Micha Rapé Lab
@micharapelab.bsky.social
Professor and Head of the Division of Molecular Therapeutics in MCB, UC Berkeley
Founder, Nurix and Lyterian Therapeutics
Excited about stress responses, ubiquitin, proteasome, targeted protein degradation, drug discovery
Founder, Nurix and Lyterian Therapeutics
Excited about stress responses, ubiquitin, proteasome, targeted protein degradation, drug discovery
Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12
Centered on the transcription factor NRF2 and its E3 ligase CUL3KEAP1, the oxidative stress response protects cells from damage by reactive oxygen spe…
www.sciencedirect.com
September 11, 2025 at 2:03 PM
Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Micha Rapé Lab
Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉
aprecruit.berkeley.edu/JPF05098
aprecruit.berkeley.edu/JPF05098
August 21, 2025 at 4:00 AM
Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉
aprecruit.berkeley.edu/JPF05098
aprecruit.berkeley.edu/JPF05098
Excited about turning basic science into new therapeutic modalities? Want to work with brilliant and *friendly* colleagues? Hoping to be part of a public university that shapes California? Then come join us #MolecularTherapeutics, @ucberkeleyofficial.bsky.social !!!
aprecruit.berkeley.edu/JPF05098
aprecruit.berkeley.edu/JPF05098
Assistant Professor -Molecular Therapeutics - Molecular and Cell Biology
University of California, Berkeley is hiring. Apply now!
aprecruit.berkeley.edu
August 21, 2025 at 4:42 PM
Excited about turning basic science into new therapeutic modalities? Want to work with brilliant and *friendly* colleagues? Hoping to be part of a public university that shapes California? Then come join us #MolecularTherapeutics, @ucberkeleyofficial.bsky.social !!!
aprecruit.berkeley.edu/JPF05098
aprecruit.berkeley.edu/JPF05098
Reposted by Micha Rapé Lab
Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...
“Revolutionary Science Comes from Unexpected Angles”
magazine.hms.harvard.edu
July 29, 2025 at 4:00 PM
Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...
Reposted by Micha Rapé Lab
UC Berkeley isn’t just the No. 1 public research university in the nation — it’s a force for the public good. youtu.be/z0MokpvFauc?...
UC Berkeley research builds a better tomorrow
YouTube video by UC Berkeley
youtu.be
July 1, 2025 at 6:48 PM
UC Berkeley isn’t just the No. 1 public research university in the nation — it’s a force for the public good. youtu.be/z0MokpvFauc?...
Reposted by Micha Rapé Lab
Congrats to MCB postdocs Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab) for being selected as 2025 Jane Coffin Childs Fellows! 🎉👏 @jcchildsfund.bsky.social @nogaleslab.bsky.social @micharapelab.bsky.social www.jccfund.org/fellows/clas...
June 25, 2025 at 6:32 PM
Congrats to MCB postdocs Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab) for being selected as 2025 Jane Coffin Childs Fellows! 🎉👏 @jcchildsfund.bsky.social @nogaleslab.bsky.social @micharapelab.bsky.social www.jccfund.org/fellows/clas...
Many congratulations to Heegwang Roh for being selected as a Jane Coffin Childs postdoctoral fellow! Go Heegwang!
www.jccfund.org/wp-content/u...
www.jccfund.org/wp-content/u...
www.jccfund.org
June 24, 2025 at 9:02 PM
Many congratulations to Heegwang Roh for being selected as a Jane Coffin Childs postdoctoral fellow! Go Heegwang!
www.jccfund.org/wp-content/u...
www.jccfund.org/wp-content/u...
Very excited about these unique opportunities - for advancing groundbreaking science and for our students to advance their careers - at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social
June 8, 2025 at 12:46 AM
Very excited about these unique opportunities - for advancing groundbreaking science and for our students to advance their careers - at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social
Congratulations James! From basic discovery to drugging it in such a short time! Amazing work out of #MolecularTherapeutics @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social!!!
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Brief Skytorial!
1/9
Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS
FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced
forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...
www.pnas.org
May 29, 2025 at 8:56 PM
Congratulations James! From basic discovery to drugging it in such a short time! Amazing work out of #MolecularTherapeutics @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social!!!
Congratulations to our grad students Rachael McMinimy and Chris Padovani, who yesterday received their degrees from @ucberkeleyofficial.bsky.social! Thank you for everything, and we will miss you!
May 24, 2025 at 5:35 PM
Congratulations to our grad students Rachael McMinimy and Chris Padovani, who yesterday received their degrees from @ucberkeleyofficial.bsky.social! Thank you for everything, and we will miss you!
