Paul Jenkins
@pjenkinslab.bsky.social
Associate Professor, Pharmacology, Psychiatry, Neuroscience, Sports, Occasional trouble-making. Oxford comma enthusiast. Hates cilantro. He/him. Views are my own.
Reposted by Paul Jenkins
Dendritic excitations primarily mediate back-propagation in CA1 pyramidal neurons during behavior https://www.biorxiv.org/content/10.64898/2026.01.03.696606v1
January 4, 2026 at 5:15 AM
Dendritic excitations primarily mediate back-propagation in CA1 pyramidal neurons during behavior https://www.biorxiv.org/content/10.64898/2026.01.03.696606v1
Reposted by Paul Jenkins
During Fiona Hill's testimony to Congress on Oct 14, 2019, she described how Trump and Putin discussed exchanging Ukraine for Venezuela. The quid pro quo was if Trump refuses to help Ukraine fight off a Russian invasion, Putin would not help Venezuela (a Russian ally) resist a US takeover.
January 4, 2026 at 2:36 AM
During Fiona Hill's testimony to Congress on Oct 14, 2019, she described how Trump and Putin discussed exchanging Ukraine for Venezuela. The quid pro quo was if Trump refuses to help Ukraine fight off a Russian invasion, Putin would not help Venezuela (a Russian ally) resist a US takeover.
Reposted by Paul Jenkins
Kidnapping the leader of a foreign state without any declaration of war and announcing it via social media is full-on rogue state stuff. From the world’s number one superpower.
January 3, 2026 at 9:56 AM
Kidnapping the leader of a foreign state without any declaration of war and announcing it via social media is full-on rogue state stuff. From the world’s number one superpower.
Very cool paper and glad to see the ankyrin-G-GFP mouse getting used! Cre-dependent live labeling of the AIS allows in vivo, longitudinal tracking of AIS position changes in response to stimuli. Here it is being used to track changes in response to fear learning. Congrats, Jan, Maren, and team!
Very cool paper from @jangrundemann.bsky.social lab! Axon initial segment dynamics during associative fear learning | Nature Neuroscience share.google/GH5iaWUINB5w...
Axon initial segment dynamics during associative fear learning - Nature Neuroscience
Benoit, Ganea et al. show that changes in axon initial segment (AIS) length in the prefrontal cortex of mice accompany fear learning and extinction, revealing AIS plasticity as a key feature of neuron...
share.google
January 2, 2026 at 11:27 AM
Very cool paper and glad to see the ankyrin-G-GFP mouse getting used! Cre-dependent live labeling of the AIS allows in vivo, longitudinal tracking of AIS position changes in response to stimuli. Here it is being used to track changes in response to fear learning. Congrats, Jan, Maren, and team!
Reposted by Paul Jenkins
Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2
Spatial barcoding reveals reaction radii and contact-dependent mechanism of proximity labeling - Nature Chemical Biology
A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...
www.nature.com
December 31, 2025 at 5:53 PM
Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2
Fun in one of my favorite cities, Heidelberg! 🇩🇪
December 31, 2025 at 12:52 PM
Fun in one of my favorite cities, Heidelberg! 🇩🇪
Reposted by Paul Jenkins
I hopped we would be well over this in 2025, but let me scream it one more time:
"mRNAs LEVELS DO NOT CORRELATE WITH PROTEINS AMOUNTS, NOR THEIR PTMs AND CERTAINLY NOT THEIR SUB-CELLULAR FUNCTIONS/TURNOVER."
So yeah, cells with similar RNA expression patterns can have different functions. Duh 🙄
"mRNAs LEVELS DO NOT CORRELATE WITH PROTEINS AMOUNTS, NOR THEIR PTMs AND CERTAINLY NOT THEIR SUB-CELLULAR FUNCTIONS/TURNOVER."
