This Review explores the evolution of SARS-CoV-2 since its emergence in late 2019 and discusses how the changes in the various variants and subvariants have affected the viral life cycle and ongoing t...

The co-discoverer of the structure of DNA helped to strengthen a US research institute and wrote a classic textbook, but also earned a reputation for racist and sexist comments.

The identification of a non-canonical SUMO-interacting motif (SIM) within the Rep protein of tomato yellow leaf curl virus (TYLCV) reveals a connection between viral replication and a protein modifica...

DENV is a mosquito-borne virus that can cause severe illness, particularly in tropical and subtropical regions. In 2015, a strain of DENV-2 caused a major outbreak in Taiwan with high mortality rates....

Tomato spotted wilt virus (TSWV) is a highly destructive plant pathogen transmitted by thrips, including Frankliniella occidentalis, in a circulative and propagative manner. To counter viral infection...

Hepatitis B virus (HBV) is a hepatotropic DNA virus that infects over 250 million people worldwide and causes serious liver diseases. HBV infection can modulate host cellular processes, potentially in...

Texas health officials say the state has a seen a fourfold increase in whooping cough cases compared with last year.

In Michigan, 113,000 birds were affected on a turkey farm in Ottawa County, the state's third detection in commercial turkeys in less than a week.

Mpox re-emerged globally in 2022 with atypical clinical features and efficient human-to-human transmission, which underscores the need to better understand host immune responses. We conducted an integ...

DISC1 attenuates Zika virus infection and congenital Zika syndrome by promoting autophagy via AMPK-mTOR signaling and is implicated in ZIKV-induced long-term neurological deficits.

Hepatitis C virus (HCV) infection induces extensive rearrangements of host cytoplasmic membranes, leading to the formation of multiple membranous structures that facilitate RNA replication. Current kn...

Rabies is a fatal zoonosis that impairs host immune function, yet effects on peripheral lymphoid architecture are poorly defined. During a 2021–2022 rabies virus (RABV) outbreak in South Africa, we co...

Entering its second decade, philanthropy with Facebook fortune has shed social causes and now focuses on ambitious science dream

npj Vaccines - A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness

npj Vaccines - Recombinant AAV vaccine expressing PEDV S1 enhances immunity with superior neonatal protection

Coronaviruses remodel host membranes through the action of non-structural proteins to generate double-membrane vesicles (DMVs), which serve as platforms for viral replication-transcription complexes (RTCs). Deciphering the molecular mechanisms governing DMV assembly and RTC recruitment is critical for understanding coronavirus replication and identifying novel antiviral targets. Here, we developed a surrogate system that recapitulates DMV formation in the absence of viral replication, enabling genetic manipulation and functional dissection of individual proteins. Using this system, we demonstrate that expression of the SARS-CoV-2 nsp3-10 polyprotein is sufficient to drive DMV formation and reveal a pivotal role for the membrane-associated element (MAE) of nsp6 in this process. These findings establish a tractable model for investigating coronavirus-induced membrane remodeling and underscore the essential contributions of nsp6 to DMV biogenesis.