Thank you to Michael Ward for presenting his amazing science addressing urgent problems in neurodegenerative disease at a joint #MolecularTherapeutics, @mti-ucb.bsky.social, and Neuroscience talk at @ucberkeleyofficial.bsky.social today! Great science helping patients is more important than ever!
May 20, 2025 at 10:01 PM
Thank you to Michael Ward for presenting his amazing science addressing urgent problems in neurodegenerative disease at a joint #MolecularTherapeutics, @mti-ucb.bsky.social, and Neuroscience talk at @ucberkeleyofficial.bsky.social today! Great science helping patients is more important than ever!
Congratulations to #MolecularTherapeutics faculty and
@mti-ucb.bsky.social member @olzmannlab.bsky.social for receiving the Beatriz Manz award for 'transformational teaching and community service'. Glad to have you as a friend and colleague @ucberkeleyofficial.bsky.social, James!
@mti-ucb.bsky.social member @olzmannlab.bsky.social for receiving the Beatriz Manz award for 'transformational teaching and community service'. Glad to have you as a friend and colleague @ucberkeleyofficial.bsky.social, James!
May 15, 2025 at 5:29 PM
Congratulations to #MolecularTherapeutics faculty and
@mti-ucb.bsky.social member @olzmannlab.bsky.social for receiving the Beatriz Manz award for 'transformational teaching and community service'. Glad to have you as a friend and colleague @ucberkeleyofficial.bsky.social, James!
@mti-ucb.bsky.social member @olzmannlab.bsky.social for receiving the Beatriz Manz award for 'transformational teaching and community service'. Glad to have you as a friend and colleague @ucberkeleyofficial.bsky.social, James!
Reposted by Micha Rapé Lab
🌍 Meet Dr. Matt Welch, 2025 MTI Innovator Awardee!
His lab is developing selective inhibitors of parasite-specific kinesins - a new and safer strategy to treat African sleeping sickness and related diseases.
A leap forward in neglected tropical disease drug discovery.
#MTI #GlobalHealth
His lab is developing selective inhibitors of parasite-specific kinesins - a new and safer strategy to treat African sleeping sickness and related diseases.
A leap forward in neglected tropical disease drug discovery.
#MTI #GlobalHealth
May 9, 2025 at 4:18 AM
🌍 Meet Dr. Matt Welch, 2025 MTI Innovator Awardee!
His lab is developing selective inhibitors of parasite-specific kinesins - a new and safer strategy to treat African sleeping sickness and related diseases.
A leap forward in neglected tropical disease drug discovery.
#MTI #GlobalHealth
His lab is developing selective inhibitors of parasite-specific kinesins - a new and safer strategy to treat African sleeping sickness and related diseases.
A leap forward in neglected tropical disease drug discovery.
#MTI #GlobalHealth
Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Molecular basis of SIFI activity in the integrated stress response - Nature
Nature - Molecular basis of SIFI activity in the integrated stress response
www.nature.com
May 7, 2025 at 10:27 AM
Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Micha Rapé Lab
🧠 Meet Dr. Ehud Isacoff, 2025 MTI Innovator Awardee!
His lab is using FRET-based biosensors to find compounds that fine-tune glutamate receptors - unlocking new treatments for depression, including hard-to-treat cases.
A new era of brain-targeted molecular therapeutics.
#MTI #Neurobiology #FRET
His lab is using FRET-based biosensors to find compounds that fine-tune glutamate receptors - unlocking new treatments for depression, including hard-to-treat cases.
A new era of brain-targeted molecular therapeutics.
#MTI #Neurobiology #FRET
May 3, 2025 at 12:00 AM
🧠 Meet Dr. Ehud Isacoff, 2025 MTI Innovator Awardee!
His lab is using FRET-based biosensors to find compounds that fine-tune glutamate receptors - unlocking new treatments for depression, including hard-to-treat cases.
A new era of brain-targeted molecular therapeutics.
#MTI #Neurobiology #FRET
His lab is using FRET-based biosensors to find compounds that fine-tune glutamate receptors - unlocking new treatments for depression, including hard-to-treat cases.
A new era of brain-targeted molecular therapeutics.
#MTI #Neurobiology #FRET
Thank you to @brentstockwell.bsky.social of @columbiauniversity.bsky.social for visiting #MolecularTherapeutics at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social and presenting a tour-de-force through the ferroptosis field!
May 2, 2025 at 4:58 PM
Thank you to @brentstockwell.bsky.social of @columbiauniversity.bsky.social for visiting #MolecularTherapeutics at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social and presenting a tour-de-force through the ferroptosis field!
Congratulations to #MolecularTherapeutics faculty and @mti-ucb.bsky.social member Markita Landry on winning a Guggenheim Fellowship! So cool to work with such amazing colleagues on a daily basis!
news.berkeley.edu/2025/04/22/t...
news.berkeley.edu/2025/04/22/t...
