berkeleyMCB
@berkeleymcb.bsky.social
Molecular & Cell Biology (MCB) Department at UC Berkeley | curiosity driven basic research, education, training and a commitment to public service. 🧪🐻
mcb.berkeley.edu/
mcb.berkeley.edu/
Congrats to MCB's Evan Miller on receiving this grant from the Camille and Henry Dreyfus Foundation! 👏🎉
November 6, 2025 at 12:38 AM
Congrats to MCB's Evan Miller on receiving this grant from the Camille and Henry Dreyfus Foundation! 👏🎉
Reposted by berkeleyMCB
Coming up November 6th — join us to hear about the latest in #CRISPR for human health from IGI's Brad Ringeisen, Fyodor Urnov, and Carlotta Ronda as part of @ucberkeleyofficial.bsky.social's Basic Science Lights the Way lecture series! Register here: https://basicscience.berkeley.edu/
October 31, 2025 at 4:01 PM
Coming up November 6th — join us to hear about the latest in #CRISPR for human health from IGI's Brad Ringeisen, Fyodor Urnov, and Carlotta Ronda as part of @ucberkeleyofficial.bsky.social's Basic Science Lights the Way lecture series! Register here: https://basicscience.berkeley.edu/
Reposted by berkeleyMCB
Andrew Dillin is a professor of immunology and molecular medicine in the Department of Molecular and Cell Biology.
In his spare time, he is forming a new Center for Unmet, Rare and Emerging Diseases (CURED) that aims to discover cures other organizations are not pursuing.
gobears.me/47pCGn5
In his spare time, he is forming a new Center for Unmet, Rare and Emerging Diseases (CURED) that aims to discover cures other organizations are not pursuing.
gobears.me/47pCGn5
Introducing CURED
Driven by the motto Fiat Lux, Berkeley illuminates the world.
gobears.me
October 29, 2025 at 7:47 PM
Andrew Dillin is a professor of immunology and molecular medicine in the Department of Molecular and Cell Biology.
In his spare time, he is forming a new Center for Unmet, Rare and Emerging Diseases (CURED) that aims to discover cures other organizations are not pursuing.
gobears.me/47pCGn5
In his spare time, he is forming a new Center for Unmet, Rare and Emerging Diseases (CURED) that aims to discover cures other organizations are not pursuing.
gobears.me/47pCGn5
Reposted by berkeleyMCB
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 8:45 PM
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
Reposted by berkeleyMCB
We’re thrilled to see this groundbreaking work from
@mti-ucb.bsky.social Faculty Co-director @dannomura.bsky.social! TRACERs represent a significant leap forward in targeting “undruggable” transcription factors with small molecules. We are honored to support this work!
#Epigenetics #DrugDiscovery
@mti-ucb.bsky.social Faculty Co-director @dannomura.bsky.social! TRACERs represent a significant leap forward in targeting “undruggable” transcription factors with small molecules. We are honored to support this work!
#Epigenetics #DrugDiscovery
We unveil TRACERs, Transcriptional Regulation via Active Control of Epigenetic Reprogramming: a new small-molecule-based induced-proximity modality that silences transcription factors by recruiting endogenous corepressor complexes for locus-specific repression.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Targeted Transcriptional Repression by Induced Proximity
Most cancer driving proteins remain undruggable due to the absence of ligandable pockets and their reliance on intrinsically disordered or protein-DNA/protein-protein interactions. Transcription facto...
www.biorxiv.org
October 23, 2025 at 11:16 PM
We’re thrilled to see this groundbreaking work from
@mti-ucb.bsky.social Faculty Co-director @dannomura.bsky.social! TRACERs represent a significant leap forward in targeting “undruggable” transcription factors with small molecules. We are honored to support this work!
#Epigenetics #DrugDiscovery
@mti-ucb.bsky.social Faculty Co-director @dannomura.bsky.social! TRACERs represent a significant leap forward in targeting “undruggable” transcription factors with small molecules. We are honored to support this work!
#Epigenetics #DrugDiscovery
Congrats to MCB's Professor (Affiliated) Daniel Fletcher on his election to the National Academy of Medicine! 🎉👏
October 21, 2025 at 10:26 PM
Congrats to MCB's Professor (Affiliated) Daniel Fletcher on his election to the National Academy of Medicine! 🎉👏
Reposted by berkeleyMCB
UC Berkeley PIs & collaborators: MTI invites proposals for its newly launched Parkinson’s Therapeutics Program!
