Lorenz Lab
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sonjalorenzlab.bsky.social
Lorenz Lab
@sonjalorenzlab.bsky.social
Independent Research Group @ the Max Planck Institute for Multidisciplinary Sciences, Goettingen, Germany
@mpi-nat.bsky.social
We love ubiquitin, kinases, and good food.
Exciting! Yet another Spotlight article has come out today in @cp-trendsparasitol.bsky.social, featuring our work on kinase-ligase crosstalk in a Leishmania virulence factor. Thanks so much, @jnpruneda.bsky.social and Shun-Je Bhark! www.sciencedirect.com/science/arti...
Practicing self-control: Leishmania TKUL exhibits intramolecular kinase-ubiquitin ligase crosstalk
Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, poses an immense global health burden in desperate need of additional foun…
www.sciencedirect.com
October 29, 2025 at 1:44 PM
Thanks so much, Richard de Heiden and Monique Mulder, for featuring exciting findings on drug-like small-molecule ubiquitination by my research group and that of Jonathan Ostrem. Check out thisTiBS spotlight: www.sciencedirect.com/science/arti...
Drug ubiquitination: an unwelcome mode of action or a novel modality
Recent reports by Orth, Pohl, et al. and Li, Garcia-Rivera et al. show that ubiquitin can mark drug-like molecules in cells. This non-canonical ubiqui…
www.sciencedirect.com
October 29, 2025 at 9:08 AM
Exciting opening for a lab technician in the Rink department @mpi-nat.bsky.social:
www.mpinat.mpg.de/5123253/36-25
The lab is looking for a technician to support and develop next-generation sequencing applications. Please forward the announcement:
Technische Assistenz (w/m/d) - zur Unterstützung und Entwicklung  von Next-Generation Sequencing Anwendungen -
Die Abteilung Gewebedynamik und Regeneration (Prof. Dr. Jochen Rink) sucht eine Technische Assistenz (w/m/d) - zur Unterstützung und Entwicklung von Next-Generation Sequencing Anwendungen -
www.mpinat.mpg.de
October 20, 2025 at 11:11 AM
Reposted by Lorenz Lab
Tropical disease Leishmaniasis affects the world’s poorest regions. Scientists led by Thornton Fokkens & Sonja Lorenz @sonjalorenzlab.bsky.social have shown that leishmania parasites require the protein TKUL to maintain infections of host cells. 👇 (1/3)
October 17, 2025 at 8:31 AM
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…
www.sciencedirect.com
September 24, 2025 at 3:30 PM
Reposted by Lorenz Lab
Surprising tag: Scientists from @sonjalorenzlab.bsky.social and colleagues have now discovered that the human ligase HUWE1 can tag synthetic drug-like molecules in cells with ubiquitin. Their finding could open up new avenues in drug discovery and biotechnology.
@compbiophys.bsky.social
September 17, 2025 at 10:46 AM
Join us - in person or online - for the Göttinger Literaturherbst, a literature festival with a unique science series. We will feature Katalin Karikó, among other research leaders.
Honoured to host Julian Nida-Rümelin on the pressing topic of democracy, 29 Oct.
www.mpinat.mpg.de/5094670/pr_2...
September 6, 2025 at 4:07 PM
We’re excited that our article on the ubiquitination of drug-like small molecules in cells has been selected as an Editorial Highlight in #NatureCommun! 🎉
Check it out here 👉 www.nature.com/ncomms/edito...
Editors' Highlights | Nature Communications
Editors' Highlights
www.nature.com
September 4, 2025 at 5:29 AM
Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social#NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk
Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...
rdcu.be
September 2, 2025 at 11:55 AM
Are you interested in a science policy career? Check out this interesting opening an EMBO! www.embo.org/vacancy/poli...
Policy Assistant, EMBO Policy Programme – EMBO
Your role  As Policy Assistant, you will support the daily operations of the EMBO Policy Programme and contribute to projects on topics such as research assessment, research integrity, and science–pol...
www.embo.org
September 1, 2025 at 10:35 AM
Congrats to our lab member, Sait! And thanks very much to all who supported his application! Looking forward to great discoveries to come.
Congratulations to Sait Şeyhanlı @sonjalorenzlab.bsky.social on securing a coveted Boehringer Ingelheim PhD Fellowship 🎉! The Boehringer Ingelheim Fonds supports exceptional young scientists worldwide in their PhD projects in basic biomedical science. ‬‬‬‬
August 30, 2025 at 8:06 AM
Reposted by Lorenz Lab
Summer is now☀️, literature autumn next 🍂📖.
The program of the literature festival Göttinger Literaturherbst is out – and our scientific lecture series from Oct 24 to Nov 2 features brilliant Nobel Prize laureates, scientists, & non-fiction authors tackling big questions. Get your tickets!
August 15, 2025 at 9:34 AM
Congratulations to our lab member, Dr. Thornton Fokkens, for his outstanding research, flawless PhD defense, and smooth climb to the Gänseliesel, the Göttingen landmark that is kissed by all new graduates!
July 25, 2025 at 6:31 PM
Congratulations to our fantastic @mpi-nat.bsky.social student representatives at the Lindau Nobel Laureates Meeting! Have fun! #LINO25
Delighted that Rosi Junker from @sonjalorenzlab.bsky.social can attend. Many thanks to all supporters, including Brenda Schulman, @embo.org and GGNB Goettingen!
June 30, 2025 at 7:10 AM
Reposted by Lorenz Lab
Europe’s choice is clear.

To put science at the heart of its economy.

To become the home of scientific freedom and collaboration.

And to welcome talent from all over the world.

I’m glad to present the first elements of our Choose Europe Initiative.

europa.eu/!TTbWbJ
May 5, 2025 at 10:00 AM
Reposted by Lorenz Lab
We @natsmb.nature.com recently published an insightful manuscript on ubiquitin-independent proteasomal degradation via the NUB1-FAT10 axis by the lab of Andreas Martin. A very interesting read found here: www.nature.com/articles/s41...
NUB1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome - Nature Structural & Molecular Biology
Here, Arkinson et al. reconstitute NUB1-mediated FAT10 degradation by the human 26S proteasome and use biochemistry, cryo-EM and hydrogen–deuterium exchange to show that NUB1 acts as an ATP-independen...
www.nature.com
April 15, 2025 at 8:58 AM
Fantastic Ubiquitin CSH Meeting! Great science, reunion with old friends and many new contacts. Thanks to the master organizers: @annebertolotti.bsky.social, @labthoma.bsky.social, and Achim Werner!
April 6, 2025 at 12:00 PM
Hi! Our lab has moved to Bluesky! We will discontinue our Twitter presence in the near future, so please watch out our news here!
April 6, 2025 at 11:44 AM