Sri Kosuri
@srikosuri.bsky.social
Cofounder/CEO Octant
BoD Ginkgo Bioworks
Defense Science Board for Emerging Biotech
Fmr: Associate Professor, UCLA
BoD Ginkgo Bioworks
Defense Science Board for Emerging Biotech
Fmr: Associate Professor, UCLA
Reposted by Sri Kosuri
Tags, reporters, luciferase — oh my!
To celebrate the expansion of the Promega Plasmid Collection, we’re spotlighting some of our most popular blogs on the technologies researchers rely on every day — tools you can access through Addgene.
To celebrate the expansion of the Promega Plasmid Collection, we’re spotlighting some of our most popular blogs on the technologies researchers rely on every day — tools you can access through Addgene.
September 23, 2025 at 2:01 PM
Tags, reporters, luciferase — oh my!
To celebrate the expansion of the Promega Plasmid Collection, we’re spotlighting some of our most popular blogs on the technologies researchers rely on every day — tools you can access through Addgene.
To celebrate the expansion of the Promega Plasmid Collection, we’re spotlighting some of our most popular blogs on the technologies researchers rely on every day — tools you can access through Addgene.
I wrote down some of my thoughts down on the current race to build virtual cell models. Overall, excited and wary about the work ahead. Also, it's my first post to Substack; getting more excited about it as a replacement for X and Blue Sky.
srikosuri.substack.com/p/the-elusiv...
srikosuri.substack.com/p/the-elusiv...
The elusive virtual cell
Rosetta Stone or Moby Dick?
srikosuri.substack.com
July 6, 2025 at 6:56 PM
I wrote down some of my thoughts down on the current race to build virtual cell models. Overall, excited and wary about the work ahead. Also, it's my first post to Substack; getting more excited about it as a replacement for X and Blue Sky.
srikosuri.substack.com/p/the-elusiv...
srikosuri.substack.com/p/the-elusiv...
Lux Capital & @wolfejosh.bsky.social are launching the Lux Science Helpline - a $100M commitment to support American scientists whose research is threatened by funding cuts, bureaucratic hurdles, and career roadblocks - that expands our Lux Labs program.
www.luxcapital.com/news/our-hel...
www.luxcapital.com/news/our-hel...
Our Helpline for American Scientists
www.luxcapital.com
May 9, 2025 at 10:10 PM
Lux Capital & @wolfejosh.bsky.social are launching the Lux Science Helpline - a $100M commitment to support American scientists whose research is threatened by funding cuts, bureaucratic hurdles, and career roadblocks - that expands our Lux Labs program.
www.luxcapital.com/news/our-hel...
www.luxcapital.com/news/our-hel...
An update: After the diagnosis change to AML/myeloid sarcoma, we got a lot of great input. We’ve decided to go to St Jude’s to enroll in a clinical trial. We left for Memphis yesterday. We’ll be staying here for the next several months. Anxious but ready for the path ahead.
March 4, 2025 at 12:27 AM
An update: After the diagnosis change to AML/myeloid sarcoma, we got a lot of great input. We’ve decided to go to St Jude’s to enroll in a clinical trial. We left for Memphis yesterday. We’ll be staying here for the next several months. Anxious but ready for the path ahead.
Quick update: Thanks so much for the outpouring of support and help. We learned a lot in the last week and the tumor is actually a myeloid sarcoma likely derived from early AML, with the hope of possible targeted therapies as well (KMT2Ar).
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 22, 2025 at 1:40 AM
Quick update: Thanks so much for the outpouring of support and help. We learned a lot in the last week and the tumor is actually a myeloid sarcoma likely derived from early AML, with the hope of possible targeted therapies as well (KMT2Ar).
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Serenity now
a man in a kitchen with a sweater on that says oh no i am fine serenity now .
ALT: a man in a kitchen with a sweater on that says oh no i am fine serenity now .
media.tenor.com
January 28, 2025 at 1:54 PM
Serenity now
Reposted by Sri Kosuri
This is part of my effort of rewriting all materials for my UT Austin dataviz class in Quarto. It's going very well. Most importantly, I now have live exercises integrated into the site, thanks to Quarto live. Check it out here: wilkelab.org/SDS366/
January 8, 2025 at 8:03 PM
This is part of my effort of rewriting all materials for my UT Austin dataviz class in Quarto. It's going very well. Most importantly, I now have live exercises integrated into the site, thanks to Quarto live. Check it out here: wilkelab.org/SDS366/
Reposted by Sri Kosuri
Check out our work, where we discover how receptor GPCR senses pH! We solved a longstanding question by developing foundational GPCR DMS tech dev + structural bio! Led by brilliant PhD student @matthewkhoward.bsky.social and Nick Hoppe w/ @amanglik.bsky.social!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
January 6, 2025 at 11:47 PM
Check out our work, where we discover how receptor GPCR senses pH! We solved a longstanding question by developing foundational GPCR DMS tech dev + structural bio! Led by brilliant PhD student @matthewkhoward.bsky.social and Nick Hoppe w/ @amanglik.bsky.social!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Sri Kosuri
Today's holiday ☕ reading is this 2024 paper on PARIS, a bacterial defense system shaped like a literal propeller that responds to viral infection by hitting the cellular self-destruct button - cleaving an essential tRNA. www.nature.com/articles/s41...
