"The reduction in naive CD4+ and CD8+ T cells further supports the notion of persistent immune activation in these patients, potentially due to chronic persistence of SARS-CoV-2 antigens in tissues or hyperimmune activation and autoimmunity."
The dysregulated immune system in #LongCovid with #MECFS. with sex-specific changes, increased inflammation (as seen by cells, chemokines and cytokines), and disrupted hormone levels www.cell.com/cell-reports...
November 7, 2025 at 7:10 PM
"The reduction in naive CD4+ and CD8+ T cells further supports the notion of persistent immune activation in these patients, potentially due to chronic persistence of SARS-CoV-2 antigens in tissues or hyperimmune activation and autoimmunity."
Another great study from @nickjonesimmuno.bsky.social lab and collaborators, highlighting a novel metabolic target to modulate T cell function in context of autoimmunity
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
www.nature.com
November 5, 2025 at 7:44 AM
Another great study from @nickjonesimmuno.bsky.social lab and collaborators, highlighting a novel metabolic target to modulate T cell function in context of autoimmunity
and no, steroids do not make me hungry. certainly 1 week of steroids couldn't last 3 mos!
the only thing that makes me really hungry is gluten exposure, & the only thing it makes me hungry for is gluten. super weird neuropsych effect bc it produces "opioid-like" chemicals due to autoimmunity
the only thing that makes me really hungry is gluten exposure, & the only thing it makes me hungry for is gluten. super weird neuropsych effect bc it produces "opioid-like" chemicals due to autoimmunity
November 6, 2025 at 9:59 PM
and no, steroids do not make me hungry. certainly 1 week of steroids couldn't last 3 mos!
the only thing that makes me really hungry is gluten exposure, & the only thing it makes me hungry for is gluten. super weird neuropsych effect bc it produces "opioid-like" chemicals due to autoimmunity
the only thing that makes me really hungry is gluten exposure, & the only thing it makes me hungry for is gluten. super weird neuropsych effect bc it produces "opioid-like" chemicals due to autoimmunity
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
www.nature.com
November 3, 2025 at 10:20 AM
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human Th1 cell metabolism: Implications for antiviral defense and autoimmunity - Check out our new paper in Life Science Alliance: www.life-science-alliance.org/content/9/1/...
Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation
T helper (Th) cell lineages are linked to metabolism, but precise mechanisms in human Th1 cells remain unclear. We addressed this question by in vitro stimulation and CRISPR/Cas9-mediated gene editing...
www.life-science-alliance.org
November 4, 2025 at 8:59 AM
Human Th1 cell metabolism: Implications for antiviral defense and autoimmunity - Check out our new paper in Life Science Alliance: www.life-science-alliance.org/content/9/1/...
all that said, i did not mean to imply this above. neurodevelopmental disabilities, like other outcomes of sars2 infections—including autoimmunity—are conditions so many of us live fulfilling lives with; primarily made more difficult by inaccessible & ableist human-created systems we can change now.
I really hope some members of the Covid cautious community doesn't take this and run and be incredibly ableist in portraying neurodevelopmental disabilities as a horrible outcome.
“Among the 861 children whose mothers were SARS-CoV-2–positive during pregnancy, 140 (16.3%) received a neurodevelopmental diagnosis by 3 years of age, compared with 1,680 (9.7%) of the 17,263 remaining children from SARS-CoV-2–negative pregnancies.” www.massgeneralbrigham.org/en/about/new...
November 1, 2025 at 7:12 PM
all that said, i did not mean to imply this above. neurodevelopmental disabilities, like other outcomes of sars2 infections—including autoimmunity—are conditions so many of us live fulfilling lives with; primarily made more difficult by inaccessible & ableist human-created systems we can change now.
Imagine if there was something about as simple as putting shoes or pants on that reduced the risk of:
Heart attack
Stroke
Autoimmunity
Dementia
Liver & kidney problems
Diabetes
Possibly even cancer
And more...
Oh wait! There is! A well fitting FFP3 respirator does exactly that!
Heart attack
Stroke
Autoimmunity
Dementia
Liver & kidney problems
Diabetes
Possibly even cancer
And more...
Oh wait! There is! A well fitting FFP3 respirator does exactly that!
November 1, 2025 at 9:46 PM
Imagine if there was something about as simple as putting shoes or pants on that reduced the risk of:
Heart attack
Stroke
Autoimmunity
Dementia
Liver & kidney problems
Diabetes
Possibly even cancer
And more...
Oh wait! There is! A well fitting FFP3 respirator does exactly that!
Heart attack
Stroke
Autoimmunity
Dementia
Liver & kidney problems
Diabetes
Possibly even cancer
And more...
Oh wait! There is! A well fitting FFP3 respirator does exactly that!