Offering up to 3 awards of $90k, and additional funded access to MTI's drug-hunting infrastructure.
🗓️ Deadline: Nov 16, 2025
More info 👇
moleculartherapeutics.org/mti-launches...
Offering up to 3 awards of $90k, and additional funded access to MTI's drug-hunting infrastructure.
🗓️ Deadline: Nov 16, 2025
More info 👇
moleculartherapeutics.org/mti-launches...
MTI Launches Parkinson’s Therapeutics Program, Invites Proposals
BERKELEY — UC Berkeley’s Molecular Therapeutics Initiative (MTI) has launched a new funding program to accelerate drug discovery for Parkinson’s disease and related synucleinopathies.
moleculartherapeutics.org
October 17, 2025 at 9:27 AM
UC Berkeley PIs & collaborators: MTI invites proposals for its newly launched Parkinson’s Therapeutics Program!
Offering up to 3 awards of $90k, and additional funded access to MTI's drug-hunting infrastructure.
🗓️ Deadline: Nov 16, 2025
More info 👇
moleculartherapeutics.org/mti-launches...
Offering up to 3 awards of $90k, and additional funded access to MTI's drug-hunting infrastructure.
🗓️ Deadline: Nov 16, 2025
More info 👇
moleculartherapeutics.org/mti-launches...
Reposted by berkeleyMCB
I'm hiring a lab technician to help me explore some exciting new questions about virus-host interactions! Biochemistry and/or mammalian cell culture experience is desired.
October 17, 2025 at 7:58 PM
I'm hiring a lab technician to help me explore some exciting new questions about virus-host interactions! Biochemistry and/or mammalian cell culture experience is desired.
Reposted by berkeleyMCB
FWIW we also find that flies show coagulopathy, another big cause of death of cancer patients pubmed.ncbi.nlm.nih.gov/37354901/
Systemic coagulopathy promotes host lethality in a new Drosophila tumor model - PubMed
Malignant tumors trigger a complex network of inflammatory and wound repair responses, prompting Dvorak's characterization of tumors as "wounds that never heal."<sup>1</sup> Some of these responses le...
pubmed.ncbi.nlm.nih.gov
October 18, 2025 at 2:45 PM
FWIW we also find that flies show coagulopathy, another big cause of death of cancer patients pubmed.ncbi.nlm.nih.gov/37354901/
Reposted by berkeleyMCB
Eric Topol interviews Jennifer Doudna on the bright future of genome editing therapy in curing disease (Apple Podcasts). There’s an FDA-approved CRISPR therapy for sickle cell disease out now with others to come. [youtube.com]
Jennifer Doudna: The Exciting Future of Genome Editing
The most significant life science breakthrough of our time is just getting started.
Subscribe for more Ground Truths: https://erictopol.substack.com/
www.youtube.com
April 16, 2024 at 5:06 PM
Eric Topol interviews Jennifer Doudna on the bright future of genome editing therapy in curing disease (Apple Podcasts). There’s an FDA-approved CRISPR therapy for sickle cell disease out now with others to come. [youtube.com]
Reposted by berkeleyMCB
@mti-ucb.bsky.social is proud to have contributed to this exciting look at innovation at @ucberkeleyofficial.bsky.social.
Congrats to all involved on bringing "Startup Campus" to life!
#StartupCampus #BerkeleyInnovation #MTI
Congrats to all involved on bringing "Startup Campus" to life!
#StartupCampus #BerkeleyInnovation #MTI
🌟 SkyDeck’s latest newsletter is here!
📘 “Startup Campus” book launch - watch the powerhouse UC Berkeley innovation panel tinyurl.com/UCBPanelSC
🏅 UC’s record-breaking 5 Nobel Prizes in one week
🚀 Fundraising wins for SkyDeck alums
🔗 Read more: tinyurl.com/1017News
📘 “Startup Campus” book launch - watch the powerhouse UC Berkeley innovation panel tinyurl.com/UCBPanelSC
🏅 UC’s record-breaking 5 Nobel Prizes in one week
🚀 Fundraising wins for SkyDeck alums
🔗 Read more: tinyurl.com/1017News
October 19, 2025 at 5:15 AM
@mti-ucb.bsky.social is proud to have contributed to this exciting look at innovation at @ucberkeleyofficial.bsky.social.
Congrats to all involved on bringing "Startup Campus" to life!
#StartupCampus #BerkeleyInnovation #MTI
Congrats to all involved on bringing "Startup Campus" to life!
