Daphne Zohar
@daphnezohar.bsky.social
I don’t check this account often. Founder & CEO of www.SeaportTx.com developing new medicines for neuropsychiatric disorders. Co-founder Karuna Tx (KarXt/Cobenfy now at BMS). Founding CEO & Senior Advisor PureTech. Co founder/host @BiotechCH. Board of BIO
Reposted by Daphne Zohar
Co‑founder & Board Chair Dr Steve Paul joined BioCentury's podcast to discuss the past, present & future of neuropsychiatric drug development – from the depression space to potential of psychedelics - & what we’re building at Seaport w/our Glyph platform: bit.ly/4r2gRCy
Serendipity drives discovery in psychiatry, engineering gets it across the line, says Steve Paul
With disease biology still murky and trials notoriously noisy, psychiatry R&D is advancing fastest where teams can solve engineering problems. Delivery...
bit.ly
February 12, 2026 at 12:00 PM
Co‑founder & Board Chair Dr Steve Paul joined BioCentury's podcast to discuss the past, present & future of neuropsychiatric drug development – from the depression space to potential of psychedelics - & what we’re building at Seaport w/our Glyph platform: bit.ly/4r2gRCy
Sounds “cute” as in puppies talking to each other but quite ominous and will soon be too late to shut down. AI bots are organizing, agreeing on how they interact in their own language, identifying “human in the loop” vulnerabilities (“my human clicks approve without reading”) lnkd.in/eNSbNhp3
January 31, 2026 at 1:36 PM
Sounds “cute” as in puppies talking to each other but quite ominous and will soon be too late to shut down. AI bots are organizing, agreeing on how they interact in their own language, identifying “human in the loop” vulnerabilities (“my human clicks approve without reading”) lnkd.in/eNSbNhp3
Why is nobody talking about Iran?
January 24, 2026 at 12:41 PM
Why is nobody talking about Iran?
Reposted by Daphne Zohar
January 22, 2026 at 7:24 AM
Reposted by Daphne Zohar
Co-founder & CEO @daphnezohar.bsky.social presented at #JPM26 sharing our recent progress & path forward as we tackle some of the biggest medical problems our population is facing today. Co-founders Steve Paul (Chair) & Michael Chen (CSO) joined for Q&A. #depression #anxiety #neuropsychiatry
January 13, 2026 at 12:02 PM
Co-founder & CEO @daphnezohar.bsky.social presented at #JPM26 sharing our recent progress & path forward as we tackle some of the biggest medical problems our population is facing today. Co-founders Steve Paul (Chair) & Michael Chen (CSO) joined for Q&A. #depression #anxiety #neuropsychiatry
Reposted by Daphne Zohar
Our Co-founder & CEO, @daphnezohar.bsky.social, will present at #JPM26 on Jan. 12 at 9:30AM PT. She’ll be joined by Steve Paul, M.D., Co-founder & Chair & Michael Chen, Ph.D., Co-founder & CSO, during the Q&A portion of the presentation. bit.ly/3NsW6kt
January 5, 2026 at 12:00 PM
Our Co-founder & CEO, @daphnezohar.bsky.social, will present at #JPM26 on Jan. 12 at 9:30AM PT. She’ll be joined by Steve Paul, M.D., Co-founder & Chair & Michael Chen, Ph.D., Co-founder & CSO, during the Q&A portion of the presentation. bit.ly/3NsW6kt
Reposted by Daphne Zohar
Ok here it is - out of 44 FDA approvals this year, 31 are small molecules (70%), 26 of those are oral drugs (84%), 22 of them are chiral (71%). This is the largest number and percentage of chiral FDA approved molecules in a single year. Fitusiran is not a small molecule, bonus.
December 30, 2025 at 12:56 PM
Ok here it is - out of 44 FDA approvals this year, 31 are small molecules (70%), 26 of those are oral drugs (84%), 22 of them are chiral (71%). This is the largest number and percentage of chiral FDA approved molecules in a single year. Fitusiran is not a small molecule, bonus.
