berkeleyMCB
@berkeleymcb.bsky.social
Molecular & Cell Biology (MCB) Department at UC Berkeley | curiosity driven basic research, education, training and a commitment to public service. 🧪🐻
mcb.berkeley.edu/
mcb.berkeley.edu/
Reposted by berkeleyMCB
🎺New paper alert🎺 Out now in Nature Chemical Biology from IGI's Jennifer Doudna (Doudna Lab) and collaborators: Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap
Read here: https://ow.ly/izGo50XAkog
Read here: https://ow.ly/izGo50XAkog
Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap - Nature Chemical Biology
A multiscale photoproximity labeling proteomics workflow captures dynamic neighborhoods of extracellular and intracellular epidermal growth factor (EGF) receptor interactomes during early, middle and late signaling upon activation by EGF.
ow.ly
December 16, 2025 at 4:00 PM
🎺New paper alert🎺 Out now in Nature Chemical Biology from IGI's Jennifer Doudna (Doudna Lab) and collaborators: Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap
Read here: https://ow.ly/izGo50XAkog
Read here: https://ow.ly/izGo50XAkog
Reposted by berkeleyMCB
@mti-ucb.bsky.social, we are thrilled that our Executive Director, Dr. Julia Schaletzky, is highlighted in @ucberkeleyofficial.bsky.social’s Top Stories of 2025 for her work advancing campus viewpoint diversity. Read here to learn more: news.berkeley.edu/2025/12/15/n...
Nobel wins, psychedelic lilies and a mission to Mars: UC Berkeley's top stories of 2025 - Berkeley News
A look at some of the campus's biggest stories chronicled by UC Berkeley News.
news.berkeley.edu
December 17, 2025 at 3:52 AM
@mti-ucb.bsky.social, we are thrilled that our Executive Director, Dr. Julia Schaletzky, is highlighted in @ucberkeleyofficial.bsky.social’s Top Stories of 2025 for her work advancing campus viewpoint diversity. Read here to learn more: news.berkeley.edu/2025/12/15/n...
Reposted by berkeleyMCB
Research in Filipa Rijo-Ferrera’s lab at #UCBerkeley shows both #parasites and their #mosquito hosts share #circadian rhythms that time biting and transmissibility. Targeting these internal clocks may offer a new path to reducing #malaria and other mosquito-borne illnesses.
bit.ly/4q3El9s
bit.ly/4q3El9s
Research on the circadian rhythm of mosquitos seeks new ways to fight parasitic diseases
Researchers are uncovering new ways to understand how malaria parasites and their mosquito carriers keep track of time.
publichealth.berkeley.edu
December 11, 2025 at 9:48 PM
Research in Filipa Rijo-Ferrera’s lab at #UCBerkeley shows both #parasites and their #mosquito hosts share #circadian rhythms that time biting and transmissibility. Targeting these internal clocks may offer a new path to reducing #malaria and other mosquito-borne illnesses.
bit.ly/4q3El9s
bit.ly/4q3El9s
Reposted by berkeleyMCB
ICYMI: #CRISPR co-inventor Jennifer Doudna joins @euanashley.bsky.social on Episode 3 of The Future of Medicine for a deep, wide-ranging conversation about how #GeneEditing is reshaping the landscape of modern medicine. Watch on our YouTube or stream here: https://bit.ly/43LGRZv
December 18, 2025 at 9:08 PM
ICYMI: #CRISPR co-inventor Jennifer Doudna joins @euanashley.bsky.social on Episode 3 of The Future of Medicine for a deep, wide-ranging conversation about how #GeneEditing is reshaping the landscape of modern medicine. Watch on our YouTube or stream here: https://bit.ly/43LGRZv
Reposted by berkeleyMCB
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Self-renewal of neuronal mitochondria through asymmetric division
Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...
www.biorxiv.org
December 18, 2025 at 8:36 PM
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Reposted by berkeleyMCB
Addition Therapeutics, a spinout of QB3-Berkeley affiliate Kathleen Collins' lab, has emerged from stealth with $100M in funding from SR One, the Gates Foundation, and more. Its PRINT platform uses retrotransposon machinery to deliver precise gene therapy.
www.fiercebiotech.com/biotech/addi...
www.fiercebiotech.com/biotech/addi...
