Immunology Podcast
@immunologypodcast.com
Join us as we discuss the latest immunology research, policy, and news with field experts. Brought to you by @stemcell.com.
🔗 immunologypodcast.com
🔗 immunologypodcast.com
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🎤 Our next episode it out!
We chat with Professor Matteo Iannacone ( @iannaconelab.bsky.social ) from @@unisr.bsky.socialabout his work understanding the generation of dysfunctional adaptive immune cells in chronic #HepatitisBVirus infection.
🎧 Listen now: https://bit.ly/4o2W8xa
We chat with Professor Matteo Iannacone ( @iannaconelab.bsky.social ) from @@unisr.bsky.socialabout his work understanding the generation of dysfunctional adaptive immune cells in chronic #HepatitisBVirus infection.
🎧 Listen now: https://bit.ly/4o2W8xa
We have a new episode out!
Dr. @camilahcoelho.bsky.social from Icahn School of Medicine talks about her lab’s work on mpox and other emerging viruses, her approach to #mentorship, and how her MBA education helps her in science.
Listen now: bit.ly/43M7r4x
Dr. @camilahcoelho.bsky.social from Icahn School of Medicine talks about her lab’s work on mpox and other emerging viruses, her approach to #mentorship, and how her MBA education helps her in science.
Listen now: bit.ly/43M7r4x
November 12, 2025 at 8:57 PM
We have a new episode out!
Dr. @camilahcoelho.bsky.social from Icahn School of Medicine talks about her lab’s work on mpox and other emerging viruses, her approach to #mentorship, and how her MBA education helps her in science.
Listen now: bit.ly/43M7r4x
Dr. @camilahcoelho.bsky.social from Icahn School of Medicine talks about her lab’s work on mpox and other emerging viruses, her approach to #mentorship, and how her MBA education helps her in science.
Listen now: bit.ly/43M7r4x
This week: A group led by Drs. Masayuki Amagai, Hayato Takahashi, and Miho Mukai converted conventional effector T cells into functional and stable Tregs.
Read the paper: https://bit.ly/4qKYimH
Catch the discussion on our latest episode: https://bit.ly/43M7r4x
Read the paper: https://bit.ly/4qKYimH
Catch the discussion on our latest episode: https://bit.ly/43M7r4x
Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris
Functionally stable regulatory T cells converted in vitro from pathogenic T cells can confer antigen-specific immunosuppression in pemphigus vulgaris.
bit.ly
November 7, 2025 at 5:12 PM
This week: A group led by Drs. Masayuki Amagai, Hayato Takahashi, and Miho Mukai converted conventional effector T cells into functional and stable Tregs.
Read the paper: https://bit.ly/4qKYimH
Catch the discussion on our latest episode: https://bit.ly/43M7r4x
Read the paper: https://bit.ly/4qKYimH
Catch the discussion on our latest episode: https://bit.ly/43M7r4x
📢 Laine Goudy, Dr. Luke Gilbert's lab, and their collaborators recently developed a new #epigenetic editing platform that safely reprograms multiple genes in human T cells.
📃 https://go.nature.com/3JQdKNL
🗨️ https://bit.ly/43M7r4x
📃 https://go.nature.com/3JQdKNL
🗨️ https://bit.ly/43M7r4x
November 6, 2025 at 11:49 PM
📢 Laine Goudy, Dr. Luke Gilbert's lab, and their collaborators recently developed a new #epigenetic editing platform that safely reprograms multiple genes in human T cells.
📃 https://go.nature.com/3JQdKNL
🗨️ https://bit.ly/43M7r4x
📃 https://go.nature.com/3JQdKNL
🗨️ https://bit.ly/43M7r4x
Our next episode features Dr. Camila Coelho ( @camilahcoelho.bsky.social ) from Icahn School of Medicine at Mount Sinai!
