Willow Coyote-Maestas
@willowcoyote.bsky.social
Assistant Professor at @UCSF_BTS | @HHMINEWS HGF | | Loving membrane proteins every day https://www.wcoyotelab.com
Reposted by Willow Coyote-Maestas
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 7, 2025 at 11:43 PM
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
Reposted by Willow Coyote-Maestas
Zara was one of the best people I've crossed paths with in this career, in this life. A fissure has opened with her departure, and I will miss her terribly.
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
November 1, 2025 at 1:05 AM
Zara was one of the best people I've crossed paths with in this career, in this life. A fissure has opened with her departure, and I will miss her terribly.
Reposted by Willow Coyote-Maestas
Zara was an inspiration. We never met in person but became friends through Leading Edge. She zealously advocated for her ideals, but was also passionate about helping others realize why they should too. Her loss is gutting & the world is the worse for it. RIP, I'll do my best to continue the fight.
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
October 31, 2025 at 4:44 PM
Zara was an inspiration. We never met in person but became friends through Leading Edge. She zealously advocated for her ideals, but was also passionate about helping others realize why they should too. Her loss is gutting & the world is the worse for it. RIP, I'll do my best to continue the fight.
Reposted by Willow Coyote-Maestas
We are all better because of the energy, inspiration, brilliance, and tenacity that Zara was. A bright light, role model, advocate & snarky tweeter... everything I needed in a person when I was navigating dark times when we met in 2021. You will be missed deeply, Zara, but never forgotten ❤️
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
October 31, 2025 at 5:20 PM
We are all better because of the energy, inspiration, brilliance, and tenacity that Zara was. A bright light, role model, advocate & snarky tweeter... everything I needed in a person when I was navigating dark times when we met in 2021. You will be missed deeply, Zara, but never forgotten ❤️
Reposted by Willow Coyote-Maestas
Zara was a great inspiration and mentor... Its really sad the excellent often leave us too soon... You will be missed Zara 💕
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
October 31, 2025 at 8:01 PM
Zara was a great inspiration and mentor... Its really sad the excellent often leave us too soon... You will be missed Zara 💕
Reposted by Willow Coyote-Maestas
Zara will be missed. Such terrible news.
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
October 31, 2025 at 9:01 PM
Zara will be missed. Such terrible news.
Reposted by Willow Coyote-Maestas
Zara Weinberg was a brilliant, loving, and beautiful woman. She inspired everyone who she interacted with, and always strived to make the world a better place for everyone. Tho the world is a little less bright today without her, her memory will always be a blessing.
She was truly one of the best.
She was truly one of the best.
October 30, 2025 at 8:55 PM
Zara Weinberg was a brilliant, loving, and beautiful woman. She inspired everyone who she interacted with, and always strived to make the world a better place for everyone. Tho the world is a little less bright today without her, her memory will always be a blessing.
She was truly one of the best.
She was truly one of the best.
Reposted by Willow Coyote-Maestas
Truly one of the best. We worked on various initiatives/wrote a paper together, and had the best conference meet ups. She was a bold and tireless advocate for change. Last time we met, we had a great time trying new cuisine and imagining a future that’s so different for trainees than we experienced.
Zara Weinberg was a brilliant, loving, and beautiful woman. She inspired everyone who she interacted with, and always strived to make the world a better place for everyone. Tho the world is a little less bright today without her, her memory will always be a blessing.
She was truly one of the best.
She was truly one of the best.
October 30, 2025 at 9:59 PM
Truly one of the best. We worked on various initiatives/wrote a paper together, and had the best conference meet ups. She was a bold and tireless advocate for change. Last time we met, we had a great time trying new cuisine and imagining a future that’s so different for trainees than we experienced.
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
October 31, 2025 at 1:18 PM
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
Reposted by Willow Coyote-Maestas
We are #hiring for a Tenure Track Assistant Professor position in the Department of Molecular&Cellular Physiology (med.stanford.edu/mcp.html) at @stanfordmedicine.bsky.social. Please apply or forward the opportunity to anybody who might be interested.
facultypositions.stanford.edu/en-us/job/49...
facultypositions.stanford.edu/en-us/job/49...
