Reposted by Alice Ting
I'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.
August 27, 2025 at 9:44 PM
I'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.
Proximity-specific ribosome profiling using LOV-BirA reveals two distinct strategies for mitochondrially-localized translation: one for long coding sequences and one for short. It was a pleasure to contribute to this beautiful work from Jonathan Weissman @weissmanlab.bsky.social and Jingchuan Luo
August 27, 2025 at 3:29 PM
Proximity-specific ribosome profiling using LOV-BirA reveals two distinct strategies for mitochondrially-localized translation: one for long coding sequences and one for short. It was a pleasure to contribute to this beautiful work from Jonathan Weissman @weissmanlab.bsky.social and Jingchuan Luo
LOV-BirA, light regulated biotin ligase, engineered by Song-Yi Lee
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
August 27, 2025 at 3:26 PM
LOV-BirA, light regulated biotin ligase, engineered by Song-Yi Lee
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Alice Ting
A new paper from @aliceyting.bsky.social reports on LaccID, an engineered laccase, that enables hydrogen peroxide-free proximity labeling and electron microscopy of cell surfaces
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Directed evolution of LaccID for cell surface proximity labeling and electron microscopy - Nature Chemical Biology
LaccID, an engineered laccase, enables hydrogen-peroxide-free proximity labeling and electron microscopy (EM) in mammalian cells. Notably, LaccID is selectively active at the cell surface, enabling th...
www.nature.com
August 1, 2025 at 7:51 PM
A new paper from @aliceyting.bsky.social reports on LaccID, an engineered laccase, that enables hydrogen peroxide-free proximity labeling and electron microscopy of cell surfaces
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Can a single researcher test over half a million chemical reactions in <3 days? Yes, using Jeff Martell’s new DNA-encoded combinatorial screening platform. Check out his lab’s exciting new preprint 👇
Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr...
New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
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New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
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DNA-Scaffolded Ultrahigh-Throughput Reaction Screening
Discovering and optimizing reactions is central to synthetic chemistry. However, chemical reactions are traditionally screened using relatively low-throughput methods, prohibiting exploration of diver...
chemrxiv.org
August 18, 2025 at 4:06 PM
Can a single researcher test over half a million chemical reactions in <3 days? Yes, using Jeff Martell’s new DNA-encoded combinatorial screening platform. Check out his lab’s exciting new preprint 👇
We are hiring a new lab manager! Our wonderful lab manager Albert is headed off to grad school and we are looking to fill his position this summer. This is a great opportunity for a new graduate to spend a couple years immersed in research before applying to PhD or MD programs. 50% of the job is...
March 26, 2025 at 5:39 PM
We are hiring a new lab manager! Our wonderful lab manager Albert is headed off to grad school and we are looking to fill his position this summer. This is a great opportunity for a new graduate to spend a couple years immersed in research before applying to PhD or MD programs. 50% of the job is...
Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of
February 26, 2025 at 11:21 PM
Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of
Tetanus on demand! (not for bioweapons, but for neuroscience research)
Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release.
To harness this toxicity and use it as a beneficial tool for neuroscience,
Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release.
To harness this toxicity and use it as a beneficial tool for neuroscience,
January 30, 2025 at 2:30 PM
Tetanus on demand! (not for bioweapons, but for neuroscience research)
Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release.
To harness this toxicity and use it as a beneficial tool for neuroscience,
Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release.
To harness this toxicity and use it as a beneficial tool for neuroscience,
Are you a Japanese student interested in a postdoctoral fellowship in the US? The Chan Zuckerberg Initiative has an exciting new fully-funded Global Science Scholars program to pair students who have received their undergraduate or doctoral degrees in Japan with US bioengineering and biomedical...
Global Science Scholars Postdoctoral Fellowship Program SS-F
Apply for the new international postdoctoral fellowship program from the CZ Biohub Network and Stellar Science Foundation.
czbiohub.org
January 9, 2025 at 6:21 PM
Are you a Japanese student interested in a postdoctoral fellowship in the US? The Chan Zuckerberg Initiative has an exciting new fully-funded Global Science Scholars program to pair students who have received their undergraduate or doctoral degrees in Japan with US bioengineering and biomedical...
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
December 4, 2024 at 4:05 PM
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..