Using a multi-step stimulation protocol, a team shows they can convert self-reacting, pathological CD4 T cells into stable antigen-specific regulatory T cells to suppress autoimmunity and treat pemphigus vulgaris in mice.
Learn more in #ScienceTranslationalMedicine: https://scim.ag/47qLomt
Learn more in #ScienceTranslationalMedicine: https://scim.ag/47qLomt
Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris
Functionally stable regulatory T cells converted in vitro from pathogenic T cells can confer antigen-specific immunosuppression in pemphigus vulgaris.
scim.ag
October 30, 2025 at 3:08 PM
Using a multi-step stimulation protocol, a team shows they can convert self-reacting, pathological CD4 T cells into stable antigen-specific regulatory T cells to suppress autoimmunity and treat pemphigus vulgaris in mice.
Learn more in #ScienceTranslationalMedicine: https://scim.ag/47qLomt
Learn more in #ScienceTranslationalMedicine: https://scim.ag/47qLomt
Welcome to our 9th Core Investigator and first physician-scientist, John Pluvinage. His team investigates the hidden overlap between autoimmunity and neurodegeneration, developing targeted treatments for mysterious neurological cases and common dementias.
October 29, 2025 at 3:25 PM
Welcome to our 9th Core Investigator and first physician-scientist, John Pluvinage. His team investigates the hidden overlap between autoimmunity and neurodegeneration, developing targeted treatments for mysterious neurological cases and common dementias.
TW mental health
Somewhat my mantra
From „Hi Ren“ by Ren
When I was seventeen years old, I shouted out into an empty room, into a blank canvas that I would defeat the forces of evil
And for the next ten years of my life I suffered the consequences...
With autoimmunity illness, and psychosis
1/4
Somewhat my mantra
From „Hi Ren“ by Ren
When I was seventeen years old, I shouted out into an empty room, into a blank canvas that I would defeat the forces of evil
And for the next ten years of my life I suffered the consequences...
With autoimmunity illness, and psychosis
1/4
October 29, 2025 at 9:05 PM
TW mental health
Somewhat my mantra
From „Hi Ren“ by Ren
When I was seventeen years old, I shouted out into an empty room, into a blank canvas that I would defeat the forces of evil
And for the next ten years of my life I suffered the consequences...
With autoimmunity illness, and psychosis
1/4
Somewhat my mantra
From „Hi Ren“ by Ren
When I was seventeen years old, I shouted out into an empty room, into a blank canvas that I would defeat the forces of evil
And for the next ten years of my life I suffered the consequences...
With autoimmunity illness, and psychosis
1/4
That’s what happens when you have no real, natural fears to modulate your fear system. Like the hygiene hypothesis of autoimmunity.
October 25, 2025 at 1:10 PM
That’s what happens when you have no real, natural fears to modulate your fear system. Like the hygiene hypothesis of autoimmunity.
Gosh million dollar Q. Endothelial damage feels plausible to me, but then, what drives that—persistent pathogen, autoimmunity, other?
Think we just don’t know yet. I hope research keeps knocking on all doors. Prematurely narrowing focus to just one hypothesis hasn’t served other diseases well.
Think we just don’t know yet. I hope research keeps knocking on all doors. Prematurely narrowing focus to just one hypothesis hasn’t served other diseases well.
October 26, 2025 at 4:59 AM
Gosh million dollar Q. Endothelial damage feels plausible to me, but then, what drives that—persistent pathogen, autoimmunity, other?
Think we just don’t know yet. I hope research keeps knocking on all doors. Prematurely narrowing focus to just one hypothesis hasn’t served other diseases well.
Think we just don’t know yet. I hope research keeps knocking on all doors. Prematurely narrowing focus to just one hypothesis hasn’t served other diseases well.
And likely some implications for understanding the cross-section between mechanisms of autoimmunity and anti-tumour immunity.
October 24, 2025 at 2:56 AM
And likely some implications for understanding the cross-section between mechanisms of autoimmunity and anti-tumour immunity.
🚨🧵 by Vipin M. Vashishtha aka @vipintukur:
"Understanding Long COVID
➡️ Long COVID isn’t one disease — it’s a complex web of immune, vascular, and metabolic dysfunctions.
From fatigue & brain fog to heart & lung complications..."
Full 🧵:
threadreaderapp.com/thread/19810...
"Understanding Long COVID
➡️ Long COVID isn’t one disease — it’s a complex web of immune, vascular, and metabolic dysfunctions.
From fatigue & brain fog to heart & lung complications..."
Full 🧵:
threadreaderapp.com/thread/19810...
October 24, 2025 at 1:49 AM
🚨🧵 by Vipin M. Vashishtha aka @vipintukur:
"Understanding Long COVID
➡️ Long COVID isn’t one disease — it’s a complex web of immune, vascular, and metabolic dysfunctions.
From fatigue & brain fog to heart & lung complications..."
