Daphne Zohar
@daphnezohar.bsky.social
I don’t check this account often. Founder & CEO of www.SeaportTx.com developing new medicines for neuropsychiatric disorders. Co-founder Karuna Tx (KarXt/Cobenfy now at BMS). Founding CEO & Senior Advisor PureTech. Co founder/host @BiotechCH. Board of BIO
Proud of friend, #BiotechCEOSisterhood co-founder Sheila Gujrathi launching *The Mirror Effect* Amazon today!
Takeaways:
1. Internal glass ceiling = real
2. Toxic environments? Walk
3. Build your Personal BoD
4. Negotiate w/out compromising
5. Lead with kindness (not niceness) → inspire
Takeaways:
1. Internal glass ceiling = real
2. Toxic environments? Walk
3. Build your Personal BoD
4. Negotiate w/out compromising
5. Lead with kindness (not niceness) → inspire
November 4, 2025 at 12:51 PM
Proud of friend, #BiotechCEOSisterhood co-founder Sheila Gujrathi launching *The Mirror Effect* Amazon today!
Takeaways:
1. Internal glass ceiling = real
2. Toxic environments? Walk
3. Build your Personal BoD
4. Negotiate w/out compromising
5. Lead with kindness (not niceness) → inspire
Takeaways:
1. Internal glass ceiling = real
2. Toxic environments? Walk
3. Build your Personal BoD
4. Negotiate w/out compromising
5. Lead with kindness (not niceness) → inspire
Reposted by Daphne Zohar
Mark your calendars! #BiotechHangout & @biotechtv.bsky.social will be back at #JPM26. Join us at Persona to meet up with biotech friends IRL on Tuesday, January 13 from 7-10pm. Interested in sponsoring? Email team@biotechhangout.com for more information. Additional registration information to come.
October 21, 2025 at 1:15 PM
Mark your calendars! #BiotechHangout & @biotechtv.bsky.social will be back at #JPM26. Join us at Persona to meet up with biotech friends IRL on Tuesday, January 13 from 7-10pm. Interested in sponsoring? Email team@biotechhangout.com for more information. Additional registration information to come.
Reposted by Daphne Zohar
Members of our exec team joined Fierce Biotech’s #Fierce15 awards to celebrate our recognition, honoring our team's work developing new medicines for #depression & #anxiety. It's also a reflection of the strong momentum & growth since our launch last year. bit.ly/3VSOQQ7
October 9, 2025 at 6:36 PM
Members of our exec team joined Fierce Biotech’s #Fierce15 awards to celebrate our recognition, honoring our team's work developing new medicines for #depression & #anxiety. It's also a reflection of the strong momentum & growth since our launch last year. bit.ly/3VSOQQ7
Reposted by Daphne Zohar
We convened top neuropsych experts, sell-side analysts, investors, & biopharma leaders for a unique roundtable discussion on the opportunities & excitement in #neuropsychiatry & what’s next as #MentalHealth conditions continue to impact millions globally. See below for some takeaways
October 8, 2025 at 11:02 AM
We convened top neuropsych experts, sell-side analysts, investors, & biopharma leaders for a unique roundtable discussion on the opportunities & excitement in #neuropsychiatry & what’s next as #MentalHealth conditions continue to impact millions globally. See below for some takeaways
Reposted by Daphne Zohar
𝐂𝐨𝐦𝐩𝐚𝐧𝐲 𝐓𝐨𝐮𝐫: BiotechTV visited the new offices of @seaporttx.bsky.social today and was given a tour by Founder & CEO @daphnezohar.bsky.social
July 21, 2025 at 11:46 PM
𝐂𝐨𝐦𝐩𝐚𝐧𝐲 𝐓𝐨𝐮𝐫: BiotechTV visited the new offices of @seaporttx.bsky.social today and was given a tour by Founder & CEO @daphnezohar.bsky.social
Reposted by Daphne Zohar
For @biotechtv.bsky.social's Biotech CEO Sisterhood series, our CEO @daphnezohar.bsky.social spoke to Sophie Kornowski on her journey leading Boston Pharmaceuticals to a $2B deal w/ GSK. Check this out for insights from both leaders on dealmaking, leadership strategies & mentorship: bit.ly/4m55kzG
Biotech CEO Sisterhood: As CEO, Sophie Kornowski sold Boston Pharmaceuticals to GSK earlier this year for up to $2 billion. She shares her thoughts on the biopharma business and leadership
Interviewed by Sisterhood editorial board member Daphne Zohar, Sophie Kornowski shares her keys to creating great assets, commercialization, partnerships, and, ultimately, executing a successful deal ...