Tune in tomorrow to learn about her work on emerging viruses. 🦠
Tune in tomorrow to learn about her work on emerging viruses. 🦠
November 4, 2025 at 12:51 AM
Our next episode features Dr. Camila Coelho ( @camilahcoelho.bsky.social ) from Icahn School of Medicine at Mount Sinai!
Tune in tomorrow to learn about her work on emerging viruses. 🦠
Tune in tomorrow to learn about her work on emerging viruses. 🦠
📢 New in @nature.com!
Work led by Dr. Zihai Li at the Pelotonia Institute for Immuno-Oncology have shown that #ProteotoxicStress, induced by protein aggregation, is not merely a consequence, but a driver, of the exhausted T cell state.
📄: https://go.nature.com/47zVDog
🎧: https://bit.ly/3LlRCeo
Work led by Dr. Zihai Li at the Pelotonia Institute for Immuno-Oncology have shown that #ProteotoxicStress, induced by protein aggregation, is not merely a consequence, but a driver, of the exhausted T cell state.
📄: https://go.nature.com/47zVDog
🎧: https://bit.ly/3LlRCeo
October 27, 2025 at 4:30 PM
📢 New in @nature.com!
Work led by Dr. Zihai Li at the Pelotonia Institute for Immuno-Oncology have shown that #ProteotoxicStress, induced by protein aggregation, is not merely a consequence, but a driver, of the exhausted T cell state.
📄: https://go.nature.com/47zVDog
🎧: https://bit.ly/3LlRCeo
Work led by Dr. Zihai Li at the Pelotonia Institute for Immuno-Oncology have shown that #ProteotoxicStress, induced by protein aggregation, is not merely a consequence, but a driver, of the exhausted T cell state.
📄: https://go.nature.com/47zVDog
🎧: https://bit.ly/3LlRCeo
New work from the lab of Dr. Wan-Lin Lo at @utah.edu demonstrates that age-dependent Zap70 expression regulates negative selection and thymic #Treg cell development.
Study🗒️: https://go.nature.com/4o9oqWn
Episode 🔊: https://bit.ly/3LlRCeo
Study🗒️: https://go.nature.com/4o9oqWn
Episode 🔊: https://bit.ly/3LlRCeo
October 24, 2025 at 4:52 PM
New work from the lab of Dr. Wan-Lin Lo at @utah.edu demonstrates that age-dependent Zap70 expression regulates negative selection and thymic #Treg cell development.
Study🗒️: https://go.nature.com/4o9oqWn
Episode 🔊: https://bit.ly/3LlRCeo
Study🗒️: https://go.nature.com/4o9oqWn
Episode 🔊: https://bit.ly/3LlRCeo
Congrats to Drs. Mary Brunkow and Fred Ramsdell on receiving the #NobelPrize in Physiology or Medicine! 🏆
We discuss their early work identifying #FOXP3 as a master regulator of regulatory T cells.
🎧 https://bit.ly/3LlRCeo
We discuss their early work identifying #FOXP3 as a master regulator of regulatory T cells.
🎧 https://bit.ly/3LlRCeo
October 23, 2025 at 4:37 PM
Congrats to Drs. Mary Brunkow and Fred Ramsdell on receiving the #NobelPrize in Physiology or Medicine! 🏆
We discuss their early work identifying #FOXP3 as a master regulator of regulatory T cells.
🎧 https://bit.ly/3LlRCeo
We discuss their early work identifying #FOXP3 as a master regulator of regulatory T cells.
🎧 https://bit.ly/3LlRCeo
In this week's episode, we review the seminal study from Dr. Sakaguchi that led to his recent #NobelPrize!
It shows that a population of T cells expressing the IL-2 receptor α chain acts to maintain self-tolerance by suppressing other T cells.
📃: https://bit.ly/49f551F
🎧: https://bit.ly/3LlRCeo
It shows that a population of T cells expressing the IL-2 receptor α chain acts to maintain self-tolerance by suppressing other T cells.
📃: https://bit.ly/49f551F
🎧: https://bit.ly/3LlRCeo
October 22, 2025 at 6:57 PM
In this week's episode, we review the seminal study from Dr. Sakaguchi that led to his recent #NobelPrize!
