2025 at 12:55 PM
affinity, specificity, and selectivity as well as how targeting loops can allosterically alter protein activity.
We are looking to hire a postdoc to support this work, particularly allosteric mechanisms of molecular glue formation. If you are interested, check out our ad: lnkd.in/g-kyiTST (1/2)
We are looking to hire a postdoc to support this work, particularly allosteric mechanisms of molecular glue formation. If you are interested, check out our ad: lnkd.in/g-kyiTST (1/2)
Reposted by Neel Shah
Honored to receive the 2026 DeLano Award from @asbmb.bsky.social. Warren wrote PyMOL which I spend several hours a day with -- a hero for open & accessible software. Helen Berman, another of my heroes, nominated me (with help from Ruth Nussinov & Janet Thornton), three women I admire tremendously.
September 5, 2025 at 10:35 PM
Honored to receive the 2026 DeLano Award from @asbmb.bsky.social. Warren wrote PyMOL which I spend several hours a day with -- a hero for open & accessible software. Helen Berman, another of my heroes, nominated me (with help from Ruth Nussinov & Janet Thornton), three women I admire tremendously.
Reposted by Neel Shah
Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk
rdcu.be/eDzPk
Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...
rdcu.be
September 2, 2025 at 11:55 AM
Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk
rdcu.be/eDzPk
Reposted by Neel Shah
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
August 28, 2025 at 8:47 PM
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
Reposted by Neel Shah
Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out:
eeik.fa.us2.oraclecloud.com/hcmUI/Candid...
Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.
eeik.fa.us2.oraclecloud.com/hcmUI/Candid...
Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.
Asst Professor - Molecular Biology - Computational Biochemist
The Department of Molecular Biology (MOLB) and the School of Computing (SoC) at the University of Wyoming seeks candidates for a tenure-track position at the rank of Assistant Professor starting in th...
eeik.fa.us2.oraclecloud.com
August 28, 2025 at 4:16 PM
Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out:
eeik.fa.us2.oraclecloud.com/hcmUI/Candid...
Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.
eeik.fa.us2.oraclecloud.com/hcmUI/Candid...
Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.