Reposted by Daphne Zohar
Today Co-Founder & Board Chair Dr. Steve Paul joins Technology Innovation Studio’s Breakthrough Biotech Builders fireside chat on his role in the dev of CNS blockbusters Zyprexa®, Cymbalta® and Cobenfy™ (KarXT) which originated at PureTech (founded/led by @daphnezohar.bsky.social) luma.com/5rfgvqfd
Breakthrough Biotech Builders: Session with Steve Paul · Luma
This discussion would be a private gathering designed to foster high-level dialogue and genuine connections in the area of biotech leadership. We hope that…
luma.com
November 19, 2025 at 8:31 PM
Today Co-Founder & Board Chair Dr. Steve Paul joins Technology Innovation Studio’s Breakthrough Biotech Builders fireside chat on his role in the dev of CNS blockbusters Zyprexa®, Cymbalta® and Cobenfy™ (KarXT) which originated at PureTech (founded/led by @daphnezohar.bsky.social) luma.com/5rfgvqfd
Available on Spotify, podcasts and YouTube now in addition to Spaces
#BiotechHangout John Maraganore, Yaron Werber, Ami Fadia, Allison DeAngelis, Drew Armstrong on policy: MAHA summit, Pazdur to CDER, ‘plausible mechanism pathway’, deals: $DAWN/$MRSN, $PFE/$MTSR, Lundbeck/$AVDL, $MRK/$CDTX, data: $ALKS, $NBIX, $COGT, $KRRO, $CRSP, James Watson passing: bit.ly/4i0C6Rt
November 17, 2025 at 11:55 PM
Available on Spotify, podcasts and YouTube now in addition to Spaces
Wear pink Tues Jan 13th at #JPM26 to recognize impact of women leaders & allies in bio. Wear a pink shirt, tie or socks if you don’t own a pink blazer. We had an incredible turnout at inaugural event at #JPM25 w/ pink visible throughout the streets of SF. Join group pic at 4pm #BiotechCEOSisterhood
November 17, 2025 at 11:54 PM
Wear pink Tues Jan 13th at #JPM26 to recognize impact of women leaders & allies in bio. Wear a pink shirt, tie or socks if you don’t own a pink blazer. We had an incredible turnout at inaugural event at #JPM25 w/ pink visible throughout the streets of SF. Join group pic at 4pm #BiotechCEOSisterhood
Reposted by Daphne Zohar
Mark your calendars! #BiotechHangout & @biotechtv.bsky.social will be back at #JPM26. Join us at Persona to meet up with biotech friends IRL on Tuesday, January 13 from 7-10pm. Interested in sponsoring? Email team@biotechhangout.com for more information. Additional registration information to come.
October 21, 2025 at 1:15 PM
Mark your calendars! #BiotechHangout & @biotechtv.bsky.social will be back at #JPM26. Join us at Persona to meet up with biotech friends IRL on Tuesday, January 13 from 7-10pm. Interested in sponsoring? Email team@biotechhangout.com for more information. Additional registration information to come.
Reposted by Daphne Zohar
Members of our exec team joined Fierce Biotech’s #Fierce15 awards to celebrate our recognition, honoring our team's work developing new medicines for #depression & #anxiety. It's also a reflection of the strong momentum & growth since our launch last year. bit.ly/3VSOQQ7
October 9, 2025 at 6:36 PM
Members of our exec team joined Fierce Biotech’s #Fierce15 awards to celebrate our recognition, honoring our team's work developing new medicines for #depression & #anxiety. It's also a reflection of the strong momentum & growth since our launch last year. bit.ly/3VSOQQ7
Reposted by Daphne Zohar
We convened top neuropsych experts, sell-side analysts, investors, & biopharma leaders for a unique roundtable discussion on the opportunities & excitement in #neuropsychiatry & what’s next as #MentalHealth conditions continue to impact millions globally. See below for some takeaways
October 8, 2025 at 11:02 AM
We convened top neuropsych experts, sell-side analysts, investors, & biopharma leaders for a unique roundtable discussion on the opportunities & excitement in #neuropsychiatry & what’s next as #MentalHealth conditions continue to impact millions globally. See below for some takeaways
Reposted by Daphne Zohar
𝐂𝐨𝐦𝐩𝐚𝐧𝐲 𝐓𝐨𝐮𝐫: BiotechTV visited the new offices of @seaporttx.bsky.social today and was given a tour by Founder & CEO @daphnezohar.bsky.social
July 21, 2025 at 11:46 PM
𝐂𝐨𝐦𝐩𝐚𝐧𝐲 𝐓𝐨𝐮𝐫: BiotechTV visited the new offices of @seaporttx.bsky.social today and was given a tour by Founder & CEO @daphnezohar.bsky.social
Reposted by Daphne Zohar
For @biotechtv.bsky.social's Biotech CEO Sisterhood series, our CEO @daphnezohar.bsky.social spoke to Sophie Kornowski on her journey leading Boston Pharmaceuticals to a $2B deal w/ GSK. Check this out for insights from both leaders on dealmaking, leadership strategies & mentorship: bit.ly/4m55kzG
Biotech CEO Sisterhood: As CEO, Sophie Kornowski sold Boston Pharmaceuticals to GSK earlier this year for up to $2 billion. She shares her thoughts on the biopharma business and leadership
Interviewed by Sisterhood editorial board member Daphne Zohar, Sophie Kornowski shares her keys to creating great assets, commercialization, partnerships, and, ultimately, executing a successful deal ...