bit.ly
July 18, 2025 at 5:44 PM
For @biotechtv.bsky.social's Biotech CEO Sisterhood series, our CEO @daphnezohar.bsky.social spoke to Sophie Kornowski on her journey leading Boston Pharmaceuticals to a $2B deal w/ GSK. Check this out for insights from both leaders on dealmaking, leadership strategies & mentorship: bit.ly/4m55kzG
Reposted by Daphne Zohar
Pleased to announce the first patient has been dosed in our Ph2b BUOY-1 study of GlyphAllo™ (SPT-300) in #MDD w/ or w/o anxious distress, an important milestone for Seaport’s pipeline that brings us closer to a potential new treatment for patients w/ MDD: bit.ly/3Uhn3YB
July 17, 2025 at 11:02 AM
Pleased to announce the first patient has been dosed in our Ph2b BUOY-1 study of GlyphAllo™ (SPT-300) in #MDD w/ or w/o anxious distress, an important milestone for Seaport’s pipeline that brings us closer to a potential new treatment for patients w/ MDD: bit.ly/3Uhn3YB
Reposted by Daphne Zohar
#BiotechHangout Eric Schmidt, Brad Loncar, Tim Opler, Tess Cameron on M&A: $MRK/$VRNA, $ABBV/Capstan, biotech takeouts, M&A wave, pharma’s $150B in LOE, plus Trump’s BBB/tariffs, $XBI & MFN, FDA’s CRL disclosures, $CAPR, $KALV, $PROK, obesity trends, $RARE/$MREO, $ABBV/Ichnos: bit.ly/3TuICVp
July 11, 2025 at 1:03 PM
#BiotechHangout Eric Schmidt, Brad Loncar, Tim Opler, Tess Cameron on M&A: $MRK/$VRNA, $ABBV/Capstan, biotech takeouts, M&A wave, pharma’s $150B in LOE, plus Trump’s BBB/tariffs, $XBI & MFN, FDA’s CRL disclosures, $CAPR, $KALV, $PROK, obesity trends, $RARE/$MREO, $ABBV/Ichnos: bit.ly/3TuICVp
Reposted by Daphne Zohar
The Seaport crew kicked off summer with a fun gathering! Great opportunity to connect out of the office, strengthening our mission to develop life-changing medicines for #neuropsychiatric disorders. Looking forward to more moments together and progress towards transforming lives!
June 30, 2025 at 1:27 PM
The Seaport crew kicked off summer with a fun gathering! Great opportunity to connect out of the office, strengthening our mission to develop life-changing medicines for #neuropsychiatric disorders. Looking forward to more moments together and progress towards transforming lives!
Reposted by Daphne Zohar
As #MentalHealthMonth closes, we welcomed a @namicommunicate.bsky.social patient representative to share his journey w/ mental health conditions. His story inspires our work at Seaport to help those struggling & develop new medicines for #depression & #anxiety. More: www.nami.org
May 30, 2025 at 11:04 AM
As #MentalHealthMonth closes, we welcomed a @namicommunicate.bsky.social patient representative to share his journey w/ mental health conditions. His story inspires our work at Seaport to help those struggling & develop new medicines for #depression & #anxiety. More: www.nami.org
Reposted by Daphne Zohar
#BiotechHangout: Chris Garabedian, Josh Schimmer, Nina Kjellson, Mike Yee, Tim Opler on market sentiment – where is the M&A?, FDA/CBER, wind downs vs reverse mergers, policy: #MAHA & COVID vaccine, $REGN/23andMe, data: $RCKT, psychedelics, $PRTA, $SPRO/$GSK, $GILD, $SMMT, #ASCO & more bit.ly/4dCFzDT
May 30, 2025 at 1:08 PM
#BiotechHangout: Chris Garabedian, Josh Schimmer, Nina Kjellson, Mike Yee, Tim Opler on market sentiment – where is the M&A?, FDA/CBER, wind downs vs reverse mergers, policy: #MAHA & COVID vaccine, $REGN/23andMe, data: $RCKT, psychedelics, $PRTA, $SPRO/$GSK, $GILD, $SMMT, #ASCO & more bit.ly/4dCFzDT
Reposted by Daphne Zohar
Two people were shot and killed outside a Jewish LGBTQ event in D.C.
Man, woman shot and killed in front of Capital Jewish Museum in DC
A man and woman were shot and killed in front of the Capital Jewish Museum in Northwest D.C. Wednesday evening. The shooting took place in the area of 3rd and F streets in Northwest — in front of the ...
www.nbcwashington.com
May 22, 2025 at 3:05 AM
Two people were shot and killed outside a Jewish LGBTQ event in D.C.