So yeah, cells with similar RNA expression patterns can have different functions. Duh 🙄
Evidence suggests that transcriptionally similar cells can be functionally diverse
go.nature.com/3N4lT2d
go.nature.com/3N4lT2d
Does a cell’s gene expression always reflect its function?
Transcriptionally similar neurons can be functionally diverse.
go.nature.com
December 30, 2025 at 10:24 AM
I hopped we would be well over this in 2025, but let me scream it one more time:
"mRNAs LEVELS DO NOT CORRELATE WITH PROTEINS AMOUNTS, NOR THEIR PTMs AND CERTAINLY NOT THEIR SUB-CELLULAR FUNCTIONS/TURNOVER."
So yeah, cells with similar RNA expression patterns can have different functions. Duh 🙄
"mRNAs LEVELS DO NOT CORRELATE WITH PROTEINS AMOUNTS, NOR THEIR PTMs AND CERTAINLY NOT THEIR SUB-CELLULAR FUNCTIONS/TURNOVER."
So yeah, cells with similar RNA expression patterns can have different functions. Duh 🙄
Reflecting on autocrats that really like to build huge things while outside the former Nazi rally grounds is a bit too on the nose for today's times
December 26, 2025 at 1:58 PM
Reflecting on autocrats that really like to build huge things while outside the former Nazi rally grounds is a bit too on the nose for today's times
Reposted by Paul Jenkins
Interesting preprint from the Boyce lab! Sec23IP (protein linking COPII inner and outer coats) is regulated by O-GlcNAcylation. Site-specific modification of its disordered domain controls O-GlcNAcylation, Sec31A recruitment, COPII assembly, and ER exit site function.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 22, 2025 at 12:23 PM
Interesting preprint from the Boyce lab! Sec23IP (protein linking COPII inner and outer coats) is regulated by O-GlcNAcylation. Site-specific modification of its disordered domain controls O-GlcNAcylation, Sec31A recruitment, COPII assembly, and ER exit site function.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Paul Jenkins
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
December 22, 2025 at 2:57 PM
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
Reposted by Paul Jenkins
She let me know that they recently received guidance that, ONLY for the January EI deadline (1/27/2026) and the February ESI deadline (2/3/2026), PIs can submit MIRAs even if their previous application (R35, R01, R15, R21, and R37) is still considered under review.
December 19, 2025 at 7:17 PM
She let me know that they recently received guidance that, ONLY for the January EI deadline (1/27/2026) and the February ESI deadline (2/3/2026), PIs can submit MIRAs even if their previous application (R35, R01, R15, R21, and R37) is still considered under review.
Reposted by Paul Jenkins
On this day in 1934, Albert William Kaline was born in Baltimore, MD. In his 22 seasons as a player with Detroit, he hit 399 home runs, including two in a memorable 1968 World Series. Here’s my painting of him with the Tigers in June of 1954, his first full year with the club.
December 19, 2025 at 7:14 PM
On this day in 1934, Albert William Kaline was born in Baltimore, MD. In his 22 seasons as a player with Detroit, he hit 399 home runs, including two in a memorable 1968 World Series. Here’s my painting of him with the Tigers in June of 1954, his first full year with the club.
Reposted by Paul Jenkins
The name "Popular Science" doesn't mean we shift our coverage depending on public opinion. It means we cover relevant subjects that are rigorously researched, reliable, and grounded in reality.
And trans lives are grounded in reality.
We see y'all. No matter what.
www.popsci.com/science/tran...
And trans lives are grounded in reality.
We see y'all. No matter what.
www.popsci.com/science/tran...
First-of-a-kind study shows encouraging data for trans kids who socially transition
Ninety-four percent of participants in a new study stood firm in their trans identity after five years, and "detransitioning" is rare.
www.popsci.com
December 18, 2025 at 5:16 PM
The name "Popular Science" doesn't mean we shift our coverage depending on public opinion. It means we cover relevant subjects that are rigorously researched, reliable, and grounded in reality.
And trans lives are grounded in reality.