Stanford | Faculty Positions: Details - Assistant Professor of Molecular and Cellular Physiology
facultypositions.stanford.edu
October 29, 2025 at 5:13 PM
We are #hiring for a Tenure Track Assistant Professor position in the Department of Molecular&Cellular Physiology (med.stanford.edu/mcp.html) at @stanfordmedicine.bsky.social. Please apply or forward the opportunity to anybody who might be interested.
facultypositions.stanford.edu/en-us/job/49...
facultypositions.stanford.edu/en-us/job/49...
Reposted by Willow Coyote-Maestas
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes
Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...
www.science.org
October 2, 2025 at 10:55 PM
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
I love writing spontaneous and unsolicited reviews. I would be thrilled folks did it to me too! I think it gets the heart of what we do science for - giving and getting feedback to get closer to the ‘truth’! Otherwise why post a preprint if you don’t want people to read and respond?
Why hasn't Preprint Peer Review caught on more?
I discovered a small, but simple reason - authors are missing out on the JOY of getting feedback because they aren't notified when feedback occurs.
more in thread below!
I discovered a small, but simple reason - authors are missing out on the JOY of getting feedback because they aren't notified when feedback occurs.
more in thread below!
September 8, 2025 at 9:12 PM
I love writing spontaneous and unsolicited reviews. I would be thrilled folks did it to me too! I think it gets the heart of what we do science for - giving and getting feedback to get closer to the ‘truth’! Otherwise why post a preprint if you don’t want people to read and respond?
Reposted by Willow Coyote-Maestas
Check out MitoScribe in our new preprint led by Linhan Wang: www.biorxiv.org/content/10.1...
It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store information about historical signaling in a cell. Single cell resolution at scale (see next post)!
It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store information about historical signaling in a cell. Single cell resolution at scale (see next post)!
September 8, 2025 at 5:13 PM
Check out MitoScribe in our new preprint led by Linhan Wang: www.biorxiv.org/content/10.1...
It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store information about historical signaling in a cell. Single cell resolution at scale (see next post)!
It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store information about historical signaling in a cell. Single cell resolution at scale (see next post)!
Reposted by Willow Coyote-Maestas
1st day of classes went well for this associate professor! I’ll ride this tenure/promotion wave for another week.
I’m teaching a new chemical biology class this semester. Excited to bring computational chemistry topics & hands-on activities in the computer lab.
Also still masking this semester!
I’m teaching a new chemical biology class this semester. Excited to bring computational chemistry topics & hands-on activities in the computer lab.
Also still masking this semester!
August 26, 2025 at 4:29 PM
1st day of classes went well for this associate professor! I’ll ride this tenure/promotion wave for another week.
I’m teaching a new chemical biology class this semester. Excited to bring computational chemistry topics & hands-on activities in the computer lab.
Also still masking this semester!
I’m teaching a new chemical biology class this semester. Excited to bring computational chemistry topics & hands-on activities in the computer lab.
Also still masking this semester!
Reposted by Willow Coyote-Maestas
Latest pre-print from our lab is out. Great work by @alexbendel.bsky.social and team.
Full deep mutational scan of an entire human protein interaction domain family
2M quantitative measurement of protein-protein interaction -> deep learning model to predict PPI from sequence
More details 👇
Full deep mutational scan of an entire human protein interaction domain family
2M quantitative measurement of protein-protein interaction -> deep learning model to predict PPI from sequence
More details 👇
I am happy to finally share this preprint of my PhD project in @guillaumediss.bsky.social lab at the FMI in Basel.
We used ddPCA to map the genetic architecture of the entire human bZIP interaction network.
www.biorxiv.org/content/10.1...
Thanks to all our co-authors for the great collaboration!
We used ddPCA to map the genetic architecture of the entire human bZIP interaction network.
www.biorxiv.org/content/10.1...
Thanks to all our co-authors for the great collaboration!
The genetic architecture of the human bZIP family
Generative biology holds the promise to transform our ability to design and understand living systems by creating novel proteins, pathways, and organisms with tailored functions that address challenge...
www.biorxiv.org
August 25, 2025 at 3:37 PM
Latest pre-print from our lab is out. Great work by @alexbendel.bsky.social and team.