#StartupCampus #BerkeleyInnovation #MTI
Reposted by berkeleyMCB
The University of California just set a world record: 5 Nobel Prizes awarded to its faculty and alumni this year! 🏆🥇
A feat that underscores the impact of bold science and strong research ecosystems.
Read more here: www.universityofcalifornia.edu/news/uc-wins...
#NobelPrize #Research #Innovation
A feat that underscores the impact of bold science and strong research ecosystems.
Read more here: www.universityofcalifornia.edu/news/uc-wins...
#NobelPrize #Research #Innovation
UC wins 5 Nobel Prizes in 3 days — and sets a new world record
These discoveries span decades and disciplines, but they all have one important thing in common: They’ve all relied on competitive funding from the federal government.
www.universityofcalifornia.edu
October 19, 2025 at 5:28 AM
The University of California just set a world record: 5 Nobel Prizes awarded to its faculty and alumni this year! 🏆🥇
A feat that underscores the impact of bold science and strong research ecosystems.
Read more here: www.universityofcalifornia.edu/news/uc-wins...
#NobelPrize #Research #Innovation
A feat that underscores the impact of bold science and strong research ecosystems.
Read more here: www.universityofcalifornia.edu/news/uc-wins...
#NobelPrize #Research #Innovation
Reposted by berkeleyMCB
13 years ago, the revolutionary genetic tool #CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and Jennifer Doudna won a #NobelPrize for in 2020.
On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN
On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
A prokaryotic RNA–directed targeting system can be designed to cleave any DNA sequence.
scim.ag
October 20, 2025 at 7:33 PM
13 years ago, the revolutionary genetic tool #CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and Jennifer Doudna won a #NobelPrize for in 2020.
On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN
On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN
Reposted by berkeleyMCB
Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → mapped axons & myelin across two mouse olfactory bulbs (WT vs NPC1).
October 17, 2025 at 12:30 AM
Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → mapped axons & myelin across two mouse olfactory bulbs (WT vs NPC1).
Welcome to Thomas Mann who will be joining the MCB department as an assistant professor of Immunology and Molecular Medicine on Jan. 1st 2026! 🎉
mcb.berkeley.edu/news-and-eve...
mcb.berkeley.edu/news-and-eve...
October 16, 2025 at 7:33 PM
Welcome to Thomas Mann who will be joining the MCB department as an assistant professor of Immunology and Molecular Medicine on Jan. 1st 2026! 🎉
mcb.berkeley.edu/news-and-eve...
mcb.berkeley.edu/news-and-eve...
Reposted by berkeleyMCB
Please join us in congratulating ASBMB member Jennifer Doudna, who has been awarded the prestigious 2026 Joseph Priestley Medal for her groundbreaking work on #RNA molecules with enzymatic functions by @acs.org.
ow.ly/8l9u50X8Sre #ASBMBMemberNews
ow.ly/8l9u50X8Sre #ASBMBMemberNews
Doudna wins Priestley Medal
She will receive a $20,000 research grant and will formally accept the honor at the ACS Spring 2026 conference.
ow.ly
October 11, 2025 at 1:41 PM
Please join us in congratulating ASBMB member Jennifer Doudna, who has been awarded the prestigious 2026 Joseph Priestley Medal for her groundbreaking work on #RNA molecules with enzymatic functions by @acs.org.
ow.ly/8l9u50X8Sre #ASBMBMemberNews
ow.ly/8l9u50X8Sre #ASBMBMemberNews
Reposted by berkeleyMCB
In advance of his November visit, @protocolsio.bsky.social prez Lenny Teytelman (@lteytelman.bsky.social) spoke to Berkeley's Leah Keiser about his path to founding a startup acquired by @springernature.com. Read the interview:
qb3.berkeley.edu/news/profess...
qb3.berkeley.edu/news/profess...
October 13, 2025 at 6:59 PM
In advance of his November visit, @protocolsio.bsky.social prez Lenny Teytelman (@lteytelman.bsky.social) spoke to Berkeley's Leah Keiser about his path to founding a startup acquired by @springernature.com. Read the interview:
qb3.berkeley.edu/news/profess...
qb3.berkeley.edu/news/profess...
Reposted by berkeleyMCB
New paper from the lab. Molecular characterization of the symbiont-containing organelle with proteomics and reverse genetics in Aiptasia and coral.