bit.ly
July 18, 2025 at 5:44 PM
For @biotechtv.bsky.social's Biotech CEO Sisterhood series, our CEO @daphnezohar.bsky.social spoke to Sophie Kornowski on her journey leading Boston Pharmaceuticals to a $2B deal w/ GSK. Check this out for insights from both leaders on dealmaking, leadership strategies & mentorship: bit.ly/4m55kzG
Reposted by Daphne Zohar
Pleased to announce the first patient has been dosed in our Ph2b BUOY-1 study of GlyphAllo™ (SPT-300) in #MDD w/ or w/o anxious distress, an important milestone for Seaport’s pipeline that brings us closer to a potential new treatment for patients w/ MDD: bit.ly/3Uhn3YB
July 17, 2025 at 11:02 AM
Pleased to announce the first patient has been dosed in our Ph2b BUOY-1 study of GlyphAllo™ (SPT-300) in #MDD w/ or w/o anxious distress, an important milestone for Seaport’s pipeline that brings us closer to a potential new treatment for patients w/ MDD: bit.ly/3Uhn3YB
Reposted by Daphne Zohar
#BiotechHangout Eric Schmidt, Brad Loncar, Tim Opler, Tess Cameron on M&A: $MRK/$VRNA, $ABBV/Capstan, biotech takeouts, M&A wave, pharma’s $150B in LOE, plus Trump’s BBB/tariffs, $XBI & MFN, FDA’s CRL disclosures, $CAPR, $KALV, $PROK, obesity trends, $RARE/$MREO, $ABBV/Ichnos: bit.ly/3TuICVp
July 11, 2025 at 1:03 PM
#BiotechHangout Eric Schmidt, Brad Loncar, Tim Opler, Tess Cameron on M&A: $MRK/$VRNA, $ABBV/Capstan, biotech takeouts, M&A wave, pharma’s $150B in LOE, plus Trump’s BBB/tariffs, $XBI & MFN, FDA’s CRL disclosures, $CAPR, $KALV, $PROK, obesity trends, $RARE/$MREO, $ABBV/Ichnos: bit.ly/3TuICVp
Reposted by Daphne Zohar
The Seaport crew kicked off summer with a fun gathering! Great opportunity to connect out of the office, strengthening our mission to develop life-changing medicines for #neuropsychiatric disorders. Looking forward to more moments together and progress towards transforming lives!
June 30, 2025 at 1:27 PM
The Seaport crew kicked off summer with a fun gathering! Great opportunity to connect out of the office, strengthening our mission to develop life-changing medicines for #neuropsychiatric disorders. Looking forward to more moments together and progress towards transforming lives!