Reposted by Daphne Zohar
This #MentalHealthMonth, we joined @namicommunicate.bsky.social's annual #NAMIWalks to combat stigma & promote mental health awareness. We stand with those affected by mental illness & are dedicated to developing new medicines for #depression & #anxiety. More about NAMI www.nami.org
May 20, 2025 at 11:03 AM
This #MentalHealthMonth, we joined @namicommunicate.bsky.social's annual #NAMIWalks to combat stigma & promote mental health awareness. We stand with those affected by mental illness & are dedicated to developing new medicines for #depression & #anxiety. More about NAMI www.nami.org
Reposted by Daphne Zohar
#BiotechHangout: Sam Fazeli, John Maraganore, Nina Kjellson, Matt Gline on MFN: 30-day ultimatum, 180 days negotiation, reimportation, ex-US prices, DTC, Roche, $SNY, plus: budget reconciliation, IRA, $RXRX, Galapagos, $CTMX, $GSK buys Boston, $GSK/iTeos, $NVO CEO, RNA deals: bit.ly/3S3vhTh
May 16, 2025 at 1:00 PM
#BiotechHangout: Sam Fazeli, John Maraganore, Nina Kjellson, Matt Gline on MFN: 30-day ultimatum, 180 days negotiation, reimportation, ex-US prices, DTC, Roche, $SNY, plus: budget reconciliation, IRA, $RXRX, Galapagos, $CTMX, $GSK buys Boston, $GSK/iTeos, $NVO CEO, RNA deals: bit.ly/3S3vhTh
Seems like Bluesky is losing momentum? Wouldn’t mind having one less place to check/post. Curious to hear from others
May 13, 2025 at 2:00 PM
Seems like Bluesky is losing momentum? Wouldn’t mind having one less place to check/post. Curious to hear from others
Important provisions added to reconciliation bills would be positive for bio if passed:
ORPHAN Cures Act included, amend IRA
PBM reforms delinking compensation from list price, increasing transparency & banning spread pricing in Medicaid
Tax fix to allow for immediate deduction of R&D costs
ORPHAN Cures Act included, amend IRA
PBM reforms delinking compensation from list price, increasing transparency & banning spread pricing in Medicaid
Tax fix to allow for immediate deduction of R&D costs
May 13, 2025 at 1:44 PM
Important provisions added to reconciliation bills would be positive for bio if passed:
ORPHAN Cures Act included, amend IRA
PBM reforms delinking compensation from list price, increasing transparency & banning spread pricing in Medicaid
Tax fix to allow for immediate deduction of R&D costs
ORPHAN Cures Act included, amend IRA
PBM reforms delinking compensation from list price, increasing transparency & banning spread pricing in Medicaid
Tax fix to allow for immediate deduction of R&D costs
Cantor has put out some really interesting notes lately. Dueling takes from Eric Schmidt & Josh Schimmer on short selling last week and then this week a thoughtful critique of issues that are ailing our industry. Link below:
cantor2.bluematrix.com/sellside/Ema...
cantor2.bluematrix.com/sellside/Ema...
May 4, 2025 at 2:05 PM
Cantor has put out some really interesting notes lately. Dueling takes from Eric Schmidt & Josh Schimmer on short selling last week and then this week a thoughtful critique of issues that are ailing our industry. Link below:
cantor2.bluematrix.com/sellside/Ema...
cantor2.bluematrix.com/sellside/Ema...
Reposted by Daphne Zohar
#BiotechHangout: Eric Schmidt, Sam Fazeli, Adam Feuerstein, Peter Kolchinsky on $XBI, market & macro trends, latest from FDA/Washington, Q1 earnings trends: tariffs, M&A & drug launches, data: $SMMT/Akeso & #AUA2025 & #AACR25 recap ($PFE, $JNJ, $BNTX, $CGON, China ADCs): twitter.com/i/spaces/1gq...
May 2, 2025 at 1:08 PM
#BiotechHangout: Eric Schmidt, Sam Fazeli, Adam Feuerstein, Peter Kolchinsky on $XBI, market & macro trends, latest from FDA/Washington, Q1 earnings trends: tariffs, M&A & drug launches, data: $SMMT/Akeso & #AUA2025 & #AACR25 recap ($PFE, $JNJ, $BNTX, $CGON, China ADCs): twitter.com/i/spaces/1gq...
