Tina Perica
@glukozica.bsky.social
Assistant professor of Biochemistry, University of Zurich
Lab: https://perica.bioc.uzh.ch
Too school for cool
Lab: https://perica.bioc.uzh.ch
Too school for cool
May her memory be a blessing.
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
November 1, 2025 at 9:22 AM
May her memory be a blessing.
Reposted by Tina Perica
The amount of AI generated art in slides at this conference, primarily used by older scientists, is killing me. Scientists please. Don’t use these ai platforms to make your figures or slides. They look bad and I have yet to see them meaningfully improve the message of talks.
October 31, 2025 at 3:09 AM
The amount of AI generated art in slides at this conference, primarily used by older scientists, is killing me. Scientists please. Don’t use these ai platforms to make your figures or slides. They look bad and I have yet to see them meaningfully improve the message of talks.
Oh, bloody brilliant! Guess what I’m replying next time I don’t care to review something!
Nothing can prepare you for the factual basis behind this 'wokeness gone too far' anecdote.
October 28, 2025 at 3:26 PM
Oh, bloody brilliant! Guess what I’m replying next time I don’t care to review something!
Reposted by Tina Perica
The @nytimes.com decided last year what the story was; Trump II was the righteous punishment visited upon their interns and junior staffers and grandchildren for being so annoying about MeToo and BLM, and once they understood that and repented, they could have democracy back.
October 21, 2025 at 1:57 AM
The @nytimes.com decided last year what the story was; Trump II was the righteous punishment visited upon their interns and junior staffers and grandchildren for being so annoying about MeToo and BLM, and once they understood that and repented, they could have democracy back.
Reposted by Tina Perica
I wrote a blog post about the future of structural bioinformatics.
Where to go after AlphaFold? How do we avoid the field becoming a load of half-baked LLMs?
Let me know what you think.
jgreener64.github.io/posts/struct...
Where to go after AlphaFold? How do we avoid the field becoming a load of half-baked LLMs?
Let me know what you think.
jgreener64.github.io/posts/struct...
Where next for structural bioinformatics?
jgreener64.github.io
October 15, 2025 at 2:16 PM
I wrote a blog post about the future of structural bioinformatics.
Where to go after AlphaFold? How do we avoid the field becoming a load of half-baked LLMs?
Let me know what you think.
jgreener64.github.io/posts/struct...
Where to go after AlphaFold? How do we avoid the field becoming a load of half-baked LLMs?
Let me know what you think.
jgreener64.github.io/posts/struct...
Skeetorial on our BRAF preprint!
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer
The RAF/MEK/ERK signaling cascade regulates cell proliferation and differentiation and is frequently dysregulated in cancer. Approximately 90% of RAF-mutant cancers harbour mutations in B-type of Rapi...
tinyurl.com
October 14, 2025 at 8:17 AM
Skeetorial on our BRAF preprint!
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
Reposted by Tina Perica
For every Nobel that goes to a criminally under-recognized woman scientist (Brunkow, Karikó), or fails to go (Candy Lee), a week of mourning and reform for an academic system wherein you can do Nobel-prize-worthy-work and still end up without a conceivable path to being a professor.
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
October 6, 2025 at 10:13 AM
For every Nobel that goes to a criminally under-recognized woman scientist (Brunkow, Karikó), or fails to go (Candy Lee), a week of mourning and reform for an academic system wherein you can do Nobel-prize-worthy-work and still end up without a conceivable path to being a professor.
Seems like they also listen to Ghost at Science!
Last year, a special issue of Science explored the complex and close associations #rats share with humans—from their ubiquity in the human environment to their crucial role as biomedical models.
🐀 Learn more: https://scim.ag/46VBOrb #ScienceMagArchives
🐀 Learn more: https://scim.ag/46VBOrb #ScienceMagArchives
September 29, 2025 at 2:46 PM
Seems like they also listen to Ghost at Science!
First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1
September 28, 2025 at 10:33 AM
First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)
Reposted by Tina Perica
In case you missed it: an essential piece from Olúfẹ́mi O. Táíwò from earlier this week:
www.bostonreview.net/articles/how...
www.bostonreview.net/articles/how...
How Can We Live Together? - Boston Review
Ezra Klein is wrong: shame is essential.
www.bostonreview.net
September 27, 2025 at 11:34 AM
In case you missed it: an essential piece from Olúfẹ́mi O. Táíwò from earlier this week:
www.bostonreview.net/articles/how...
www.bostonreview.net/articles/how...
Reposted by Tina Perica
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1
September 27, 2025 at 5:46 AM
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1
Slightly diminish a book
Windy Heights
Windy Heights
Slightly diminish a book
100 Days of Solitude
100 Days of Solitude
Slightly diminish a book
The State and Nonviolent Civil Disobedience
The State and Nonviolent Civil Disobedience
September 8, 2025 at 1:59 PM
Slightly diminish a book
Windy Heights
Windy Heights
Reposted by Tina Perica
Monumental effort from @maxbillmann.bsky.social and colleagues, quantifying genetic interactions among 4 million human gene pairs. Lots of features associated with genetic interaction & GI degree conserved from yeast. www.biorxiv.org/content/10.1...
A global genetic interaction map of a human cell reveals conserved principles of genetic networks
We generated a genome-scale, genetic interaction network from the analysis of more than 4 million double mutants in the haploid human cell line, HAP1. The network maps ∼90,000 genetic interactions, in...
www.biorxiv.org
August 20, 2025 at 11:00 AM
Monumental effort from @maxbillmann.bsky.social and colleagues, quantifying genetic interactions among 4 million human gene pairs. Lots of features associated with genetic interaction & GI degree conserved from yeast. www.biorxiv.org/content/10.1...
