Chris Parker
@chrisgparker.bsky.social
Professor @ Scripps Research | Department of Chemistry | chemical biology & chemical proteomics
Reposted by Chris Parker
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
Scripps Research team identifies sugar molecules that trigger placental formation
ow.ly
November 8, 2025 at 12:25 AM
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
Reposted by Chris Parker
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
www.nature.com
October 30, 2025 at 10:27 AM
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Reposted by Chris Parker
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 5:35 PM
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...
pubs.acs.org
October 21, 2025 at 3:55 PM
Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
Check out our recent collaboration with @abbvie.bsky.social in @cp-cellchembiol.bsky.social. We identifed compounds that potently clear tau aggregates. After chemoproteomics and functional studies, we found it covalently targets ER protein P4HB (after metabolic activation).
Discovery of a tau-aggregate clearing compound that covalently targets P4HB
The improper folding and aggregation of tau are linked to several neurodegenerative diseases affecting millions worldwide. However, the pathogenesis o…
www.sciencedirect.com
October 6, 2025 at 5:01 PM
Check out our recent collaboration with @abbvie.bsky.social in @cp-cellchembiol.bsky.social. We identifed compounds that potently clear tau aggregates. After chemoproteomics and functional studies, we found it covalently targets ER protein P4HB (after metabolic activation).
Happy to share the finalized version of this work out in @angewandtechemie.bsky.social.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
September 12, 2025 at 5:53 PM
Happy to share the finalized version of this work out in @angewandtechemie.bsky.social.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Happy to share our contribution to this special issue dedicated to "Proximity-Induced Chemical Biology". We provide our take on targeted protein acetylation.
Nice work Wesley and Roy!
pubs.acs.org/doi/10.1021/...
Nice work Wesley and Roy!
pubs.acs.org/doi/10.1021/...
Targeted Protein Acetylation Through Chemically Induced Proximity
ConspectusProtein acetylation is a pervasive and reversible post-translational modification (PTM) that impacts various protein features including stability, localization, and interactions and regulate...
pubs.acs.org
August 13, 2025 at 10:32 PM
Happy to share our contribution to this special issue dedicated to "Proximity-Induced Chemical Biology". We provide our take on targeted protein acetylation.
Nice work Wesley and Roy!
pubs.acs.org/doi/10.1021/...
Nice work Wesley and Roy!
pubs.acs.org/doi/10.1021/...
Reposted by Chris Parker
Congrats to Benjamin Cravatt on receiving the 2025 Tetrahedron Prize for Creativity in Bioorganic & Medicinal Chemistry from @elsevierconnect.bsky.social, honoring his pioneering activity-based protein profiling (ABPP) to study and target disease-relevant proteins.
Benjamin Cravatt awarded Tetrahedron Prize for Creativity - Scripps Research Magazine
Benjamin Cravatt, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Research, will receive the 2025 Tetrahedron Prize for Creativity in Bioorganic and Medicinal Chemistry. Established in ...
magazine.scripps.edu
August 13, 2025 at 12:13 AM
Congrats to Benjamin Cravatt on receiving the 2025 Tetrahedron Prize for Creativity in Bioorganic & Medicinal Chemistry from @elsevierconnect.bsky.social, honoring his pioneering activity-based protein profiling (ABPP) to study and target disease-relevant proteins.
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
Post-Translational Modifications Remodel Proteome-Wide Ligandability
Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...
www.biorxiv.org
August 3, 2025 at 2:36 PM
Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...