Addition Tx does the math and emerges from stealth with $100M, biotech vets on exec team
University of California spinout Addition Therapeutics has uncloaked, revealing “breakthrough” PRINT technology it hopes will fuel a new wave of genetic medicine. | University of California spinout Ad...
www.fiercebiotech.com
December 19, 2025 at 9:29 PM
Addition Therapeutics, a spinout of QB3-Berkeley affiliate Kathleen Collins' lab, has emerged from stealth with $100M in funding from SR One, the Gates Foundation, and more. Its PRINT platform uses retrotransposon machinery to deliver precise gene therapy.
www.fiercebiotech.com/biotech/addi...
www.fiercebiotech.com/biotech/addi...
Happy Holidays from MCB! 2025 has been a year marked by exciting discoveries, shared successes, and the remarkable resilience and dedication of our community. We hope you enjoy our year-end video highlighting some of our 2025 memories together.
vimeo.com/1147759879?f...
vimeo.com/1147759879?f...
2025 | Happy Holidays from berkeleyMCB!
This is "2025 | Happy Holidays from berkeleyMCB!" by berkeleyMCB on Vimeo, the home for high quality videos and the people who love them.
vimeo.com
December 19, 2025 at 8:58 PM
Happy Holidays from MCB! 2025 has been a year marked by exciting discoveries, shared successes, and the remarkable resilience and dedication of our community. We hope you enjoy our year-end video highlighting some of our 2025 memories together.
vimeo.com/1147759879?f...
vimeo.com/1147759879?f...
Congrats to MCB's James Olzmann! 🎉👏 @olzmannlab.bsky.social
Eight Rausser College faculty were recently named among the world’s most influential researchers, according to a new report from analytics firm @clarivateag.bsky.social. Learn more about the methodology and see who made the list: nature.berkeley.edu/news/rausser...
December 15, 2025 at 11:09 PM
Congrats to MCB's James Olzmann! 🎉👏 @olzmannlab.bsky.social
Reposted by berkeleyMCB
My wonderful lab members at our holiday party. I was quite nostalgic about celebrating together this year. But my misty eyes quickly dried when someone, who shall not be named, would not let me keep banana-grams during the White Elephant gift exchange!
December 13, 2025 at 4:15 PM
My wonderful lab members at our holiday party. I was quite nostalgic about celebrating together this year. But my misty eyes quickly dried when someone, who shall not be named, would not let me keep banana-grams during the White Elephant gift exchange!
Reposted by berkeleyMCB
Excited to highlight our latest bioRxiv led by grad student Zoe Duong and Qian Shao. We report a chemistry-centric, chemoproteomics-enabled strategy to discover non-degradative molecular glues for transcriptional rewiring.
🔗 www.biorxiv.org/content/10.6...
Discovery of Non-Degradative Covalent Molecular Glues for Transcriptional Reprogramming
Transcriptional reprogramming through induced proximity has emerged as a powerful strategy for modulating the expression of oncogenic and tumor-suppressive genes. Inspired by transcriptional reprogram...
www.biorxiv.org
December 14, 2025 at 7:36 PM
Excited to highlight our latest bioRxiv led by grad student Zoe Duong and Qian Shao. We report a chemistry-centric, chemoproteomics-enabled strategy to discover non-degradative molecular glues for transcriptional rewiring.
🔗 www.biorxiv.org/content/10.6...
Reposted by berkeleyMCB
The first-ever personalized CRISPR medicine, genomics meets AI + automation, editing gut microbes for health + climate applications, field trials for climate-resistant crops — 2025 has been an exciting year for the IGI! Learn about these + more in our annual Impact Report: https://ow.ly/h2OA50XIAVV
December 15, 2025 at 4:10 PM
The first-ever personalized CRISPR medicine, genomics meets AI + automation, editing gut microbes for health + climate applications, field trials for climate-resistant crops — 2025 has been an exciting year for the IGI! Learn about these + more in our annual Impact Report: https://ow.ly/h2OA50XIAVV
Reposted by berkeleyMCB
New from IGI's @marsonlab.bsky.social and @juliacarnevale.bsky.social, with co-authors @jenniferdoudna.bsky.social, @j-eyquem.bsky.social, James Nuñez!
Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social
December 15, 2025 at 5:56 PM
New from IGI's @marsonlab.bsky.social and @juliacarnevale.bsky.social, with co-authors @jenniferdoudna.bsky.social, @j-eyquem.bsky.social, James Nuñez!
Reposted by berkeleyMCB
*First preprint from our lab* !!!!!
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
December 15, 2025 at 6:26 PM
*First preprint from our lab* !!!!!
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
Portnoy Lab microbiologists brought hands-on science to a local elementary school by creating a Microbe Circuit—sparking curiosity and inspiring future scientists. 🧪🦠
mcb.berkeley.edu/news-and-eve...
mcb.berkeley.edu/news-and-eve...
December 15, 2025 at 4:28 PM
Portnoy Lab microbiologists brought hands-on science to a local elementary school by creating a Microbe Circuit—sparking curiosity and inspiring future scientists. 🧪🦠
mcb.berkeley.edu/news-and-eve...
mcb.berkeley.edu/news-and-eve...
Reposted by berkeleyMCB
Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In vivo models bring FSP1 inhibitors to life - Nature Cell Biology
FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...
www.nature.com
December 12, 2025 at 4:15 PM
Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by berkeleyMCB
Which came first — the comb jelly or the sponge? The battle over the root of the animal tree of life rages on, with the latest research from QB3-Berkeley's Nicole King coming down on the side of the sponge. Read more from the UC Berkeley news team: news.berkeley.edu/2025/11/19/d...
Did the first animal look like a sponge or a comb jelly? The debate continues. - Berkeley News
Two years ago, a novel analysis by UC Berkeley researchers pointed to comb jellies as the root of the animal tree of life. Another Berkeley group now says it’s sponges.
news.berkeley.edu
December 4, 2025 at 11:30 PM
Which came first — the comb jelly or the sponge? The battle over the root of the animal tree of life rages on, with the latest research from QB3-Berkeley's Nicole King coming down on the side of the sponge. Read more from the UC Berkeley news team: news.berkeley.edu/2025/11/19/d...
Reposted by berkeleyMCB
🎧 Berkeley Talks: For Nobel laureate Randy Schekman, it began with pond scum and a toy microscope. Hear more in his podcast on Berkeley News. news.berkeley.edu/2025/11/28/b...
Berkeley Talks: For Nobel laureate Randy Schekman, it began with pond scum and a toy microscope - Berkeley News
“I just could not believe the world that was revealed,” the UC Berkeley professor said of the microorganisms he saw through the plastic lens. He went on to win the Nobel Prize in Physiology or Medicin...
news.berkeley.edu
December 4, 2025 at 11:28 PM
🎧 Berkeley Talks: For Nobel laureate Randy Schekman, it began with pond scum and a toy microscope. Hear more in his podcast on Berkeley News. news.berkeley.edu/2025/11/28/b...
Reposted by berkeleyMCB
Out today in Science Magazine — First author Veronika Kivenson and PIs Jill Banfield (The Banfield Lab) and Alanna Schepartz team up to reveal a new genetic code in #archaea, with implications for #methane and #climate, and #bioengineering! Learn more: https://ow.ly/Kuem50Xurh0
December 8, 2025 at 3:50 PM
Out today in Science Magazine — First author Veronika Kivenson and PIs Jill Banfield (The Banfield Lab) and Alanna Schepartz team up to reveal a new genetic code in #archaea, with implications for #methane and #climate, and #bioengineering! Learn more: https://ow.ly/Kuem50Xurh0
Reposted by berkeleyMCB
Out now in the The Atlantic — IGI's Jennifer Doudna and Fyodor Urnov on this year's remarkable progress in using #CRISPR to treat rare diseases. Read here: https://ow.ly/5vJ750XFQon
December 8, 2025 at 5:42 PM
Out now in the The Atlantic — IGI's Jennifer Doudna and Fyodor Urnov on this year's remarkable progress in using #CRISPR to treat rare diseases. Read here: https://ow.ly/5vJ750XFQon
Reposted by berkeleyMCB
Congratulations to Matthew and Josh! Check out our extensible Python based 2DTM package, check out our example adaptations for optimizing template parameters and constrained searches and customize to suit your own experiments. Stay tuned for exciting future developments in the pipeline :)
Now out in full form. Again, a big thanks to #teamtomo and @alisterburt.bsky.social for developing the infrastructure to build this on. journals.iucr.org/d/issues/202...
Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology
In situ cryo-EM coupled with 2D template matching (2DTM) holds the potential to visualize the cellular structureome in context, but further developments are required to make this a reality. We describ...
journals.iucr.org
December 9, 2025 at 4:20 AM
Congratulations to Matthew and Josh! Check out our extensible Python based 2DTM package, check out our example adaptations for optimizing template parameters and constrained searches and customize to suit your own experiments. Stay tuned for exciting future developments in the pipeline :)
Reposted by berkeleyMCB
The Sudmant Lab & Wilsterman Lab are hiring a postdoc! Come work on the genetics and evolution of the placenta and dissecting genetic adaptations to altitude in deer mice!
Check out more details here: evol.mcmaster.ca/brian/evoldi...
www.sudmantlab.org
www.thewilstermanlab.com
Please Share!
Check out more details here: evol.mcmaster.ca/brian/evoldi...
www.sudmantlab.org
www.thewilstermanlab.com
Please Share!
https://evol.mcmaster.ca/brian/evoldir/PostDocs//UCalifornia_Berkeley.Genomics
Postdoc:UCBerkeley.Genomics
Postdoctoral position(s) in computational biology and genomics
Keywords: Genomics; single cell genomics; evolution; reproduction;
ecology; human disease; computational bi...
evol.mcmaster.ca
December 9, 2025 at 5:20 AM
The Sudmant Lab & Wilsterman Lab are hiring a postdoc! Come work on the genetics and evolution of the placenta and dissecting genetic adaptations to altitude in deer mice!
Check out more details here: evol.mcmaster.ca/brian/evoldi...
www.sudmantlab.org
www.thewilstermanlab.com
Please Share!
Check out more details here: evol.mcmaster.ca/brian/evoldi...
www.sudmantlab.org
www.thewilstermanlab.com
Please Share!
Reposted by berkeleyMCB
📣 Last mito911 webinar of 2025! Join us for @micharapelab.bsky.social on Dec 11th 8am PST.
Register here: us06web.zoom.us/webinar/regi...
Register here: us06web.zoom.us/webinar/regi...
December 9, 2025 at 4:20 PM
📣 Last mito911 webinar of 2025! Join us for @micharapelab.bsky.social on Dec 11th 8am PST.
Register here: us06web.zoom.us/webinar/regi...
Register here: us06web.zoom.us/webinar/regi...
Reposted by berkeleyMCB
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 7:52 AM
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
Reposted by berkeleyMCB
Huge credit to @bmanohar.bsky.social for leading this collaborative effort, based at @innovativegenomics.bsky.social & @berkeleymcb.bsky.social, with major contributions from OSU's Krys Bankiewicz & Russ Lonser, as well as crucial support from NIH's SCGE consortium @scge.bsky.social
December 2, 2025 at 9:11 AM
Huge credit to @bmanohar.bsky.social for leading this collaborative effort, based at @innovativegenomics.bsky.social & @berkeleymcb.bsky.social, with major contributions from OSU's Krys Bankiewicz & Russ Lonser, as well as crucial support from NIH's SCGE consortium @scge.bsky.social
Reposted by berkeleyMCB
Honored that this work represents my first "first-author" preprint of my PhD journey at
@berkeleymcb.bsky.social. Grateful for the incredible mentorship and collaborations. Neuro-PERC was a true multi-institution effort. Read the thread for the details!
@berkeleymcb.bsky.social. Grateful for the incredible mentorship and collaborations. Neuro-PERC was a true multi-institution effort. Read the thread for the details!
Big news! Our team developed Neuro-PERC, a non-viral CRISPR delivery platform for genome editing of the brain. In our new preprint - bit.ly/NeuroPERC_pre - we report efficient editing in multiple models & species, including field-first results in large animals (pigs) 🧵👇
bit.ly
December 2, 2025 at 7:05 PM
Honored that this work represents my first "first-author" preprint of my PhD journey at
@berkeleymcb.bsky.social. Grateful for the incredible mentorship and collaborations. Neuro-PERC was a true multi-institution effort. Read the thread for the details!
@berkeleymcb.bsky.social. Grateful for the incredible mentorship and collaborations. Neuro-PERC was a true multi-institution effort. Read the thread for the details!