Roland Dunbrack 🏳️🌈
@rolanddunbrack.bsky.social
Computational structural biologist @Fox Chase Cancer Center. Gay, out & proud since 1986. I support transgender & nonbinary people. Living with CLL/SLL. Video about my LGBTQ+ life in science: https://tinyurl.com/45srzjdw. Views my own, not my employer's.
Reposted by Roland Dunbrack 🏳️🌈
Minneapolis Mayor Jacob Frey to the Trump regime’s ICE troops following their murder of a US Citizen:
"To ICE: Get the fuck out of Minneapolis. We don't want you here"
"To ICE: Get the fuck out of Minneapolis. We don't want you here"
January 7, 2026 at 7:33 PM
Minneapolis Mayor Jacob Frey to the Trump regime’s ICE troops following their murder of a US Citizen:
"To ICE: Get the fuck out of Minneapolis. We don't want you here"
"To ICE: Get the fuck out of Minneapolis. We don't want you here"
This appeared today: www.asbmb.org/asbmb-today/...
Mapping proteins, one side chain at a time
Roland Dunbrack Jr. will receive the ASBMB DeLano Award for Computational Biosciences at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.
www.asbmb.org
January 8, 2026 at 2:25 AM
This appeared today: www.asbmb.org/asbmb-today/...
Reposted by Roland Dunbrack 🏳️🌈
We are only one week into the new year. I did not know how angry I could get but I am finding out fast.
a close up of a cartoon character with a very angry face and a tie .
ALT: a close up of a cartoon character with a very angry face and a tie .
media.tenor.com
January 8, 2026 at 1:27 AM
We are only one week into the new year. I did not know how angry I could get but I am finding out fast.
Reposted by Roland Dunbrack 🏳️🌈
Letter of resignation from @jennifer-troyer.bsky.social former Dir of Extramural Ops at NHGRI
"The NIH is not only no longer the organization that I love but is now an organization that I can no longer be a part of and retain my integrity and self-respect."
www.linkedin.com/posts/jennif...
1/6
"The NIH is not only no longer the organization that I love but is now an organization that I can no longer be a part of and retain my integrity and self-respect."
www.linkedin.com/posts/jennif...
1/6
Letter of resignation | Jennifer Troyer
Reposting: As many of you know, I recently chose to leave the position I worked hard to achieve, the work that I love, and the team of people that could not have been better to do this work with. It ...
www.linkedin.com
January 6, 2026 at 6:26 PM
Letter of resignation from @jennifer-troyer.bsky.social former Dir of Extramural Ops at NHGRI
"The NIH is not only no longer the organization that I love but is now an organization that I can no longer be a part of and retain my integrity and self-respect."
www.linkedin.com/posts/jennif...
1/6
"The NIH is not only no longer the organization that I love but is now an organization that I can no longer be a part of and retain my integrity and self-respect."
www.linkedin.com/posts/jennif...
1/6
I am just feeling despair at the state of things in this country and the prospects of 3 more years (at least) of this tyranny and kakistocracy. So many institutions seem on board with it, including scientific institutions like NIH, CDC, and FDA which have been degraded to the point of criminality.
January 7, 2026 at 3:16 AM
I am just feeling despair at the state of things in this country and the prospects of 3 more years (at least) of this tyranny and kakistocracy. So many institutions seem on board with it, including scientific institutions like NIH, CDC, and FDA which have been degraded to the point of criminality.
I recently saw a non-profit healthcare executive of my acquaintance show a photo of a young Elon Musk in a slideshow with some “inspirational” quote of his, and I almost threw up.
Elon Musk's AI chatbot Grok is under fire for generating sexualized images of women and children without consent.
Musk's AI chatbot faces global backlash over sexualized images of women and children
Elon Musk's AI chatbot Grok is under fire for generating sexualized images of women and children without consent.
bit.ly
January 7, 2026 at 2:34 AM
I recently saw a non-profit healthcare executive of my acquaintance show a photo of a young Elon Musk in a slideshow with some “inspirational” quote of his, and I almost threw up.
Thomas is always worth reading. Subscribe!
Sunday reading:
America is no longer a democracy. That doesn’t mean authoritarianism has won. There is reason to feel more optimistic now than last spring.
But the country needs a democratic transformation rather than merely a restoration of the pre-Trump status quo.