We're excited to share with everyone a preprint of our manuscript that resolves the cellular origins of the symbiosome in cnidarian-algal symbiosis through proteomics of the symbiosome, RNAi, and CRISPR/Cas9 experiments. ⬇️
www.biorxiv.org/content/10.1...
Read on below!
1/12 🧵
www.biorxiv.org/content/10.1...
Read on below!
1/12 🧵
October 13, 2025 at 10:02 PM
New paper from the lab. Molecular characterization of the symbiont-containing organelle with proteomics and reverse genetics in Aiptasia and coral.
Reposted by berkeleyMCB
Thrilled to share our new cryo-ET preprint on astrocytes, a collaboration with @mengmengfu.bsky.social here at @ucberkeleyofficial.bsky.social, revealing the nm-scale cytoskeletal architecture of ramified astrocytes reminiscing in vivo morphology. Check out the cytoskeleton compartmentalization!
Excited to share our preprint on cytoskeletal organization in astrocytes!
biorxiv.org/content/10.110…
Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes.
Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓
1/x
biorxiv.org/content/10.110…
Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes.
Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓
1/x
https://biorxiv.org/content/10.110…
October 13, 2025 at 11:02 PM
Thrilled to share our new cryo-ET preprint on astrocytes, a collaboration with @mengmengfu.bsky.social here at @ucberkeleyofficial.bsky.social, revealing the nm-scale cytoskeletal architecture of ramified astrocytes reminiscing in vivo morphology. Check out the cytoskeleton compartmentalization!
Reposted by berkeleyMCB
We used live-cell imaging with plus-end binding protein EB3 to determine microtubule polarity in astrocytes for the first time. They are ~88% plus-ends out.
3/x
3/x
October 13, 2025 at 8:44 PM
We used live-cell imaging with plus-end binding protein EB3 to determine microtubule polarity in astrocytes for the first time. They are ~88% plus-ends out.
3/x
3/x
Reposted by berkeleyMCB
Coming up November 6th — join us to hear about the latest in #CRISPR for human health from IGI's Brad Ringeisen, Fyodor Urnov, and Carlotta Ronda as part of @ucberkeleyofficial.bsky.social's Basic Science Lights the Way lecture series! Register here: https://basicscience.berkeley.edu/
October 15, 2025 at 4:01 PM
Coming up November 6th — join us to hear about the latest in #CRISPR for human health from IGI's Brad Ringeisen, Fyodor Urnov, and Carlotta Ronda as part of @ucberkeleyofficial.bsky.social's Basic Science Lights the Way lecture series! Register here: https://basicscience.berkeley.edu/
Reposted by berkeleyMCB
October 15, 2025 at 8:14 PM
Reminder 🎗️: Applications for Assistant Professor of Molecular Therapeutics in MCB are due on 10/20/25!
We're Hiring! Assistant Professor of Molecular Therapeutics in MCB. Learn more and apply online:
aprecruit.berkeley.edu/JPF05098
aprecruit.berkeley.edu/JPF05098
October 15, 2025 at 10:03 PM
Reminder 🎗️: Applications for Assistant Professor of Molecular Therapeutics in MCB are due on 10/20/25!
Reminder 🎗️: Applications for Assistant Professor of Immunology and Molecular Medicine in MCB are due on 10/20/25!
We're Hiring! Assistant Professor of Immunology and Molecular Medicine in MCB. Learn more and apply online:
aprecruit.berkeley.edu/JPF05096
aprecruit.berkeley.edu/JPF05096
October 15, 2025 at 10:03 PM
Reminder 🎗️: Applications for Assistant Professor of Immunology and Molecular Medicine in MCB are due on 10/20/25!
Reposted by berkeleyMCB
Excited about turning basic science into new therapeutic modalities? Want to work with brilliant and *friendly* colleagues? Hoping to be part of a public university that shapes California? Then come join us #MolecularTherapeutics, @ucberkeleyofficial.bsky.social !!!
aprecruit.berkeley.edu/JPF05098
aprecruit.berkeley.edu/JPF05098
Assistant Professor -Molecular Therapeutics - Molecular and Cell Biology
University of California, Berkeley is hiring. Apply now!
aprecruit.berkeley.edu
August 21, 2025 at 4:42 PM
Excited about turning basic science into new therapeutic modalities? Want to work with brilliant and *friendly* colleagues? Hoping to be part of a public university that shapes California? Then come join us #MolecularTherapeutics, @ucberkeleyofficial.bsky.social !!!
aprecruit.berkeley.edu/JPF05098
aprecruit.berkeley.edu/JPF05098