Unterholzner Lab
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unterholznerlab.bsky.social
Unterholzner Lab
@unterholznerlab.bsky.social
92 followers 180 following 2 posts
Our group at @BLSLancasterUni investigates how the innate immune system detects infection and injury. We like DNA sensing, host-pathogen interactions and cancer immunology.
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blslancasteruni.bsky.social
Congratulations to BLS Lecturer Dr Amy Saunders who has co-authored research featured on the front cover of this week's issue of #ScienceSignaling!

Dr Saunders' research has updated our understanding of how glycans help immune cells move into skin in psoriasis.

www.science.org/doi/10.1126/...
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.
www.science.org
November 6, 2025 at 3:40 PM
Reposted by Unterholzner Lab
lancasteruni.bsky.social
Congratulations to Prof Alona Armstrong of Lancaster Environment Centre for being named on The ENDS Report's Power List 2025, which spotlights the environmental professionals who have made the greatest impact in the past two years 🌍💡

@alona-armstrong.bsky.social | @endsreport.com
Power List 2025: The academics shaping the science on environmental issues
ENDS Report's Power List spotlights the environmental professionals who have made the greatest impact in the past two years. Here, we meet those working in science, research and development who are co...
https://www.endsreport.com/article/1917287/power-list-2025-academics-shaping-science-environmental-issues]
May 22, 2025 at 3:03 PM
Reposted by Unterholzner Lab
gunnarns.bsky.social
Closing on soon - you have until the 14th to apply for our interdisciplinary PhD studentship - develop new cell-based infection models & AI analysis to study infections and discover antimicrobials. Link below.
April 12, 2025 at 5:00 PM
Reposted by Unterholzner Lab
natsmb.nature.com
New online: Transcription stress causes an inflammatory response via release of IL-1α
Transcription stress causes an inflammatory response via release of IL-1α
Nature Structural & Molecular Biology, Published online: 11 April 2025; doi:10.1038/s41594-025-01525-5DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.
go.nature.com
April 11, 2025 at 11:53 AM
unterholznerlab.bsky.social
We have written a News&Views piece in @natsmb.nature.com on a recent paper by @buissonlab.bsky.social. Their work adds transcription stress to the landscape of danger signals detected by the innate immune system.
Link for free access here: rdcu.be/ehkTV
April 11, 2025 at 1:35 PM
Reposted by Unterholzner Lab
buissonlab.bsky.social
Today @naturesmb.bsky.social 🥳, we report that the activation of NF-κB after DNA damage can occur through two distinct mechanisms. While ATM triggers NF-κB activation after DSBs, we found that IRAK1 specifically induces NF-κB in response to DNA damage causing transcriptional stress.
ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage - Nature Structural & Molecular Biology
In this study, the authors show that DNA-damage-mediated transcriptional stress induces NF-κB through IRAK1, allowing damaged cells with impaired transcription to initiate an inflammatory response wit...
www.nature.com
January 6, 2025 at 3:17 PM
unterholznerlab.bsky.social
Pre-print alert! Together with @stapleslab.bsky.social and @cejkalab.bsky.social we find that IFI16 binds to stalled replication forks where it acts as innate immune sensor for replication stress, and protects the nascent DNA from degradation. 👇👇
April 10, 2025 at 7:23 AM