It shows that a population of T cells expressing the IL-2 receptor α chain acts to maintain self-tolerance by suppressing other T cells.
📃: https://bit.ly/49f551F
🎧: https://bit.ly/3LlRCeo
It shows that a population of T cells expressing the IL-2 receptor α chain acts to maintain self-tolerance by suppressing other T cells.
📃: https://bit.ly/49f551F
🎧: https://bit.ly/3LlRCeo
🎤 Our next episode it out!
We chat with Professor Matteo Iannacone ( @iannaconelab.bsky.social ) from @@unisr.bsky.socialabout his work understanding the generation of dysfunctional adaptive immune cells in chronic #HepatitisBVirus infection.
🎧 Listen now: https://bit.ly/4o2W8xa
We chat with Professor Matteo Iannacone ( @iannaconelab.bsky.social ) from @@unisr.bsky.socialabout his work understanding the generation of dysfunctional adaptive immune cells in chronic #HepatitisBVirus infection.
🎧 Listen now: https://bit.ly/4o2W8xa
October 21, 2025 at 5:28 PM
🎤 Our next episode it out!
We chat with Professor Matteo Iannacone ( @iannaconelab.bsky.social ) from @@unisr.bsky.socialabout his work understanding the generation of dysfunctional adaptive immune cells in chronic #HepatitisBVirus infection.
🎧 Listen now: https://bit.ly/4o2W8xa
We chat with Professor Matteo Iannacone ( @iannaconelab.bsky.social ) from @@unisr.bsky.socialabout his work understanding the generation of dysfunctional adaptive immune cells in chronic #HepatitisBVirus infection.
🎧 Listen now: https://bit.ly/4o2W8xa
Reposted by Immunology Podcast
Dr. Heather Parsons has been awarded the Maudslien Endowed Chair in Breast Cancer Precision Oncology Research.
Dr. Parsons’ research at @fredhutch.org focuses on a type of cancer marker called circulating tumor DNA (#ctDNA) that can be detected in human blood.
🎈 Congrats! https://bit.ly/3LlEpST
Dr. Parsons’ research at @fredhutch.org focuses on a type of cancer marker called circulating tumor DNA (#ctDNA) that can be detected in human blood.
🎈 Congrats! https://bit.ly/3LlEpST
October 21, 2025 at 4:46 PM
Dr. Heather Parsons has been awarded the Maudslien Endowed Chair in Breast Cancer Precision Oncology Research.
Dr. Parsons’ research at @fredhutch.org focuses on a type of cancer marker called circulating tumor DNA (#ctDNA) that can be detected in human blood.
🎈 Congrats! https://bit.ly/3LlEpST
Dr. Parsons’ research at @fredhutch.org focuses on a type of cancer marker called circulating tumor DNA (#ctDNA) that can be detected in human blood.
🎈 Congrats! https://bit.ly/3LlEpST
Reposted by Immunology Podcast
Online now: ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death
ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death
TNF and type I IFNs are recognized as important drivers of skin inflammation. Priem et al. show that LC3-independent autophagy represses the ability of TNFR1 to directly trigger cGAS/STING-dependent type I IFN production and ZBP1 cytotoxicity, which prevents the development of a severe inflammatory skin disorder.
dlvr.it
October 20, 2025 at 2:49 PM
Online now: ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death
Reposted by Immunology Podcast
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
Author summary Recent epidemic-causing coronaviruses, including SARS-CoV-2, originated in bats. Large numbers of such viruses circulate in bats and pose clear and present risks to humans. However, our...
journals.plos.org
October 17, 2025 at 3:51 PM
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Reposted by Immunology Podcast
Deletion of the X-escapee gene Kdm6a in microglia reverses the disease-associated microglial translatome and has protective effects in female mice
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 15, 2025 at 7:21 PM
Deletion of the X-escapee gene Kdm6a in microglia reverses the disease-associated microglial translatome and has protective effects in female mice
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Immunology Podcast
Quantification of timelapse 3D tumor spheroid killing activity of NK cells using a live-cell imaging system @plosone.org journals.plos.org/plosone/arti...