This week’s piece:
America is no longer a democracy. That doesn’t mean authoritarianism has won. There is reason to feel more optimistic now than last spring.
But the country needs a democratic transformation rather than merely a restoration of the pre-Trump status quo.
This week’s piece:
Where Are You Going, America?
America is no longer a democracy. Authoritarianism has not won. But merely restoring the pre-Trump status quo won’t work. The country needs a democratic transformation.
steady.page
January 7, 2026 at 1:45 AM
Thomas is always worth reading. Subscribe!
Reposted by Roland Dunbrack 🏳️🌈
Y’all, Democracy Americana is a fantastic newsletter and really deserves your support (and is not Substack)
If you’ll indulge me for a second:
The newsletter has really struggled to attract new subscribers since I left Substack - while the monthly churn (existing subscribers canceling their subscription) has gone up significantly.
Not sure what the reasons are. But it is definitely concerning.
The newsletter has really struggled to attract new subscribers since I left Substack - while the monthly churn (existing subscribers canceling their subscription) has gone up significantly.
Not sure what the reasons are. But it is definitely concerning.
Sunday reading:
America is no longer a democracy. That doesn’t mean authoritarianism has won. There is reason to feel more optimistic now than last spring.
But the country needs a democratic transformation rather than merely a restoration of the pre-Trump status quo.
This week’s piece:
America is no longer a democracy. That doesn’t mean authoritarianism has won. There is reason to feel more optimistic now than last spring.
But the country needs a democratic transformation rather than merely a restoration of the pre-Trump status quo.
This week’s piece:
January 4, 2026 at 4:13 PM
Y’all, Democracy Americana is a fantastic newsletter and really deserves your support (and is not Substack)
Reposted by Roland Dunbrack 🏳️🌈
My readership now shrinks with every piece I publish. You don’t need to know much about the newsletter business to see how that math doesn’t work. Not sure yet how to handle this.
For now, I’ll just ask you to consider supporting Democracy Americana in whichever way you see fit:
For now, I’ll just ask you to consider supporting Democracy Americana in whichever way you see fit:
Democracy Americana
A newsletter on U.S. politics and history - and the ongoing struggle over how much democracy, and for whom, there should be in America
steady.page
January 4, 2026 at 4:14 PM
My readership now shrinks with every piece I publish. You don’t need to know much about the newsletter business to see how that math doesn’t work. Not sure yet how to handle this.
For now, I’ll just ask you to consider supporting Democracy Americana in whichever way you see fit:
For now, I’ll just ask you to consider supporting Democracy Americana in whichever way you see fit:
Reposted by Roland Dunbrack 🏳️🌈
Eyes wide open, folks. They're revealing the supervillain plot.
January 5, 2026 at 5:53 PM
Eyes wide open, folks. They're revealing the supervillain plot.
I updated ipSAE code to handle Boltz2 files properly -- non-standard chainIDs/order, PDB input as well as mmCIF; other pull requests. github.com/DunbrackLab/.... Also updated preprint--fixed Latin grammar error in title - very embarrassing and added new figure. www.biorxiv.org/content/10.1...
pip install ipsae
from www.linkedin.com/in/ullah-sam...
www.youtube.com/watch?v=A5ph...
PyPI pypi.org/project/ipsae/
His github fork github.com/ullahsamee/I...
My github github.com/DunbrackLab/...
Paper www.biorxiv.org/content/10.1...
For designed protein binders www.biorxiv.org/content/10.1...
from www.linkedin.com/in/ullah-sam...
www.youtube.com/watch?v=A5ph...
PyPI pypi.org/project/ipsae/
His github fork github.com/ullahsamee/I...
My github github.com/DunbrackLab/...
Paper www.biorxiv.org/content/10.1...
For designed protein binders www.biorxiv.org/content/10.1...
Screen binders using ipSAE
YouTube video by ProteinDesignStudio
www.youtube.com
January 3, 2026 at 11:06 AM
I updated ipSAE code to handle Boltz2 files properly -- non-standard chainIDs/order, PDB input as well as mmCIF; other pull requests. github.com/DunbrackLab/.... Also updated preprint--fixed Latin grammar error in title - very embarrassing and added new figure. www.biorxiv.org/content/10.1...