We see y'all. No matter what.
www.popsci.com/science/tran...
And trans lives are grounded in reality.
We see y'all. No matter what.
www.popsci.com/science/tran...
Excellent work, past me... That clears up everything.
December 17, 2025 at 7:03 PM
Excellent work, past me... That clears up everything.
Epic bullshit. 50% of researchers using AI for peer review. We're so cooked.
December 16, 2025 at 9:22 PM
Epic bullshit. 50% of researchers using AI for peer review. We're so cooked.
Reposted by Paul Jenkins
BREAKING: Mike Johnson orders second strike on surviving citizens clinging to the wreckage of this economy.
December 16, 2025 at 5:33 PM
BREAKING: Mike Johnson orders second strike on surviving citizens clinging to the wreckage of this economy.
Reposted by Paul Jenkins
“Basic neuroscience hasn’t produced new drugs.” 💊
Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab.
I wrote a Perspective on why this matters. @thetransmitter.bsky.social
www.thetransmitter.org/drug-develop...
Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab.
I wrote a Perspective on why this matters. @thetransmitter.bsky.social
www.thetransmitter.org/drug-develop...
How basic neuroscience has paved the path to new drugs
A growing list of medications—such as zuranolone for postpartum depression, suzetrigine for pain, and the gepants class of migraine medicines—exist because of insights from basic research.
www.thetransmitter.org
December 15, 2025 at 3:15 PM
“Basic neuroscience hasn’t produced new drugs.” 💊
Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab.
I wrote a Perspective on why this matters. @thetransmitter.bsky.social
www.thetransmitter.org/drug-develop...
Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab.
I wrote a Perspective on why this matters. @thetransmitter.bsky.social
www.thetransmitter.org/drug-develop...
Really interesting deficits in sensory coding in Scn2a heterozygous mice and rescue of these deficits with CRISPRa in adults. Implications for EEG-accessible biomarkers for Scn2a loss-of-function...
New work from @danfeldman.bsky.social's lab, exploring sensory representations in Scn2a loss of function mice. Whisker representations are blurred, akin to cortical visual impairment often seen in SCN2A kiddos. Rescuable w/ @nadavahituv.bsky.social's CRISPRa @P30!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Degraded sensory coding in a mouse model of Scn2a-related disorder and its rescue by CRISPRa gene activation
Heterozygous loss-of-function mutations in SCN2A, a sodium channel gene expressed in cortical pyramidal (PYR) cells, lead to a neurodevelopmental disorder characterized by autism, intellectual disabil...
www.biorxiv.org
December 15, 2025 at 4:49 PM
Really interesting deficits in sensory coding in Scn2a heterozygous mice and rescue of these deficits with CRISPRa in adults. Implications for EEG-accessible biomarkers for Scn2a loss-of-function...
Reposted by Paul Jenkins
Dunno who needs to hear this, but before your start writing your reviewer comments, eat a cookie. Only you can prevent rude reviews.
December 15, 2025 at 3:22 PM
Dunno who needs to hear this, but before your start writing your reviewer comments, eat a cookie. Only you can prevent rude reviews.
There is no rock bottom. So vile.
December 15, 2025 at 3:28 PM
There is no rock bottom. So vile.
ERA Commons having a totally normal one...
December 15, 2025 at 1:54 PM
ERA Commons having a totally normal one...
Reposted by Paul Jenkins
Reposted by Paul Jenkins
the snow has fallen such that it looks like a little child, standing on a pile of snow, watching the snow fall
December 13, 2025 at 1:01 PM
the snow has fallen such that it looks like a little child, standing on a pile of snow, watching the snow fall
New lab photo just dropped. This is the kind of stuff I am subjected to. 🤣 #justoneoftheladies #flowinglocks #sororitysquat
December 12, 2025 at 4:42 PM
New lab photo just dropped. This is the kind of stuff I am subjected to. 🤣 #justoneoftheladies #flowinglocks #sororitysquat