October 15, 2025 at 4:26 PM
Quantification of timelapse 3D tumor spheroid killing activity of NK cells using a live-cell imaging system @plosone.org journals.plos.org/plosone/arti...
What is the relationship between food allergies and #AtopicDermatitis?
We cover a @cp-immunity.bsky.social paper from Boston Children's Hospital that explores how S. aureus skin colonization can lead to exaggerated #anaphylaxis.
Check it out on our latest episode: https://bit.ly/4mXBKMr
We cover a @cp-immunity.bsky.social paper from Boston Children's Hospital that explores how S. aureus skin colonization can lead to exaggerated #anaphylaxis.
Check it out on our latest episode: https://bit.ly/4mXBKMr
October 9, 2025 at 8:47 PM
What is the relationship between food allergies and #AtopicDermatitis?
We cover a @cp-immunity.bsky.social paper from Boston Children's Hospital that explores how S. aureus skin colonization can lead to exaggerated #anaphylaxis.
Check it out on our latest episode: https://bit.ly/4mXBKMr
We cover a @cp-immunity.bsky.social paper from Boston Children's Hospital that explores how S. aureus skin colonization can lead to exaggerated #anaphylaxis.
Check it out on our latest episode: https://bit.ly/4mXBKMr
Reposted by Immunology Podcast
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
October 9, 2025 at 6:06 PM
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
🔔 New episode alert!
Dr. Robin Orozco ( @robsorozco.bsky.social ) from the @universityofkansas.bsky.social joins us to chat about her work on allelic variation and immune responses.
Stream it here or on any podcast app: https://bit.ly/46Jf7GI
Dr. Robin Orozco ( @robsorozco.bsky.social ) from the @universityofkansas.bsky.social joins us to chat about her work on allelic variation and immune responses.
Stream it here or on any podcast app: https://bit.ly/46Jf7GI
October 8, 2025 at 1:00 AM
🔔 New episode alert!
Dr. Robin Orozco ( @robsorozco.bsky.social ) from the @universityofkansas.bsky.social joins us to chat about her work on allelic variation and immune responses.
Stream it here or on any podcast app: https://bit.ly/46Jf7GI
Dr. Robin Orozco ( @robsorozco.bsky.social ) from the @universityofkansas.bsky.social joins us to chat about her work on allelic variation and immune responses.
Stream it here or on any podcast app: https://bit.ly/46Jf7GI
Reposted by Immunology Podcast
Want to see immune cells in 3D? We’ve published a protocol for 5-plex 3D imaging of whole lymph nodes, revealing germinal centers at single-cell resolution. So many possibilities ahead! Congratulations Victoire Boulat!
tinyurl.com/y9ekha8c
#Microscopy #Immunology #SpatialBiology
tinyurl.com/y9ekha8c
#Microscopy #Immunology #SpatialBiology
October 6, 2025 at 4:23 PM
Want to see immune cells in 3D? We’ve published a protocol for 5-plex 3D imaging of whole lymph nodes, revealing germinal centers at single-cell resolution. So many possibilities ahead! Congratulations Victoire Boulat!
tinyurl.com/y9ekha8c
#Microscopy #Immunology #SpatialBiology
tinyurl.com/y9ekha8c
#Microscopy #Immunology #SpatialBiology
Our next guest is Dr. Robin Orozco ( @robsorozco.bsky.social ) from @universityofkansas.bsky.social
Her research focuses on the role of allelic variations in immunity.🧬
🔔 Tune in to the episode on Tuesday!
Her research focuses on the role of allelic variations in immunity.🧬
🔔 Tune in to the episode on Tuesday!
October 6, 2025 at 9:18 PM
Our next guest is Dr. Robin Orozco ( @robsorozco.bsky.social ) from @universityofkansas.bsky.social
Her research focuses on the role of allelic variations in immunity.🧬
🔔 Tune in to the episode on Tuesday!