Full 🧵:
threadreaderapp.com/thread/19810...
"Understanding Long COVID
➡️ Long COVID isn’t one disease — it’s a complex web of immune, vascular, and metabolic dysfunctions.
From fatigue & brain fog to heart & lung complications..."
Full 🧵:
threadreaderapp.com/thread/19810...
Proposed contributors to Long COVID include
persistent viral infection
latent virus reactivation,
immune dysregulation
autoimmunity
gut microbiota alterations
mitochondrial dysfunction
endothelial injury and coagulation abnormalities
www.tandfonline.com/doi/full/10....
persistent viral infection
latent virus reactivation,
immune dysregulation
autoimmunity
gut microbiota alterations
mitochondrial dysfunction
endothelial injury and coagulation abnormalities
www.tandfonline.com/doi/full/10....
October 23, 2025 at 5:37 AM
Proposed contributors to Long COVID include
persistent viral infection
latent virus reactivation,
immune dysregulation
autoimmunity
gut microbiota alterations
mitochondrial dysfunction
endothelial injury and coagulation abnormalities
www.tandfonline.com/doi/full/10....
persistent viral infection
latent virus reactivation,
immune dysregulation
autoimmunity
gut microbiota alterations
mitochondrial dysfunction
endothelial injury and coagulation abnormalities
www.tandfonline.com/doi/full/10....
#Medsky🧪 #IDsky #Autoimmunity #immunosky #Publichealth Several #casereports have documented instances of acute viral induced #myopathy from #postcovid ,highlighting muscle pain, weakness & elevated muscle enzymes as common features.
October 17, 2025 at 3:41 AM
#Medsky🧪 #IDsky #Autoimmunity #immunosky #Publichealth Several #casereports have documented instances of acute viral induced #myopathy from #postcovid ,highlighting muscle pain, weakness & elevated muscle enzymes as common features.
This afternoon, we're excited to be joined by @georgearobinson.bsky.social from @ucl.ac.uk for our next @britsocimm.bsky.social MIG seminar:
“The interferon nexus: sex differences, autoimmunity, and cardiovascular disease”
📅 Thursday 16th October
🕐 3 pm
📍 Michael Smith Lecture Theatre
#ImmunoSky
“The interferon nexus: sex differences, autoimmunity, and cardiovascular disease”
📅 Thursday 16th October
🕐 3 pm
📍 Michael Smith Lecture Theatre
#ImmunoSky
October 16, 2025 at 8:13 AM
This afternoon, we're excited to be joined by @georgearobinson.bsky.social from @ucl.ac.uk for our next @britsocimm.bsky.social MIG seminar:
“The interferon nexus: sex differences, autoimmunity, and cardiovascular disease”
📅 Thursday 16th October
🕐 3 pm
📍 Michael Smith Lecture Theatre
#ImmunoSky
“The interferon nexus: sex differences, autoimmunity, and cardiovascular disease”
📅 Thursday 16th October
🕐 3 pm
📍 Michael Smith Lecture Theatre
#ImmunoSky
want to know more about the ways SARS2 and autoimmunity are related? i’ve gotchu covered with my ever growing ✨mega-thread✨ of literature in the quote 👇🏻
📌 mega-thread of autoimmunity x covid ❗
things you may find:
- studies showing sars2 infection leads to autoimmunity
- studies showing impacts of sars2 on autoimmune people
- anything else i feel like fits
things you may find:
- studies showing sars2 infection leads to autoimmunity
- studies showing impacts of sars2 on autoimmune people
- anything else i feel like fits
Wanna be just like me— the shitty part? Get your very own autoimmune disease by joining in with widespread covid denial and government austerity!
Wanna be just like me— the cool part? Ventilate, filter, mask up. #covidcautious
jamanetwork.com/journals/jam...
Wanna be just like me— the cool part? Ventilate, filter, mask up. #covidcautious
jamanetwork.com/journals/jam...
October 15, 2025 at 9:27 PM
want to know more about the ways SARS2 and autoimmunity are related? i’ve gotchu covered with my ever growing ✨mega-thread✨ of literature in the quote 👇🏻
it is unfortunately not rare to develop an autoimmune disease after an acute covid infection.
ive been autoimmune since i was 12, finally diagnosed at 22, comin up on 32 now—i know i make autoimmunity look [teen girl squad voice] ✨💁🏻♀️ soOoOo good 💁🏻♀️✨ but please hear me when i say: the mask sucks less.
ive been autoimmune since i was 12, finally diagnosed at 22, comin up on 32 now—i know i make autoimmunity look [teen girl squad voice] ✨💁🏻♀️ soOoOo good 💁🏻♀️✨ but please hear me when i say: the mask sucks less.
I teach all of my classes in an N95 because my gift from having COVID (pre-vaccine) is an autoimmune disease that destroys my kidney function. COVID gave me kidney failure, which will require a kidney transplant. What's the #1 cause of death (aside from CKD) in patients waiting for dialysis? COVID.
