Sergey Kryazhimskiy
@skryazhi.bsky.social
Work in progress | Evolution | Ecology | Systems Biology | Experiments | Theory | Running a lab @ucsdbiosciences | http://sklab.science | https://thoughtsforbreakfast.wordpress.com/
Reposted by Sergey Kryazhimskiy
Every year #ESEB distinguishes a young evolutionary biologist with the John Maynard Smith Prize! Nominations for the 2026 prize are due by January 15th!
Find out more here: eseb.org/prizes-fundi...
Find out more here: eseb.org/prizes-fundi...
November 11, 2025 at 10:50 AM
Every year #ESEB distinguishes a young evolutionary biologist with the John Maynard Smith Prize! Nominations for the 2026 prize are due by January 15th!
Find out more here: eseb.org/prizes-fundi...
Find out more here: eseb.org/prizes-fundi...
Reposted by Sergey Kryazhimskiy
15-year-old bug 😐 in an industry that has the highest profit margins possible pretty much
www.theguardian.com/science/2017...
www.theguardian.com/science/2017...
November 23, 2025 at 3:45 PM
15-year-old bug 😐 in an industry that has the highest profit margins possible pretty much
www.theguardian.com/science/2017...
www.theguardian.com/science/2017...
Reposted by Sergey Kryazhimskiy
Absolutely. Even if he weren't a damaged creep, his approach to scientific evidence is completely disqualifying.
We know the answer; We just don't have the science yet
There is no study that says that it is not true.
Bye, bye Bobby. You've "gone wild" enough. You going to kill lots of people.
We know the answer; We just don't have the science yet
There is no study that says that it is not true.
Bye, bye Bobby. You've "gone wild" enough. You going to kill lots of people.
November 21, 2025 at 3:10 PM
Absolutely. Even if he weren't a damaged creep, his approach to scientific evidence is completely disqualifying.
We know the answer; We just don't have the science yet
There is no study that says that it is not true.
Bye, bye Bobby. You've "gone wild" enough. You going to kill lots of people.
We know the answer; We just don't have the science yet
There is no study that says that it is not true.
Bye, bye Bobby. You've "gone wild" enough. You going to kill lots of people.
Reposted by Sergey Kryazhimskiy
Epic paper!!
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:56 PM
Epic paper!!
Reposted by Sergey Kryazhimskiy
It's been a busy few months for our group so wanted to highlight a few other recent preprints we’ve posted that I haven’t had the chance to share yet... (1/n)
Excited to share some new work led by grad student Sophie Walton (w/ @petrovadmitri.bsky.social). We used in vitro gut communities to study how natural selection acts on strains of the same species as they compete within larger communities. Check out Sophie's thread below for details!
Super excited that the bulk of my PhD work is now preprinted! Here we used whole-community competition, or coalescence, experiments to quantify selection acting on genetically diverged strains within larger communities. (1/n)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 16, 2025 at 3:26 PM
It's been a busy few months for our group so wanted to highlight a few other recent preprints we’ve posted that I haven’t had the chance to share yet... (1/n)
Reposted by Sergey Kryazhimskiy
Trump’s HHS put me on “non-disciplinary” admin leave today. This was retaliation for speaking up. Moves like this are designed to silence us. Let’s not let.
www.tiktok.com/t/ZP8Dteoop/
www.tiktok.com/t/ZP8Dteoop/
I guess I am hitting a nerve, because they just put me on admin leave.
TikTok video by Jenna
www.tiktok.com
November 13, 2025 at 11:18 PM
Trump’s HHS put me on “non-disciplinary” admin leave today. This was retaliation for speaking up. Moves like this are designed to silence us. Let’s not let.