Fixing my ipSAE github for Boltz2. When Boltz reports pair_chains_iptm, labeling chains "0", "1", is it aligning on the first chain and scoring the second one, or the other way around? It gets 0.56,0.47. When I recalculate asymmetric ipTM, I get aligning on A,scoring B = 0.41. for B->A, 0.49
January 3, 2026 at 8:17 AM
Fixing my ipSAE github for Boltz2. When Boltz reports pair_chains_iptm, labeling chains "0", "1", is it aligning on the first chain and scoring the second one, or the other way around? It gets 0.56,0.47. When I recalculate asymmetric ipTM, I get aligning on A,scoring B = 0.41. for B->A, 0.49
Nice description of ipTM problems & how actifPTM, LIS, & ipSAE fix those for scoring protein-protein interactions.
New script on ipSAE github: af2rechain.py takes an input AF2 model of one protein & breaks it into chains given domain boundaries for input to ipSAE to calculate intraprotein ipSAE.
New script on ipSAE github: af2rechain.py takes an input AF2 model of one protein & breaks it into chains given domain boundaries for input to ipSAE to calculate intraprotein ipSAE.
January 3, 2026 at 12:10 AM
Nice description of ipTM problems & how actifPTM, LIS, & ipSAE fix those for scoring protein-protein interactions.
New script on ipSAE github: af2rechain.py takes an input AF2 model of one protein & breaks it into chains given domain boundaries for input to ipSAE to calculate intraprotein ipSAE.
New script on ipSAE github: af2rechain.py takes an input AF2 model of one protein & breaks it into chains given domain boundaries for input to ipSAE to calculate intraprotein ipSAE.
Reposted by Roland Dunbrack 🏳️🌈
This guy should never be allowed back into academia.
Looking at you, Stanford University
www.statnews.com/2025/12/31/n...
Looking at you, Stanford University
www.statnews.com/2025/12/31/n...
NIH director says DEI-related grants that were restored under a court order won’t be renewed
NIH Director Jay Bhattacharya told a podcaster that DEI-related grants restored under a court order won't be renewed in 2026
www.statnews.com
January 2, 2026 at 5:44 PM
This guy should never be allowed back into academia.
Looking at you, Stanford University
www.statnews.com/2025/12/31/n...
Looking at you, Stanford University
www.statnews.com/2025/12/31/n...
Reposted by Roland Dunbrack 🏳️🌈
orcas have the chance to do the funniest thing
December 31, 2025 at 5:25 PM
orcas have the chance to do the funniest thing
Leave Will alone! There is no "right" way to come out. Coming out is hard and is always a bit awkward, especially when the world is coming to an end in a few minutes and you just gotta get it done with everybody all at once. #StrangerThings
December 30, 2025 at 1:49 AM
Leave Will alone! There is no "right" way to come out. Coming out is hard and is always a bit awkward, especially when the world is coming to an end in a few minutes and you just gotta get it done with everybody all at once. #StrangerThings
Honestly, I don’t want to read your 🚨🚨preprint🚨🚨 this week either.
Journal invitations to peer review over the last 2 weeks of the year: Hi! Wanna do some free work?
My out of office:
My out of office:
a man is laying on a couch wearing a blue shirt and making a funny face .
ALT: a man is laying on a couch wearing a blue shirt and making a funny face .
media.tenor.com
December 28, 2025 at 12:31 AM
Honestly, I don’t want to read your 🚨🚨preprint🚨🚨 this week either.
Reposted by Roland Dunbrack 🏳️🌈
Trump Assures Wall Street He’ll Go Back To Just Fucking Over Poor People Soon https://theonion.com/trump-assures-wall-street-hell-go-back-to-just-fucking-over-poor-people-soon/
December 27, 2025 at 9:15 PM
Trump Assures Wall Street He’ll Go Back To Just Fucking Over Poor People Soon https://theonion.com/trump-assures-wall-street-hell-go-back-to-just-fucking-over-poor-people-soon/
Reposted by Roland Dunbrack 🏳️🌈
"Results from experiments with N = 4 or less are shown to be highly misleading (...). For a cut-off of 2-fold expression differences, we find an N of 6-7 mice is required to consistently decrease the false positive rate to below 50%, and the detection sensitivity to above 50%"
Optimized murine sample sizes for RNA sequencing studies revealed from large scale comparative analysis - Nature Communications
Determining the appropriate sample size (N) for bulk RNA sequencing experiments is critical to ensure reliable results. Here the authors perform an unusually large N experiment (N = 30 per group), ana...
