Guillaume Diss
@guillaumediss.bsky.social
Group Leader at @fmiscience.bsky.social
We study the genetic architecture of protein function to develop predictive and generative AI models
We study the genetic architecture of protein function to develop predictive and generative AI models
Reposted by Guillaume Diss
✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes - Nature
A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-...
www.nature.com
October 16, 2025 at 7:49 AM
✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Guillaume Diss
Paper alert! doi.org/10.1038/s443... - "A scheduler for rhythmic gene expression". We show how 9 txn factors suffice for rhythmic gene expression of thousands of genes with any phase or amplitude in #Celegans larvae (and also look at the tissues where oscillations happen) 1/n
October 10, 2025 at 2:17 PM
Paper alert! doi.org/10.1038/s443... - "A scheduler for rhythmic gene expression". We show how 9 txn factors suffice for rhythmic gene expression of thousands of genes with any phase or amplitude in #Celegans larvae (and also look at the tissues where oscillations happen) 1/n
Reposted by Guillaume Diss
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
The functional landscape of the human ubiquitinome
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...
www.biorxiv.org
October 9, 2025 at 7:07 AM
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
Reposted by Guillaume Diss
Dear colleagues!
@davidmccandlish.bsky.social and I are serving as guest editors for the new special issue of GENETICS on fitness landscapes:
doi.org/10.1093/gene...
Submissions are due on March 18, 2026. Please spread the word! And reach out if you have questions.
@davidmccandlish.bsky.social and I are serving as guest editors for the new special issue of GENETICS on fitness landscapes:
doi.org/10.1093/gene...
Submissions are due on March 18, 2026. Please spread the word! And reach out if you have questions.
The Fitness Landscape: A Call for Papers
Ruth Isaacson; The Fitness Landscape: A Call for Papers, Genetics, , iyaf206, https://doi.org/10.1093/genetics/iyaf206
doi.org
October 8, 2025 at 5:59 AM
Dear colleagues!
@davidmccandlish.bsky.social and I are serving as guest editors for the new special issue of GENETICS on fitness landscapes:
doi.org/10.1093/gene...
Submissions are due on March 18, 2026. Please spread the word! And reach out if you have questions.
@davidmccandlish.bsky.social and I are serving as guest editors for the new special issue of GENETICS on fitness landscapes:
doi.org/10.1093/gene...
Submissions are due on March 18, 2026. Please spread the word! And reach out if you have questions.
Reposted by Guillaume Diss
We have two open positions for a ML and a LLM engineer to launch a machine learning expertise unit in our center @vibai.bsky.social, see vib.ai/en/opportuni...
vib.ai
September 23, 2025 at 11:21 AM
We have two open positions for a ML and a LLM engineer to launch a machine learning expertise unit in our center @vibai.bsky.social, see vib.ai/en/opportuni...
Reposted by Guillaume Diss
📣The Turco group is seeking a computational biologist to analyze large omics datasets. Work on cutting-edge 3D organoid models of the human placenta and be embedded in our Computational Biology Platform (part of @sib.swiss). Apply here: www.fmi.ch/education-ca...
September 12, 2025 at 7:02 AM
📣The Turco group is seeking a computational biologist to analyze large omics datasets. Work on cutting-edge 3D organoid models of the human placenta and be embedded in our Computational Biology Platform (part of @sib.swiss). Apply here: www.fmi.ch/education-ca...
Reposted by Guillaume Diss
I am excited to announce that we are looking for a Lab Manager @fmiscience.bsky.social in Basel. If you want to be part of a growing team investigating development and tissue formation, and are enthusiastic about helping set up a new lab, please check out the role:
www.fmi.ch/education-ca...
www.fmi.ch/education-ca...
September 14, 2025 at 11:46 AM
I am excited to announce that we are looking for a Lab Manager @fmiscience.bsky.social in Basel. If you want to be part of a growing team investigating development and tissue formation, and are enthusiastic about helping set up a new lab, please check out the role:
www.fmi.ch/education-ca...
www.fmi.ch/education-ca...
Reposted by Guillaume Diss
Open PhD position in the Luck lab at IMB in Mainz, Germany, in the field of AI and computational structural biology. Check out project description here: www.imb.de/students-pos...
Funded as part of the European Training Network ProAIomics cordis.europa.eu/project/id/1...
Funded as part of the European Training Network ProAIomics cordis.europa.eu/project/id/1...
September 10, 2025 at 7:01 AM
Open PhD position in the Luck lab at IMB in Mainz, Germany, in the field of AI and computational structural biology. Check out project description here: www.imb.de/students-pos...
Funded as part of the European Training Network ProAIomics cordis.europa.eu/project/id/1...
Funded as part of the European Training Network ProAIomics cordis.europa.eu/project/id/1...
Reposted by Guillaume Diss
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
September 8, 2025 at 8:15 AM
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Latest pre-print from our lab is out. Great work by @alexbendel.bsky.social and team.
Full deep mutational scan of an entire human protein interaction domain family
2M quantitative measurement of protein-protein interaction -> deep learning model to predict PPI from sequence
More details 👇
Full deep mutational scan of an entire human protein interaction domain family
2M quantitative measurement of protein-protein interaction -> deep learning model to predict PPI from sequence
More details 👇
I am happy to finally share this preprint of my PhD project in @guillaumediss.bsky.social lab at the FMI in Basel.
We used ddPCA to map the genetic architecture of the entire human bZIP interaction network.
www.biorxiv.org/content/10.1...
Thanks to all our co-authors for the great collaboration!
We used ddPCA to map the genetic architecture of the entire human bZIP interaction network.
www.biorxiv.org/content/10.1...
Thanks to all our co-authors for the great collaboration!
The genetic architecture of the human bZIP family
Generative biology holds the promise to transform our ability to design and understand living systems by creating novel proteins, pathways, and organisms with tailored functions that address challenge...
www.biorxiv.org
August 25, 2025 at 3:37 PM
Latest pre-print from our lab is out. Great work by @alexbendel.bsky.social and team.
Full deep mutational scan of an entire human protein interaction domain family
2M quantitative measurement of protein-protein interaction -> deep learning model to predict PPI from sequence
More details 👇
Full deep mutational scan of an entire human protein interaction domain family
2M quantitative measurement of protein-protein interaction -> deep learning model to predict PPI from sequence
More details 👇