(and i think it is a demand that stems from fear more than a rational assessment of the threat environment)
October 15, 2025 at 9:26 PM
it is unfortunately not rare to develop an autoimmune disease after an acute covid infection.
ive been autoimmune since i was 12, finally diagnosed at 22, comin up on 32 now—i know i make autoimmunity look [teen girl squad voice] ✨💁🏻♀️ soOoOo good 💁🏻♀️✨ but please hear me when i say: the mask sucks less.
ive been autoimmune since i was 12, finally diagnosed at 22, comin up on 32 now—i know i make autoimmunity look [teen girl squad voice] ✨💁🏻♀️ soOoOo good 💁🏻♀️✨ but please hear me when i say: the mask sucks less.
I mean we similar rapid separation for GLP1 drugs across inflammatory diseases, i wonder if there’s just some major regulatory of autoimmunity which gets clobbered by hyperglycemia
October 16, 2025 at 11:56 AM
I mean we similar rapid separation for GLP1 drugs across inflammatory diseases, i wonder if there’s just some major regulatory of autoimmunity which gets clobbered by hyperglycemia
💙 Why Very Severe ME/CFS Can Cause Paralysis 💙
It’s not psychological — it’s biological.
⚡ Energy failure, nerve signal breakdown, brainstem inflammation, blood flow collapse, & autoimmunity can all cause paralysis in ME/CFS.
It’s not psychological — it’s biological.
⚡ Energy failure, nerve signal breakdown, brainstem inflammation, blood flow collapse, & autoimmunity can all cause paralysis in ME/CFS.
October 14, 2025 at 9:38 PM
💙 Why Very Severe ME/CFS Can Cause Paralysis 💙
It’s not psychological — it’s biological.
⚡ Energy failure, nerve signal breakdown, brainstem inflammation, blood flow collapse, & autoimmunity can all cause paralysis in ME/CFS.
It’s not psychological — it’s biological.
⚡ Energy failure, nerve signal breakdown, brainstem inflammation, blood flow collapse, & autoimmunity can all cause paralysis in ME/CFS.
And if you needed any more convincing about the importance of #Tregs, check out this #Viewpoint written by Shimon for @jem.org's 125th anniversary about the role of Tregs in immunological self-tolerance and autoimmunity 👉 rupress.org/jem/article/...
Taking regulatory T cells into medicine | Journal of Experimental Medicine | Rockefeller University Press
Shimon Sakaguchi recounts the work that lead to the identification of regulatory T cells.
rupress.org
October 9, 2025 at 8:13 PM
And if you needed any more convincing about the importance of #Tregs, check out this #Viewpoint written by Shimon for @jem.org's 125th anniversary about the role of Tregs in immunological self-tolerance and autoimmunity 👉 rupress.org/jem/article/...
So excited to share our preprint uncovering FGFR3 autoantibodies as pathogenic drivers of pain sensitization.
Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity.
#PainResearch #Autoimmunity
Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity.
#PainResearch #Autoimmunity
Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy
Sensory neuronopathies (SNN) and small fiber neuropathies (SFN) are debilitating disorders associated with neuropathic pain, yet their underlying mechanisms remain poorly understood. Autoantibodies ag...
www.biorxiv.org
October 9, 2025 at 5:05 PM
So excited to share our preprint uncovering FGFR3 autoantibodies as pathogenic drivers of pain sensitization.
Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity.
#PainResearch #Autoimmunity
Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity.
#PainResearch #Autoimmunity
The #ColtonConsortium was proud to serve as lead sponsor of the 2025 FASEB #Autoimmunity Conference in Niagara Falls this summer—an influential gathering that advances autoimmune research and fosters collaboration among scientists and clinicians worldwide. Read the recap: https://bit.ly/46Yk1hZ
October 9, 2025 at 2:05 PM
The #ColtonConsortium was proud to serve as lead sponsor of the 2025 FASEB #Autoimmunity Conference in Niagara Falls this summer—an influential gathering that advances autoimmune research and fosters collaboration among scientists and clinicians worldwide. Read the recap: https://bit.ly/46Yk1hZ
ICYMI: a special collection spotlighting recent, cutting-edge research on the mechanistic aspects of innate immune signaling upon #infection, in #autoimmunity, and in #neurodegeneration.
rupress.org/jem/collecti...
#InnateImmunity
rupress.org/jem/collecti...
#InnateImmunity
October 8, 2025 at 2:07 PM
ICYMI: a special collection spotlighting recent, cutting-edge research on the mechanistic aspects of innate immune signaling upon #infection, in #autoimmunity, and in #neurodegeneration.
rupress.org/jem/collecti...
#InnateImmunity
rupress.org/jem/collecti...
#InnateImmunity