Hannah Kiely-Collins
@hannahkielycollins.bsky.social
Senior Chemical Biologist at the Francis Crick Institute 👩🏻🔬 | Prev. PhD in Bernardes Group, University of Cambridge 🧪| Prev. MSci @impchemistry | 🎾 🇮🇪 🇬🇧 🧘🏻♀️|
Reposted by Hannah Kiely-Collins
Crazy new pre-print from TSRI: fix whole mice, clear them transparent, click on fluorophores, & use light sheet microscopy to visualize where drugs bind throughout the body. Find ibrutinib-yne in low BTK heart & blood vessels, correlates with cardiac side effects.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 5, 2025 at 1:39 PM
Crazy new pre-print from TSRI: fix whole mice, clear them transparent, click on fluorophores, & use light sheet microscopy to visualize where drugs bind throughout the body. Find ibrutinib-yne in low BTK heart & blood vessels, correlates with cardiac side effects.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
high quality conference stash 👌🧦 #ABPP2025 @li-corenv.bsky.social @selvita
March 31, 2025 at 8:50 PM
high quality conference stash 👌🧦 #ABPP2025 @li-corenv.bsky.social @selvita
The sun is shining in London for the first day of #ABPP2025 ! Really excited to welcome everyone to the Crick later with an incredible lineup for the first session @abpp2025.bsky.social
March 30, 2025 at 10:01 AM
The sun is shining in London for the first day of #ABPP2025 ! Really excited to welcome everyone to the Crick later with an incredible lineup for the first session @abpp2025.bsky.social
Reposted by Hannah Kiely-Collins
🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...
Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq
Targeted protein degradation (TPD) is an emerging therapeutic modality in which small molecules are used to recruit targets to the natural protein degradation machinery of the cell. Molecular glue deg...
www.biorxiv.org
March 21, 2025 at 4:17 AM
🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...
Reposted by Hannah Kiely-Collins
On this day in 1879, Maud Menten was born in Port Lambton, Ontario.
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
March 20, 2025 at 6:01 PM
On this day in 1879, Maud Menten was born in Port Lambton, Ontario.
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
Reposted by Hannah Kiely-Collins
This excellent commentary is a must-read for cancer biologists (and all biologists, really).
Probing cancer with small-molecule tools—Progress and challenges: Cancer Cell www.cell.com/cancer-cell/...
Probing cancer with small-molecule tools—Progress and challenges: Cancer Cell www.cell.com/cancer-cell/...
Our Cancer Cell Commentary reviews progress on chemical probes since Arrowsmith et al. (Nat Chem Biol 2015) and the launch of the Chemical Probes Portal. We highlight key issues, propose solutions, and outline a path to a quality probe for every human protein. #ChemicalProbes
March 2, 2025 at 11:34 AM
This excellent commentary is a must-read for cancer biologists (and all biologists, really).
Probing cancer with small-molecule tools—Progress and challenges: Cancer Cell www.cell.com/cancer-cell/...
Probing cancer with small-molecule tools—Progress and challenges: Cancer Cell www.cell.com/cancer-cell/...
Reposted by Hannah Kiely-Collins
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
A Bifunctional Degrader Reads Out in Phase 3
www.science.org
March 12, 2025 at 6:53 PM
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
Reposted by Hannah Kiely-Collins
This week we hosted the inaugural Chemistry at the @crick.ac.uk symposium. Nearly 200 attendees enjoyed great talks from a range of group leaders across chemistry, biology, and translation. Huge thanks to our sponsors Cresset, IDT, Buchi, Merck, Dotmatics, WuXi, MedChem Express, and Enamine
March 7, 2025 at 9:14 AM
This week we hosted the inaugural Chemistry at the @crick.ac.uk symposium. Nearly 200 attendees enjoyed great talks from a range of group leaders across chemistry, biology, and translation. Huge thanks to our sponsors Cresset, IDT, Buchi, Merck, Dotmatics, WuXi, MedChem Express, and Enamine
Reposted by Hannah Kiely-Collins
Reposted by Hannah Kiely-Collins
Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...
Molecular glue unexpectedly mimics the effect of cancer mutations
Protein structures could guide the design of molecular glue degraders.
www.nature.com
February 18, 2025 at 6:38 PM
Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...
Reposted by Hannah Kiely-Collins
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by Hannah Kiely-Collins
Check out our recent efforts in chemrxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
February 5, 2025 at 7:46 AM
Check out our recent efforts in chemrxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...