Her research focuses on the role of allelic variations in immunity.🧬
🔔 Tune in to the episode on Tuesday!
Happy #InternationalPodcastDay! 🥳 We're celebrating by counting down our top three episodes of the year below. 👇
October 1, 2025 at 5:18 AM
Happy #InternationalPodcastDay! 🥳 We're celebrating by counting down our top three episodes of the year below. 👇
Dr. Dayana Rivadeneira and a team in Dr. Greg Delgoffe's lab showed that dysfunctional T cells in cancer harbor damaged #telomeres, which arise from oxidative stress.
📄 - https://bit.ly/42MrvmK
🗨️ - https://bit.ly/4mybUyr
📄 - https://bit.ly/42MrvmK
🗨️ - https://bit.ly/4mybUyr
September 25, 2025 at 4:10 PM
Dr. Dayana Rivadeneira and a team in Dr. Greg Delgoffe's lab showed that dysfunctional T cells in cancer harbor damaged #telomeres, which arise from oxidative stress.
📄 - https://bit.ly/42MrvmK
🗨️ - https://bit.ly/4mybUyr
📄 - https://bit.ly/42MrvmK
🗨️ - https://bit.ly/4mybUyr
This week: Dr. Upasana Das Adhikari and a team in Dr. Douglas Kwon's lab at the Ragon Institute of Mass General Brigham, MIT, and Harvard studied how immunometabolic defects disrupt the intestinal barrier in people with #HIV.
Paper: https://bit.ly/46wC5zp
Discussion: https://bit.ly/4mybUyr
Paper: https://bit.ly/46wC5zp
Discussion: https://bit.ly/4mybUyr
September 24, 2025 at 7:06 PM
This week: Dr. Upasana Das Adhikari and a team in Dr. Douglas Kwon's lab at the Ragon Institute of Mass General Brigham, MIT, and Harvard studied how immunometabolic defects disrupt the intestinal barrier in people with #HIV.
Paper: https://bit.ly/46wC5zp
Discussion: https://bit.ly/4mybUyr
Paper: https://bit.ly/46wC5zp
Discussion: https://bit.ly/4mybUyr
🔪 "On a knife’s edge between #pathogen control and #autoimmunity!"
Learn about Dr. Harikesh Wong's research on how #Tregs prevent autoimmunity during infection.
@hswonglab.bsky.social
📍 https://bit.ly/4mybUyr
Learn about Dr. Harikesh Wong's research on how #Tregs prevent autoimmunity during infection.
@hswonglab.bsky.social
📍 https://bit.ly/4mybUyr
September 23, 2025 at 11:14 PM
🔪 "On a knife’s edge between #pathogen control and #autoimmunity!"
Learn about Dr. Harikesh Wong's research on how #Tregs prevent autoimmunity during infection.
@hswonglab.bsky.social
📍 https://bit.ly/4mybUyr
Learn about Dr. Harikesh Wong's research on how #Tregs prevent autoimmunity during infection.
@hswonglab.bsky.social
📍 https://bit.ly/4mybUyr
Reposted by Immunology Podcast
Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
September 22, 2025 at 9:20 AM
Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...
Join us next week for a conversation with Dr. Harikesh Wong ( @hswonglab.bsky.social ) from the @ragoninstitute.bsky.social !
Check out his team's work on how #Tregs prevent #autoimmunity: https://bit.ly/3IuYdlL
Check out his team's work on how #Tregs prevent #autoimmunity: https://bit.ly/3IuYdlL
September 19, 2025 at 8:51 PM
Join us next week for a conversation with Dr. Harikesh Wong ( @hswonglab.bsky.social ) from the @ragoninstitute.bsky.social !
Check out his team's work on how #Tregs prevent #autoimmunity: https://bit.ly/3IuYdlL
Check out his team's work on how #Tregs prevent #autoimmunity: https://bit.ly/3IuYdlL