A virally encoded tRNA neutralizes the PARIS antiviral defence system - Nature
Structural and functional studies reveal how viral proteins trigger the phage antirestriction induced system (PARIS) to degrade host tRNA and how viral tRNAs suppress the PARIS nuclease and thereby ov...
www.nature.com
December 24, 2024 at 3:18 PM
Today's holiday ☕ reading is this 2024 paper on PARIS, a bacterial defense system shaped like a literal propeller that responds to viral infection by hitting the cellular self-destruct button - cleaving an essential tRNA. www.nature.com/articles/s41...
Reposted by Sri Kosuri
Really beautiful paper by @kjarmache.bsky.social revealing read-write mechanisms of histone ubiquitylation by Polycomb complexes - through an intricate interplay of ubiquitin binding and ubiquitin transfer. Congratulations to all authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1 - Nature
Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their roles in maintaining e...
www.nature.com
December 22, 2024 at 4:30 PM
Really beautiful paper by @kjarmache.bsky.social revealing read-write mechanisms of histone ubiquitylation by Polycomb complexes - through an intricate interplay of ubiquitin binding and ubiquitin transfer. Congratulations to all authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sri Kosuri
Out now - National Academies consensus report on Understanding and Addressing Misinformation About Science 🧪
It was a privilege to serve as one of the 15 committee members from a wide range of scientific disciplines who put this report together. Quick 🧵1/
www.nationalacademies.org/our-work/und...
It was a privilege to serve as one of the 15 committee members from a wide range of scientific disciplines who put this report together. Quick 🧵1/
www.nationalacademies.org/our-work/und...
December 19, 2024 at 6:20 PM
Out now - National Academies consensus report on Understanding and Addressing Misinformation About Science 🧪
It was a privilege to serve as one of the 15 committee members from a wide range of scientific disciplines who put this report together. Quick 🧵1/
www.nationalacademies.org/our-work/und...
It was a privilege to serve as one of the 15 committee members from a wide range of scientific disciplines who put this report together. Quick 🧵1/
www.nationalacademies.org/our-work/und...
Reposted by Sri Kosuri
In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations
Rabies virus causes nearly 60,000 human deaths annually. Antibodies that target the rabies glycoprotein (G) are being developed as post-exposure prophylactics, but mutations in G can render such antib...
www.biorxiv.org
December 18, 2024 at 8:39 PM
In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Reposted by Sri Kosuri
What do GWAS and rare variant burden tests discover, and why?
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Specificity, length, and luck: How genes are prioritized by rare and common variant association studies
Standard genome-wide association studies (GWAS) and rare variant burden tests are essential tools for identifying trait-relevant genes. Although these methods are conceptually similar, we show by anal...
www.biorxiv.org
December 17, 2024 at 7:05 AM
What do GWAS and rare variant burden tests discover, and why?
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
The responses to this are why change is not really going to happen within the universities themselves. I’m excited that AI has the possibility to break the cost curves to broad access to education. Lots of work to do, and thanks to those putting in that work to build a brighter future.
So excited to tell you about my new venture with @afinetheorem.bsky.social called All Day TA (@alldayta.bsky.social) open.substack.com/pub/joshuaga...
Introducing All Day TA
My new venture designed to bring AI responsibly into college education
open.substack.com
December 16, 2024 at 5:52 PM
The responses to this are why change is not really going to happen within the universities themselves. I’m excited that AI has the possibility to break the cost curves to broad access to education. Lots of work to do, and thanks to those putting in that work to build a brighter future.