www.tiktok.com/t/ZP8Dteoop/
www.tiktok.com/t/ZP8Dteoop/
Reposted by Sergey Kryazhimskiy
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
November 11, 2025 at 1:20 AM
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
Reposted by Sergey Kryazhimskiy
Up to 323 cancelled CSR study sections. That's more than the 204 sections cancelled earlier this year. Rescheduling is going to be a hot mess with NIH staff reductions and study section members heading into finals and holidays that limit availability. 🧪
Been a rough year for federally funded scientists, and I hate to add another tab to this spreadsheet. So far, the shutdown has resulted in cancellation of 161 CSR study sections. 🧪https://docs.google.com/spreadsheets/d/1lLEx14q7HKrlYahQYJaN6aHKpMqSMJwX4aenyL5g_ZU/edit?usp=sharing
2025 Study section tracking
docs.google.com
November 11, 2025 at 9:44 PM
Up to 323 cancelled CSR study sections. That's more than the 204 sections cancelled earlier this year. Rescheduling is going to be a hot mess with NIH staff reductions and study section members heading into finals and holidays that limit availability. 🧪
Reposted by Sergey Kryazhimskiy
A devastating set of decisions on the part of UC leadership to withdraw support from our nationally recognized postdoc program that prioritizes research excellence combined with addressing our university public service mission. www.insidehighered.com/news/faculty...
UC to Stop Funding Systemwide Postdoc Program
Established in 1984 to encourage women and minority Ph.D.s to pursue academia, the program has attracted right-wing criticism for prioritizing diverse candidates.
www.insidehighered.com
November 5, 2025 at 6:53 PM
A devastating set of decisions on the part of UC leadership to withdraw support from our nationally recognized postdoc program that prioritizes research excellence combined with addressing our university public service mission. www.insidehighered.com/news/faculty...
Reposted by Sergey Kryazhimskiy
Applications are currently being accepted for UBC's ✨️ Biodiversity Postdoctoral Fellowship ✨️ (two positions!!), due Jan. 15
Please share far and wide 🚀
(See thread)
Please share far and wide 🚀
(See thread)
Postdoctoral Fellowship Opportunities
Biodiversity Postdoctoral Fellowship, 2-year (2026-2028) - 2 positions OPENAt UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in resea...
biodiversity.ubc.ca
November 3, 2025 at 5:25 PM
Applications are currently being accepted for UBC's ✨️ Biodiversity Postdoctoral Fellowship ✨️ (two positions!!), due Jan. 15
Please share far and wide 🚀
(See thread)
Please share far and wide 🚀
(See thread)
Reposted by Sergey Kryazhimskiy
Harvard PD looking for help identifying these people
November 2, 2025 at 1:48 AM
Harvard PD looking for help identifying these people
Reposted by Sergey Kryazhimskiy
New York Times editorial board has compiled "a list of 12 markers of democratic erosion." www.nytimes.com/interactive/...
This is what "not the odds, but the stakes" was all about.
During the 2024 campaign, those 12 markers could have been in place and operating to guide news coverage everywhere.
This is what "not the odds, but the stakes" was all about.
During the 2024 campaign, those 12 markers could have been in place and operating to guide news coverage everywhere.
October 31, 2025 at 2:36 PM
New York Times editorial board has compiled "a list of 12 markers of democratic erosion." www.nytimes.com/interactive/...
This is what "not the odds, but the stakes" was all about.
During the 2024 campaign, those 12 markers could have been in place and operating to guide news coverage everywhere.
This is what "not the odds, but the stakes" was all about.
During the 2024 campaign, those 12 markers could have been in place and operating to guide news coverage everywhere.
Reposted by Sergey Kryazhimskiy
Well reported story on the PBS News Hour about science cuts and the ongoing and potential brain drain.
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
Top researchers consider leaving U.S. amid funding cuts: 'The science world is ending'
YouTube video by PBS NewsHour
www.youtube.com
October 30, 2025 at 11:36 AM
Well reported story on the PBS News Hour about science cuts and the ongoing and potential brain drain.
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
Reposted by Sergey Kryazhimskiy
Terrific thread w/ >2 great stories about labor movements that galvanize communities.
Even if you know the stories well (where 'redneck' comes from, 'bread and roses') it's still thought provoking, e.g. how do we strengthen science coalitions?
Even if you know the stories well (where 'redneck' comes from, 'bread and roses') it's still thought provoking, e.g. how do we strengthen science coalitions?
JD Vance claims that diversity weakens unions, as people end up distrusting each other and not organizing.