Two Berkeley professors receive prestigious Guggenheim fellowships - Berkeley News
Philosopher Hannah Ginsborg will use the award to write a book about the relation between norms and reasons, while chemical engineer Markita del Carpio Landry will try to find molecules in little-stud...
news.berkeley.edu
April 29, 2025 at 11:42 PM
Congratulations to #MolecularTherapeutics faculty and @mti-ucb.bsky.social member Markita Landry on winning a Guggenheim Fellowship! So cool to work with such amazing colleagues on a daily basis!
news.berkeley.edu/2025/04/22/t...
news.berkeley.edu/2025/04/22/t...
Congratulations!
🧬 Announcing the 2025 Innovator Awardees!
Proud to support 6 researchers with $90K + resources.
🔬Lareau: CRISPR for retinitis pigmentosa
🧪Hurley: Cancer inhibitors
✨Sherriff & Olzmann: Molecular glues
🥼Welch: Sleeping sickness
🧫Isacoff: Fast-acting antidepressants
Advancing innovation at Berkeley
Proud to support 6 researchers with $90K + resources.
🔬Lareau: CRISPR for retinitis pigmentosa
🧪Hurley: Cancer inhibitors
✨Sherriff & Olzmann: Molecular glues
🥼Welch: Sleeping sickness
🧫Isacoff: Fast-acting antidepressants
Advancing innovation at Berkeley
April 26, 2025 at 2:48 AM
Congratulations!
Wonderful talk by @rushika-perera.bsky.social of @ucsfhealth.bsky.social today in our @mti-ucb.bsky.social/#MolecularTherapeutics seminar series at @ucberkeleyofficial.bsky.social today, presenting cool data about organ-selective metastasis! Thank you!!!
April 24, 2025 at 11:54 PM
Wonderful talk by @rushika-perera.bsky.social of @ucsfhealth.bsky.social today in our @mti-ucb.bsky.social/#MolecularTherapeutics seminar series at @ucberkeleyofficial.bsky.social today, presenting cool data about organ-selective metastasis! Thank you!!!
New paper from @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social faculty member @robzonculab.bsky.social ! Congratulations!!!
AKAP11 recruits PKA holoenzymes to #autophagosomes in a bidirectional functional association, both promoting downstream PKA signaling and increasing AKAP11-PKA complex degradation
@robzonculab.bsky.social @ucberkeleyofficial.bsky.social
www.embopress.org/doi/full/10....
@robzonculab.bsky.social @ucberkeleyofficial.bsky.social
www.embopress.org/doi/full/10....
April 23, 2025 at 4:22 PM
New paper from @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social faculty member @robzonculab.bsky.social ! Congratulations!!!
Congratulations to Mangyu and Denis! @ucberkeleyofficial.bsky.social
Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction by Mangyu Choe, Denis V. Titov et al at @ucberkeleyofficial.bsky.social http://dlvr.it/TKF1S6
April 18, 2025 at 4:31 PM
Congratulations to Mangyu and Denis! @ucberkeleyofficial.bsky.social
Huge thank you to Leon Chen of The Column Group, who taught our #MolecularTherapeutics grad students the ins-and-outs of biotech today! 🙏
April 17, 2025 at 2:51 AM
Huge thank you to Leon Chen of The Column Group, who taught our #MolecularTherapeutics grad students the ins-and-outs of biotech today! 🙏
One of the best things about teaching (and doing research) at @ucberkeleyofficial.bsky.social is our environment. Huge thanks to Arnav Metha of The Column Group, who taught our #MolecularTherapeutics grad students the ins-and-outs of clinical trials!
April 10, 2025 at 4:12 PM
One of the best things about teaching (and doing research) at @ucberkeleyofficial.bsky.social is our environment. Huge thanks to Arnav Metha of The Column Group, who taught our #MolecularTherapeutics grad students the ins-and-outs of clinical trials!
Thank you to Spark NS for helping us turn the ubiquitin system against Parkinson's Disease! Kudos to @ucberkeleyofficial.bsky.social student Srividya Chandrasekhar and postdoc Josh Sheetz for their groundbreaking work!
sparkns.org/programs/pro...
sparkns.org/programs/pro...
Projects
sparkns.org
April 4, 2025 at 9:33 AM
Thank you to Spark NS for helping us turn the ubiquitin system against Parkinson's Disease! Kudos to @ucberkeleyofficial.bsky.social student Srividya Chandrasekhar and postdoc Josh Sheetz for their groundbreaking work!
sparkns.org/programs/pro...
sparkns.org/programs/pro...