Reposted by Daphne Zohar
#Depression & #anxiety are among the most common & disabling #mentalhealth conditions. This #MentalHealthAwarenessMonth we're spotlighting our commitment to developing better medicines & reducing the stigma for those dealing w/these conditions. Learn more: www.seaporttx.com
May 1, 2025 at 11:00 AM
#Depression & #anxiety are among the most common & disabling #mentalhealth conditions. This #MentalHealthAwarenessMonth we're spotlighting our commitment to developing better medicines & reducing the stigma for those dealing w/these conditions. Learn more: www.seaporttx.com
“When Secretary Kennedy offers a suggestion to me, he always adds, “You decide for yourself.” So, yes, there is independence.” New interview with Marty Makary sheds more light on re-org (no plans), PDUFA dates, morale and his independence from RFK insidemedicine.substack.com/p/exclusive-...
Exclusive: In conversation with FDA Commissioner Dr. Marty Makary.
In our wide-ranging Q&A, Dr. Makary outlines his vision, addresses low morale, asserts his independence, explains his stance on Novavax, and says "no" to an agency reorganization.
insidemedicine.substack.com
April 29, 2025 at 12:59 PM
“When Secretary Kennedy offers a suggestion to me, he always adds, “You decide for yourself.” So, yes, there is independence.” New interview with Marty Makary sheds more light on re-org (no plans), PDUFA dates, morale and his independence from RFK insidemedicine.substack.com/p/exclusive-...
Reposted by Daphne Zohar
#BiotechHangout: Daphne Zohar, Josh Schimmer, Tim Opler, John Maraganore, Paul Matteis on macroenvironment, $XBI, $SWTX $MRCG takeout rumors, policy: (FDA, tariffs), data: ($BMY, $QURE, #AUA25: $JNJ/$CGON), Trump vs. Harvard, buyside & short-selling, CEO survival tips: x.com/biotechch/st...
April 25, 2025 at 5:23 PM
#BiotechHangout: Daphne Zohar, Josh Schimmer, Tim Opler, John Maraganore, Paul Matteis on macroenvironment, $XBI, $SWTX $MRCG takeout rumors, policy: (FDA, tariffs), data: ($BMY, $QURE, #AUA25: $JNJ/$CGON), Trump vs. Harvard, buyside & short-selling, CEO survival tips: x.com/biotechch/st...
Reposted by Daphne Zohar
We're at #SOBP2025 to present new preclinical data on SPT-320, a novel oral prodrug of agomelatine. SPT-320 increased lymphatic transport >50% compared to <1% agomelatine alone & increased plasma exposure >10-fold. SPT-320 progressing into clinic for #GAD. bit.ly/4ixtOzs
April 24, 2025 at 11:01 AM
We're at #SOBP2025 to present new preclinical data on SPT-320, a novel oral prodrug of agomelatine. SPT-320 increased lymphatic transport >50% compared to <1% agomelatine alone & increased plasma exposure >10-fold. SPT-320 progressing into clinic for #GAD. bit.ly/4ixtOzs
Makary interview: “Why does it take 10 years to bring a drug to market in US? People are dying. Our # 1 goal is delivering cures, meaningful treatments, healthier food” 1 randomized controlled trial & then intense post marketing surveillance (link for full text):
www.linkedin.com/posts/daphne...
www.linkedin.com/posts/daphne...
X | Daphne Zohar
Takeaways from this new Marty Makary M.D., M.P.H. interview on Megyn Kelly:
-“Why does it take 10 years to bring a drug to market in US? People are dying. Our # 1 goal is delivering cures, meaningfu...
www.linkedin.com
April 18, 2025 at 12:56 PM
Makary interview: “Why does it take 10 years to bring a drug to market in US? People are dying. Our # 1 goal is delivering cures, meaningful treatments, healthier food” 1 randomized controlled trial & then intense post marketing surveillance (link for full text):
www.linkedin.com/posts/daphne...
www.linkedin.com/posts/daphne...
Insider close to administration: Elon’s DOGE work almost done. Lutnick & Navarro losing influence & Bessent gaining. Most interesting: “If Secretary of HHS makes it through the year I’ll be shocked.” Oz important. Last night’s EO opportunity “pill penalty.” Sounds like they’re coming after CVS/PBMs
April 16, 2025 at 3:14 PM
Insider close to administration: Elon’s DOGE work almost done. Lutnick & Navarro losing influence & Bessent gaining. Most interesting: “If Secretary of HHS makes it through the year I’ll be shocked.” Oz important. Last night’s EO opportunity “pill penalty.” Sounds like they’re coming after CVS/PBMs