Reposted by Sri Kosuri
I'm thrilled to announce a new preprint describing collaborative work with Ajay Jain and Ann Cleves Jain, "Deep-Learning Based Docking Methods: Fair Comparisons to Conventional Docking Workflows".
arxiv.org/abs/2412.02889
arxiv.org/abs/2412.02889
Deep-Learning Based Docking Methods: Fair Comparisons to Conventional Docking Workflows
The diffusion learning method, DiffDock, for docking small-molecule ligands into protein binding sites was recently introduced. Results included comparisons to more conventional docking approaches, wi...
arxiv.org
December 5, 2024 at 4:21 PM
I'm thrilled to announce a new preprint describing collaborative work with Ajay Jain and Ann Cleves Jain, "Deep-Learning Based Docking Methods: Fair Comparisons to Conventional Docking Workflows".
arxiv.org/abs/2412.02889
arxiv.org/abs/2412.02889
Reposted by Sri Kosuri
"Wuhan lab samples hold no close relatives to virus behind COVID"
That should settle it, right? The problem, of course, it won't because we're dealing with conspiracy theories and not scientific inquiry - no amount of additional data will change un-evidenced beliefs.
www.nature.com/articles/d41...
That should settle it, right? The problem, of course, it won't because we're dealing with conspiracy theories and not scientific inquiry - no amount of additional data will change un-evidenced beliefs.
www.nature.com/articles/d41...
Wuhan lab samples hold no close relatives to virus behind COVID
Shi Zhengli, the virologist at centre of COVID lab-leak theory, reveals coronavirus sequences from Wuhan institute.
www.nature.com
December 6, 2024 at 5:42 PM
"Wuhan lab samples hold no close relatives to virus behind COVID"
That should settle it, right? The problem, of course, it won't because we're dealing with conspiracy theories and not scientific inquiry - no amount of additional data will change un-evidenced beliefs.
www.nature.com/articles/d41...
That should settle it, right? The problem, of course, it won't because we're dealing with conspiracy theories and not scientific inquiry - no amount of additional data will change un-evidenced beliefs.
www.nature.com/articles/d41...
Is there a way to do starter pack for people to block? Would love to just block folks en masse that are cheering on the execution of a company CEO b/c they hate capitalism or whatever. It's insufferable.
Agreed. I've seen some quite shocking posts from US colleagues about it actually. And these are prestigious scientists I'm talking about too. 😔
not really casting the first stone as I've done my fair share of glib posting about grim news but seeing Americans begin joking about a health insurance CEO getting shot in broad daylight immediately after it happened really makes you realise just how coarse the discourse has got over there
December 5, 2024 at 4:23 PM
Is there a way to do starter pack for people to block? Would love to just block folks en masse that are cheering on the execution of a company CEO b/c they hate capitalism or whatever. It's insufferable.
Reposted by Sri Kosuri
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
December 4, 2024 at 4:05 PM
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
Reposted by Sri Kosuri
Have been thinking about Brian Thompson and his family all day. This one hits home. You kiss your kids goodbye and get on a plane, eat dinner with colleagues prepare your presentation and walk toward the conference hotel. A scenario we all have lived dozens of times. The family must be devastated 😞
December 4, 2024 at 10:36 PM
Have been thinking about Brian Thompson and his family all day. This one hits home. You kiss your kids goodbye and get on a plane, eat dinner with colleagues prepare your presentation and walk toward the conference hotel. A scenario we all have lived dozens of times. The family must be devastated 😞
Reposted by Sri Kosuri
First post on bsky to highlight our latest work on smell receptors (www.nature.com/articles/s41...). Odorant receptors are notoriously challenging to work with - we used a classic strategy from protein engineering to get a peek into how these receptors recognize such a diversity of smells.
December 4, 2024 at 4:59 AM
First post on bsky to highlight our latest work on smell receptors (www.nature.com/articles/s41...). Odorant receptors are notoriously challenging to work with - we used a classic strategy from protein engineering to get a peek into how these receptors recognize such a diversity of smells.
Reposted by Sri Kosuri
December 4, 2024 at 4:40 AM
Reposted by Sri Kosuri
The final report from the COVID Sub Committee is released and it is as expected given that the origin "has been contorted by politics, while scientific discourse has been abandoned in pursuit of a preferred, coordinated narrative", as I stated in my written testimony.
BUT, there's a bombshell.. 🧵👇
BUT, there's a bombshell.. 🧵👇
December 3, 2024 at 2:18 AM
The final report from the COVID Sub Committee is released and it is as expected given that the origin "has been contorted by politics, while scientific discourse has been abandoned in pursuit of a preferred, coordinated narrative", as I stated in my written testimony.
BUT, there's a bombshell.. 🧵👇
BUT, there's a bombshell.. 🧵👇
Reposted by Sri Kosuri
Three BioML starter packs now!
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
December 3, 2024 at 3:27 AM
Three BioML starter packs now!
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Reposted by Sri Kosuri