Full deep mutational scan of an entire human protein interaction domain family
2M quantitative measurement of protein-protein interaction -> deep learning model to predict PPI from sequence
More details 👇
Full deep mutational scan of an entire human protein interaction domain family
2M quantitative measurement of protein-protein interaction -> deep learning model to predict PPI from sequence
More details 👇
Reposted by Willow Coyote-Maestas
Congrats Kevin Allan, Jesse Zhan, @tymillerlab.bsky.social, @tesarlab.bsky.social, et al
It was fun to do some super-resolution microscopy to help look into how a cell matures, all while sending a lot of spooky faces to Paul and Kevin since, unlike these Sox6 ko cells, I have yet to mature 😱😱😱😱😱
It was fun to do some super-resolution microscopy to help look into how a cell matures, all while sending a lot of spooky faces to Paul and Kevin since, unlike these Sox6 ko cells, I have yet to mature 😱😱😱😱😱
August 25, 2025 at 7:21 PM
Congrats Kevin Allan, Jesse Zhan, @tymillerlab.bsky.social, @tesarlab.bsky.social, et al
It was fun to do some super-resolution microscopy to help look into how a cell matures, all while sending a lot of spooky faces to Paul and Kevin since, unlike these Sox6 ko cells, I have yet to mature 😱😱😱😱😱
It was fun to do some super-resolution microscopy to help look into how a cell matures, all while sending a lot of spooky faces to Paul and Kevin since, unlike these Sox6 ko cells, I have yet to mature 😱😱😱😱😱
Reposted by Willow Coyote-Maestas
I am happy to finally share this preprint of my PhD project in @guillaumediss.bsky.social lab at the FMI in Basel.
We used ddPCA to map the genetic architecture of the entire human bZIP interaction network.
www.biorxiv.org/content/10.1...
Thanks to all our co-authors for the great collaboration!
We used ddPCA to map the genetic architecture of the entire human bZIP interaction network.
www.biorxiv.org/content/10.1...
Thanks to all our co-authors for the great collaboration!
The genetic architecture of the human bZIP family
Generative biology holds the promise to transform our ability to design and understand living systems by creating novel proteins, pathways, and organisms with tailored functions that address challenge...
www.biorxiv.org
August 25, 2025 at 3:30 PM
I am happy to finally share this preprint of my PhD project in @guillaumediss.bsky.social lab at the FMI in Basel.
We used ddPCA to map the genetic architecture of the entire human bZIP interaction network.
www.biorxiv.org/content/10.1...
Thanks to all our co-authors for the great collaboration!
We used ddPCA to map the genetic architecture of the entire human bZIP interaction network.
www.biorxiv.org/content/10.1...
Thanks to all our co-authors for the great collaboration!
Reposted by Willow Coyote-Maestas
I got to share a bit about Indigenous values in chemistry on this pod! Thanks @nature for the feature and joining some an amazing list of ChangeMakers!
Latest from the Nature Careers Podcast 🔊 How Indigenous values permeate my chemistry teaching and research
go.nature.com/45KuNsB
go.nature.com/45KuNsB
How Indigenous values permeate my chemistry teaching and research
Joslynn Lee describes why she seeks to bridge the Native American worldview with Western science.
go.nature.com
August 13, 2025 at 2:45 AM
I got to share a bit about Indigenous values in chemistry on this pod! Thanks @nature for the feature and joining some an amazing list of ChangeMakers!
Reposted by Willow Coyote-Maestas
Assistant Professor position in Traditional Ecological Knowledge at Stanford University. Applications due Sept 30, 2025
facultypositions.stanford.edu/en-us/job/49...
facultypositions.stanford.edu/en-us/job/49...
Stanford | Faculty Positions: Details - Assistant Professor in Traditional Ecological Knowledge
facultypositions.stanford.edu
August 6, 2025 at 7:47 PM
Assistant Professor position in Traditional Ecological Knowledge at Stanford University. Applications due Sept 30, 2025
facultypositions.stanford.edu/en-us/job/49...
facultypositions.stanford.edu/en-us/job/49...
Reposted by Willow Coyote-Maestas
ProDomino is a machine learning-based method that predicts domain insertion sites and helps guide the engineering of functional multi-domain proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 4, 2025 at 3:24 PM
ProDomino is a machine learning-based method that predicts domain insertion sites and helps guide the engineering of functional multi-domain proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Awesome work from @jingyour.bsky.social, @hjp.bsky.social and a lil bit us!