Reposted by Daphne Zohar
As #MentalHealthMonth closes, we welcomed a @namicommunicate.bsky.social patient representative to share his journey w/ mental health conditions. His story inspires our work at Seaport to help those struggling & develop new medicines for #depression & #anxiety. More: www.nami.org
May 30, 2025 at 11:04 AM
As #MentalHealthMonth closes, we welcomed a @namicommunicate.bsky.social patient representative to share his journey w/ mental health conditions. His story inspires our work at Seaport to help those struggling & develop new medicines for #depression & #anxiety. More: www.nami.org
Reposted by Daphne Zohar
#BiotechHangout: Chris Garabedian, Josh Schimmer, Nina Kjellson, Mike Yee, Tim Opler on market sentiment – where is the M&A?, FDA/CBER, wind downs vs reverse mergers, policy: #MAHA & COVID vaccine, $REGN/23andMe, data: $RCKT, psychedelics, $PRTA, $SPRO/$GSK, $GILD, $SMMT, #ASCO & more bit.ly/4dCFzDT
May 30, 2025 at 1:08 PM
#BiotechHangout: Chris Garabedian, Josh Schimmer, Nina Kjellson, Mike Yee, Tim Opler on market sentiment – where is the M&A?, FDA/CBER, wind downs vs reverse mergers, policy: #MAHA & COVID vaccine, $REGN/23andMe, data: $RCKT, psychedelics, $PRTA, $SPRO/$GSK, $GILD, $SMMT, #ASCO & more bit.ly/4dCFzDT
Reposted by Daphne Zohar
Two people were shot and killed outside a Jewish LGBTQ event in D.C.
Man, woman shot and killed in front of Capital Jewish Museum in DC
A man and woman were shot and killed in front of the Capital Jewish Museum in Northwest D.C. Wednesday evening. The shooting took place in the area of 3rd and F streets in Northwest — in front of the ...
www.nbcwashington.com
May 22, 2025 at 3:05 AM
Two people were shot and killed outside a Jewish LGBTQ event in D.C.
Reposted by Daphne Zohar
This #MentalHealthMonth, we joined @namicommunicate.bsky.social's annual #NAMIWalks to combat stigma & promote mental health awareness. We stand with those affected by mental illness & are dedicated to developing new medicines for #depression & #anxiety. More about NAMI www.nami.org
May 20, 2025 at 11:03 AM
This #MentalHealthMonth, we joined @namicommunicate.bsky.social's annual #NAMIWalks to combat stigma & promote mental health awareness. We stand with those affected by mental illness & are dedicated to developing new medicines for #depression & #anxiety. More about NAMI www.nami.org
Reposted by Daphne Zohar
#BiotechHangout: Sam Fazeli, John Maraganore, Nina Kjellson, Matt Gline on MFN: 30-day ultimatum, 180 days negotiation, reimportation, ex-US prices, DTC, Roche, $SNY, plus: budget reconciliation, IRA, $RXRX, Galapagos, $CTMX, $GSK buys Boston, $GSK/iTeos, $NVO CEO, RNA deals: bit.ly/3S3vhTh
May 16, 2025 at 1:00 PM
#BiotechHangout: Sam Fazeli, John Maraganore, Nina Kjellson, Matt Gline on MFN: 30-day ultimatum, 180 days negotiation, reimportation, ex-US prices, DTC, Roche, $SNY, plus: budget reconciliation, IRA, $RXRX, Galapagos, $CTMX, $GSK buys Boston, $GSK/iTeos, $NVO CEO, RNA deals: bit.ly/3S3vhTh
Seems like Bluesky is losing momentum? Wouldn’t mind having one less place to check/post. Curious to hear from others
May 13, 2025 at 2:00 PM
Seems like Bluesky is losing momentum? Wouldn’t mind having one less place to check/post. Curious to hear from others
Important provisions added to reconciliation bills would be positive for bio if passed:
ORPHAN Cures Act included, amend IRA
PBM reforms delinking compensation from list price, increasing transparency & banning spread pricing in Medicaid
Tax fix to allow for immediate deduction of R&D costs
ORPHAN Cures Act included, amend IRA
PBM reforms delinking compensation from list price, increasing transparency & banning spread pricing in Medicaid
Tax fix to allow for immediate deduction of R&D costs
May 13, 2025 at 1:44 PM
Important provisions added to reconciliation bills would be positive for bio if passed:
ORPHAN Cures Act included, amend IRA
PBM reforms delinking compensation from list price, increasing transparency & banning spread pricing in Medicaid
Tax fix to allow for immediate deduction of R&D costs
ORPHAN Cures Act included, amend IRA
PBM reforms delinking compensation from list price, increasing transparency & banning spread pricing in Medicaid
Tax fix to allow for immediate deduction of R&D costs