Reposted by Tina Perica
I also really dislike that talking about AI in this way by journalists - and discrediting humans who actually worked on a paper in the process - is basically free advertising for the AI industry.
August 15, 2025 at 6:14 AM
I also really dislike that talking about AI in this way by journalists - and discrediting humans who actually worked on a paper in the process - is basically free advertising for the AI industry.
Reposted by Tina Perica
ECRs who probably did the bulk of the work go completely unmentioned in the piece, in lieu of putting all credit on some anonymous and benevolent AI force that's probably just a few tens of millions of weights in a PyTorch model
AI designs new superbug-killing antibiotics for gonorrhoea and MRSA
Two new potential drugs have been designed by AI to kill drug-resistant bacteria, in a major Massachusetts Institute of Technology study.
www.bbc.com
August 15, 2025 at 6:14 AM
ECRs who probably did the bulk of the work go completely unmentioned in the piece, in lieu of putting all credit on some anonymous and benevolent AI force that's probably just a few tens of millions of weights in a PyTorch model
Reposted by Tina Perica
I really dislike how science has started calling almost any fancy computational technique AI. 🧪
The framing of this entire article makes it sound like a benevolent AI independently made these drugs.
That is *pure fantasy*.
Instead: a team of scientists made a machine learning model for a study.
The framing of this entire article makes it sound like a benevolent AI independently made these drugs.
That is *pure fantasy*.
Instead: a team of scientists made a machine learning model for a study.
August 15, 2025 at 6:14 AM
I really dislike how science has started calling almost any fancy computational technique AI. 🧪
The framing of this entire article makes it sound like a benevolent AI independently made these drugs.
That is *pure fantasy*.
Instead: a team of scientists made a machine learning model for a study.
The framing of this entire article makes it sound like a benevolent AI independently made these drugs.
That is *pure fantasy*.
Instead: a team of scientists made a machine learning model for a study.
Reposted by Tina Perica
We are excited to share our preprint describing DirectContacts2! Here we develop a machine learning model to discriminate between direct and indirect protein interactions. We use our model to construct a highly accurate wiring diagram of the human cell.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
DirectContacts2: A network of direct physical protein interactions derived from high-throughput mass spectrometry experiments
Cellular function is driven by the activity proteins in stable complexes. Protein complex assembly depends on the direct physical association of component proteins. Advances in macromolecular structur...
www.biorxiv.org
July 29, 2025 at 8:58 PM
We are excited to share our preprint describing DirectContacts2! Here we develop a machine learning model to discriminate between direct and indirect protein interactions. We use our model to construct a highly accurate wiring diagram of the human cell.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tina Perica
When you’re so busy crowing about your political motivations that you forget to pretend you did it for the Jews.
Linda McMahon on Columbia settlement: "This is a monumental victory for conservatives who wanted to do things on these elite campuses for a long time because we had such far left-leaning professors."
July 24, 2025 at 12:32 PM
When you’re so busy crowing about your political motivations that you forget to pretend you did it for the Jews.
Reposted by Tina Perica
These NPG spinoff journals are out of control
June 29, 2025 at 4:50 PM
These NPG spinoff journals are out of control
This. It’s such a no-brainer, really
I think the ERC is 15-20% of the EU research and innovation budget. A lot of the other EU grants schemes are, in my opinion, going to large collaborative grants that aren't as efficient or doing as exciting research. Even making the ERC 50% of the research budget could make a great impact
April 19, 2025 at 8:06 AM
This. It’s such a no-brainer, really
Reposted by Tina Perica
April 17, 2025 at 4:26 PM
Reposted by Tina Perica
We are looking for a postdoctoral fellow to join us to explore telomerase regulation by histones. Please get in touch if this may interest you.
Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach.
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs
April 16, 2025 at 5:25 PM
We are looking for a postdoctoral fellow to join us to explore telomerase regulation by histones. Please get in touch if this may interest you.
Reposted by Tina Perica
How can an individual protein show adaptation? The light- and temp-sensitive BcLOV4 gives a pulse of translocation during a step input of light. Answer in our preprint: *intra-molecular* feed-forward regulation. bit.ly/3Rg9veD
A @bugajlab.bsky.social collab with @nmrkaygee.bsky.social 🧵
A @bugajlab.bsky.social collab with @nmrkaygee.bsky.social 🧵
April 15, 2025 at 2:46 PM
How can an individual protein show adaptation? The light- and temp-sensitive BcLOV4 gives a pulse of translocation during a step input of light. Answer in our preprint: *intra-molecular* feed-forward regulation. bit.ly/3Rg9veD
A @bugajlab.bsky.social collab with @nmrkaygee.bsky.social 🧵
A @bugajlab.bsky.social collab with @nmrkaygee.bsky.social 🧵
Reposted by Tina Perica
DOGE is a criminal conspiracy to defraud the people of the United States
Oh dear you’re going to want to read this. Looks like DOGErs were caught exfiltrating NLRB data, likely on unions, for private (seemingly Elony) use. This is must read. What we’ve all suspected. But now details. www.npr.org/2025/04/15/n...
A whistleblower's disclosure details how DOGE may have taken sensitive labor data
A whistleblower tells Congress and NPR that DOGE may have taken sensitive labor data and hid its tracks. "None of that ... information should ever leave the agency," said a former NLRB official.
www.npr.org
April 15, 2025 at 12:47 PM
DOGE is a criminal conspiracy to defraud the people of the United States
Not to worry, it will all trickle down to the poor racists!
“He made 2.5 million today and he made $900 million. That’s not bad.”
Sounds like market manipulation to me. That’s bad.
Sounds like market manipulation to me. That’s bad.
April 10, 2025 at 12:46 PM
Not to worry, it will all trickle down to the poor racists!