Hannah Kiely-Collins
@hannahkielycollins.bsky.social
Senior Chemical Biologist at the Francis Crick Institute 👩🏻🔬 | Prev. PhD in Bernardes Group, University of Cambridge 🧪| Prev. MSci @impchemistry | 🎾 🇮🇪 🇬🇧 🧘🏻♀️|
To close the first session, Matt Child will discuss advances in high-throughout chemoproteogenomics 🧫 His group have previously used a chemoproteomic approach combined with CRISPR to identify reactive cysteines in Toxoplasma gondii www.nature.com/articles/s41...
CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery - Nature Microbiology
A CRISPR-based oligo recombineering (CORe) approach functionally prioritizes electrophile-sensitive cysteines in Toxoplasma gondii and promotes anti-parasitic drug discovery.
www.nature.com
March 30, 2025 at 10:45 AM
To close the first session, Matt Child will discuss advances in high-throughout chemoproteogenomics 🧫 His group have previously used a chemoproteomic approach combined with CRISPR to identify reactive cysteines in Toxoplasma gondii www.nature.com/articles/s41...
Excited for @chrisgparker.bsky.social ‘s talk about Photoaffinity-based Chemical Proteomics! ⚡️
His group’s work to simplify the identification of the labelling site of diazirine-based probes using predictive models is very cool, amongst other recent PAL developments
www.nature.com/articles/s41...
His group’s work to simplify the identification of the labelling site of diazirine-based probes using predictive models is very cool, amongst other recent PAL developments
www.nature.com/articles/s41...
Enhanced mapping of small-molecule binding sites in cells - Nature Chemical Biology
A chemoproteomic workflow was developed to determine the interaction sites of photoaffinity probes in cells, enabling the identification of diverse binding pockets and providing evidence of their trac...
www.nature.com
March 30, 2025 at 10:19 AM
Excited for @chrisgparker.bsky.social ‘s talk about Photoaffinity-based Chemical Proteomics! ⚡️
His group’s work to simplify the identification of the labelling site of diazirine-based probes using predictive models is very cool, amongst other recent PAL developments
www.nature.com/articles/s41...
His group’s work to simplify the identification of the labelling site of diazirine-based probes using predictive models is very cool, amongst other recent PAL developments
www.nature.com/articles/s41...
Next up we’ll have a talk from @stephanhacker2.bsky.social about identifying electrophiles to target amino acids beyond cysteine, including the first probes to globally monitor tryptophans, histidines and arginines ✨
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Profiling the proteome-wide selectivity of diverse electrophiles
Targeted covalent inhibitors are powerful entities in drug discovery, but their application has so far mainly been limited to addressing cysteine residues. The development of cysteine-directed covalen...
chemrxiv.org
March 30, 2025 at 10:10 AM
Next up we’ll have a talk from @stephanhacker2.bsky.social about identifying electrophiles to target amino acids beyond cysteine, including the first probes to globally monitor tryptophans, histidines and arginines ✨
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
First keynote speaker is Emily Balskus, whose lab focus on developing chemical modulators of the human microbiome, such as small molecule urease inhibitors to prevent liver injury.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
A Small-Molecule Inhibitor of Gut Bacterial Urease Protects the Host from Liver Injury
Hyperammonemia is characterized by the accumulation of ammonia within the bloodstream upon liver injury. Left untreated, hyperammonemia contributes to conditions such as hepatic encephalopathy that ha...
pubs.acs.org
March 30, 2025 at 10:05 AM
First keynote speaker is Emily Balskus, whose lab focus on developing chemical modulators of the human microbiome, such as small molecule urease inhibitors to prevent liver injury.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...