New stats framework for mutational scanswhere we measure multiple phenotypes like expression & activity. Jingyou is able to pull out immediately patterns that took us otherwise weeks to months data digging. Amazing work!
New stats framework for mutational scanswhere we measure multiple phenotypes like expression & activity. Jingyou is able to pull out immediately patterns that took us otherwise weeks to months data digging. Amazing work!
How do we decouple the effects of two functional phenotypes in protein deep mutational scanning (DMS)?
Meet Cosmos, our new statistical framework for causal inference in multi-phenotype DMS.
www.biorxiv.org/content/10.1...
[1/n]
Meet Cosmos, our new statistical framework for causal inference in multi-phenotype DMS.
www.biorxiv.org/content/10.1...
[1/n]
Cosmos: A Position-Resolution Causal Model for Direct and Indirect Effects in Protein Functions
Multi-phenotype deep mutational scanning (DMS) experiments provide a powerful means to dissect how protein variants affect different layers of molecular function, such as abundance, surface expression...
www.biorxiv.org
August 4, 2025 at 4:35 PM
Awesome work from @jingyour.bsky.social, @hjp.bsky.social and a lil bit us!
New stats framework for mutational scanswhere we measure multiple phenotypes like expression & activity. Jingyou is able to pull out immediately patterns that took us otherwise weeks to months data digging. Amazing work!
New stats framework for mutational scanswhere we measure multiple phenotypes like expression & activity. Jingyou is able to pull out immediately patterns that took us otherwise weeks to months data digging. Amazing work!
So lucky to have the brilliant @jingyour.bsky.social joining the lab as a postdoc! It’s been inspiring collaborating the last couple years and I can’t wait to see the extraordinary things she’ll do :)
Perfect first day: receiving a set of new pipettes! Can’t wait to do more cool experiments with the lab for the next few years. @willowcoyote.bsky.social
August 1, 2025 at 12:14 AM
So lucky to have the brilliant @jingyour.bsky.social joining the lab as a postdoc! It’s been inspiring collaborating the last couple years and I can’t wait to see the extraordinary things she’ll do :)
Reposted by Willow Coyote-Maestas
Super proud of my first student, @jingyour.bsky.social! Well done! Looking forward to the amazing work you will do in the future 🥲 bsky.app/profile/jing...
Thrilled to share that I just successfully defended my PhD! Thanks to my committee, collaborators, and everyone who’d supported me throughout my seven years at UCLA. A special thank you to my PI Harold for his incredible mentorship! @hjp.bsky.social
July 21, 2025 at 11:15 PM
Super proud of my first student, @jingyour.bsky.social! Well done! Looking forward to the amazing work you will do in the future 🥲 bsky.app/profile/jing...
Reposted by Willow Coyote-Maestas
Thrilled to share that I just successfully defended my PhD! Thanks to my committee, collaborators, and everyone who’d supported me throughout my seven years at UCLA. A special thank you to my PI Harold for his incredible mentorship! @hjp.bsky.social
July 21, 2025 at 9:35 PM
Thrilled to share that I just successfully defended my PhD! Thanks to my committee, collaborators, and everyone who’d supported me throughout my seven years at UCLA. A special thank you to my PI Harold for his incredible mentorship! @hjp.bsky.social
Reposted by Willow Coyote-Maestas
🧪🖥️🧬 It's here!! Our second MPRA, which is totally different from the first. For starters, there's no human sequences anywhere!
Instead there's marsupials, wolves, pandas and a lot of hard work from lab members past & present, chief amongst them @navya-shukla.bsky.social (looking for a postdoc btw)
Instead there's marsupials, wolves, pandas and a lot of hard work from lab members past & present, chief amongst them @navya-shukla.bsky.social (looking for a postdoc btw)
Dissecting functional regulatory convergence over 160 million years of therian evolution https://www.biorxiv.org/content/10.1101/2025.07.10.662670v1
July 11, 2025 at 9:46 PM
🧪🖥️🧬 It's here!! Our second MPRA, which is totally different from the first. For starters, there's no human sequences anywhere!
Instead there's marsupials, wolves, pandas and a lot of hard work from lab members past & present, chief amongst them @navya-shukla.bsky.social (looking for a postdoc btw)
Instead there's marsupials, wolves, pandas and a lot of hard work from lab members past & present, chief amongst them @navya-shukla.bsky.social (looking for a postdoc btw)