Let me tell you two menswear stories related to this claim. 🧵
Let me tell you two menswear stories related to this claim. 🧵
October 30, 2025 at 2:08 PM
Terrific thread w/ >2 great stories about labor movements that galvanize communities.
Even if you know the stories well (where 'redneck' comes from, 'bread and roses') it's still thought provoking, e.g. how do we strengthen science coalitions?
Even if you know the stories well (where 'redneck' comes from, 'bread and roses') it's still thought provoking, e.g. how do we strengthen science coalitions?
Reposted by Sergey Kryazhimskiy
We have an open PhD position (application deadline 9 January 2026) in "Theory of fitness landscapes" at @unibe.ch 🤓⛰️📊👩💻🎓: banklab.github.io/positions/
Please share widely!
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
Please share widely!
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
October 28, 2025 at 4:22 PM
We have an open PhD position (application deadline 9 January 2026) in "Theory of fitness landscapes" at @unibe.ch 🤓⛰️📊👩💻🎓: banklab.github.io/positions/
Please share widely!
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
Please share widely!
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
Reposted by Sergey Kryazhimskiy
I started a new job in Montpellier, France!
Happy about new opportunities, sad about the state of things in the US.
abetterscientist.wordpress.com/2025/10/26/w...
Happy about new opportunities, sad about the state of things in the US.
abetterscientist.wordpress.com/2025/10/26/w...
We left the US and moved to France
Hello readers, I got big updates! Some of you already know this, but it’s getting more real and more official every month: my family and I have left the US and moved to France! A few months ago I q…
abetterscientist.wordpress.com
October 27, 2025 at 7:19 PM
I started a new job in Montpellier, France!
Happy about new opportunities, sad about the state of things in the US.
abetterscientist.wordpress.com/2025/10/26/w...
Happy about new opportunities, sad about the state of things in the US.
abetterscientist.wordpress.com/2025/10/26/w...
Yeah, this is the curse of my life. And yet, grants without deadlines (e.g., NSF) are so much worse!
And of course the real problem is that grant proposals have deadlines and manuscripts do not.
October 23, 2025 at 4:29 PM
Yeah, this is the curse of my life. And yet, grants without deadlines (e.g., NSF) are so much worse!
Reposted by Sergey Kryazhimskiy
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
October 22, 2025 at 5:46 PM
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sergey Kryazhimskiy
Biology PhD program directors who want to join the conversation, my email and DM are open.
Fewer grad students means less science, but many STEM PhD programs in the US are cutting back on admissions this year due to federal funding uncertainties. Words by me for @nature.com:
www.nature.com/articles/d41...
@emsque.bsky.social @ucsdcooperlab.bsky.social @julieposselt.bsky.social 🧪
www.nature.com/articles/d41...
@emsque.bsky.social @ucsdcooperlab.bsky.social @julieposselt.bsky.social 🧪
US PhD admissions shrink as fears over Trump’s cuts take hold
Some doctoral programmes are admitting no students at all amid uncertainty about federal science funding.
www.nature.com
October 21, 2025 at 9:13 PM
Biology PhD program directors who want to join the conversation, my email and DM are open.
Reposted by Sergey Kryazhimskiy
Once again, EVERY R1 research university depends on federal funding for ~15-25% of its budget. You simply can't unplug the largest or 2nd-largest source of $$ of every R1 university & expect it not to have devastating consequences for graduate education, which will spill over to undergrad education.
Wow. Harvard nuking its PhD programs
- Science PhD admissions reduced by more than 75%
- Arts & Humanities reduced by about 60%
- Social Sciences by 50–70%
- History by 60%
- Biology by 75%
- The German department will lose all PhD seats
- Sociology from six PhD students to zero
- Science PhD admissions reduced by more than 75%
- Arts & Humanities reduced by about 60%
- Social Sciences by 50–70%
- History by 60%
- Biology by 75%
- The German department will lose all PhD seats
- Sociology from six PhD students to zero
Harvard FAS Cuts Ph.D. Seats By More Than Half Across Next Two Admissions Cycles | News | The Harvard Crimson
The Faculty of Arts and Sciences slashed the number of Ph.D. student admissions slots for the Science division by more than 75 percent and for the Arts & Humanities division by about 60 percent for th...
www.thecrimson.com
October 21, 2025 at 6:01 PM
Once again, EVERY R1 research university depends on federal funding for ~15-25% of its budget. You simply can't unplug the largest or 2nd-largest source of $$ of every R1 university & expect it not to have devastating consequences for graduate education, which will spill over to undergrad education.