www.nature.com
December 27, 2025 at 3:51 PM
"Results from experiments with N = 4 or less are shown to be highly misleading (...). For a cut-off of 2-fold expression differences, we find an N of 6-7 mice is required to consistently decrease the false positive rate to below 50%, and the detection sensitivity to above 50%"
Reposted by Roland Dunbrack 🏳️🌈
If you’re wondering why your friends in academia are a little on edge right now, it’s because an eighteen-year-old who hasn’t done the reading, doesn’t look at the assignment, and has does no critical thinking skills more complex than “because I think it’s in the Bible” can literally end your career
The University of Oklahoma has removed an instructor who was accused by a student of religious discrimination over a failing grade on a psychology paper in which she cited the Bible and argued that promoting a “belief in multiple genders” was “demonic.” https://cnn.it/4b6g3rd
Oklahoma instructor removed from teaching for failing a Bible-based gender essay | CNN
The University of Oklahoma has removed an instructor who was accused by a student of religious discrimination over a failing grade on a psychology paper in which she cited the Bible and argued that promoting a “belief in multiple genders” was “demonic.”
cnn.it
December 24, 2025 at 6:21 PM
If you’re wondering why your friends in academia are a little on edge right now, it’s because an eighteen-year-old who hasn’t done the reading, doesn’t look at the assignment, and has does no critical thinking skills more complex than “because I think it’s in the Bible” can literally end your career
@acs.org has still not returned its inclusivity guides based on race/ethnicity or gender/sex/sexual-orientation/gender-identity. The idea that they "paused" them for "review and refinement" was a cover for caving to the Trump administration. @professor-dave.bsky.social
www.acs.org/about/inclus...
www.acs.org/about/inclus...
December 25, 2025 at 1:44 AM
@acs.org has still not returned its inclusivity guides based on race/ethnicity or gender/sex/sexual-orientation/gender-identity. The idea that they "paused" them for "review and refinement" was a cover for caving to the Trump administration. @professor-dave.bsky.social
www.acs.org/about/inclus...
www.acs.org/about/inclus...
Reposted by Roland Dunbrack 🏳️🌈
After buying it for $18.8 billion, Walgreens' new private equity owner has eliminated paid holidays for all hourly workers on Christmas and New Year's.
Last year, Walgreens had a CEO-to-Worker pay gap of 410 to 1.
Corporate greed that would make even Scrooge blush.
Last year, Walgreens had a CEO-to-Worker pay gap of 410 to 1.
Corporate greed that would make even Scrooge blush.
December 24, 2025 at 8:01 PM
After buying it for $18.8 billion, Walgreens' new private equity owner has eliminated paid holidays for all hourly workers on Christmas and New Year's.
Last year, Walgreens had a CEO-to-Worker pay gap of 410 to 1.
Corporate greed that would make even Scrooge blush.
Last year, Walgreens had a CEO-to-Worker pay gap of 410 to 1.
Corporate greed that would make even Scrooge blush.
I just listened to his speech. It's as bad as you might think. He actually says "If you want to Make American Great Again, you have to Make America Healthy Again." So he's all MAGA. He's only ever spoken to right-wing outlets. He's also a terrible speaker. www.youtube.com/watch?v=Hq7F...
December 22, 2025 at 11:35 PM
I just listened to his speech. It's as bad as you might think. He actually says "If you want to Make American Great Again, you have to Make America Healthy Again." So he's all MAGA. He's only ever spoken to right-wing outlets. He's also a terrible speaker. www.youtube.com/watch?v=Hq7F...
Reposted by Roland Dunbrack 🏳️🌈
#JohnsHopkins @ucsfmedicine.bsky.social and @stanfordmedicine.bsky.social are not obliged to take back Marty Makary, Vinay Prasad & Jay Bhattacharya when they leave the administration.
December 20, 2025 at 8:02 PM
#JohnsHopkins @ucsfmedicine.bsky.social and @stanfordmedicine.bsky.social are not obliged to take back Marty Makary, Vinay Prasad & Jay Bhattacharya when they leave the administration.
Reposted by Roland Dunbrack 🏳️🌈
Then there is the wild unpredictability of OneDrive/Sharepoint permissions.
December 21, 2025 at 7:03 PM
Then there is the wild unpredictability of OneDrive/Sharepoint permissions.