A big congratulations to the newly minted Dr. Forrest @inesforrest.bsky.social. Super proud! A big thanks to her committee members @michael-erb.bsky.social @wisemanlab.bsky.social @fleurmferguson.bsky.social @shenvi.bsky.social
April 26, 2025 at 12:47 AM
A big congratulations to the newly minted Dr. Forrest @inesforrest.bsky.social. Super proud! A big thanks to her committee members @michael-erb.bsky.social @wisemanlab.bsky.social @fleurmferguson.bsky.social @shenvi.bsky.social
Reposted by Chris Parker
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
www.cnn.com
April 9, 2025 at 11:30 AM
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Reposted by Chris Parker
Beyond thrilled to share that my PhD work is now available as a preprint! 🥳 A huge thank you to my amazing colleagues, mentors and collaborators at @scripps.edu and @abbvie.bsky.social who supported and contributed to this project!
Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @inesforrest.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...
www.biorxiv.org
March 24, 2025 at 7:34 AM
Beyond thrilled to share that my PhD work is now available as a preprint! 🥳 A huge thank you to my amazing colleagues, mentors and collaborators at @scripps.edu and @abbvie.bsky.social who supported and contributed to this project!
Reposted by Chris Parker
The sun is shining in London for the first day of #ABPP2025 ! Really excited to welcome everyone to the Crick later with an incredible lineup for the first session @abpp2025.bsky.social
March 30, 2025 at 10:01 AM
The sun is shining in London for the first day of #ABPP2025 ! Really excited to welcome everyone to the Crick later with an incredible lineup for the first session @abpp2025.bsky.social
Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @inesforrest.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...
www.biorxiv.org
March 23, 2025 at 7:09 AM
Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @inesforrest.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Chris Parker
🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...
Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq
Targeted protein degradation (TPD) is an emerging therapeutic modality in which small molecules are used to recruit targets to the natural protein degradation machinery of the cell. Molecular glue deg...
www.biorxiv.org
March 21, 2025 at 4:17 AM
🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...
Reposted by Chris Parker
OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs."
www.sandiegouniontribune.com/2025/02/25/o...
www.sandiegouniontribune.com/2025/02/25/o...
Opinion: Science funding cuts are based on flawed logic. Here’s the truth.
Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…
www.sandiegouniontribune.com
February 25, 2025 at 7:57 PM
OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs."
www.sandiegouniontribune.com/2025/02/25/o...
www.sandiegouniontribune.com/2025/02/25/o...
Reposted by Chris Parker
I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….
February 19, 2025 at 8:22 PM
I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….
Reposted by Chris Parker
🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start.
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
February 19, 2025 at 7:55 PM
🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start.
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
Reposted by Chris Parker
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
February 12, 2025 at 4:20 PM
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
Check out our recent efforts in chemrxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
February 5, 2025 at 7:46 AM
Check out our recent efforts in chemrxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Reposted by Chris Parker
Insightful perspective by the group of Ben Cravatt with first author @xiaoyuzhang.bsky.social in @nchembio.bsky.social. They discuss reasons, why expanding the repertoire of E3s for TPD has converged on few "frequent hitters" and how additional E3 targets could be identified. doi.org/10.1038/s415...
January 29, 2025 at 6:30 AM
Insightful perspective by the group of Ben Cravatt with first author @xiaoyuzhang.bsky.social in @nchembio.bsky.social. They discuss reasons, why expanding the repertoire of E3s for TPD has converged on few "frequent hitters" and how additional E3 targets could be identified. doi.org/10.1038/s415...
Congrats Ben!!!
Congratulations to Scripps Research Prof. Benjamin Cravatt, PhD, on receiving the 2025 William H. Nichols Medal from
@amerchemsociety.bsky.social for his pioneering work in activity-based protein profiling, advancing drug discovery for cancer & neurological disorders.
@amerchemsociety.bsky.social for his pioneering work in activity-based protein profiling, advancing drug discovery for cancer & neurological disorders.
Scripps Research professor awarded the 2025 Nichols Medal by American Chemical Society - Scripps Research Magazine
In recognition for developing activity-based protein profiling and advancing covalent drug discovery, Professor Benjamin Cravatt, PhD, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Re...
magazine.scripps.edu
January 8, 2025 at 3:05 PM
Congrats Ben!!!