Reposted by Sergey Kryazhimskiy
This is even worse for the Harvards of the world, but it's true of EVERY R1 research university:
The entire business model of R1 public universities rests on 4 revenue sources:
1. Federal grants
2. Private gifts/endowments
3. Tuition (esp. from foreign students)
4. State $
For decades, 📈 in 1-3 offset a secular 📉 in 4. Now, 1 & 3 are being decimated & 4 ain't coming back. The math is clear.
1. Federal grants
2. Private gifts/endowments
3. Tuition (esp. from foreign students)
4. State $
For decades, 📈 in 1-3 offset a secular 📉 in 4. Now, 1 & 3 are being decimated & 4 ain't coming back. The math is clear.
October 21, 2025 at 6:02 PM
This is even worse for the Harvards of the world, but it's true of EVERY R1 research university:
Reposted by Sergey Kryazhimskiy
Wow. Harvard nuking its PhD programs
- Science PhD admissions reduced by more than 75%
- Arts & Humanities reduced by about 60%
- Social Sciences by 50–70%
- History by 60%
- Biology by 75%
- The German department will lose all PhD seats
- Sociology from six PhD students to zero
- Science PhD admissions reduced by more than 75%
- Arts & Humanities reduced by about 60%
- Social Sciences by 50–70%
- History by 60%
- Biology by 75%
- The German department will lose all PhD seats
- Sociology from six PhD students to zero
Harvard FAS Cuts Ph.D. Seats By More Than Half Across Next Two Admissions Cycles | News | The Harvard Crimson
The Faculty of Arts and Sciences slashed the number of Ph.D. student admissions slots for the Science division by more than 75 percent and for the Arts & Humanities division by about 60 percent for th...
www.thecrimson.com
October 21, 2025 at 5:11 PM
Wow. Harvard nuking its PhD programs
- Science PhD admissions reduced by more than 75%
- Arts & Humanities reduced by about 60%
- Social Sciences by 50–70%
- History by 60%
- Biology by 75%
- The German department will lose all PhD seats
- Sociology from six PhD students to zero
- Science PhD admissions reduced by more than 75%
- Arts & Humanities reduced by about 60%
- Social Sciences by 50–70%
- History by 60%
- Biology by 75%
- The German department will lose all PhD seats
- Sociology from six PhD students to zero
Reposted by Sergey Kryazhimskiy
I’m excited to announce the launch of my lab at EPFL in Jan 2026 🎉. We’ll combine evolution & synthetic biology to study and (re)engineer bacterial communication.
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
October 20, 2025 at 6:14 PM
I’m excited to announce the launch of my lab at EPFL in Jan 2026 🎉. We’ll combine evolution & synthetic biology to study and (re)engineer bacterial communication.
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
Reposted by Sergey Kryazhimskiy
Paper is finally out!! Thanks to reviewers we dig deeper on the differences between domestication events -spoiler alert: it doesn't matter that much. nph.onlinelibrary.wiley.com/doi/full/10....
October 16, 2025 at 9:00 PM
Paper is finally out!! Thanks to reviewers we dig deeper on the differences between domestication events -spoiler alert: it doesn't matter that much. nph.onlinelibrary.wiley.com/doi/full/10....
Reposted by Sergey Kryazhimskiy
😳😂
U.S. House Speaker Mike Johnson calls Sunday's naked bike ride in protest of the Portland ICE facility and and Trump troop deployment "the most threatening thing I’ve seen yet"
www.oregonlive.com/portland/202...
www.oregonlive.com/portland/202...
October 15, 2025 at 1:15 AM
😳😂